Actin-based force generation and cell adhesion in tissue morphogenesis

The generation of organismal form - morphogenesis - arises from forces produced at the cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here, we review how mechanisms of actin-based force generation are deployed during animal morphogenesis to sculpt organs a...

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Bibliographic Details
Published in:Current biology Vol. 31; no. 10; p. R667
Main Authors: Clarke, D Nathaniel, Martin, Adam C
Format: Journal Article
Language:English
Published: England 24.05.2021
Subjects:
Actin Cytoskeleton
Actins - metabolism
Animals
Cell Adhesion
Cytoskeleton
Morphogenesis
ISSN:1879-0445, 1879-0445
Online Access:Get more information
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Summary:The generation of organismal form - morphogenesis - arises from forces produced at the cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here, we review how mechanisms of actin-based force generation are deployed during animal morphogenesis to sculpt organs and organisms. Furthermore, we consider how cytoskeletal forces are coupled through cell adhesions to propagate across tissues, and discuss cases where cytoskeletal force or adhesion is patterned across a tissue to direct shape changes. Together, our review provides a conceptual framework that reflects our current understanding of animal morphogenesis and gives perspectives on future opportunities for study.
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ISSN:1879-0445
1879-0445
DOI:10.1016/j.cub.2021.03.031