TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier dysfunction and subepithelial fibrosis. A fun...

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Vydané v:Mucosal immunology Ročník 13; číslo 1; s. 110 - 117
Hlavní autori: Duong, L.D., Rawson, R., Bezryadina, A., Manresa, M.C., Newbury, R.O., Dohil, R., Liu, Z., Barrett, K., Kurten, R., Aceves, S.S.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York Elsevier Inc 01.01.2020
Nature Publishing Group US
Elsevier Limited
Predmet:
Allergology
Antibodies
Autoimmune diseases
Biomedical and Life Sciences
Biomedicine
Biopsy
Cell Adhesion
Cells, Cultured
Child
Collagen
Contractility
Dysphagia
E-cadherin
Eosinophilic Esophagitis - genetics
Eosinophilic Esophagitis - immunology
Epithelial cells
Epithelial Cells - physiology
Esophageal diseases
Esophagitis
Esophagus
Female
Fibroblasts
Fibroblasts - physiology
Fibrosis
Gastroenterology
Gastrointestinal diseases
Gelatinase A
Gene expression
Gene polymorphism
Genetic Association Studies
Genotype
Genotype & phenotype
Humans
Immunology
Inflammation
Intestinal Mucosa - immunology
Intestinal Mucosa - pathology
Leukocytes (eosinophilic)
Localization
Lymphocytes T
Male
Mucosa
Polymorphism, Single Nucleotide
Single-nucleotide polymorphism
Spheroids
Stricture
Transcription
Transforming Growth Factor beta1 - genetics
Transforming growth factor-b1
ISSN:1933-0219, 1935-3456, 1935-3456
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Abstract Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier dysfunction and subepithelial fibrosis. A functional SNP in the TGFβ1 gene that increases its transcription (C-509T) is associated with elevated numbers of esophageal TGFβ1-expressing cells. We utilized esophageal biopsies and fibroblasts from TT-genotype EoE children to understand if TGFβ1 influenced fibroblast and epithelial cell function in vivo. Genotype TT EoE esophageal fibroblasts had higher baseline TGFβ1, collagen1α1, periostin, and MMP2 (p < 0.05) gene expression and distinct contractile properties compared with CC genotype (n = 6 subjects per genotype). In vitro TGFβ1 exposure caused greater induction of target gene expression in genotype CC fibroblasts (p < 0.05). Esophageal biopsies from TT-genotype subjects had significantly less epithelial membrane-bound E-cadherin (p < 0.01) and wider cluster distribution at nanometer resolution. TGFβ1 treatment of stratified primary human esophageal epithelial cells and spheroids disrupted transepithelial resistance (p < 0.001) and E-cadherin localization (p < 0.0001). A TGFβ1-receptor-I inhibitor improved TGFβ1-mediated E-cadherin mislocalization. These data suggest that EoE severity can depend on genotypic differences that increase in vivo exposure to TGFβ1. TGFβ1 inhibition may be a useful therapy in subsets of EoE patients.
AbstractList Eosinophilic esophagitis (EoE) is a chronic Th2 antigen driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier dysfunction and subepithelial fibrosis. A functional SNP in the TGFβ1 gene that increases its transcription (C-509T) associates with elevated numbers of esophageal TGFβ1 expressing cells. We utilized esophageal biopsies and fibroblasts from TT genotype EoE children to understand if TGFβ1 influenced fibroblast and epithelial cell function in vivo. Genotype TT EoE esophageal fibroblasts had higher baseline TGFβ1, collagen1α1, periostin, and MMP-2 (p<.05) gene expression and distinct contractile properties compared with CC genotype (n=6 subjects per genotype). In vitro TGFβ1 exposure caused greater induction of target gene expression in genotype CC fibroblasts (p<.05). Esophageal biopsies from TT genotype subjects had significantly less epithelial membrane bound E-cadherin (p<.01) and wider cluster distribution at nanometer resolution. TGFβ1 treatment of stratified primary human esophageal epithelial cells and spheroids disrupted transepithelial resistance (p<.001) and E-cadherin localization (p<.0001). A TGFβ1-receptor-I inhibitor improved TGFβ1-mediated E-cadherin mislocalization. These data suggest that EoE severity can depend on genotypic differences that increase in vivo exposure to TGFβ1. TGFβ1 inhibition may be a useful therapy in subsets of EoE patients.
Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier dysfunction and subepithelial fibrosis. A functional SNP in the TGFβ1 gene that increases its transcription (C-509T) is associated with elevated numbers of esophageal TGFβ1-expressing cells. We utilized esophageal biopsies and fibroblasts from TT-genotype EoE children to understand if TGFβ1 influenced fibroblast and epithelial cell function in vivo. Genotype TT EoE esophageal fibroblasts had higher baseline TGFβ1, collagen1α1, periostin, and MMP2 (p < 0.05) gene expression and distinct contractile properties compared with CC genotype (n = 6 subjects per genotype). In vitro TGFβ1 exposure caused greater induction of target gene expression in genotype CC fibroblasts (p < 0.05). Esophageal biopsies from TT-genotype subjects had significantly less epithelial membrane-bound E-cadherin (p < 0.01) and wider cluster distribution at nanometer resolution. TGFβ1 treatment of stratified primary human esophageal epithelial cells and spheroids disrupted transepithelial resistance (p < 0.001) and E-cadherin localization (p < 0.0001). A TGFβ1-receptor-I inhibitor improved TGFβ1-mediated E-cadherin mislocalization. These data suggest that EoE severity can depend on genotypic differences that increase in vivo exposure to TGFβ1. TGFβ1 inhibition may be a useful therapy in subsets of EoE patients.
Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier dysfunction and subepithelial fibrosis. A functional SNP in the TGFβ1 gene that increases its transcription (C-509T) is associated with elevated numbers of esophageal TGFβ1-expressing cells. We utilized esophageal biopsies and fibroblasts from TT-genotype EoE children to understand if TGFβ1 influenced fibroblast and epithelial cell function in vivo. Genotype TT EoE esophageal fibroblasts had higher baseline TGFβ1, collagen1α1, periostin, and MMP2 (p < 0.05) gene expression and distinct contractile properties compared with CC genotype (n = 6 subjects per genotype). In vitro TGFβ1 exposure caused greater induction of target gene expression in genotype CC fibroblasts (p < 0.05). Esophageal biopsies from TT-genotype subjects had significantly less epithelial membrane-bound E-cadherin (p < 0.01) and wider cluster distribution at nanometer resolution. TGFβ1 treatment of stratified primary human esophageal epithelial cells and spheroids disrupted transepithelial resistance (p < 0.001) and E-cadherin localization (p < 0.0001). A TGFβ1-receptor-I inhibitor improved TGFβ1-mediated E-cadherin mislocalization. These data suggest that EoE severity can depend on genotypic differences that increase in vivo exposure to TGFβ1. TGFβ1 inhibition may be a useful therapy in subsets of EoE patients.Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier dysfunction and subepithelial fibrosis. A functional SNP in the TGFβ1 gene that increases its transcription (C-509T) is associated with elevated numbers of esophageal TGFβ1-expressing cells. We utilized esophageal biopsies and fibroblasts from TT-genotype EoE children to understand if TGFβ1 influenced fibroblast and epithelial cell function in vivo. Genotype TT EoE esophageal fibroblasts had higher baseline TGFβ1, collagen1α1, periostin, and MMP2 (p < 0.05) gene expression and distinct contractile properties compared with CC genotype (n = 6 subjects per genotype). In vitro TGFβ1 exposure caused greater induction of target gene expression in genotype CC fibroblasts (p < 0.05). Esophageal biopsies from TT-genotype subjects had significantly less epithelial membrane-bound E-cadherin (p < 0.01) and wider cluster distribution at nanometer resolution. TGFβ1 treatment of stratified primary human esophageal epithelial cells and spheroids disrupted transepithelial resistance (p < 0.001) and E-cadherin localization (p < 0.0001). A TGFβ1-receptor-I inhibitor improved TGFβ1-mediated E-cadherin mislocalization. These data suggest that EoE severity can depend on genotypic differences that increase in vivo exposure to TGFβ1. TGFβ1 inhibition may be a useful therapy in subsets of EoE patients.
Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal rigidity, strictures, and dysphagia. TGFβ1 drives esophageal remodeling including epithelial barrier dysfunction and subepithelial fibrosis. A functional SNP in the TGFβ1 gene that increases its transcription (C-509T) is associated with elevated numbers of esophageal TGFβ1-expressing cells. We utilized esophageal biopsies and fibroblasts from TT-genotype EoE children to understand if TGFβ1 influenced fibroblast and epithelial cell function in vivo. Genotype TT EoE esophageal fibroblasts had higher baseline TGFβ1, collagen1α1, periostin, and MMP2 ( p  < 0.05) gene expression and distinct contractile properties compared with CC genotype ( n  = 6 subjects per genotype). In vitro TGFβ1 exposure caused greater induction of target gene expression in genotype CC fibroblasts ( p  < 0.05). Esophageal biopsies from TT-genotype subjects had significantly less epithelial membrane-bound E-cadherin ( p  < 0.01) and wider cluster distribution at nanometer resolution. TGFβ1 treatment of stratified primary human esophageal epithelial cells and spheroids disrupted transepithelial resistance ( p  < 0.001) and E-cadherin localization ( p  < 0.0001). A TGFβ1-receptor-I inhibitor improved TGFβ1-mediated E-cadherin mislocalization. These data suggest that EoE severity can depend on genotypic differences that increase in vivo exposure to TGFβ1. TGFβ1 inhibition may be a useful therapy in subsets of EoE patients.
Author Newbury, R.O.
Rawson, R.
Bezryadina, A.
Barrett, K.
Aceves, S.S.
Manresa, M.C.
Kurten, R.
Dohil, R.
Liu, Z.
Duong, L.D.
AuthorAffiliation 3 Department of Bioengineering, University of California, San Diego
7 Arkansas Children’s Research Institute and University of Arkansas for Medical Sciences, Little Rock, Arkansas
6 Department of Medicine, University of California, San Diego
4 Department of Pathology, University of California, San Diego, Rady Children’s Hospital, San Diego
5 Division of Gastroenterology
2 Department of Pediatrics, University of California, San Diego and Rady Children’s Hospital San Diego
1 Division of Allergy & Immunology, University of California, San Diego and Rady Children’s Hospital San Diego
AuthorAffiliation_xml – name: 6 Department of Medicine, University of California, San Diego
– name: 2 Department of Pediatrics, University of California, San Diego and Rady Children’s Hospital San Diego
– name: 1 Division of Allergy & Immunology, University of California, San Diego and Rady Children’s Hospital San Diego
– name: 3 Department of Bioengineering, University of California, San Diego
– name: 4 Department of Pathology, University of California, San Diego, Rady Children’s Hospital, San Diego
– name: 5 Division of Gastroenterology
– name: 7 Arkansas Children’s Research Institute and University of Arkansas for Medical Sciences, Little Rock, Arkansas
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Cites_doi 10.1126/scitranslmed.aap9736
10.1164/rccm.200704-561OC
10.1097/MPG.0000000000001100
10.1111/j.1398-9995.2009.02142.x
10.1016/j.jaci.2010.08.050
10.1016/j.jaci.2015.05.045
10.1152/ajpgi.00454.2011
10.1038/ajg.2017.202
10.1111/all.13244
10.1164/rccm.200307-973OC
10.1038/mi.2017.72
10.1016/S1081-1206(10)60359-6
10.1016/j.jaci.2011.02.040
10.1016/j.cgh.2014.07.034
10.1038/ng.547
10.1097/MPG.0000000000000668
10.1016/j.gie.2013.10.027
10.1016/j.jcmgh.2018.01.011
10.1016/j.celrep.2014.09.027
10.1016/j.anai.2018.05.035
10.1053/j.gastro.2010.09.037
10.1016/j.jaci.2012.03.005
10.1159/000086227
10.1038/mi.2008.15
10.1016/j.cgh.2013.03.020
10.1016/j.gie.2015.11.019
10.1053/j.gastro.2013.08.015
10.1172/jci.insight.86355
10.1164/rccm.200808-1268OC
10.1016/j.jaci.2013.02.030
10.1016/j.humimm.2013.11.008
10.1016/j.jaci.2016.02.028
10.1016/j.jaci.2014.04.004
10.1016/S0016-5085(18)30706-6
10.1371/journal.pone.0144651
10.1016/j.jaci.2018.05.008
10.1007/s00535-018-1498-3
10.1038/s41424-018-0003-x
10.1097/MPG.0000000000002144
10.1126/scitranslmed.3006448
10.1038/ctg.2017.27
10.1016/j.jaci.2006.10.016
10.1038/ng.3033
10.1016/j.gtc.2014.02.002
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RK: Provided samples, analyzed data, critically reviewed the manuscript
LDD: Designed, performed, and analyzed experiments and data, assisted in manuscript preparation, and critically reviewed the manuscript
RR: Designed, performed, and analyzed experiments and data, assisted in manuscript preparation, and critically reviewed the manuscript
SSA: Designed experiments, procured funding, analyzed experimental data, wrote the manuscript
AB: Designed, performed, and analyzed experiments and data, assisted in manuscript preparation, and critically reviewed the manuscript
Author Contributions
ZL: Provided essential expertise, analyzed data, critically reviewed the manuscript
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elsevier_clinicalkey_doi_10_1038_s41385_019_0214_9
PublicationCentury 2000
PublicationDate 20200100
PublicationDateYYYYMMDD 2020-01-01
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  year: 2020
  text: 20200100
PublicationDecade 2020
PublicationPlace New York
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– name: United States
– name: Kidlington
PublicationSubtitle The official publication of the Society for Mucosal Immunology
PublicationTitle Mucosal immunology
PublicationTitleAbbrev Mucosal Immunol
PublicationTitleAlternate Mucosal Immunol
PublicationYear 2020
Publisher Elsevier Inc
Nature Publishing Group US
Elsevier Limited
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References 1022–1033 (2018).
Whelan, Muir, Nakagawa (bib33) 2018; 5
Muir, Wang, Nakagawa (bib27) 2019; 54
Eluri (bib43) 2017; 8
Rajan (bib11) 2016; 137
Beppu, Yang, Luk, Newbury, Palmquist, Dohil, Kurten, Broide, Aceves (bib30) 2015; 61
Kagalwalla (bib25) 2012; 129
Davis (bib16) 2016; 1
Greuter, T. et al. Maintenance treatment of eosinophilic esophagitis with swallowed topical steroids alters disease course over a 5-year follow-up period in adult patients.
Eluri (bib12) 2016; 83
Beppu (bib28) 2014; 134
Blanchard (bib31) 2008; 1
Wolf (bib44) 2015; 13
Dellon (bib3) 2014; 43
Nicodeme (bib7) 2013; 11
Aceves (bib21) 2010; 65
Schoepfer (bib5) 2013; 145
Liacouras (bib2) 2011; 128
225–231 (2019).
