New Arylalkylamine N-Acetyltransferase in Silkworm (Bombyx mori) Affects Integument Pigmentation

Dopamine is a precursor for melanin synthesis. Arylalkylamine N-acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could catalyze the transformation from dopamine to dopamine-N-acetyldopamine. In this study, we identified a new AANAT gene in the silkworm (Bombyx m...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Applied biochemistry and biotechnology Jg. 175; H. 7; S. 3447 - 3457
Hauptverfasser:	Long, Yaohang, Li, Jiaorong, Zhao, Tianfu, Li, Guannan, Zhu, Yong
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Boston Springer-Verlag 01.04.2015 Springer US Springer Nature B.V
Schlagworte:	Amino acids Animals Arylalkylamine N-Acetyltransferase - biosynthesis Arylalkylamine N-Acetyltransferase - genetics Arylalkylamine N-Acetyltransferase - metabolism Biochemistry Biotechnology Bombyx - enzymology Bombyx mori Butterflies & moths Chemistry Chemistry and Materials Science complementary DNA Dopamine Enzymatic activity enzyme activity Enzymes Gene Expression Regulation, Enzymologic genes genetically modified organisms head high performance liquid chromatography integument Integumentary System Liquid chromatography melanin Melanins - biosynthesis melatonin Melatonin - biosynthesis metabolism Pigmentation Pigmentation - genetics Pigments quantitative polymerase chain reaction silkworms acetyltransferase (AANAT) Dopamine Transgenic silkworm Arylalkylamine Melanin Integument color
ISSN:	0273-2289, 1559-0291, 1559-0291
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	Dopamine is a precursor for melanin synthesis. Arylalkylamine N-acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could catalyze the transformation from dopamine to dopamine-N-acetyldopamine. In this study, we identified a new AANAT gene in the silkworm (Bombyx mori) and assessed its role in the silkworm. The cDNA of this gene encodes 233 amino acids that shares 57 % amino acid identity with the Bm-iAANAT protein. We thus refer to this gene as Bm-iAANAT2. To investigate the role of Bm-iAANAT2, we constructed a transgenic interference system using a 3xp3 promoter to suppress the expression of Bm-iAANAT2 in the silkworm. We observed that melanin deposition occurs in the head and integument in transgenic lines. To verify the melanism pattern, dopamine content and the enzyme activity of AANAT were determined by high-performance liquid chromatography (HPLC). We found that an increase in dopamine levels affects melanism patterns on the heads of transgenic B. mori. A reduction in the enzyme activity of AANAT leads to changes in dopamine levels. We analyzed the expression of the Bm-iAANAT2 genes by qPCR and found that the expression of Bm-iAANAT2 gene is significantly lower in transgenic lines. Our results lead us to conclude that Bm-iAANAT2 is a new arylalkylamine N-acetyltransferase gene in the silkworm and is involved in the metabolism of the dopamine to avoid the generation of melanin.
AbstractList	Dopamine is a precursor for melanin synthesis. Arylalkylamine N-acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could catalyze the transformation from dopamine to dopamine-N-acetyldopamine. In this study, we identified a new AANAT gene in the silkworm (Bombyx mori) and assessed its role in the silkworm. The cDNA of this gene encodes 233 amino acids that shares 57 % amino acid identity with the Bm-iAANAT protein. We thus refer to this gene as Bm-iAANAT2. To investigate the role of Bm-iAANAT2, we constructed a transgenic interference system using a 3xp3 promoter to suppress the expression of Bm-iAANAT2 in the silkworm. We observed that melanin deposition occurs in the head and integument in transgenic lines. To verify the melanism pattern, dopamine content and the enzyme activity of AANAT were determined by high-performance liquid chromatography (HPLC). We found that an increase in dopamine levels affects melanism patterns on the heads of transgenic B. mori. A reduction in the enzyme activity of AANAT leads to changes in dopamine levels. We analyzed the expression of the Bm-iAANAT2 genes by qPCR and found that the expression of Bm-iAANAT2 gene is significantly lower in transgenic lines. Our results lead us to conclude that Bm-iAANAT2 is a new arylalkylamine N-acetyltransferase gene in the silkworm and is involved in the metabolism of the dopamine to avoid the generation of melanin. Dopamine is a precursor for melanin synthesis. Arylalkylamine N -acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could catalyze the transformation from dopamine to dopamine- N -acetyldopamine. In this study, we identified a new AANAT gene in the silkworm ( Bombyx mori ) and assessed its role in the silkworm. The cDNA of this gene encodes 233 amino acids that shares 57 % amino acid identity with the Bm-iAANAT protein. We thus refer to this gene as Bm-iAANAT2. To investigate the role of Bm-iAANAT2 , we constructed a transgenic interference system using a 3xp3 promoter to suppress the expression of