Monolithically Integrated μLEDs on Silicon Neural Probes for High-Resolution Optogenetic Studies in Behaving Animals
We report a scalable method to monolithically integrate microscopic light emitting diodes (μLEDs) and recording sites onto silicon neural probes for optogenetic applications in neuroscience. Each μLED and recording site has dimensions similar to a pyramidal neuron soma, providing confined emission a...
Saved in:
| Published in: | Neuron (Cambridge, Mass.) Vol. 88; no. 6; pp. 1136 - 1148 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
16.12.2015
|
| Subjects: | |
| ISSN: | 1097-4199 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | We report a scalable method to monolithically integrate microscopic light emitting diodes (μLEDs) and recording sites onto silicon neural probes for optogenetic applications in neuroscience. Each μLED and recording site has dimensions similar to a pyramidal neuron soma, providing confined emission and electrophysiological recording of action potentials and local field activity. We fabricated and implanted the four-shank probes, each integrated with 12 μLEDs and 32 recording sites, into the CA1 pyramidal layer of anesthetized and freely moving mice. Spikes were robustly induced by 60 nW light power, and fast population oscillations were induced at the microwatt range. To demonstrate the spatiotemporal precision of parallel stimulation and recording, we achieved independent control of distinct cells ∼ 50 μm apart and of differential somato-dendritic compartments of single neurons. The scalability and spatiotemporal resolution of this monolithic optogenetic tool provides versatility and precision for cellular-level circuit analysis in deep structures of intact, freely moving animals. |
|---|---|
| AbstractList | We report a scalable method to monolithically integrate microscopic light emitting diodes (μLEDs) and recording sites onto silicon neural probes for optogenetic applications in neuroscience. Each μLED and recording site has dimensions similar to a pyramidal neuron soma, providing confined emission and electrophysiological recording of action potentials and local field activity. We fabricated and implanted the four-shank probes, each integrated with 12 μLEDs and 32 recording sites, into the CA1 pyramidal layer of anesthetized and freely moving mice. Spikes were robustly induced by 60 nW light power, and fast population oscillations were induced at the microwatt range. To demonstrate the spatiotemporal precision of parallel stimulation and recording, we achieved independent control of distinct cells ∼ 50 μm apart and of differential somato-dendritic compartments of single neurons. The scalability and spatiotemporal resolution of this monolithic optogenetic tool provides versatility and precision for cellular-level circuit analysis in deep structures of intact, freely moving animals. |
| Author | Buzsáki, György Wu, Fan Ku, Pei-Cheng Wise, Kensall D Stark, Eran Yoon, Euisik |