Greuter (bib9) 2017; 112
Kwiatek (bib6) 2011; 140
Nguyen, Fernando, Biette, Hammer, Capocelli, Kitzenberg, Glover, Colgan, Furuta, Masterson (bib40) 2017; 11
Rawson (bib32) 2016; 138
(2015).
Dellon, E. S. et al. Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE Conference.
Aceves, Newbury, Dohil, Bastian, Broide (bib35) 2007; 119
Muir (bib26) 2016; 63
.
Sharma (bib22) 2009; 179
Rochman, M. et al. Profound loss of esophageal tissue differentiation in eosinophilic esophagitis.
1527–1535 (2018).
Salam, Gauderman, McConnell, Lin, Gilliland (bib23) 2007; 176
Rawson (bib20) 2015; 10
Khalil, El Nahas, Blakemore (bib39) 2005; 101
Muir, A. B. et al. Eosinophilic esophagitis associated chemical and mechanical microenvironment shapes esophageal fibroblast behavior.
Dellon (bib8) 2014; 79
Simon, Page, Vogel, Bussmann, Blanchard, Straumann, Simon (bib42) 2017; 73
Chen (bib47) 2012; 303
Azouz (bib17) 2018; 10
Fahey (bib13) 2018; 9
Che (bib38) 2014; 75
Kottyan (bib15) 2014; 46
Rochman, Azouz, Rothenberg (bib36) 2018; 142
Aceves (bib29) 2010; 126
Silverman (bib24) 2004; 169
Abonia (bib19) 2013; 132
Doshi, A. et al. IL-9 alters epithelial barrier and E-cadherin in eosinophilic esophagitis.
Spergel (bib4) 2018; 121
DeWard, Cramer, Lagasse (bib34) 2014; 9
Frischmeyer-Guerrerio (bib18) 2013; 5
Aceves, Newbury, Dohil, Bastian, Dohil (bib45) 2009; 103
Rothenberg (bib14) 2010; 42
10–23 (2017).
GreuterTLong-term treatment of eosinophilic esophagitis with swallowed topical corticosteroids: development and evaluation of a therapeutic conceptAm. J. Gastroenterol.2017112152715351:CAS:528:DC%2BC2sXhs1Sktr3N28719593
AcevesSSNewburyRODohilMABastianJFDohilRA symptom scoring tool for identifying pediatric patients with eosinophilic esophagitis and correlating symptoms with inflammationAnn. Allergy Asthma Immunol.200910340140619927538
ChenXBile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteinsAm. J. Physiol. Gastrointest. Liver Physiol.2012303G199G2081:CAS:528:DC%2BC38Xht1OksrzM22575221
SalamMTGaudermanWJMcConnellRLinPCGillilandFDTransforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthmaAm. J. Respir. Crit. Care Med.2007176119211991:CAS:528:DC%2BD1cXpvVKmsA%3D%3D176736952176104
MuirABWangJXNakagawaHEpithelial-stromal crosstalk and fibrosis in eosinophilic esophagitisJ. Gastroenterol.20195410181:CAS:528:DC%2BC1cXhsFSqt7rJ30101408
EluriSThe extremely narrow-caliber esophagus is a treatment-resistant subphenotype of eosinophilic esophagitisGastrointest. Endosc.2016831142114826608127
AzouzNPThe antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responsesSci. Transl. Med.201810444
RawsonRTGF-beta1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitisJ. Allergy Clin. Immunol.2016138791800 e41:CAS:528:DC%2BC28XosVSmsLs%3D272120825014565
SpergelJMSummary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conferenceAnn. Allergy Asthma Immunol.2018121281284300301466139263
MuirABEosinophilic esophagitis-associated chemical and mechanical microenvironment shapes esophageal fibroblast behaviorJ. Pediatr. Gastroenterol. Nutr.2016632002091:CAS:528:DC%2BC28Xht1ahurfE267276584929044
DavisBPEosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairmentJCI Insight20161e86355271586754855700
AcevesSSNewburyRODohilRBastianJFBroideDHEsophageal remodeling in pediatric eosinophilic esophagitisJ. Allergy Clin. Immunol.20071192062121:CAS:528:DC%2BD2sXit1Orsg%3D%3D17208603
BlanchardCPeriostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responsesMucosal Immunol.200812892961:CAS:528:DC%2BD1cXntFSjsb8%3D190791902683986
LiacourasCAEosinophilic esophagitis: updated consensus recommendations for children and adultsJ. Allergy Clin. Immunol.2011128320e621477849quiz1–2
SharmaSVariants in TGFB1, dust mite exposure, and disease severity in children with asthmaAm. J. Respir. Crit. Care Med.20091793563621:CAS:528:DC%2BD1MXjvVylsLc%3D19096005
WhelanKAMuirABNakagawaHEsophageal 3D culture systems as modeling tools in esophageal epithelial pathobiology and personalized medicineCell Mol. Gastroenterol. Hepatol.20185461478297136605924738
Dellon, E. S. et al. Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 155, 1022–1033 (2018).
FaheyLMFood allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitisClin. Transl. Gastroenterol.20189139295111655862152
KagalwallaAFEosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatmentJ. Allergy Clin. Immunol.2012129138796 e7224652123340537
CheZThe association between the C-509T and T869C polymorphisms of TGF-beta1 gene and the risk of asthma: a meta-analysisHum. Immunol.2014751411501:CAS:528:DC%2BC3sXitVSht7%2FM24269701
Muir, A. B. et al. Eosinophilic esophagitis associated chemical and mechanical microenvironment shapes esophageal fibroblast behavior. J. Pediatr. Gastroenterol. Nutr. (2015).
DellonESA phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic diseaseGastrointest. Endosc.20147957785 e424275329
Doshi, A. et al. IL-9 alters epithelial barrier and E-cadherin in eosinophilic esophagitis. J. Pediatr. Gastroenterol. Nutr. 68, 225–231 (2019).
DeWardADCramerJLagasseECellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell populationCell Rep.201497017111:CAS:528:DC%2BC2cXhslOrtL3E253739074223874
Rochman, M. et al. Profound loss of esophageal tissue differentiation in eosinophilic esophagitis. J. Allergy Clin. Immunol. 142, 10–23 (2017).
RochmanMAzouzNPRothenbergMEEpithelial origin of eosinophilic esophagitisJ. Allergy Clin. Immunol.201814210231:CAS:528:DC%2BC1cXht1yis7vL29980278
DellonESEpidemiology of eosinophilic esophagitisGastroenterol. Clin. North Am.201443201218248135104019938
SchoepferAMDelay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent mannerGastroenterology201314512306 e1-223954315
RawsonRThe TGFbeta1 promoter SNP C-509T and food sensitization promote esophageal remodeling in pediatric eosinophilic esophagitisPLoS One201510e0144651266564234678166
EluriSDiminishing effectiveness of long-term maintenance topical steroid therapy in PPI non-responsive eosinophilic esophagitisClin. Transl. Gastroenterol.20178e971:CAS:528:DC%2BC2sXps1GqtbY%3D286174485518950
NicodemeFEsophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitisClin. Gastroenterol. Hepatol.20131111017 e1235912793790569
SilvermanESTransforming growth factor-beta1 promoter polymorphism C-509T is associated with asthmaAm. J. Respir. Crit. Care Med.200416921421914597484
WolfWAPredictors of response to steroid therapy for eosinophilic esophagitis and treatment of steroid-refractory patientsClin. Gastroenterol. Hepatol.20151345245825086190
AcevesSSMast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contractionJ. allergy Clin. Immunol.20101261198204 e41:CAS:528:DC%2BC3cXhsFantbbL21047675
AcevesSSResolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroidsAllergy2010651091161:CAS:528:DC%2BC3cXhtFOms78%3D19796194
RothenbergMECommon variants at 5q22 associate with pediatric eosinophilic esophagitisNat. Genet.2010422892911:CAS:528:DC%2BC3cXivVCitL0%3D202085343740732
Greuter, T. et al. Maintenance treatment of eosinophilic esophagitis with swallowed topical steroids alters disease course over a 5-year follow-up period in adult patients. Clin. Gastroenterol. Hepatol.112, 1527–1535 (2018).