Bm-iAANAT2 in the silkworm. We observed that melanin deposition occurs in the head and integument in transgenic lines. To verify the melanism pattern, dopamine content and the enzyme activity of AANAT were determined by high-performance liquid chromatography (HPLC). We found that an increase in dopamine levels affects melanism patterns on the heads of transgenic B. mori . A reduction in the enzyme activity of AANAT leads to changes in dopamine levels. We analyzed the expression of the Bm-iAANAT2 genes by qPCR and found that the expression of Bm-iAANAT2 gene is significantly lower in transgenic lines. Our results lead us to conclude that Bm-iAANAT2 is a new arylalkylamine N -acetyltransferase gene in the silkworm and is involved in the metabolism of the dopamine to avoid the generation of melanin. Dopamine is a precursor for melanin synthesis. Arylalkylamine N-acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could catalyze the transformation from dopamine to dopamine-N-acetyldopamine. In this study, we identified a new AANAT gene in the silkworm (Bombyx mori) and assessed its role in the silkworm. The cDNA of this gene encodes 233 amino acids that shares 57 % amino acid identity with the Bm-iAANAT protein. We thus refer to this gene as Bm-iAANAT2. To investigate the role of Bm-iAANAT2, we constructed a transgenic interference system using a 3xp3 promoter to suppress the expression of Bm-iAANAT2 in the silkworm. We observed that melanin deposition occurs in the head and integument in transgenic lines. To verify the melanism pattern, dopamine content and the enzyme activity of AANAT were determined by high-performance liquid chromatography (HPLC). We found that an increase in dopamine levels affects melanism patterns on the heads of transgenic B. mori. A reduction in the enzyme activity of AANAT leads to changes in dopamine levels. We analyzed the expression of the Bm-iAANAT2 genes by qPCR and found that the expression of Bm-iAANAT2 gene is significantly lower in transgenic lines. Our results lead us to conclude that Bm-iAANAT2 is a new arylalkylamine N-acetyltransferase gene in the silkworm and is involved in the metabolism of the dopamine to avoid the generation of melanin. Dopamine is a precursor for melanin synthesis. Arylalkylamine N-acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could catalyze the transformation from dopamine to dopamine-N-acetyldopamine. In this study, we identified a new AANAT gene in the silkworm (Bombyx mori) and assessed its role in the silkworm. The cDNA of this gene encodes 233 amino acids that shares 57 % amino acid identity with the Bm-iAANAT protein. We thus refer to this gene as Bm-iAANAT2. To investigate the role of Bm-iAANAT2, we constructed a transgenic interference system using a 3xp3 promoter to suppress the expression of Bm-iAANAT2 in the silkworm. We observed that melanin deposition occurs in the head and integument in transgenic lines. To verify the melanism pattern, dopamine content and the enzyme activity of AANAT were determined by high-performance liquid chromatography (HPLC). We found that an increase in dopamine levels affects melanism patterns on the heads of transgenic B. mori. A reduction in the enzyme activity of AANAT leads to changes in dopamine levels. We analyzed the expression of the Bm-iAANAT2 genes by qPCR and found that the expression of Bm-iAANAT2 gene is significantly lower in transgenic lines. Our results lead us to conclude that Bm-iAANAT2 is a new arylalkylamine N-acetyltransferase gene in the silkworm and is involved in the metabolism of the dopamine to avoid the generation of melanin.Dopamine is a precursor for melanin synthesis. Arylalkylamine N-acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could catalyze the transformation from dopamine to dopamine-N-acetyldopamine. In this study, we identified a new AANAT gene in the silkworm (Bombyx mori) and assessed its role in the silkworm. The cDNA of this gene encodes 233 amino acids that shares 57 % amino acid identity with the Bm-iAANAT protein. We thus refer to this gene as Bm-iAANAT2. To investigate the role of Bm-iAANAT2, we constructed a transgenic interference system using a 3xp3 promoter to suppress the expression of Bm-iAANAT2 in the silkworm. We observed that melanin deposition occurs in the head and integument in transgenic lines. To verify the melanism pattern, dopamine content and the enzyme activity of AANAT were determined by high-performance liquid chromatography (HPLC). We found that an increase in dopamine levels affects melanism patterns on the heads of transgenic B. mori. A reduction in the enzyme activity of AANAT leads to changes in dopamine levels. We analyzed the expression of the Bm-iAANAT2 genes by qPCR and found that the expression of Bm-iAANAT2 gene is significantly lower in transgenic lines. Our results lead us to conclude that Bm-iAANAT2 is a new arylalkylamine N-acetyltransferase gene in the silkworm and is involved in the metabolism of the dopamine to avoid the generation of melanin.