| Author_xml | – sequence: 1 givenname: Fan surname: Wu fullname: Wu, Fan organization: Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA – sequence: 2 givenname: Eran surname: Stark fullname: Stark, Eran organization: NYU Neuroscience Institute, East River Science Park, Alexandria Center, 450 East 29th Street, 9th Floor, New York, NY 10016, USA; Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel; Sagol School of Neuroscience, Tel Aviv University, 69978 Tel Aviv, Israel – sequence: 3 givenname: Pei-Cheng surname: Ku fullname: Ku, Pei-Cheng organization: Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA – sequence: 4 givenname: Kensall D surname: Wise fullname: Wise, Kensall D organization: Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA – sequence: 5 givenname: György surname: Buzsáki fullname: Buzsáki, György email: gyorgy.buzsaki@nyumc.org organization: NYU Neuroscience Institute, East River Science Park, Alexandria Center, 450 East 29th Street, 9th Floor, New York, NY 10016, USA. Electronic address: gyorgy.buzsaki@nyumc.org – sequence: 6 givenname: Euisik surname: Yoon fullname: Yoon, Euisik email: esyoon@umich.edu organization: Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA. Electronic address: esyoon@umich.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26627311$$D View this record in MEDLINE/PubMed |
| BookMark | eNo1kM1KAzEUhYMoVqtvIJKlm6lzk8y0WfpTrVCt-LMeMpk7bSRN6iQj9N18Bp_JgHX1weHj3sM5JvvOOyTkDPIR5FBefowc9p13I5ZDkaJRztkeOYJcjjMBUg7IcQgfeQ6ikHBIBqws2ZgDHJH-0TtvTVwZrazd0gcXcdmpiA39-Z5PbwP1jr4aa3TiU3qiLH3ufI2Btr6jM7NcZS8YvO2jScZiE_0SHUaj6WvsG5M84-g1rtSXcUt65cxa2XBCDtoEPN1xSN7vpm83s2y-uH-4uZpnWpQ8ZtBM8qZEwWRbt-2E10wpUDW0dSll2RTNRHAtOddaADbA63FKBHIsJWrVajYkF393N53_7DHEam2CRmuVQ9-HCsYFgBRCsKSe79S-XmNTbbrUtNtW_1OxX8aQcA0 |
| CitedBy_id | crossref_primary_10_1002_adfm_201704335 crossref_primary_10_1039_D2QM01319C crossref_primary_10_1007_s10544_017_0190_3 crossref_primary_10_1038_s41551_020_0516_y crossref_primary_10_1117_1_NPh_11_S1_S11512 crossref_primary_10_1109_TBME_2020_3001242 crossref_primary_10_1016_j_neuron_2017_09_033 crossref_primary_10_1088_1741_2552_aba41f crossref_primary_10_1016_j_cap_2024_08_002 crossref_primary_10_1088_1741_2552_acd870 crossref_primary_10_1109_ACCESS_2020_3007517 crossref_primary_10_1063_5_0125103 crossref_primary_10_3390_mi16090983 crossref_primary_10_1016_j_pbiomolbio_2019_11_004 crossref_primary_10_1088_1741_2552_aadbb2 crossref_primary_10_1126_science_adv5638 crossref_primary_10_1002_smll_202302241 crossref_primary_10_1002_adfm_202000896 crossref_primary_10_7554_eLife_71720 crossref_primary_10_1038_s41583_019_0140_6 crossref_primary_10_1002_sdtp_16546 crossref_primary_10_1088_1741_2552_aabc94 crossref_primary_10_1016_j_snb_2016_12_096 crossref_primary_10_1038_s41551_021_00683_3 crossref_primary_10_1088_1361_6439_abeb30 crossref_primary_10_1038_s41467_020_15840_6 crossref_primary_10_1109_TBCAS_2018_2852267 crossref_primary_10_1088_1361_6439_ab2a53 crossref_primary_10_1016_j_neuron_2020_09_043 crossref_primary_10_1016_j_neuron_2018_11_002 crossref_primary_10_1038_s41378_022_00451_6 crossref_primary_10_1002_adom_202302044 crossref_primary_10_1049_el_2019_0300 