RajanJLong-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroidsJ. Allergy Clin. Immunol.201613714756 e81:CAS:528:DC%2BC2MXht1KmtbjL26233926
BeppuLYTGF-beta1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitisJ. Allergy Clin. Immunol.201413411007 e41:CAS:528:DC%2BC2cXotFOku70%3D248355034231011
BeppuLisaYangTomLukMichelleNewburyRobert O.PalmquistJacobDohilRanjanKurtenRichard C.BroideDavid H.AcevesSeema S.MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid TherapyJournal of Pediatric Gastroenterology and Nutrition20156121941991:CAS:528:DC%2BC2MXht1Ogu7bL255391924478274
SimonD.PageB.VogelM.BussmannC.BlanchardC.StraumannA.SimonH.-U.Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitisAllergy201773123924728712126
Frischmeyer-GuerrerioPATGFbeta receptor mutations impose a strong predisposition for human allergic diseaseSci. Transl. Med.20135195ra94238844663905327
KottyanLCGenome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic diseaseNat. Genet.2014468959001:CAS:528:DC%2BC2cXhtFGqsbjN250171044121957
AboniaJPHigh prevalence of eosinophilic esophagitis in patients with inherited connective tissue disordersJ. Allergy Clin. Immunol.201313237838623608731
KhalilMSEl NahasAMBlakemoreAITransforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiencyNephron Exp. Nephrol.2005101e31e411:CAS:528:DC%2BD2MXpsFWjtLk%3D15942255
KwiatekMAMechanical properties of the esophagus in eosinophilic esophagitisGastroenterology2011140829020858491
NguyenNFernandoS DBietteK AHammerJ ACapocelliK EKitzenbergD AGloverL EColganS PFurutaG TMastersonJ CTGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitisMucosal Immunology2017112415426288320265825237
Rajan (10.1038/s41385-019-0214-9_bib11) 2016; 137
Silverman (10.1038/s41385-019-0214-9_bib24) 2004; 169
Davis (10.1038/s41385-019-0214-9_bib16) 2016; 1
Dellon (10.1038/s41385-019-0214-9_bib3) 2014; 43
Abonia (10.1038/s41385-019-0214-9_bib19) 2013; 132
Salam (10.1038/s41385-019-0214-9_bib23) 2007; 176
Muir (10.1038/s41385-019-0214-9_bib27) 2019; 54
Beppu (10.1038/s41385-019-0214-9_bib30) 2015; 61
Sharma (10.1038/s41385-019-0214-9_bib22) 2009; 179
Schoepfer (10.1038/s41385-019-0214-9_bib5) 2013; 145
Fahey (10.1038/s41385-019-0214-9_bib13) 2018; 9
DeWard (10.1038/s41385-019-0214-9_bib34) 2014; 9
Rochman (10.1038/s41385-019-0214-9_bib36) 2018; 142
Blanchard (10.1038/s41385-019-0214-9_bib31) 2008; 1
Simon (10.1038/s41385-019-0214-9_bib42) 2017; 73
Wolf (10.1038/s41385-019-0214-9_bib44) 2015; 13
Kottyan (10.1038/s41385-019-0214-9_bib15) 2014; 46
Eluri (10.1038/s41385-019-0214-9_bib12) 2016; 83
Dellon (10.1038/s41385-019-0214-9_bib8) 2014; 79
10.1038/s41385-019-0214-9_bib46
10.1038/s41385-019-0214-9_bib41
Kagalwalla (10.1038/s41385-019-0214-9_bib25) 2012; 129
Muir (10.1038/s41385-019-0214-9_bib26) 2016; 63
Azouz (10.1038/s41385-019-0214-9_bib17) 2018; 10
Eluri (10.1038/s41385-019-0214-9_bib43) 2017; 8
Spergel (10.1038/s41385-019-0214-9_bib4) 2018; 121
Nguyen (10.1038/s41385-019-0214-9_bib40) 2017; 11
Rawson (10.1038/s41385-019-0214-9_bib20) 2015; 10
Rawson (10.1038/s41385-019-0214-9_bib32) 2016; 138
Nicodeme (10.1038/s41385-019-0214-9_bib7) 2013; 11
Aceves (10.1038/s41385-019-0214-9_bib35) 2007; 119
Frischmeyer-Guerrerio (10.1038/s41385-019-0214-9_bib18) 2013; 5
Aceves (10.1038/s41385-019-0214-9_bib29) 2010; 126
Beppu (10.1038/s41385-019-0214-9_bib28) 2014; 134
Whelan (10.1038/s41385-019-0214-9_bib33) 2018; 5
Kwiatek (10.1038/s41385-019-0214-9_bib6) 2011; 140
Rothenberg (10.1038/s41385-019-0214-9_bib14) 2010; 42
Aceves (10.1038/s41385-019-0214-9_bib21) 2010; 65
Khalil (10.1038/s41385-019-0214-9_bib39) 2005; 101
Chen (10.1038/s41385-019-0214-9_bib47) 2012; 303
Greuter (10.1038/s41385-019-0214-9_bib9) 2017; 112
Liacouras (10.1038/s41385-019-0214-9_bib2) 2011; 128
Che (10.1038/s41385-019-0214-9_bib38) 2014; 75
10.1038/s41385-019-0214-9_bib1
10.1038/s41385-019-0214-9_bib37
Aceves (10.1038/s41385-019-0214-9_bib45) 2009; 103
10.1038/s41385-019-0214-9_bib10
References_xml – volume: 134
  start-page: 1100
  year: 2014
  end-page: 7 e4
  ident: bib28
  article-title: TGF-beta1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis
  publication-title: J. Allergy Clin. Immunol.
– reference: , 1022–1033 (2018).
– volume: 75
  start-page: 141
  year: 2014
  end-page: 150
  ident: bib38
  article-title: The association between the C-509T and T869C polymorphisms of TGF-beta1 gene and the risk of asthma: a meta-analysis
  publication-title: Hum. Immunol.
– volume: 179
  start-page: 356
  year: 2009
  end-page: 362
  ident: bib22
  article-title: Variants in TGFB1, dust mite exposure, and disease severity in children with asthma
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 138
  start-page: 791
  year: 2016
  end-page: 800 e4
  ident: bib32
  article-title: TGF-beta1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
  publication-title: J. Allergy Clin. Immunol.
– volume: 63
  start-page: 200
  year: 2016
  end-page: 209
  ident: bib26
  article-title: Eosinophilic esophagitis-associated chemical and mechanical microenvironment shapes esophageal fibroblast behavior
  publication-title: J. Pediatr. Gastroenterol. Nutr.
– volume: 137
  start-page: 147
  year: 2016
  end-page: 56 e8
  ident: bib11
  article-title: Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids
  publication-title: J. Allergy Clin. Immunol.
