One Dose of Tranexamic Acid Is Safe and Effective in Revision Knee Arthroplasty

Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and transfu...

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Veröffentlicht in:	The Journal of arthroplasty Jg. 28; H. 8; S. 112 - 115
Hauptverfasser:	Smit, Kevin M., Naudie, Douglas D.R., Ralley, Fiona E., Berta, Donna M., Howard, James L.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.09.2013
Schlagworte:	Aged Antifibrinolytic Agents - adverse effects Antifibrinolytic Agents - therapeutic use Arthroplasty, Replacement, Knee blood loss Blood Loss, Surgical - prevention & control Blood Transfusion - statistics & numerical data Cohort Studies Dose-Response Relationship, Drug Female Hemoglobins - metabolism Humans Male Middle Aged Orthopedics Reoperation Retrospective Studies revision knee arthroplasty tranexamic acid Tranexamic Acid - adverse effects Tranexamic Acid - therapeutic use Treatment Outcome blood loss tranexamic acid revision knee arthroplasty
ISSN:	0883-5403, 1532-8406, 1532-8406
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Abstract	Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and transfusion rates in revision TKA. We performed a retrospective comparative study on 424 patients who had undergone revision TKA between January 2006 and March 2010. A total of 178 patients did not receive TXA while 246 patients received one intraoperative dose of 20mg/kg of TXA given prior to tourniquet release. There was a significant reduction in hemoglobin loss (42±16g/L vs 38±15g/L, P=0.005), transfusion rates (30.3% vs 16.7%, P=0.001) and average amount transfused (1.1±1.9units vs 0.5±1.1units, P=0.001) in the TXA group. There was no significant difference in recorded major adverse events with the administration of TXA.
AbstractList	Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and transfusion rates in revision TKA. We performed a retrospective comparative study on 424 patients who had undergone revision TKA between January 2006 and March 2010. A total of 178 patients did not receive TXA while 246 patients received one intraoperative dose of 20mg/kg of TXA given prior to tourniquet release. There was a significant reduction in hemoglobin loss (42±16g/L vs 38±15g/L, P=0.005), transfusion rates (30.3% vs 16.7%, P=0.001) and average amount transfused (1.1±1.9units vs 0.5±1.1units, P=0.001) in the TXA group. There was no significant difference in recorded major adverse events with the administration of TXA. Abstract Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and transfusion rates in revision TKA. We performed a retrospective comparative study on 424 patients who had undergone revision TKA between January 2006 and March 2010. A total of 178 patients did not receive TXA while 246 patients received one intraoperative dose of 20 mg/kg of TXA given prior to tourniquet release. There was a significant reduction in hemoglobin loss (42 ± 16 g/L vs 38 ± 15 g/L, P = 0.005), transfusion rates (30.3% vs 16.7%, P = 0.001) and average amount transfused (1.1 ± 1.9 units vs 0.5 ± 1.1 units, P = 0.001) in the TXA group. There was no significant difference in recorded major adverse events with the administration of TXA. Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and transfusion rates in revision TKA. We performed a retrospective comparative study on 424 patients who had undergone revision TKA between January 2006 and March 2010. A total of 178 patients did not receive TXA while 246 patients received one intraoperative dose of 20mg/kg of TXA given prior to tourniquet release. There was a significant reduction in hemoglobin loss (42±16g/L vs 38±15g/L, P=0.005), transfusion rates (30.3% vs 16.7%, P=0.001) and average amount transfused (1.1±1.9units vs 0.5±1.1units, P=0.001) in the TXA group. There was no significant difference in recorded major adverse events with the administration of TXA.Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe and effective in preventing blood loss in primary TKA. The purpose of this study was to evaluate the effect of TXA on blood loss and transfusion rates in revision TKA. We performed a retrospective comparative study on 424 patients who had undergone revision TKA between January 2006 and March 2010. A total of 178 patients did not receive TXA while 246 patients received one intraoperative dose of 20mg/kg of TXA given prior to tourniquet release. There was a significant reduction in hemoglobin loss (42±16g/L vs 38±15g/L, P=0.005), transfusion rates (30.3% vs 16.7%, P=0.001) and average amount transfused (1.1±1.9units vs 0.5±1.1units, P=0.001) in the TXA group. There was no significant difference in recorded major adverse events with the administration of TXA.
Author	Naudie, Douglas D.R. Smit, Kevin M. Berta, Donna M. Howard, James L. Ralley, Fiona E.
Author_xml	– sequence: 1 givenname: Kevin M. surname: Smit fullname: Smit, Kevin M. organization: Division of Orthopaedic Surgery, Western University, London Health Sciences Centre, London, Ontario, Canada – sequence: 2 givenname: Douglas D.R. surname: Naudie fullname: Naudie, Douglas D.R. organization: Division of Orthopaedic Surgery, Western University, London Health Sciences Centre, London, Ontario, Canada – sequence: 3 givenname: Fiona E. surname: Ralley fullname: Ralley, Fiona E. organization: Department of Anesthesia and Perioperative Medicine, Western University, London Health Sciences Centre, London, Ontario, Canada – sequence: 4 givenname: Donna M. surname: Berta fullname: Berta, Donna M. organization: Ontario Transfusion Coordinator (ONTraC), London Health Sciences Centre, London, Ontario, Canada – sequence: 5 givenname: James L. surname: Howard fullname: Howard, James L. organization: Division of Orthopaedic Surgery, Western University, London Health Sciences Centre, London, Ontario, Canada
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Snippet	Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven to be safe... Abstract Revision total knee arthroplasty (TKA) has been associated with an increased risk of perioperative blood loss. Tranexamic acid (TXA) has been proven...
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SubjectTerms	Aged Antifibrinolytic Agents - adverse effects Antifibrinolytic Agents - therapeutic use Arthroplasty, Replacement, Knee blood loss Blood Loss, Surgical - prevention & control Blood Transfusion - statistics & numerical data Cohort Studies Dose-Response Relationship, Drug Female Hemoglobins - metabolism Humans Male Middle Aged Orthopedics Reoperation Retrospective Studies revision knee arthroplasty tranexamic acid Tranexamic Acid - adverse effects Tranexamic Acid - therapeutic use Treatment Outcome
Title	One Dose of Tranexamic Acid Is Safe and Effective in Revision Knee Arthroplasty
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