crossref_primary_10_1016_j_bios_2021_113473 crossref_primary_10_3389_fnins_2024_1387098 crossref_primary_10_1002_aisy_202000091 crossref_primary_10_1002_admt_202400044 crossref_primary_10_1016_j_neuron_2016_12_031 crossref_primary_10_1038_s44222_025_00289_3 crossref_primary_10_1002_adom_201701118 crossref_primary_10_1002_admt_202100225 crossref_primary_10_1007_s12264_018_0319_2 crossref_primary_10_1021_acsomega_5c01419 crossref_primary_10_1038_s41378_021_00263_0 crossref_primary_10_1126_sciadv_ads8608 crossref_primary_10_1016_j_jneumeth_2019_108397 crossref_primary_10_3389_fncir_2023_1293620 crossref_primary_10_1016_j_jlumin_2024_120951 crossref_primary_10_3390_s22239085 crossref_primary_10_1016_j_ijleo_2020_166098 crossref_primary_10_1016_j_copbio_2021_09_005 crossref_primary_10_3389_fnins_2023_1213265 crossref_primary_10_1093_nsr_nwac007 crossref_primary_10_1038_s41467_023_36217_5 crossref_primary_10_1109_TCSI_2018_2792219 crossref_primary_10_1016_j_sna_2018_11_029 crossref_primary_10_1002_adma_202303267 crossref_primary_10_1002_cphc_201701180 crossref_primary_10_1088_1741_2552_ad69c3 crossref_primary_10_1007_s40820_022_00818_4 crossref_primary_10_1016_j_conb_2017_12_007 crossref_primary_10_1038_s41563_022_01272_8 crossref_primary_10_3389_fnins_2016_00252 crossref_primary_10_1109_JSEN_2023_3257921 crossref_primary_10_1126_science_abm1891 crossref_primary_10_1016_j_copbio_2021_11_001 crossref_primary_10_1002_pssa_202300834 crossref_primary_10_1038_s43586_025_00399_7 crossref_primary_10_1016_j_tins_2022_09_002 crossref_primary_10_1557_s43577_023_00535_2 crossref_primary_10_1021_acsnano_5c04148 crossref_primary_10_1038_s41467_020_19946_9 crossref_primary_10_1088_1361_6439_aa6ad4 crossref_primary_10_3389_fnins_2019_00745 crossref_primary_10_1063_1_5145201 crossref_primary_10_1109_LED_2025_3571115 crossref_primary_10_1371_journal_pbio_3001213 crossref_primary_10_1109_TBCAS_2020_2966920 crossref_primary_10_1002_adom_202300112 crossref_primary_10_3390_s16060880 crossref_primary_10_1002_adfm_201910027 crossref_primary_10_1002_adma_202504372 crossref_primary_10_1109_TBCAS_2021_3068556 crossref_primary_10_1038_ncomms14563 crossref_primary_10_1002_adfm_201909165 crossref_primary_10_1097_j_pain_0000000000000620 crossref_primary_10_3389_fnins_2018_00771 crossref_primary_10_1016_j_neuron_2020_10_011 crossref_primary_10_1109_JSEN_2018_2791802 crossref_primary_10_1117_1_JMM_17_2_025503 crossref_primary_10_1002_adma_202300578 crossref_primary_10_3390_mi13111836 crossref_primary_10_1038_s41467_020_18472_y crossref_primary_10_2217_bem_2019_0023 crossref_primary_10_1088_1361_6528_abef2a crossref_primary_10_1016_j_mattod_2019_11_006 crossref_primary_10_1088_1741_2552_aa60b3 crossref_primary_10_1038_s41467_021_26168_0 crossref_primary_10_1038_s41467_022_28629_6 crossref_primary_10_1038_s41566_023_01335_5 crossref_primary_10_3389_fnins_2018_00764 crossref_primary_10_1038_s41596_024_01105_9 crossref_primary_10_1002_adfm_201701269 crossref_primary_10_1523_JNEUROSCI_2020_20_2020 crossref_primary_10_1109_TBCAS_2021_3138334 crossref_primary_10_3390_s20164526 crossref_primary_10_1002_sdtp_16214 