Monolithically Integrated μLEDs on Silicon Neural Probes for High-Resolution Optogenetic Studies in Behaving Animals
We report a scalable method to monolithically integrate microscopic light emitting diodes (μLEDs) and recording sites onto silicon neural probes for optogenetic applications in neuroscience. Each μLED and recording site has dimensions similar to a pyramidal neuron soma, providing confined emission a...
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| Vydáno v: | Neuron (Cambridge, Mass.) Ročník 88; číslo 6; s. 1136 - 1148 |
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| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
16.12.2015
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| ISSN: | 1097-4199 |
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| Abstract | We report a scalable method to monolithically integrate microscopic light emitting diodes (μLEDs) and recording sites onto silicon neural probes for optogenetic applications in neuroscience. Each μLED and recording site has dimensions similar to a pyramidal neuron soma, providing confined emission and electrophysiological recording of action potentials and local field activity. We fabricated and implanted the four-shank probes, each integrated with 12 μLEDs and 32 recording sites, into the CA1 pyramidal layer of anesthetized and freely moving mice. Spikes were robustly induced by 60 nW light power, and fast population oscillations were induced at the microwatt range. To demonstrate the spatiotemporal precision of parallel stimulation and recording, we achieved independent control of distinct cells ∼ 50 μm apart and of differential somato-dendritic compartments of single neurons. The scalability and spatiotemporal resolution of this monolithic optogenetic tool provides versatility and precision for cellular-level circuit analysis in deep structures of intact, freely moving animals. |
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| AbstractList | We report a scalable method to monolithically integrate microscopic light emitting diodes (μLEDs) and recording sites onto silicon neural probes for optogenetic applications in neuroscience. Each μLED and recording site has dimensions similar to a pyramidal neuron soma, providing confined emission and electrophysiological recording of action potentials and local field activity. We fabricated and implanted the four-shank probes, each integrated with 12 μLEDs and 32 recording sites, into the CA1 pyramidal layer of anesthetized and freely moving mice. Spikes were robustly induced by 60 nW light power, and fast population oscillations were induced at the microwatt range. To demonstrate the spatiotemporal precision of parallel stimulation and recording, we achieved independent control of distinct cells ∼ 50 μm apart and of differential somato-dendritic compartments of single neurons. The scalability and spatiotemporal resolution of this monolithic optogenetic tool provides versatility and precision for cellular-level circuit analysis in deep structures of intact, freely moving animals. |
| Author | Buzsáki, György Wu, Fan Ku, Pei-Cheng Wise, Kensall D Stark, Eran Yoon, Euisik |
| Author_xml | – sequence: 1 givenname: Fan surname: Wu fullname: Wu, Fan organization: Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA – sequence: 2 givenname: Eran surname: Stark fullname: Stark, Eran organization: NYU Neuroscience Institute, East River Science Park, Alexandria Center, 450 East 29th Street, 9th Floor, New York, NY 10016, USA; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, 69978 Tel Aviv, Israel – sequence: 3 givenname: Pei-Cheng surname: Ku fullname: Ku, Pei-Cheng organization: Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA – sequence: 4 givenname: Kensall D surname: Wise fullname: Wise, Kensall D organization: Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA – sequence: 5 givenname: György surname: Buzsáki fullname: Buzsáki, György email: gyorgy.buzsaki@nyumc.org organization: NYU Neuroscience Institute, East River Science Park, Alexandria Center, 450 East 29th Street, 9th Floor, New York, NY 10016, USA. Electronic address: gyorgy.buzsaki@nyumc.org – sequence: 6 givenname: Euisik surname: Yoon fullname: Yoon, Euisik email: esyoon@umich.edu organization: Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA. Electronic address: esyoon@umich.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26627311$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Behavior, Animal - physiology Male Mice Mice, Inbred C57BL Mice, Transgenic Neurons - physiology Optogenetics - instrumentation Optogenetics - methods Photic Stimulation - methods Silicon |
| Title | Monolithically Integrated μLEDs on Silicon Neural Probes for High-Resolution Optogenetic Studies in Behaving Animals |
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