Author	Li, Jiaorong Zhao, Tianfu Long, Yaohang Li, Guannan Zhu, Yong
Author_xml	– sequence: 1 fullname: Long, Yaohang – sequence: 2 fullname: Li, Jiaorong – sequence: 3 fullname: Zhao, Tianfu – sequence: 4 fullname: Li, Guannan – sequence: 5 fullname: Zhu, Yong
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/25712907$$D View this record in MEDLINE/PubMed
BookMark	eNqNks1O3DAURq2Kqgy0D9BNG6kbugj1tWM7Xk5RKUgIKlHWridzMzIkNtiJ6Lw9jkJRxQKx8d2c7_PP8R7Z8cEjIR-BHgKl6lsCRoGWFEQJAmTJ35AFCKFLyjTskAVlipeM1XqX7KV0TSmwWqh3ZJcJBUxTtSB_zvG-WMZtZ7ubvPTOY3FeLhsctt0QrU8tRpuwcL64dN3NfYh9cfA99Kvt36IP0X0tlm2LzZCKUz_gZuzRD8Uvt5mmHVzw78nb1nYJPzzOfXJ1_OP30Ul5dvHz9Gh5VjaVZEPZco3YMIVWaoa6XsuW1nULvIGKMhRirWolGwYrgFoyi8A4l7KWWitcIef75GDuvY3hbsQ0mN6lBrvOegxjMpBZBVRU9DUorXgl4TWtUmmhKjG1fnmGXocx-nzniapBZ1dT4adHalz1uDa30fU2bs0_IxmAGWhiSCli-4QANZN1M1s32bqZrJupVD3LNG5-_azQdS8m2ZxMeRe_wfjfoV8IfZ5DrQ3GbqJL5uoyQyJ_MCl1xfgDf_PGrg
CitedBy_id	crossref_primary_10_1016_j_ibmb_2019_103291 crossref_primary_10_1038_s42003_020_01177_9 crossref_primary_10_1016_j_jinsphys_2018_04_007 crossref_primary_10_1534_genetics_115_186684 crossref_primary_10_1007_s12010_016_2075_y crossref_primary_10_1007_s12104_025_10222_9 crossref_primary_10_4001_003_026_0359 crossref_primary_10_1016_j_abb_2018_11_015 crossref_primary_10_1186_s13071_020_04342_5 crossref_primary_10_3389_fmolb_2018_00066 crossref_primary_10_3390_insects13110986
Cites_doi	10.1016/S0965-1748(01)00150-3 10.1016/S0168-9525(03)00194-X 10.1016/0303-7207(95)03670-3 10.1074/jbc.273.5.3045 10.1111/j.1600-0749.2006.00316.x 10.1016/j.tree.2003.09.006 10.1093/abbs/40.9.790 10.1016/j.ibmb.2010.03.003 10.1016/j.ibmb.2007.08.006 10.1038/35003589 10.1016/0003-2697(90)90673-W 10.1038/305133a0 10.1111/j.1365-294X.2007.03380.x 10.1371/journal.pone.0071984 10.1016/S0065-2660(08)60008-5 10.1016/j.bioeng.2007.10.004 10.1007/s00441-002-0579-y 10.1242/dev.053678 10.1016/0014-5793(95)01198-N 10.1089/10445490050199081 10.1016/j.cbpb.2006.10.112 10.1016/j.ibmb.2010.01.004 10.1007/BF00221860 10.1073/pnas.1001725107 10.1074/jbc.M109.096743 10.1038/71978 10.1038/nbt771 10.1242/dev.129.8.1849 10.1534/genetics.108.096388 10.1126/science.1176980
ContentType	Journal Article
Copyright	Springer Science+Business Media New York 2015
Copyright_xml	– notice: Springer Science+Business Media New York 2015
DBID	FBQ AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7ST 7T7 7TM 7X7 7XB 88A 88E 88I 8AO 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U RC3 SOI 7X8 7QO 7SS 7S9 L.6
DOI	10.1007/s12010-015-1516-3
DatabaseName	AGRIS CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Environment Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability (subscription) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts Environment Abstracts MEDLINE - Academic Biotechnology Research Abstracts Entomology Abstracts (Full archive) AGRICOLA AGRICOLA - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Environment Abstracts ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic Entomology Abstracts Biotechnology Research Abstracts AGRICOLA AGRICOLA - Academic
DatabaseTitleList	Entomology Abstracts MEDLINE AGRICOLA ProQuest Central Student MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Engineering Chemistry
EISSN	1559-0291
EndPage	3457
ExternalDocumentID	3642553991 25712907 10_1007_s12010_015_1516_3 US201500166942
Genre	Research Support, Non-U.S. Gov't Journal Article Feature
GroupedDBID	--- -Y2 .86 .GJ .VR 06C 06D 0R~ 0VX 0VY 199 1N0 2.D 203 23M 28- 2J2 2JN 2JY 2KG 2KM 2LR 2VQ 2~H 30V 3SX 4.4 406 408 40D 40E 53G 5GY 5VS 6NX 78A 7X7 88E 88I 8AO 8CJ 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X A8Z AAAVM AABHQ AACDK AAHBH AAHNG AAIAL AAIKT AAJBT AAJKR AANXM AANZL AAPKM AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABDBE ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABMNI ABMQK ABNWP ABQBU ABQSL ABSXP ABTEG ABTHY ABTKH ABTMW ABUWG ABWNU ABXPI ACAOD ACBXY ACCUX ACDTI ACGFS ACGOD ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACZOJ ADBBV ADHIR ADHKG ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEUYN AEVLU AEXYK AFBBN AFEXP AFFNX AFGCZ AFKRA AFLOW AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHPBZ AHSBF AI. AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AOCGG ARMRJ ASPBG AVWKF AXYYD AYFIA AYJHY AZFZN AZQEC B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP D1J DDRTE DNIVK DPUIP DWQXO EBD EBLON EBS EIOEI EJD EMOBN ESBYG F5P FBQ FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ7 H13 HCIFZ HF~ HG6 HMCUK HMJXF HRMNR HVGLF HZ~ IJ- IKXTQ ITM IWAJR IXC IZQ I~X I~Z J-C J0Z JBSCW JZLTJ KOV LK8 LLZTM M1P M2P M4Y M7P MA- ML0 N2Q N9A NB0 NDZJH NF0 NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OVD P19 P2P P9N PF0 PHGZT PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNS ROL RPX RSV S16 S1Z S26 S27 S28 S3A S3B SAP SCG SCLPG SCM SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW STPWE SV3 SZN T13 T16 TEORI TSG TSV TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW VH1 W48 WK6 WK8 YLTOR ZMTXR ZXP ~02 ~A9 ~EX ~KM -4Y -58 -5G -BR -EM -~C 3V. 88A ADINQ GQ6 M0L Z5O Z7R Z7S Z7U Z7V Z7W Z7X Z7Y Z7Z Z83 Z86 Z87 Z88 Z8M Z8N Z8O Z8P Z8Q Z8R Z8S Z8T Z8W Z91 Z92 AAYXX ABBRH ABFSG ABRTQ ACSTC AEZWR AFDZB AFFHD AFHIU AFOHR AGQPQ AHWEU AIXLP ATHPR CITATION ESTFP PHGZM PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7ST 7T7 7TM 7XB 8FD 8FK C1K FR3 K9. P64 PKEHL PQEST PQUKI PRINS Q9U RC3 SOI 7X8 PUEGO 7QO 7SS 7S9 L.6