crossref_primary_10_3389_fnins_2019_00082 crossref_primary_10_1063_1_5096322 crossref_primary_10_1016_j_jneumeth_2019_108355 crossref_primary_10_1038_s41378_018_0009_2 crossref_primary_10_1007_s11426_022_1408_5 crossref_primary_10_1109_LED_2021_3130750 crossref_primary_10_3389_fnano_2021_758484 crossref_primary_10_1002_aisy_202300527 crossref_primary_10_1038_s44328_025_00024_3 crossref_primary_10_1002_aisy_202000228 crossref_primary_10_1016_j_isci_2021_103612 crossref_primary_10_1038_s41928_023_01013_y crossref_primary_10_1088_1741_2552_aa7004 crossref_primary_10_1007_s00422_025_01021_5 crossref_primary_10_1007_s12195_024_00832_z crossref_primary_10_1002_admt_202201716 crossref_primary_10_1002_advs_202001410 crossref_primary_10_1038_srep28381 crossref_primary_10_3390_cryst14030241 crossref_primary_10_1364_OE_565203 crossref_primary_10_1038_s44222_024_00184_3 crossref_primary_10_1002_admt_202000322 crossref_primary_10_1038_s41378_020_0153_3 crossref_primary_10_3390_coatings11020204 crossref_primary_10_1109_TBCAS_2021_3139891 crossref_primary_10_1063_1_4978554 crossref_primary_10_3389_fnins_2018_00659 crossref_primary_10_1063_5_0123409 crossref_primary_10_1088_1361_6439_ab003d crossref_primary_10_3389_fnana_2021_746057 crossref_primary_10_3390_ijms18081751 crossref_primary_10_1002_adhm_202300430 crossref_primary_10_1016_j_addr_2022_114399 crossref_primary_10_1038_s41596_023_00824_9 crossref_primary_10_1016_j_mee_2019_110979 crossref_primary_10_1002_lpor_202000133 crossref_primary_10_1002_adma_201800156 crossref_primary_10_1038_natrevmats_2016_93 crossref_primary_10_1016_j_biomaterials_2020_120559 crossref_primary_10_1016_j_coph_2022_102195 crossref_primary_10_1109_JPHOT_2020_3039015 crossref_primary_10_1007_s12274_018_2127_4 crossref_primary_10_1038_s41596_022_00758_8 crossref_primary_10_3390_mi12091061 crossref_primary_10_1016_j_celrep_2024_113910 crossref_primary_10_1021_acschemneuro_4c00602 crossref_primary_10_1109_TBME_2020_2966293 crossref_primary_10_1117_1_NPh_6_3_035010 crossref_primary_10_3390_mi13020199 crossref_primary_10_1038_s41596_021_00672_5 crossref_primary_10_1016_j_crmeth_2022_100208 crossref_primary_10_1371_journal_pcbi_1013097 crossref_primary_10_3389_fnins_2020_00036 crossref_primary_10_1109_LPT_2020_2977376 crossref_primary_10_1016_j_matlet_2020_129015 crossref_primary_10_1002_adem_202400499 crossref_primary_10_1016_j_neuron_2021_01_011 crossref_primary_10_1116_6_0001122 crossref_primary_10_1002_adma_201903904 crossref_primary_10_1038_s41467_024_53665_9 crossref_primary_10_1152_jn_00116_2016 crossref_primary_10_1016_j_device_2023_100245 crossref_primary_10_1109_JSSC_2019_2941529 crossref_primary_10_1016_j_jneumeth_2019_108324 crossref_primary_10_1038_s41378_021_00295_6 crossref_primary_10_1073_pnas_1902284116 crossref_primary_10_1073_pnas_1914387116 crossref_primary_10_1039_D5MH00742A crossref_primary_10_1088_1741_2552_abdd11 crossref_primary_10_1088_2058_8585_aca779 crossref_primary_10_1109_LPT_2023_3314060 crossref_primary_10_1002_wnan_1827 crossref_primary_10_1152_jn_00352_2020 crossref_primary_10_3390_photonics8060220 