Siponimod: Disentangling disability and relapses in secondary progressive multiple sclerosis

In multiple sclerosis, impact of treatment on disability progression can be confounded if treatment also reduces relapses. To distinguish siponimod's direct effects on disability progression from those on relapses in the EXPAND phase 3 trial. Three estimands, one based on principal stratum and...

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Bibliographic Details

Published in:	Multiple sclerosis Vol. 27; no. 10; p. 1564
Main Authors:	Cree, Bruce Ac, Magnusson, Baldur, Rouyrre, Nicolas, Fox, Robert J, Giovannoni, Gavin, Vermersch, Patrick, Bar-Or, Amit, Gold, Ralf, Piani Meier, Daniela, Karlsson, Göril, Tomic, Davorka, Wolf, Christian, Dahlke, Frank, Kappos, Ludwig
Format:	Journal Article
Language:	English
Published:	England 01.09.2021
Subjects:	Azetidines - therapeutic use Benzyl Compounds - therapeutic use Disease Progression Humans Multiple Sclerosis, Chronic Progressive - drug therapy Recurrence progression Multiple sclerosis relapses secondary progressive multiple sclerosis progressive multiple sclerosis siponimod
ISSN:	1477-0970, 1477-0970
Online Access:	Get more information
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