– volume: 132
  start-page: 378
  year: 2013
  end-page: 386
  ident: bib19
  article-title: High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
  publication-title: J. Allergy Clin. Immunol.
– volume: 121
  start-page: 281
  year: 2018
  end-page: 284
  ident: bib4
  article-title: Summary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conference
  publication-title: Ann. Allergy Asthma Immunol.
– volume: 11
  start-page: 1101
  year: 2013
  end-page: 7 e1
  ident: bib7
  article-title: Esophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitis
  publication-title: Clin. Gastroenterol. Hepatol.
– volume: 9
  start-page: 139
  year: 2018
  ident: bib13
  article-title: Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis
  publication-title: Clin. Transl. Gastroenterol.
– reference: , 10–23 (2017).
– volume: 46
  start-page: 895
  year: 2014
  end-page: 900
  ident: bib15
  article-title: Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease
  publication-title: Nat. Genet.
– volume: 65
  start-page: 109
  year: 2010
  end-page: 116
  ident: bib21
  article-title: Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids
  publication-title: Allergy
– volume: 54
  start-page: 10
  year: 2019
  end-page: 18
  ident: bib27
  article-title: Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis
  publication-title: J. Gastroenterol.
– volume: 11
  start-page: 415
  year: 2017
  end-page: 426
  ident: bib40
  article-title: TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis
  publication-title: Mucosal Immunology
– volume: 73
  start-page: 239
  year: 2017
  end-page: 247
  ident: bib42
  article-title: Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitis
  publication-title: Allergy
– volume: 128
  start-page: 3
  year: 2011
  end-page: 20e6
  ident: bib2
  article-title: Eosinophilic esophagitis: updated consensus recommendations for children and adults
  publication-title: J. Allergy Clin. Immunol.
– volume: 303
  start-page: G199
  year: 2012
  end-page: G208
  ident: bib47
  article-title: Bile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteins
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
– volume: 140
  start-page: 82
  year: 2011
  end-page: 90
  ident: bib6
  article-title: Mechanical properties of the esophagus in eosinophilic esophagitis
  publication-title: Gastroenterology
– volume: 1
  start-page: 289
  year: 2008
  end-page: 296
  ident: bib31
  article-title: Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
  publication-title: Mucosal Immunol.
– volume: 145
  start-page: 1230
  year: 2013
  end-page: 6 e1-2
  ident: bib5
  article-title: Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner
  publication-title: Gastroenterology
– volume: 103
  start-page: 401
  year: 2009
  end-page: 406
  ident: bib45
  article-title: A symptom scoring tool for identifying pediatric patients with eosinophilic esophagitis and correlating symptoms with inflammation
  publication-title: Ann. Allergy Asthma Immunol.
– volume: 101
  start-page: e31
  year: 2005
  end-page: e41
  ident: bib39
  article-title: Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency
  publication-title: Nephron Exp. Nephrol.
– volume: 10
  start-page: 444
  year: 2018
  ident: bib17
  article-title: The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses
  publication-title: Sci. Transl. Med.
– reference: .
– volume: 5
  start-page: 461
  year: 2018
  end-page: 478
  ident: bib33
  article-title: Esophageal 3D culture systems as modeling tools in esophageal epithelial pathobiology and personalized medicine
  publication-title: Cell Mol. Gastroenterol. Hepatol.
– reference: . (2015).
– volume: 176
  start-page: 1192
  year: 2007
  end-page: 1199
  ident: bib23
  article-title: Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma
  publication-title: Am. J. Respir. Crit. Care Med.
– volume: 61
  start-page: 194
  year: 2015
  end-page: 199
  ident: bib30
  article-title: MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy
  publication-title: Journal of Pediatric Gastroenterology and Nutrition
– volume: 43
  start-page: 201
  year: 2014
  end-page: 218
  ident: bib3
  article-title: Epidemiology of eosinophilic esophagitis
  publication-title: Gastroenterol. Clin. North Am.
– volume: 129
  start-page: 1387
  year: 2012
  end-page: 96 e7
  ident: bib25
  article-title: Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment
  publication-title: J. Allergy Clin. Immunol.
– reference: , 1527–1535 (2018).
– volume: 112
  start-page: 1527
  year: 2017
  end-page: 1535
  ident: bib9
  article-title: Long-term treatment of eosinophilic esophagitis with swallowed topical corticosteroids: development and evaluation of a therapeutic concept
  publication-title: Am. J. Gastroenterol.
– reference: Dellon, E. S. et al. Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE Conference.
– volume: 42
  start-page: 289
  year: 2010
  end-page: 291
  ident: bib14
  article-title: Common variants at 5q22 associate with pediatric eosinophilic esophagitis
  publication-title: Nat. Genet.
– volume: 10
  start-page: e0144651
  year: 2015
  ident: bib20
  article-title: The TGFbeta1 promoter SNP C-509T and food sensitization promote esophageal remodeling in pediatric eosinophilic esophagitis
  publication-title: PLoS One
– reference: Muir, A. B. et al. Eosinophilic esophagitis associated chemical and mechanical microenvironment shapes esophageal fibroblast behavior.
– volume: 8
  start-page: e97
  year: 2017
  ident: bib43
  article-title: Diminishing effectiveness of long-term maintenance topical steroid therapy in PPI non-responsive eosinophilic esophagitis
  publication-title: Clin. Transl. Gastroenterol.
– volume: 83
  start-page: 1142
  year: 2016
  end-page: 1148
  ident: bib12
  article-title: The extremely narrow-caliber esophagus is a treatment-resistant subphenotype of eosinophilic esophagitis
  publication-title: Gastrointest. Endosc.
– volume: 1
  start-page: e86355
  year: 2016
  ident: bib16
  article-title: Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment
  publication-title: JCI Insight
– volume: 126
  start-page: 1198
  year: 2010
  end-page: 204 e4
  ident: bib29
  article-title: Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction
  publication-title: J. allergy Clin. Immunol.
– reference: Rochman, M. et al. Profound loss of esophageal tissue differentiation in eosinophilic esophagitis.
– volume: 5
  start-page: 195ra94
  year: 2013
  ident: bib18
  article-title: TGFbeta receptor mutations impose a strong predisposition for human allergic disease
  publication-title: Sci. Transl. Med.
– volume: 119
  start-page: 206
  year: 2007
  end-page: 212
  ident: bib35
  article-title: Esophageal remodeling in pediatric eosinophilic esophagitis
  publication-title: J. Allergy Clin. Immunol.
– volume: 13
  start-page: 452
  year: 2015
  end-page: 458
  ident: bib44
  article-title: Predictors of response to steroid therapy for eosinophilic esophagitis and treatment of steroid-refractory patients
  publication-title: Clin. Gastroenterol. Hepatol.
– volume: 169
  start-page: 214
  year: 2004
  end-page: 219
  ident: bib24
  article-title: Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
  publication-title: Am. J. Respir. Crit. Care Med.
– reference: , 225–231 (2019).
– volume: 79
  start-page: 577
  year: 2014
  end-page: 85 e4
  ident: bib8
  article-title: A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease
  publication-title: Gastrointest. Endosc.
– reference: Greuter, T. et al. Maintenance treatment of eosinophilic esophagitis with swallowed topical steroids alters disease course over a 5-year follow-up period in adult patients.
– volume: 9
  start-page: 701
  year: 2014
  end-page: 711
  ident: bib34
  article-title: Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population
  publication-title: Cell Rep.