crossref_primary_10_1038_s41598_018_22790_z crossref_primary_10_1002_adfm_202311436 crossref_primary_10_1002_admt_202200692 crossref_primary_10_1002_hipo_22803 crossref_primary_10_1109_MSSC_2019_2939337 crossref_primary_10_1038_s41592_019_0400_4 crossref_primary_10_1088_1361_6528_ac62b1 crossref_primary_10_1109_LED_2021_3051617 crossref_primary_10_1109_TBME_2016_2609412 crossref_primary_10_1007_s00441_017_2732_7 crossref_primary_10_1002_advs_202105414 crossref_primary_10_1109_JQE_2019_2900540 crossref_primary_10_1088_1741_2552_ab581a crossref_primary_10_3390_mi7100179 crossref_primary_10_1016_j_sna_2021_112948 crossref_primary_10_1016_j_neuron_2018_09_020 crossref_primary_10_1088_1674_1056_aca9c2 crossref_primary_10_1016_j_jmapro_2024_07_100 crossref_primary_10_1038_s41467_020_15769_w crossref_primary_10_1002_jbio_201700358 crossref_primary_10_1016_j_conb_2018_01_010 crossref_primary_10_1088_1741_2552_aaa56d crossref_primary_10_1007_s12551_022_00943_9 crossref_primary_10_1002_adfm_202403562 crossref_primary_10_1038_s41467_024_55298_4 crossref_primary_10_1038_srep31117 crossref_primary_10_3390_mi9090473 crossref_primary_10_1007_s00424_020_02387_0 crossref_primary_10_1002_adma_201907478 crossref_primary_10_1016_j_cub_2023_03_032 crossref_primary_10_1002_sdtp_16130 crossref_primary_10_3389_fncir_2016_00099 crossref_primary_10_1038_s41587_023_01833_5 crossref_primary_10_1038_nprot_2016_155 crossref_primary_10_1038_s41467_022_28539_7 crossref_primary_10_1016_j_conb_2018_01_009 crossref_primary_10_1016_j_conb_2018_01_004 crossref_primary_10_3390_photonics6030092 crossref_primary_10_1007_s12274_021_3476_y crossref_primary_10_1038_s41467_018_04457_5 crossref_primary_10_1038_s44172_024_00328_8 crossref_primary_10_3389_fnins_2018_00132 crossref_primary_10_1016_j_bios_2019_111661 crossref_primary_10_1364_AO_56_003654 crossref_primary_10_1186_s11671_021_03576_1 crossref_primary_10_1016_j_mee_2018_03_023 crossref_primary_10_1152_jn_00888_2017 crossref_primary_10_1016_j_bios_2025_117942 crossref_primary_10_1038_s41587_019_0198_8 crossref_primary_10_1038_srep30961 crossref_primary_10_1002_advs_202103564 crossref_primary_10_1002_admt_202400797 crossref_primary_10_1088_1741_2552_ac3206 crossref_primary_10_1016_j_addr_2022_114339 crossref_primary_10_1109_JPHOT_2020_2977401 crossref_primary_10_1109_JSSC_2017_2764053 crossref_primary_10_1002_lpor_202301125 crossref_primary_10_1038_s41593_020_00739_8 crossref_primary_10_1016_j_bios_2020_112009 crossref_primary_10_1038_micronano_2016_66 crossref_primary_10_1002_adfm_202002644 crossref_primary_10_1631_jzus_B2300337 crossref_primary_10_3390_bios13020280 crossref_primary_10_1002_adma_201903488 crossref_primary_10_1002_adom_202101649 crossref_primary_10_1063_5_0115879 crossref_primary_10_1109_TBCAS_2018_2818818 crossref_primary_10_3389_fnins_2023_1275908 crossref_primary_10_7554_eLife_65859 crossref_primary_10_1109_TBME_2018_2882146 crossref_primary_10_1002_adom_202202184 crossref_primary_10_3390_s19051069 crossref_primary_10_1002_adfm_202420758 crossref_primary_10_1088_1741_2552_ad5762 