The Triple Combination of Meropenem, Avibactam, and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

[Display omitted] This work explores the potential of a triple combination of meropenem (MEM), a novel metallo-β-lactamase (MBL) inhibitor (indole-2-carboxylate 58 (InC58)), and a serine-β-lactamase (SBL) inhibitor (avibactam (AVI)) for broad-spectrum activity against carbapenemase-producing bacteri...

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Bibliographic Details
Published in:Engineering (Beijing, China) Vol. 38; no. 7; pp. 124 - 132
Main Authors: Ling, Zhuoren, Farley, Alistair James Macdonald, Lankapalli, Aditya, Zhang, Yanfang, Premchand-Branker, Shonnette, Cook, Kate, Baran, Andrei, Gray-Hammerton, Charlotte, Orbegozo Rubio, Claudia, Suna, Edgars, Mathias, Jordan, Brem, Jürgen, Sands, Kirsty, Nieto-Rosado, Maria, Trush, Maria Mykolaivna, Rakhi, Nadira Naznin, Martins, Willames, Zhou, Yuqing, Schofield, Christopher Joseph, Walsh, Timothy
Format: Journal Article
Language:English
Published: China Elsevier Ltd 01.07.2024
Enzymology and Applied Biocatalysis Research Center,Faculty of Chemistry and Chemical Engineering,Babes-Bolyai University,Cluj-Napoca 400028,Romania
Department of Biology & Ineos Oxford Institute for Antimicrobial Research,University of Oxford,Oxford OX1 3RE,UK%Chemistry Research Laboratory,Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research,University of Oxford,Oxford OX1 3TA,UK%Latvian Institute of Organic Synthesis,Riga LV-1006,Latvia%Department of Medical Microbiology,Division of Infection and Immunity,School of Medicine,Cardiff University,Cardiff CF14 4XN,UK%Chemistry Research Laboratory,Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research,University of Oxford,Oxford OX1 3TA,UK
Higher Education Press
Elsevier
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ISSN:2095-8099, 2096-0026
Online Access:Get full text
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