– reference: Doshi, A. et al. IL-9 alters epithelial barrier and E-cadherin in eosinophilic esophagitis.
– volume: 142
  start-page: 10
  year: 2018
  end-page: 23
  ident: bib36
  article-title: Epithelial origin of eosinophilic esophagitis
  publication-title: J. Allergy Clin. Immunol.
– reference: Doshi, A. et al. IL-9 alters epithelial barrier and E-cadherin in eosinophilic esophagitis. J. Pediatr. Gastroenterol. Nutr. 68, 225–231 (2019).
– reference: BlanchardCPeriostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responsesMucosal Immunol.200812892961:CAS:528:DC%2BD1cXntFSjsb8%3D190791902683986
– reference: BeppuLYTGF-beta1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitisJ. Allergy Clin. Immunol.201413411007 e41:CAS:528:DC%2BC2cXotFOku70%3D248355034231011
– reference: KhalilMSEl NahasAMBlakemoreAITransforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiencyNephron Exp. Nephrol.2005101e31e411:CAS:528:DC%2BD2MXpsFWjtLk%3D15942255
– reference: Greuter, T. et al. Maintenance treatment of eosinophilic esophagitis with swallowed topical steroids alters disease course over a 5-year follow-up period in adult patients. Clin. Gastroenterol. Hepatol.112, 1527–1535 (2018).
– reference: MuirABEosinophilic esophagitis-associated chemical and mechanical microenvironment shapes esophageal fibroblast behaviorJ. Pediatr. Gastroenterol. Nutr.2016632002091:CAS:528:DC%2BC28Xht1ahurfE267276584929044
– reference: BeppuLisaYangTomLukMichelleNewburyRobert O.PalmquistJacobDohilRanjanKurtenRichard C.BroideDavid H.AcevesSeema S.MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid TherapyJournal of Pediatric Gastroenterology and Nutrition20156121941991:CAS:528:DC%2BC2MXht1Ogu7bL255391924478274
– reference: AzouzNPThe antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responsesSci. Transl. Med.201810444
– reference: Muir, A. B. et al. Eosinophilic esophagitis associated chemical and mechanical microenvironment shapes esophageal fibroblast behavior. J. Pediatr. Gastroenterol. Nutr. (2015).
– reference: GreuterTLong-term treatment of eosinophilic esophagitis with swallowed topical corticosteroids: development and evaluation of a therapeutic conceptAm. J. Gastroenterol.2017112152715351:CAS:528:DC%2BC2sXhs1Sktr3N28719593
– reference: Dellon, E. S. et al. Updated international consensus diagnostic criteria for eosinophilic esophagitis: Proceedings of the AGREE Conference. Gastroenterology. 155, 1022–1033 (2018).
– reference: Rochman, M. et al. Profound loss of esophageal tissue differentiation in eosinophilic esophagitis. J. Allergy Clin. Immunol. 142, 10–23 (2017).
– reference: AboniaJPHigh prevalence of eosinophilic esophagitis in patients with inherited connective tissue disordersJ. Allergy Clin. Immunol.201313237838623608731
– reference: AcevesSSNewburyRODohilMABastianJFDohilRA symptom scoring tool for identifying pediatric patients with eosinophilic esophagitis and correlating symptoms with inflammationAnn. Allergy Asthma Immunol.200910340140619927538
– reference: NicodemeFEsophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitisClin. Gastroenterol. Hepatol.20131111017 e1235912793790569
– reference: SalamMTGaudermanWJMcConnellRLinPCGillilandFDTransforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthmaAm. J. Respir. Crit. Care Med.2007176119211991:CAS:528:DC%2BD1cXpvVKmsA%3D%3D176736952176104
– reference: DavisBPEosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairmentJCI Insight20161e86355271586754855700
– reference: WhelanKAMuirABNakagawaHEsophageal 3D culture systems as modeling tools in esophageal epithelial pathobiology and personalized medicineCell Mol. Gastroenterol. Hepatol.20185461478297136605924738
– reference: SharmaSVariants in TGFB1, dust mite exposure, and disease severity in children with asthmaAm. J. Respir. Crit. Care Med.20091793563621:CAS:528:DC%2BD1MXjvVylsLc%3D19096005
– reference: KagalwallaAFEosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatmentJ. Allergy Clin. Immunol.2012129138796 e7224652123340537
– reference: KwiatekMAMechanical properties of the esophagus in eosinophilic esophagitisGastroenterology2011140829020858491
– reference: MuirABWangJXNakagawaHEpithelial-stromal crosstalk and fibrosis in eosinophilic esophagitisJ. Gastroenterol.20195410181:CAS:528:DC%2BC1cXhsFSqt7rJ30101408
– reference: Frischmeyer-GuerrerioPATGFbeta receptor mutations impose a strong predisposition for human allergic diseaseSci. Transl. Med.20135195ra94238844663905327
– reference: ChenXBile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteinsAm. J. Physiol. Gastrointest. Liver Physiol.2012303G199G2081:CAS:528:DC%2BC38Xht1OksrzM22575221
– reference: KottyanLCGenome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic diseaseNat. Genet.2014468959001:CAS:528:DC%2BC2cXhtFGqsbjN250171044121957
– reference: CheZThe association between the C-509T and T869C polymorphisms of TGF-beta1 gene and the risk of asthma: a meta-analysisHum. Immunol.2014751411501:CAS:528:DC%2BC3sXitVSht7%2FM24269701
– reference: NguyenNFernandoS DBietteK AHammerJ ACapocelliK EKitzenbergD AGloverL EColganS PFurutaG TMastersonJ CTGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitisMucosal Immunology2017112415426288320265825237
– reference: RawsonRTGF-beta1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitisJ. Allergy Clin. Immunol.2016138791800 e41:CAS:528:DC%2BC28XosVSmsLs%3D272120825014565
– reference: AcevesSSMast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contractionJ. allergy Clin. Immunol.20101261198204 e41:CAS:528:DC%2BC3cXhsFantbbL21047675
– reference: RajanJLong-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroidsJ. Allergy Clin. Immunol.201613714756 e81:CAS:528:DC%2BC2MXht1KmtbjL26233926
– reference: WolfWAPredictors of response to steroid therapy for eosinophilic esophagitis and treatment of steroid-refractory patientsClin. Gastroenterol. Hepatol.20151345245825086190
– reference: DeWardADCramerJLagasseECellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell populationCell Rep.201497017111:CAS:528:DC%2BC2cXhslOrtL3E253739074223874
– reference: EluriSThe extremely narrow-caliber esophagus is a treatment-resistant subphenotype of eosinophilic esophagitisGastrointest. Endosc.2016831142114826608127
– reference: RothenbergMECommon variants at 5q22 associate with pediatric eosinophilic esophagitisNat. Genet.2010422892911:CAS:528:DC%2BC3cXivVCitL0%3D202085343740732
– reference: DellonESEpidemiology of eosinophilic esophagitisGastroenterol. Clin. North Am.201443201218248135104019938
– reference: RochmanMAzouzNPRothenbergMEEpithelial origin of eosinophilic esophagitisJ. Allergy Clin. Immunol.201814210231:CAS:528:DC%2BC1cXht1yis7vL29980278
– reference: AcevesSSResolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroidsAllergy2010651091161:CAS:528:DC%2BC3cXhtFOms78%3D19796194
– reference: DellonESA phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic diseaseGastrointest. Endosc.20147957785 e424275329
– reference: SimonD.PageB.VogelM.BussmannC.BlanchardC.StraumannA.SimonH.-U.Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitisAllergy201773123924728712126
– reference: AcevesSSNewburyRODohilRBastianJFBroideDHEsophageal remodeling in pediatric eosinophilic esophagitisJ. Allergy Clin. Immunol.20071192062121:CAS:528:DC%2BD2sXit1Orsg%3D%3D17208603
– reference: SilvermanESTransforming growth factor-beta1 promoter polymorphism C-509T is associated with asthmaAm. J. Respir. Crit. Care Med.200416921421914597484
– reference: RawsonRThe TGFbeta1 promoter SNP C-509T and food sensitization promote esophageal remodeling in pediatric eosinophilic esophagitisPLoS One201510e0144651266564234678166
– reference: LiacourasCAEosinophilic esophagitis: updated consensus recommendations for children and adultsJ. Allergy Clin. Immunol.2011128320e621477849quiz1–2
– reference: EluriSDiminishing effectiveness of long-term maintenance topical steroid therapy in PPI non-responsive eosinophilic esophagitisClin. Transl. Gastroenterol.20178e971:CAS:528:DC%2BC2sXps1GqtbY%3D286174485518950
– reference: FaheyLMFood allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitisClin. Transl. Gastroenterol.20189139295111655862152
– reference: SpergelJMSummary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conferenceAnn. Allergy Asthma Immunol.2018121281284300301466139263
– reference: SchoepferAMDelay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent mannerGastroenterology201314512306 e1-223954315
– volume: 10
  start-page: 444
  year: 2018
  ident: 10.1038/s41385-019-0214-9_bib17
  article-title: The antiprotease SPINK7 serves as an inhibitory checkpoint for esophageal epithelial inflammatory responses
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.aap9736
– volume: 176
  start-page: 1192
  year: 2007
  ident: 10.1038/s41385-019-0214-9_bib23
  article-title: Transforming growth factor- 1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200704-561OC
– volume: 63
  start-page: 200
  year: 2016
  ident: 10.1038/s41385-019-0214-9_bib26
  article-title: Eosinophilic esophagitis-associated chemical and mechanical microenvironment shapes esophageal fibroblast behavior
  publication-title: J. Pediatr. Gastroenterol. Nutr.