ID	FETCH-LOGICAL-c462t-f39eec27ea692e98d6f088f13c1402e55d7876c21b11862ae12336686997ebe33
IEDL.DBID	M7P
ISICitedReferencesCount	14
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000351767200017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0273-2289 1559-0291
IngestDate	Sun Sep 28 10:47:17 EDT 2025 Tue Oct 07 09:39:57 EDT 2025 Fri Sep 05 06:21:03 EDT 2025 Wed Nov 05 14:21:02 EST 2025 Mon Jul 21 05:33:30 EDT 2025 Tue Nov 18 21:43:56 EST 2025 Sat Nov 29 06:30:29 EST 2025 Fri Feb 21 02:38:30 EST 2025 Thu Apr 03 09:40:16 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	7
Keywords	acetyltransferase (AANAT) Dopamine Transgenic silkworm Arylalkylamine Melanin Integument color
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c462t-f39eec27ea692e98d6f088f13c1402e55d7876c21b11862ae12336686997ebe33
Notes	http://dx.doi.org/10.1007/s12010-015-1516-3 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
PMID	25712907
PQID	1668192013
PQPubID	54110
PageCount	11
ParticipantIDs	proquest_miscellaneous_1686710540 proquest_miscellaneous_1680434613 proquest_miscellaneous_1667957450 proquest_journals_1668192013 pubmed_primary_25712907 crossref_primary_10_1007_s12010_015_1516_3 crossref_citationtrail_10_1007_s12010_015_1516_3 springer_journals_10_1007_s12010_015_1516_3 fao_agris_US201500166942
PublicationCentury	2000
PublicationDate	2015-04-01
PublicationDateYYYYMMDD	2015-04-01
PublicationDate_xml	– month: 04 year: 2015 text: 2015-04-01 day: 01
PublicationDecade	2010
PublicationPlace	Boston
PublicationPlace_xml	– name: Boston – name: United States – name: Totowa
PublicationSubtitle	Part A: Enzyme Engineering and Biotechnology
PublicationTitle	Applied biochemistry and biotechnology
PublicationTitleAbbrev	Appl Biochem Biotechnol
PublicationTitleAlternate	Appl Biochem Biotechnol
PublicationYear	2015
Publisher	Springer-Verlag Springer US Springer Nature B.V
Publisher_xml	– name: Springer-Verlag – name: Springer US – name: Springer Nature B.V
References	Zhan, Guo, Li, Li, Li, Miao, Huang (CR13) 2010; 137 Chen, Li, Wang, Li, Li, Lv, Lu (CR3) 2013; 8 Wright (CR23) 1987; 24 Wittkopp, True, Carroll (CR24) 2002; 129 Kato, Sawada, Yamamoto, Mase, Nakagoshi (CR1) 2006; 19 CR16 De Angelis, Gastel, Klein, Cole (CR14) 1998; 273 CR15 Dai, Jiang, Wang, Xu, Cao, Wang, Fei (CR18) 2007; 24 Wittkopp, Carroll, Kopp (CR5) 2003; 19 Thomas, Zawilska, Iuvone (CR17) 1990; 184 CR12 Amherd, Hintermann, Walz, Affolter, Meyer (CR29) 2000; 19 Moussian (CR6) 2010; 40 Dai, Ma, Wang, Jiang, Wang, Fei (CR19) 2008; 40 Tsugehara, Iwai, Fujiwara, Mita, Takeda (CR11) 2007; 147 Besharse, Iuvone (CR8) 1983; 305 Gorman, An, Kanost (CR22) 2007; 37 Kohn, Wittkopp (CR26) 2007; 16 CR2 Whitmore, Foulkes, Sassone-Corsi (CR7) 2000; 404 CR4 Ganguly, Coon, Klein (CR9) 2002; 309 True (CR25) 2003; 18 CR27 Takeda, Vieillemaringe, Geffard, Rémy (CR30) 1986; 243 Itoh, Hattori, Nomura, Sumi, Suzuki (CR10) 1995; 115 Gorman, Arakane (CR21) 2010; 40 Hintermann, Jenö, Meyer (CR28) 1995; 375 Thomas, Da Rocha, Besse, Mauchamp, Chavancy (CR20) 2002; 32 1516_CR15 1516_CR16 E Hintermann (1516_CR28) 1995; 375 S Ganguly (1516_CR9) 2002; 309 KB Thomas (1516_CR17) 1990; 184 PJ Wittkopp (1516_CR24) 2002; 129 S Takeda (1516_CR30) 1986; 243 TR Wright (1516_CR23) 1987; 24 JL Thomas (1516_CR20) 2002; 32 1516_CR12 P Chen (1516_CR3) 2013; 8 JR True (1516_CR25) 2003; 18 MJ Gorman (1516_CR21) 2010; 40 D Whitmore (1516_CR7) 2000; 404 T Kato (1516_CR1) 2006; 19 B Moussian (1516_CR6) 2010; 40 PJ Wittkopp (1516_CR5) 2003; 19 MT Itoh (1516_CR10) 1995; 115 H Dai (1516_CR18) 2007; 24 1516_CR27 1516_CR4 R Amherd (1516_CR29) 2000; 19 H Dai (1516_CR19) 2008; 40 1516_CR2 T Tsugehara (1516_CR11) 2007; 147 MH Kohn (1516_CR26) 2007; 16 JC Besharse (1516_CR8) 1983; 305 MJ Gorman (1516_CR22) 2007; 37 S Zhan (1516_CR13) 2010; 137 J Angelis De (1516_CR14) 1998; 273
