CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination

In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA. CSR is initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues at t...

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Bibliographic Details

Published in:	Frontiers in immunology Vol. 8; p. 1076
Main Authors:	Marina-Zárate, Ester, Pérez-García, Arantxa, Ramiro, Almudena R.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 04.09.2017
Subjects:	activation-induced deaminase CCCTC-binding factor class switch recombination germline transcription Immunology somatic hypermutation CCCTC-binding factor somatic hypermutation class switch recombination germline transcription activation-induced deaminase
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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