crossref_primary_10_1016_j_cell_2020_02_054 crossref_primary_10_1109_JMEMS_2018_2868229 crossref_primary_10_1049_ote2_12061 crossref_primary_10_1002_adsr_202400142 crossref_primary_10_1088_1741_2552_abe805 crossref_primary_10_3390_ijms222111528 crossref_primary_10_1038_s41467_020_20763_3 crossref_primary_10_1109_LED_2017_2781247 crossref_primary_10_1007_s10544_025_00754_1 crossref_primary_10_1002_sdtp_15754 crossref_primary_10_1109_JPROC_2016_2577518 crossref_primary_10_1016_j_bios_2023_115503 crossref_primary_10_1038_s41467_019_11628_5 crossref_primary_10_3390_mi10040242 crossref_primary_10_1088_1741_2552_abb89c crossref_primary_10_1088_1741_2552_abb3b2 crossref_primary_10_1016_j_isci_2021_103681 crossref_primary_10_1038_srep22693 |
| ContentType | Journal Article |
| Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2015 Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.neuron.2015.10.032 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Biology |
| EISSN | 1097-4199 |
| EndPage | 1148 |
| ExternalDocumentID | 26627311 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIMH NIH HHS grantid: MH54671 – fundername: NINDS NIH HHS grantid: U01 NS090526 – fundername: NIBIB NIH HHS grantid: R21 EB019221 – fundername: NIBIB NIH HHS grantid: R21EB019221 – fundername: NIMH NIH HHS grantid: R01 MH054671 – fundername: NINDS NIH HHS grantid: NS075015 – fundername: NIMH NIH HHS grantid: R01 MH107396 |
| GroupedDBID | --- --K -DZ -~X 0R~ 0SF 123 1RT 1~5 26- 2WC 3V. 4.4 457 4G. 53G 5RE 62- 6I. 7-5 7RV 7X7 8C1 8FE 8FH AACTN AAEDT AAEDW AAFTH AAKRW AAKUH AALRI AAMRU AAVLU AAXUO ABJNI ABMAC ABVKL ACGFO ACGFS ACIWK ACNCT ACPRK ADBBV ADEZE ADFRT ADVLN AEFWE AENEX AEXQZ AFKRA AFTJW AGHFR AGKMS AHHHB AHMBA AITUG AKAPO AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ AQUVI ASPBG AVWKF AZFZN BAWUL BBNVY BENPR BHPHI BKEYQ BKNYI BPHCQ BVXVI CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P FCP FDB FEDTE FIRID HCIFZ HVGLF IAO IHE IHR INH IXB J1W JIG K-O KQ8 L7B LK8 LX5 M0R M0T M2M M2O M3Z M41 M7P N9A NCXOZ NPM O-L O9- OK1 P2P P6G PQQKQ PROAC RCE RIG ROL RPZ SCP SDP SES SSZ TR2 WOW 7X8 AAFWJ AAYWO ABDGV ACVFH ADCNI AEUPX AFPUW AIGII AKBMS AKYEP APXCP EFKBS |
| ID | FETCH-LOGICAL-c463t-1d80d6e429fbff83b2aa1ab1fb6996d5d843c933cc41ed13b7d844e3e69ecafc2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 364 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000368443900010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| IngestDate | Sun Sep 28 08:29:48 EDT 2025 Thu Jan 02 23:13:19 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 6 |
| Language | English |
| License | Copyright © 2015 Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c463t-1d80d6e429fbff83b2aa1ab1fb6996d5d843c933cc41ed13b7d844e3e69ecafc2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://www.cell.com/article/S0896627315009265/pdf |
| PMID | 26627311 |
| PQID | 1751194442 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | proquest_miscellaneous_1751194442 pubmed_primary_26627311 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-Dec-16 |
| PublicationDateYYYYMMDD | 2015-12-16 |