References_xml	– volume: 32 start-page: 247 issue: 3 year: 2002 end-page: 253 ident: CR20 article-title: 3× P3-EGFP marker facilitates screening for transgenic silkworm L. from the embryonic stage onwards publication-title: Insect Biochemistry and Molecular Biology doi: 10.1016/S0965-1748(01)00150-3 – volume: 19 start-page: 495 issue: 9 year: 2003 end-page: 504 ident: CR5 article-title: Evolution in black and white: genetic control of pigment patterns in publication-title: Trends in Genetics doi: 10.1016/S0168-9525(03)00194-X – volume: 115 start-page: 59 issue: 1 year: 1995 end-page: 64 ident: CR10 article-title: Melatonin and arylalkylamine N-acetyltransferase activity in the silkworm, publication-title: Molecular and Cellular Endocrinology doi: 10.1016/0303-7207(95)03670-3 – volume: 273 start-page: 3045 issue: 5 year: 1998 end-page: 3050 ident: CR14 article-title: Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3. 1.87) publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.273.5.3045 – volume: 19 start-page: 337 issue: 4 year: 2006 end-page: 345 ident: CR1 article-title: Pigment pattern formation in the quail mutant of the silkworm, : parallel increase of pteridine biosynthesis and pigmentation of melanin and ommochromes publication-title: Pigment Cell Research doi: 10.1111/j.1600-0749.2006.00316.x – volume: 18 start-page: 640 issue: 12 year: 2003 end-page: 647 ident: CR25 article-title: Insect melanism: the molecules matter publication-title: Trends in Ecology & Evolution doi: 10.1016/j.tree.2003.09.006 – ident: CR4 – ident: CR2 – ident: CR16 – ident: CR12 – volume: 40 start-page: 790 issue: 9 year: 2008 end-page: 795 ident: CR19 article-title: Knockdown of ecdysis-triggering hormone gene with a binary UAS/GAL4 RNA interference system leads to lethal ecdysis deficiency in silkworm publication-title: Acta Biochimica et Biophysica Sinica doi: 10.1093/abbs/40.9.790 – volume: 40 start-page: 363 issue: 5 year: 2010 end-page: 375 ident: CR6 article-title: Recent advances in understanding mechanisms of insect cuticle differentiation publication-title: Insect Biochemistry and Molecular Biology doi: 10.1016/j.ibmb.2010.03.003 – volume: 37 start-page: 1327 issue: 12 year: 2007 end-page: 1337 ident: CR22 article-title: Characterization of tyrosine hydroxylase from publication-title: Insect Biochemistry and Molecular Biology doi: 10.1016/j.ibmb.2007.08.006 – volume: 404 start-page: 87 issue: 6773 year: 2000 end-page: 91 ident: CR7 article-title: Light acts directly on organs and cells in culture to set the vertebrate circadian clock publication-title: Nature doi: 10.1038/35003589 – volume: 184 start-page: 228 issue: 2 year: 1990 end-page: 234 ident: CR17 article-title: Arylalkylamine (serotonin) N-acetyltransferase assay using high-performance liquid chromatography with fluorescence or electrochemical detection of N-acetyltryptamine publication-title: Analytical Biochemistry doi: 10.1016/0003-2697(90)90673-W – ident: CR27 – volume: 305 start-page: 133 year: 1983 end-page: 135 ident: CR8 article-title: Circadian clock in Xenopus eye controlling retinal serotonin N-acetyltransferase publication-title: Nature doi: 10.1038/305133a0 – volume: 16 start-page: 2831 issue: 14 year: 2007 end-page: 2833 ident: CR26 article-title: Annotating ebony on the fly publication-title: Molecular Ecology doi: 10.1111/j.1365-294X.2007.03380.x – volume: 8 start-page: e71984 issue: 8 year: 2013 ident: CR3 article-title: catalyzes the initial melanin biosynthetic step in publication-title: PloS One doi: 10.1371/journal.pone.0071984 – volume: 24 start-page: 127 year: 1987 end-page: 222 ident: CR23 article-title: The genetics of biogenic amine metabolism, sclerotization, and melanization in publication-title: Advances in Genetics doi: 10.1016/S0065-2660(08)60008-5 – volume: 24 start-page: 625 issue: 6 year: 2007 end-page: 630 ident: CR18 article-title: Development of a heat shock inducible and inheritable RNAi system in silkworm publication-title: Biomolecular Engineering doi: 10.1016/j.bioeng.2007.10.004 – volume: 309 start-page: 127 issue: 1 year: 2002 end-page: 137 ident: CR9 article-title: Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation publication-title: Cell and Tissue Research doi: 10.1007/s00441-002-0579-y – volume: 137 start-page: 4083 issue: 23 year: 2010 end-page: 4090 ident: CR13 article-title: Disruption of an N-acetyltransferase gene in the silkworm reveals a novel role in pigmentation publication-title: Development doi: 10.1242/dev.053678 – ident: CR15 – volume: 375 start-page: 148 issue: 1 year: 1995 end-page: 150 ident: CR28 article-title: Isolation and characterization of an arylalkylamine N-acetyltransferase from publication-title: FEBS Letters doi: 10.1016/0014-5793(95)01198-N – volume: 19 start-page: 697 issue: 11 year: 2000 end-page: 705 ident: CR29 article-title: Purification, cloning, and characterization of a second arylalkylamine N-acetyltransferase from publication-title: DNA and Cell Biology doi: 10.1089/10445490050199081 – volume: 147 start-page: 358 issue: 3 year: 2007 end-page: 366 ident: CR11 article-title: Cloning and characterization of insect arylalkylamine N-acetyltransferase from publication-title: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology doi: 10.1016/j.cbpb.2006.10.112 – volume: 40 start-page: 267 issue: 3 year: 2010 end-page: 273 ident: CR21 article-title: Tyrosine hydroxylase is required for cuticle sclerotization and pigmentation in publication-title: Insect Biochemistry and Molecular Biology doi: 10.1016/j.ibmb.2010.01.004 – volume: 243 start-page: 125 issue: 1 year: 1986 end-page: 128 ident: CR30 article-title: Immunohistological evidence of dopamine cells in the cephalic nervous system of the silkworm Coexistence of dopamine and α endorphin-like substance in neurosecretory cells of the suboesophageal ganglion publication-title: Cell and Tissue Research doi: 10.1007/BF00221860 – volume: 129 start-page: 1849 issue: 8 year: 2002 end-page: 1858 ident: CR24 article-title: Reciprocal functions of the Drosophila yellow and ebony proteins in the development and evolution of pigment patterns publication-title: Development – volume: 37 start-page: 1327 issue: 12 year: 2007 ident: 1516_CR22 publication-title: Insect Biochemistry and Molecular Biology doi: 10.1016/j.ibmb.2007.08.006 – ident: 1516_CR4 doi: 10.1073/pnas.1001725107 – volume: 243 start-page: 125 issue: 1 year: 1986 ident: 1516_CR30 publication-title: Cell and Tissue Research doi: 10.1007/BF00221860 – volume: 404 start-page: 87 issue: 6773 year: 2000 ident: 1516_CR7 publication-title: Nature doi: 10.1038/35003589 – ident: 1516_CR12 doi: 10.1074/jbc.M109.096743 – volume: 24 start-page: 625 issue: 6 year: 2007 ident: 1516_CR18 publication-title: Biomolecular Engineering doi: 10.1016/j.bioeng.2007.10.004 – volume: 19 start-page: 337 issue: 4 year: 2006 ident: 1516_CR1 publication-title: Pigment Cell Research doi: 10.1111/j.1600-0749.2006.00316.x – ident: 1516_CR15 doi: 10.1038/71978 – volume: 40 start-page: 790 issue: 9 year: 2008 ident: 1516_CR19 publication-title: Acta Biochimica et Biophysica Sinica doi: 10.1093/abbs/40.9.790 – volume: 40 start-page: 267 issue: 3 year: 2010 ident: 1516_CR21 publication-title: Insect Biochemistry and Molecular Biology doi: 10.1016/j.ibmb.2010.01.004 – ident: 1516_CR16 doi: 10.1038/nbt771 – volume: 273 start-page: 3045 issue: 5 year: 1998 ident: 1516_CR14 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.273.5.3045 – volume: 137 start-page: 4083 issue: 23 year: 2010 ident: 1516_CR13 publication-title: Development doi: 10.1242/dev.053678 – volume: 129 start-page: 1849 issue: 8 year: 2002 ident: 1516_CR24 publication-title: Development doi: 10.1242/dev.129.8.1849 – volume: 16 start-page: 2831 issue: 14 year: 2007 ident: 1516_CR26 publication-title: Molecular Ecology doi: 10.1111/j.1365-294X.2007.03380.x – volume: 24 start-page: 127 year: 1987 ident: 1516_CR23 publication-title: Advances in Genetics doi: 10.1016/S0065-2660(08)60008-5 – volume: 115 start-page: 59 issue: 1 year: 1995 ident: 1516_CR10 publication-title: Molecular and Cellular Endocrinology doi: 10.1016/0303-7207(95)03670-3 – volume: 375 start-page: 148 issue: 1 year: 1995 ident: 1516_CR28 publication-title: FEBS Letters doi: 10.1016/0014-5793(95)01198-N – volume: 19 start-page: 495 issue: 9 year: 2003 ident: 1516_CR5 publication-title: Trends in Genetics doi: 10.1016/S0168-9525(03)00194-X – ident: 1516_CR2 doi: 10.1534/genetics.108.096388 – volume: 305 start-page: 133 year: 1983 ident: 1516_CR8 publication-title: Nature doi: 10.1038/305133a0 – volume: 40 start-page: 363 issue: 5 year: 2010 ident: 1516_CR6 publication-title: Insect Biochemistry and Molecular Biology doi: 10.1016/j.ibmb.2010.03.003 – volume: 184 start-page: 228 issue: 2 year: 1990 ident: 1516_CR17 publication-title: Analytical Biochemistry doi: 10.1016/0003-2697(90)90673-W – volume: 32 start-page: 247 issue: 3 year: 2002 ident: 1516_CR20 publication-title: Insect Biochemistry and Molecular Biology doi: 10.1016/S0965-1748(01)00150-3 – volume: 19 start-page: 697 issue: 11 year: 2000 ident: 1516_CR29 publication-title: DNA and Cell Biology doi: 10.1089/10445490050199081 – volume: 8 start-page: e71984 issue: 8 year: 2013 ident: 1516_CR3 publication-title: PloS One doi: 10.1371/journal.pone.0071984 – volume: 18 start-page: 640 issue: 12 year: 2003 ident: 1516_CR25 publication-title: Trends in Ecology & Evolution doi: 10.1016/j.tree.2003.09.006 – ident: 1516_CR27 doi: 10.1126/science.1176980 – volume: 309 start-page: 127 issue: 1 year: 2002 ident: 1516_CR9 publication-title: Cell and Tissue Research doi: 10.1007/s00441-002-0579-y – volume: 147 start-page: 358 issue: 3 year: 2007 ident: 1516_CR11 publication-title: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology doi: 10.1016/j.cbpb.2006.10.112
SSID	ssj0012857
Score	2.1882944
Snippet	Dopamine is a precursor for melanin synthesis. Arylalkylamine N-acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could... Dopamine is a precursor for melanin synthesis. Arylalkylamine N -acetyltransferase (AANAT) is involved in the melatonin formation in insects because it could...