  doi: 10.1097/MPG.0000000000001100
– volume: 65
  start-page: 109
  year: 2010
  ident: 10.1038/s41385-019-0214-9_bib21
  article-title: Resolution of remodeling in eosinophilic esophagitis correlates with epithelial response to topical corticosteroids
  publication-title: Allergy
  doi: 10.1111/j.1398-9995.2009.02142.x
– volume: 126
  start-page: 1198
  year: 2010
  ident: 10.1038/s41385-019-0214-9_bib29
  article-title: Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction
  publication-title: J. allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2010.08.050
– volume: 137
  start-page: 147
  year: 2016
  ident: 10.1038/s41385-019-0214-9_bib11
  article-title: Long-term assessment of esophageal remodeling in patients with pediatric eosinophilic esophagitis treated with topical corticosteroids
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2015.05.045
– volume: 303
  start-page: G199
  year: 2012
  ident: 10.1038/s41385-019-0214-9_bib47
  article-title: Bile salts disrupt human esophageal squamous epithelial barrier function by modulating tight junction proteins
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00454.2011
– volume: 112
  start-page: 1527
  year: 2017
  ident: 10.1038/s41385-019-0214-9_bib9
  article-title: Long-term treatment of eosinophilic esophagitis with swallowed topical corticosteroids: development and evaluation of a therapeutic concept
  publication-title: Am. J. Gastroenterol.
  doi: 10.1038/ajg.2017.202
– volume: 73
  start-page: 239
  issue: 1
  year: 2017
  ident: 10.1038/s41385-019-0214-9_bib42
  article-title: Evidence of an abnormal epithelial barrier in active, untreated and corticosteroid-treated eosinophilic esophagitis
  publication-title: Allergy
  doi: 10.1111/all.13244
– volume: 169
  start-page: 214
  year: 2004
  ident: 10.1038/s41385-019-0214-9_bib24
  article-title: Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200307-973OC
– ident: 10.1038/s41385-019-0214-9_bib37
– volume: 11
  start-page: 415
  issue: 2
  year: 2017
  ident: 10.1038/s41385-019-0214-9_bib40
  article-title: TGF-β1 alters esophageal epithelial barrier function by attenuation of claudin-7 in eosinophilic esophagitis
  publication-title: Mucosal Immunology
  doi: 10.1038/mi.2017.72
– volume: 103
  start-page: 401
  year: 2009
  ident: 10.1038/s41385-019-0214-9_bib45
  article-title: A symptom scoring tool for identifying pediatric patients with eosinophilic esophagitis and correlating symptoms with inflammation
  publication-title: Ann. Allergy Asthma Immunol.
  doi: 10.1016/S1081-1206(10)60359-6
– volume: 128
  start-page: 3
  year: 2011
  ident: 10.1038/s41385-019-0214-9_bib2
  article-title: Eosinophilic esophagitis: updated consensus recommendations for children and adults
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2011.02.040
– volume: 13
  start-page: 452
  year: 2015
  ident: 10.1038/s41385-019-0214-9_bib44
  article-title: Predictors of response to steroid therapy for eosinophilic esophagitis and treatment of steroid-refractory patients
  publication-title: Clin. Gastroenterol. Hepatol.
  doi: 10.1016/j.cgh.2014.07.034
– volume: 42
  start-page: 289
  year: 2010
  ident: 10.1038/s41385-019-0214-9_bib14
  article-title: Common variants at 5q22 associate with pediatric eosinophilic esophagitis
  publication-title: Nat. Genet.
  doi: 10.1038/ng.547
– volume: 61
  start-page: 194
  issue: 2
  year: 2015
  ident: 10.1038/s41385-019-0214-9_bib30
  article-title: MMPs-2 and -14 Are Elevated in Eosinophilic Esophagitis and Reduced Following Topical Corticosteroid Therapy
  publication-title: Journal of Pediatric Gastroenterology and Nutrition
  doi: 10.1097/MPG.0000000000000668
– volume: 79
  start-page: 577
  year: 2014
  ident: 10.1038/s41385-019-0214-9_bib8
  article-title: A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease
  publication-title: Gastrointest. Endosc.
  doi: 10.1016/j.gie.2013.10.027
– volume: 5
  start-page: 461
  year: 2018
  ident: 10.1038/s41385-019-0214-9_bib33
  article-title: Esophageal 3D culture systems as modeling tools in esophageal epithelial pathobiology and personalized medicine
  publication-title: Cell Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2018.01.011
– volume: 9
  start-page: 701
  year: 2014
  ident: 10.1038/s41385-019-0214-9_bib34
  article-title: Cellular heterogeneity in the mouse esophagus implicates the presence of a nonquiescent epithelial stem cell population
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.09.027
– volume: 121
  start-page: 281
  year: 2018
  ident: 10.1038/s41385-019-0214-9_bib4
  article-title: Summary of the updated international consensus diagnostic criteria for eosinophilic esophagitis: AGREE conference
  publication-title: Ann. Allergy Asthma Immunol.
  doi: 10.1016/j.anai.2018.05.035
– volume: 140
  start-page: 82
  year: 2011
  ident: 10.1038/s41385-019-0214-9_bib6
  article-title: Mechanical properties of the esophagus in eosinophilic esophagitis
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2010.09.037
– volume: 129
  start-page: 1387
  year: 2012
  ident: 10.1038/s41385-019-0214-9_bib25
  article-title: Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2012.03.005
– ident: 10.1038/s41385-019-0214-9_bib1
– volume: 101
  start-page: e31
  year: 2005
  ident: 10.1038/s41385-019-0214-9_bib39
  article-title: Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency
  publication-title: Nephron Exp. Nephrol.
