Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice

Galectin 3 appears to play a proinflammatory role in several inflammatory and autoimmune diseases. Also, there is evidence that galectin 3 plays a role in both type-1 and type-2 diabetes. During obesity, hematopoietic cell-derived galectin 3 induces insulin resistance. While the role of galectin 3 e...

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Bibliographic Details
Published in:	Frontiers in endocrinology (Lausanne) Vol. 11; p. 30
Main Authors:	Petrovic, Ivica, Pejnovic, Nada, Ljujic, Biljana, Pavlovic, Sladjana, Miletic Kovacevic, Marina, Jeftic, Ilija, Djukic, Aleksandar, Draginic, Nevena, Andjic, Marijana, Arsenijevic, Nebojsa, Lukic, Miodrag L., Jovicic, Nemanja
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 07.02.2020
Subjects:	Animals apoptosis Apoptosis - genetics Cells, Cultured Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Endocrinology galectin 3 Galectin 3 - genetics inflammation Inflammation - genetics Inflammation - metabolism Inflammation - pathology Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - physiology Islets of Langerhans - metabolism Islets of Langerhans - pathology Male Mice Mice, Inbred C57BL Mice, Transgenic Organ Specificity - genetics Pancreatitis - genetics Pancreatitis - metabolism type-2 diabetes β cells apoptosis inflammation type-2 diabetes galectin 3 β cells
ISSN:	1664-2392, 1664-2392
Online Access:	Get full text
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