SourceID	proquest pubmed crossref springer fao
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	3447
SubjectTerms	Amino acids Animals Arylalkylamine N-Acetyltransferase - biosynthesis Arylalkylamine N-Acetyltransferase - genetics Arylalkylamine N-Acetyltransferase - metabolism Biochemistry Biotechnology Bombyx - enzymology Bombyx mori Butterflies & moths Chemistry Chemistry and Materials Science complementary DNA Dopamine Enzymatic activity enzyme activity Enzymes Gene Expression Regulation, Enzymologic genes genetically modified organisms head high performance liquid chromatography integument Integumentary System Liquid chromatography melanin Melanins - biosynthesis melatonin Melatonin - biosynthesis metabolism Pigmentation Pigmentation - genetics Pigments quantitative polymerase chain reaction silkworms
SummonAdditionalLinks	– databaseName: SpringerLink Contemporary Journals dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnR3LbtQwcEQLEvTAo_QRKMhIHHjIUmIndnxcKipOq4qlqLfITpxVRB5oN1t1_55xHtsiykpwycVjy5m3Z-wZgLdBhopfRzlVTGoa5lJQY8KQRsbPrJKZFNbvmk3I6TS-vFTnwzvu5XjbfUxJdpr65rFbn7gNIopWSlC-A_fR2sVOGr_Ovm9SByzuy3uiXaYMjxNjKvOuJX4zRju5bu7yM__IkXam5-zJf236KTwePE0y6VnjGdyz9T48PB0bvO3D3q1ahM_BTAgqPARfl7r8gZ8Kx8iUTlLbrsu282_tAm0eKWoyK0rXWLoi7z41lVlfk6pZFO_JpL8cQlyYcb5ycUdyXsyr4XlTfQAXZ5-_nX6hQwMGmoaCtTTnytqUSauFYlbFmchRKeUBT_FYxmwUZSjuImWBwWOKYNqiGeRCxEIpiczB-SHs1k1tj4GgHxErzYU1pqvJZlggUp1xjnPR4zAe-CMlknSoTu6aZJTJTV1lh8oEUZk4VCbcgw-bKT_70hzbgI-RvImeo-pMLmbMBXrQ2xUqZB6cjDRPBgFeJjjkSsWhg-zBm80wEsjlU3Rtm1UHI1Ukw8jfBhP7IQ_F9nVckUHnO3tw1PPc5odQo7pIofTg48hgtzb5t7998U_QL-GRw0d_H-kEdtvFyr6CB-lVWywXrzvp-gUYfhip priority: 102 providerName: Springer Nature
Title	New Arylalkylamine N-Acetyltransferase in Silkworm (Bombyx mori) Affects Integument Pigmentation
URI	https://link.springer.com/article/10.1007/s12010-015-1516-3 https://www.ncbi.nlm.nih.gov/pubmed/25712907 https://www.proquest.com/docview/1668192013 https://www.proquest.com/docview/1667957450 https://www.proquest.com/docview/1680434613 https://www.proquest.com/docview/1686710540
Volume	175
WOSCitedRecordID	wos000351767200017&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1559-0291 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0012857 issn: 0273-2289 databaseCode: M7P dateStart: 19970101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 1559-0291 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0012857 issn: 0273-2289 databaseCode: 7X7 dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1559-0291 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0012857 issn: 0273-2289 databaseCode: BENPR dateStart: 19970101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Science Database customDbUrl: eissn: 1559-0291 dateEnd: 20171231 omitProxy: false ssIdentifier: ssj0012857 issn: 0273-2289 databaseCode: M2P dateStart: 19970101 isFulltext: true titleUrlDefault: https://search.proquest.com/sciencejournals providerName: ProQuest – providerCode: PRVAVX databaseName: SpringerLink Contemporary customDbUrl: eissn: 1559-0291 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0012857 