  doi: 10.1159/000086227
– volume: 1
  start-page: 289
  year: 2008
  ident: 10.1038/s41385-019-0214-9_bib31
  article-title: Periostin facilitates eosinophil tissue infiltration in allergic lung and esophageal responses
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2008.15
– volume: 11
  start-page: 1101
  year: 2013
  ident: 10.1038/s41385-019-0214-9_bib7
  article-title: Esophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitis
  publication-title: Clin. Gastroenterol. Hepatol.
  doi: 10.1016/j.cgh.2013.03.020
– volume: 83
  start-page: 1142
  year: 2016
  ident: 10.1038/s41385-019-0214-9_bib12
  article-title: The extremely narrow-caliber esophagus is a treatment-resistant subphenotype of eosinophilic esophagitis
  publication-title: Gastrointest. Endosc.
  doi: 10.1016/j.gie.2015.11.019
– volume: 145
  start-page: 1230
  year: 2013
  ident: 10.1038/s41385-019-0214-9_bib5
  article-title: Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2013.08.015
– volume: 1
  start-page: e86355
  year: 2016
  ident: 10.1038/s41385-019-0214-9_bib16
  article-title: Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment
  publication-title: JCI Insight
  doi: 10.1172/jci.insight.86355
– volume: 179
  start-page: 356
  year: 2009
  ident: 10.1038/s41385-019-0214-9_bib22
  article-title: Variants in TGFB1, dust mite exposure, and disease severity in children with asthma
  publication-title: Am. J. Respir. Crit. Care Med.
  doi: 10.1164/rccm.200808-1268OC
– volume: 132
  start-page: 378
  year: 2013
  ident: 10.1038/s41385-019-0214-9_bib19
  article-title: High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2013.02.030
– volume: 75
  start-page: 141
  year: 2014
  ident: 10.1038/s41385-019-0214-9_bib38
  article-title: The association between the C-509T and T869C polymorphisms of TGF-beta1 gene and the risk of asthma: a meta-analysis
  publication-title: Hum. Immunol.
  doi: 10.1016/j.humimm.2013.11.008
– volume: 138
  start-page: 791
  year: 2016
  ident: 10.1038/s41385-019-0214-9_bib32
  article-title: TGF-beta1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2016.02.028
– volume: 134
  start-page: 1100
  year: 2014
  ident: 10.1038/s41385-019-0214-9_bib28
  article-title: TGF-beta1-induced phospholamban expression alters esophageal smooth muscle cell contraction in patients with eosinophilic esophagitis
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2014.04.004
– ident: 10.1038/s41385-019-0214-9_bib10
  doi: 10.1016/S0016-5085(18)30706-6
– volume: 10
  start-page: e0144651
  year: 2015
  ident: 10.1038/s41385-019-0214-9_bib20
  article-title: The TGFbeta1 promoter SNP C-509T and food sensitization promote esophageal remodeling in pediatric eosinophilic esophagitis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0144651
– volume: 142
  start-page: 10
  year: 2018
  ident: 10.1038/s41385-019-0214-9_bib36
  article-title: Epithelial origin of eosinophilic esophagitis
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2018.05.008
– volume: 54
  start-page: 10
  year: 2019
  ident: 10.1038/s41385-019-0214-9_bib27
  article-title: Epithelial-stromal crosstalk and fibrosis in eosinophilic esophagitis
  publication-title: J. Gastroenterol.
  doi: 10.1007/s00535-018-1498-3
– volume: 9
  start-page: 139
  year: 2018
  ident: 10.1038/s41385-019-0214-9_bib13
  article-title: Food allergen triggers are increased in children with the TSLP risk allele and eosinophilic esophagitis
  publication-title: Clin. Transl. Gastroenterol.
  doi: 10.1038/s41424-018-0003-x
– ident: 10.1038/s41385-019-0214-9_bib46
  doi: 10.1097/MPG.0000000000002144
– volume: 5
  start-page: 195ra94
  year: 2013
  ident: 10.1038/s41385-019-0214-9_bib18
  article-title: TGFbeta receptor mutations impose a strong predisposition for human allergic disease
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3006448
– volume: 8
  start-page: e97
  year: 2017
  ident: 10.1038/s41385-019-0214-9_bib43
  article-title: Diminishing effectiveness of long-term maintenance topical steroid therapy in PPI non-responsive eosinophilic esophagitis
  publication-title: Clin. Transl. Gastroenterol.
  doi: 10.1038/ctg.2017.27
– volume: 119
  start-page: 206
  year: 2007
  ident: 10.1038/s41385-019-0214-9_bib35
  article-title: Esophageal remodeling in pediatric eosinophilic esophagitis
  publication-title: J. Allergy Clin. Immunol.
  doi: 10.1016/j.jaci.2006.10.016
– volume: 46
  start-page: 895
  year: 2014
  ident: 10.1038/s41385-019-0214-9_bib15
  article-title: Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3033
– ident: 10.1038/s41385-019-0214-9_bib41
– volume: 43
  start-page: 201
  year: 2014
  ident: 10.1038/s41385-019-0214-9_bib3
  article-title: Epidemiology of eosinophilic esophagitis
  publication-title: Gastroenterol. Clin. North Am.
  doi: 10.1016/j.gtc.2014.02.002
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Snippet Eosinophilic esophagitis (EoE) is a chronic Th2 antigen-driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal...
Eosinophilic esophagitis (EoE) is a chronic Th2 antigen driven disorder associated with tissue remodeling. Inflammation and remodeling lead to esophageal...
SourceID pubmedcentral
proquest
pubmed
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springer
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 110
SubjectTerms Allergology
Antibodies
Autoimmune diseases
Biomedical and Life Sciences
Biomedicine
Biopsy
Cell Adhesion
Cells, Cultured
Child
Collagen
Contractility
Dysphagia
E-cadherin
Eosinophilic Esophagitis - genetics
Eosinophilic Esophagitis - immunology
Epithelial cells
Epithelial Cells - physiology
Esophageal diseases
Esophagitis
Esophagus
Female
Fibroblasts
Fibroblasts - physiology
Fibrosis
Gastroenterology
Gastrointestinal diseases
Gelatinase A
Gene expression
Gene polymorphism
Genetic Association Studies
Genotype
Genotype & phenotype
Humans
Immunology
Inflammation
Intestinal Mucosa - immunology
Intestinal Mucosa - pathology
Leukocytes (eosinophilic)
Localization
Lymphocytes T
Male
Mucosa
Polymorphism, Single Nucleotide
Single-nucleotide polymorphism
Spheroids
Stricture
Transcription
Transforming Growth Factor beta1 - genetics
Transforming growth factor-b1
Title TGFβ1 single-nucleotide polymorphism C-509T alters mucosal cell function in pediatric eosinophilic esophagitis
URI https://www.clinicalkey.com/#!/content/1-s2.0-S1933021922002458
https://link.springer.com/article/10.1038/s41385-019-0214-9
https://www.ncbi.nlm.nih.gov/pubmed/31636346
https://www.proquest.com/docview/2327331327
https://www.proquest.com/docview/2475031217
https://www.proquest.com/docview/2307727654
https://pubmed.ncbi.nlm.nih.gov/PMC6917872
Volume 13
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