| PublicationDate_xml | – month: 12 year: 2015 text: 2015-Dec-16 day: 16 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Neuron (Cambridge, Mass.) |
| PublicationTitleAlternate | Neuron |
| PublicationYear | 2015 |
| References | 26189679 - Cell. 2015 Jul 30;162(3):662-74 14615590 - Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13940-5 25402854 - Nat Neurosci. 2014 Dec;17(12):1816-24 8946321 - J Neurosci Methods. 1996 Nov;69(2):175-88 10899214 - J Neurophysiol. 2000 Jul;84(1):401-14 23503284 - Opt Lett. 2013 Mar 15;38(6):992-4 26074778 - Front Neural Circuits. 2015;9:25 17124335 - J Neural Eng. 2006 Dec;3(4):306-15 25033186 - Neuron. 2014 Jul 16;83(2):467-80 21191368 - Nat Methods. 2011 Jan;8(1):26-9 19555647 - Neuron. 2009 Jun 25;62(6):781-7 23580530 - Science. 2013 Apr 12;340(6129):211-6 20303157 - Cell. 2010 Apr 2;141(1):154-65 19829374 - Nature. 2009 Oct 15;461(7266):941-6 23985803 - J Neural Eng. 2013 Oct;10(5):056012 12878710 - J Neurophysiol. 2003 Nov;90(5):3024-39 17375185 - PLoS One. 2007;2(3):e299 22496529 - J Neurophysiol. 2012 Jul;108(1):349-63 19749750 - Nat Neurosci. 2009 Oct;12(10):1222-3 8815302 - J Neurosci Methods. 1996 Mar;65(1):1-17 21822270 - Nat Neurosci. 2011 Sep;14(9):1174-81 16474382 - Nature. 2006 Mar 30;440(7084):680-3 25532138 - Nat Methods. 2015 Feb;12(2):140-6 19167428 - J Neurosci Methods. 2009 Apr 30;179(1):90-100 22138641 - Nat Neurosci. 2012 Jan;15(1):163-70 26240336 - Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10521-6 9492204 - J Comp Neurol. 1998 Feb 16;391(3):335-52 12106490 - Eur J Neurosci. 1991;3(6):587-601 15680687 - Neuroscience. 2005;131(1):1-11 24314731 - Neuron. 2013 Dec 4;80(5):1263-76 25856489 - Neuron. 2015 Apr 8;86(1):92-105 8353611 - Hippocampus. 1993 Jul;3(3):317-30 24836505 - Neuron. 2014 Jun 4;82(5):1129-44 18160630 - J Neurosci. 2007 Dec 26;27(52):14231-8 1589772 - Science. 1992 May 15;256(5059):1025-7 16116447 - Nat Neurosci. 2005 Sep;8(9):1263-8 8646277 - Hippocampus. 1995;5(6):491-8 |
| References_xml | – reference: 14615590 - Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):13940-5 – reference: 24314731 - Neuron. 2013 Dec 4;80(5):1263-76 – reference: 22138641 - Nat Neurosci. 2012 Jan;15(1):163-70 – reference: 19749750 - Nat Neurosci. 2009 Oct;12(10):1222-3 – reference: 23985803 - J Neural Eng. 2013 Oct;10(5):056012 – reference: 20303157 - Cell. 2010 Apr 2;141(1):154-65 – reference: 8815302 - J Neurosci Methods. 1996 Mar;65(1):1-17 – reference: 26240336 - Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10521-6 – reference: 8353611 - Hippocampus. 1993 Jul;3(3):317-30 – reference: 25532138 - Nat Methods. 2015 Feb;12(2):140-6 – reference: 19167428 - J Neurosci Methods. 2009 Apr 30;179(1):90-100 – reference: 9492204 - J Comp Neurol. 1998 Feb 16;391(3):335-52 – reference: 25856489 - Neuron. 2015 Apr 8;86(1):92-105 – reference: 25033186 - Neuron. 2014 Jul 16;83(2):467-80 – reference: 12106490 - Eur J Neurosci. 1991;3(6):587-601 – reference: 17124335 - J Neural Eng. 2006 Dec;3(4):306-15 – reference: 17375185 - PLoS One. 2007;2(3):e299 – reference: 8646277 - Hippocampus. 