TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier dysfunction and subepithelial fibrosis. A fun...

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Bibliographic Details
Published in:	Mucosal immunology Vol. 13; no. 1; pp. 110 - 117
Main Authors:	Duong, L.D., Rawson, R., Bezryadina, A., Manresa, M.C., Newbury, R.O., Dohil, R., Liu, Z., Barrett, K., Kurten, R., Aceves, S.S.
Format:	Journal Article
Language:	English
Published:	New York Elsevier Inc 01.01.2020 Nature Publishing Group US Elsevier Limited
Subjects:	Allergology Antibodies Autoimmune diseases Biomedical and Life Sciences Biomedicine Biopsy Cell Adhesion Cells, Cultured Child Collagen Contractility Dysphagia E-cadherin Eosinophilic Esophagitis - genetics Eosinophilic Esophagitis - immunology Epithelial cells Epithelial Cells - physiology Esophageal diseases Esophagitis Esophagus Female Fibroblasts Fibroblasts - physiology Fibrosis Gastroenterology Gastrointestinal diseases Gelatinase A Gene expression Gene polymorphism Genetic Association Studies Genotype Genotype & phenotype Humans Immunology Inflammation Intestinal Mucosa - immunology Intestinal Mucosa - pathology Leukocytes (eosinophilic) Localization Lymphocytes T Male Mucosa Polymorphism, Single Nucleotide Single-nucleotide polymorphism Spheroids Stricture Transcription Transforming Growth Factor beta1 - genetics Transforming growth factor-b1
ISSN:	1933-0219, 1935-3456, 1935-3456
Online Access:	Get full text
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