issn: 0273-2289 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB6xLRLlwKNQGigrI3HgIYvETuz4hLZVKy6soi5Fe4vycFYr8ij7QOy_Z-wk2yJgL1wsRbEjOzOeGc-MvwF47eUo-JOgoIrJhPqFFDRNfZ8GqZtrJXMptGuLTcjxOJxOVdQ53JZdWmUvE62gzpvM-Mg_eEIY7C60WD5ef6emapSJrnYlNAawb1ASuE3di7ZRBBa2SJ-ooinDk0Uf1bRX59owsBdQ1HmC8t_00qBImr-ZnH-ES60Wunj4v_N_BA86-5OMWoZ5DHd0fQj3zvqyb4dw_xZC4RNIRwTFIHbflEn5DZsK35ExHWV6tSlX1urVC9SEZF6Tybw05aYr8ua0qdLNT1LhBN6SUZsyQozzcbY23kgSzWdVd-mpfgpXF-dfzj7RriwDzXzBVrTgSuuMSZ0IxbQKc1GgqCo8nuFhjekgyFEIiIx5KR5eBEs0KkeOqxdKSWQZzo9gr25qfQwErYtQJVzoNLVIbSnzRJbknONYtENSB9yeKHHWYZab0hllfIO2bOgYIx1jQ8eYO_BuO-S6BezY1fkYKR0nMxSo8dWEGfcP2sBC-cyBk56Ocbetl_ENER14tX2NBDJRlqTWzdr2kSqQfuDu6hO6PvfF7u8Y6EFjUTvwrGW_7YJQzhr_oXTgfc-Ptyb5r9U-372kF3BgfkCblnQCe6vFWr-Eu9mP1Xy5GMJATqVtwyHsn56Po0t8-syiod1z2F5Ovv4CVKko3Q
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgtRy4FEoDRQwEkgUZJE4iR0fEFoKVauW1Uptpd5MnDirFXmUfQD7p_iNjPPYFgF764FLLnYeE3-e-TxjzwA891JU_HGYUclETINMcKp1ENBQu6mRIhXcuHWxCdHvR2dncrACP7uzMHZbZacTa0WdVon1kb_xOLe5u5CxvDv_Sm3VKBtd7UpoNLA4NPPvuGSbvD34gOP7grG9jye7-7StKkCTgLMpzXxpTMKEiblkRkYpz3CmZZ6f4FqDmTBMEcM8YZ5G7s1ZbFC3-_hyLqVAia0DFFX-daQRLKq3Cg4WUQsWNZlFkRJQhiuZLopaH9Vrws5eSNHGcur_ZgevZXH1N4r7R3i2tnp7t_-3_3UHbrX8mvSaCXEXVky5AWu7XVm7Dbh5KQPjPdA9gmoeu8_zOP-ClwLbSJ_2EjOd59Oa1ZsxWnoyKsnxKLfltAvy8n1V6PkPUqDAO6TXbIkh1rk6nFlvKxmMhkV7qKu8D6dXIvAmrJZVabaAIHuKZOxzo3WdiU4zjydx6vt4L_Is7YDbgUAlbU52WxokVxfZpC1uFOJGWdwo34FXi1vOm4QkyzpvIbJUPESDoU6PmXVvIcfnMmAObHe4Ua3amqgL0DjwbNGMA2SjSHFpqlndR8hQBKG7rE_kBn7Alz_Hpla0KwYHHjRwXwiEdsT6R4UDrzv8X_rIf0n7cLlIT2Ft_-TTkTo66B8-gnX7M5otWNuwOh3PzGO4kXybjibjJ_WsJvD5qqfFL0BlfiI
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgngceJRCAwWMBFKhspo4iR0fEFpaVlRFq5VKpd5MnDirFXmUfQD71_h1jPPYFgF764HLXuKsMsk3M59nxjMAL7wUDX8cZlQyEdMgE5xqHQQ01G5qpEgFN249bEIMBtHpqRyuwc_uLIwtq-xsYm2o0yqxMfI9j3PbuwsZy17WlkUMD_pvz75SO0HKZlq7cRoNRI7M4jtu36ZvDg_wW79krP_-0_4H2k4YoEnA2YxmvjQmYcLEXDIjo5RnqHWZ5ye472AmDFPEM0-Yp5GHcxYbtPM-PgiXUqD0NhiK5v-qsE3L67LB4TKDwaKmyyjSA8pwV9NlVOtje00K2gsp-ltO_d984pUsrv5Gd_9I1dYesH_nf353d-F2y7tJr1GUe7Bmyg24sd-Nu9uAWxc6M94H3SNo_nH5Io_zL_hT4DUyoL3EzBb5rGb7ZoIMgIxLcjzO7Zjtguy8qwq9-EEKFPgV6TWlMsQGXUdzG4Ulw_GoaA97lZtwcikCP4D1sirNFhBkVZGMfW60rjvUaebxJE59H-9F_qUdcDtAqKTt1W5HhuTqvMu0xZBCDCmLIeU78Hp5y1nTqGTV4i1EmYpH6EjUyTGzYS_k_lwGzIHtDkOqNWdTdQ4gB54vL-MHstmluDTVvF4jZCiC0F21JnIDH7Vl5f_Ylot2J-HAwwb6S4HQv9i4qXBgt9OFCw_5L2kfrRbpGVxHbVAfDwdHj-GmfRdNZdY2rM8mc_MEriXfZuPp5Gmt4AQ-X7ZW_AKznYbf
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+New+Arylalkylamine+N-Acetyltransferase+in+Silkworm+%28Bombyx+mori%29+Affects+Integument+Pigmentation&rft.jtitle=Applied+biochemistry+and+biotechnology&rft.au=Long%2C+Yaohang&rft.au=Li%2C+Jiaorong&rft.au=Zhao%2C+Tianfu&rft.au=Li%2C+Guannan&rft.date=2015-04-01&rft.issn=0273-2289&rft.eissn=1559-0291&rft.volume=175&rft.issue=7&rft.spage=3447&rft.epage=3457&rft_id=info:doi/10.1007%2Fs12010-015-1516-3&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0273-2289&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0273-2289&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0273-2289&client=summon