1995;5(6):491-8 – reference: 12878710 - J Neurophysiol. 2003 Nov;90(5):3024-39 – reference: 8946321 - J Neurosci Methods. 1996 Nov;69(2):175-88 – reference: 10899214 - J Neurophysiol. 2000 Jul;84(1):401-14 – reference: 23503284 - Opt Lett. 2013 Mar 15;38(6):992-4 – reference: 22496529 - J Neurophysiol. 2012 Jul;108(1):349-63 – reference: 15680687 - Neuroscience. 2005;131(1):1-11 – reference: 19555647 - Neuron. 2009 Jun 25;62(6):781-7 – reference: 21822270 - Nat Neurosci. 2011 Sep;14(9):1174-81 – reference: 21191368 - Nat Methods. 2011 Jan;8(1):26-9 – reference: 16116447 - Nat Neurosci. 2005 Sep;8(9):1263-8 – reference: 26074778 - Front Neural Circuits. 2015;9:25 – reference: 1589772 - Science. 1992 May 15;256(5059):1025-7 – reference: 25402854 - Nat Neurosci. 2014 Dec;17(12):1816-24 – reference: 26189679 - Cell. 2015 Jul 30;162(3):662-74 – reference: 19829374 - Nature. 2009 Oct 15;461(7266):941-6 – reference: 23580530 - Science. 2013 Apr 12;340(6129):211-6 – reference: 16474382 - Nature. 2006 Mar 30;440(7084):680-3 – reference: 24836505 - Neuron. 2014 Jun 4;82(5):1129-44 – reference: 18160630 - J Neurosci. 2007 Dec 26;27(52):14231-8 |
| SSID | ssj0014591 |
| Score | 2.633317 |
| Snippet | We report a scalable method to monolithically integrate microscopic light emitting diodes (μLEDs) and recording sites onto silicon neural probes for... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1136 |
| SubjectTerms | Animals Behavior, Animal - physiology Male Mice Mice, Inbred C57BL Mice, Transgenic Neurons - physiology Optogenetics - instrumentation Optogenetics - methods Photic Stimulation - methods Silicon |
| Title | Monolithically Integrated μLEDs on Silicon Neural Probes for High-Resolution Optogenetic Studies in Behaving Animals |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/26627311 https://www.proquest.com/docview/1751194442 |
| Volume | 88 |
| WOSCitedRecordID | wos000368443900010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1ba9RAFB60q9AXrV21q1amIL6Ndq5JnmTRFoV2XajCvi2TuZTAdrJttsL-t_6G_ibPSbLskyD0JQ-BkGTy5VzmfOc7hHzwhpcxC54JqyPDCJwVLgaWF0J4nUXrdDdsIptM8tmsmPYbbk1Pq9zYxNZQ-9rhHvlncHMcEm6lxJflNcOpUVhd7UdoPCYDCaEMUrqy2baKoHTBN-1yLaer1YhE1VOuPyGnC4eO_CuwbB3M6fOHPtoeedaHlnTcYeEFeRTSPhmOE6TVV2v6kbZkz3YXfZ887WZQrofkFv5q5MAhJWOxWNMfG_0IT-_vzk6-NbRO9KJaAGISRSkPuMUUe4gaCvEuRZ4IwxpAh2D6c7mqAZPYGkl7jiKtEu1kGNMlHafqChD_kvw-Pfn19TvrZzEwp4xcMe7zY28CeK9YxpjLUljLbcljaSBj8trnSrpCSucUD57LMoMzKshgiuBsdOIV2Ul1CgeEhgg2RKBpEVZp7a0yIZjItS-L4I_NiBxtlnkOWMcChk2hvm3m24Uekdfdt5ovO1GOuUAle8n5m_-4-i3ZRQggK4Wbd2QQ4b3DIXni_qyq5uZ9CyI4TqbnfwGk5NbZ |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Monolithically+Integrated+%CE%BCLEDs+on+Silicon+Neural+Probes+for+High-Resolution+Optogenetic+Studies+in+Behaving+Animals&rft.jtitle=Neuron+%28Cambridge%2C+Mass.%29&rft.au=Wu%2C+Fan&rft.au=Stark%2C+Eran&rft.au=Ku%2C+Pei-Cheng&rft.au=Wise%2C+Kensall+D&rft.date=2015-12-16&rft.eissn=1097-4199&rft.volume=88&rft.issue=6&rft.spage=1136&rft.epage=1148&rft_id=info:doi/10.1016%2Fj.neuron.2015.10.032&rft.externalDBID=NO_FULL_TEXT |