Single-Biocatalyst Synthesis of Enantiopure d-Arylalanines Exploiting an Engineered d-Amino Acid Dehydrogenase

A practical and efficient biocatalytic synthesis of aromatic d‐amino acids has been developed, based on the reductive amination of the corresponding α‐keto acids via a recombinant whole cell system composed of an engineered dehydrogenase and cofactor recycling apparatus. The reaction was shown to gi...

Full description

Bibliographic Details

Published in:	Advanced synthesis & catalysis Vol. 358; no. 20; pp. 3298 - 3306
Main Authors:	Parmeggiani, Fabio, Ahmed, Syed T., Thompson, Matthew P., Weise, Nicholas J., Galman, James L., Gahloth, Deepankar, Dunstan, Mark S., Leys, David, Turner, Nicholas J.
Format:	Journal Article
Language:	English
Published:	Blackwell Publishing Ltd 20.10.2016
Subjects:	amino acids asymmetric synthesis biocatalysis Catalysis Catalysts Derivatives enzyme catalysis Enzymes oxidoreductases Recombinant Recycling Synthesis Synthesis (chemistry)
ISSN:	1615-4150, 1615-4169
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!