Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by...

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Podrobná bibliografia
Vydané v:Frontiers in immunology Ročník 8; s. 405
Hlavní autori: Su, Hua, Lei, Chun-Tao, Zhang, Chun
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media S.A 21.04.2017
Predmet:
endothelial cells
IL-6 classic signaling
IL-6 trans-signaling
Immunology
mesangial cells
podocyte
tubular epithelial cells
endothelial cells
IL-6 classic signaling
tubular epithelial cells
podocyte
IL-6 trans-signaling
mesangial cells
renal disease
ISSN:1664-3224, 1664-3224
On-line prístup:Získať plný text
Tagy: Pridať tag
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Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.
AbstractList Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.
Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.
Author Zhang, Chun
Su, Hua
Lei, Chun-Tao
AuthorAffiliation 1 Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China
AuthorAffiliation_xml – name: 1 Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China
Author_xml – sequence: 1
  givenname: Hua
  surname: Su
  fullname: Su, Hua
– sequence: 2
  givenname: Chun-Tao
  surname: Lei
  fullname: Lei, Chun-Tao
– sequence: 3
  givenname: Chun
  surname: Zhang
  fullname: Zhang, Chun
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28484449$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1159/000345151
10.1007/s12079-012-0184-0
10.1111/j.1523-1755.2002.kid556.x
10.1074/jbc.M115.649509
10.3109/08830189809042997
10.1007/s10067-015-2881-6
10.1517/14728222.2012.660307
10.1007/s10067-010-1640-y
10.1136/gut.2005.079343
10.4049/jimmunol.142.2.549
10.1016/j.bbamcr.2016.03.018
10.1172/JCI7479
10.1038/nature04753
10.1016/j.bbamcr.2011.01.034
10.1016/S0002-9149(02)03144-2
10.1038/sj.ki.5001655
10.1182/blood-2007-07-102137
10.1159/000059327
10.1007/s11596-008-0304-5
10.1182/blood-2007-01-067918
10.1046/j.1365-2141.2000.02020.x
10.4049/jimmunol.0903314
10.1084/jem.20030152
10.4049/jimmunol.159.3.1474
10.1002/j.1460-2075.1996.tb00734.x
10.4049/jimmunol.147.1.117
10.1074/jbc.273.17.10798
10.1006/cyto.1999.0550
10.1096/fj.06-5754fje
10.4049/jimmunol.1002971
10.1016/j.bbadis.2010.11.009
10.1007/s10254-003-0012-2
10.4049/jimmunol.1300229
10.1016/S0167-5699(97)01103-1
10.1681/ASN.2007040469
10.2215/CJN.03800609
10.1016/S1074-7613(00)80334-9
10.1152/ajpendo.00110.2003
10.1093/intimm/dxh396
10.1096/fj.13-242693
10.4049/jimmunol.158.12.5791
10.1159/000098004
10.1084/jem.170.4.1409
10.1038/nature04754
10.1016/j.cytogfr.2008.11.006
10.1006/cyto.1999.0635
10.1007/s00430-006-0019-9
10.1167/iovs.11-7956
10.1016/j.bbrc.2013.05.046
10.4049/jimmunol.179.4.2041
10.4049/jimmunol.0802412
10.1681/ASN.2007070744
10.1177/0961203311422711
10.1002/eji.1830230226
10.1161/01.RES.0000115557.25127.8D
10.4049/jimmunol.1302249
10.1097/00007890-200003150-00049
10.1159/000054203
10.1042/BJ20030407
10.1073/pnas.90.24.11924
10.1016/j.cyto.2007.07.184
10.1371/journal.pone.0161867
10.1016/j.cytogfr.2012.04.001
10.2165/00063030-199708060-00002
10.1097/00062752-199603010-00013
10.1016/j.immuni.2006.01.001
10.1681/ASN.2004110961
10.1016/S1074-7613(00)80162-4
10.1016/j.ejphar.2010.02.026
10.1152/ajprenal.00650.2012
10.1681/ASN.2008080879
10.1046/j.1432-1327.2001.01867.x
10.1002/sita.200600086
10.1016/j.bbrc.2003.10.013
10.1002/jcp.24461
10.1038/ki.2009.98
10.1124/mol.114.092536
10.1074/jbc.M301977200
10.4049/jimmunol.153.11.5247
10.1182/blood.V95.4.1264.004k09_1264_1273
10.1038/368339a0
10.1038/ki.2013.197
10.1016/S0272-6386(03)00353-6
10.1182/blood.V91.1.258
10.1038/75068
10.1093/ndt/gfn314
10.1016/j.cyto.2015.06.018
10.1084/jem.185.3.461
10.1016/S1074-7613(00)80501-4
10.1159/000045663
10.1016/S1471-4906(02)00013-3
10.1517/14728222.11.5.613
10.1111/j.1440-1797.2011.01547.x
10.3899/jrheum.090194
10.1186/s12885-015-1763-2
10.1158/0008-5472
10.1074/jbc.275.19.14608
10.2337/diabetes.51.2.339
10.1042/bj3000281
10.1016/0092-8674(95)90418-2
10.1073/pnas.93.15.7882
10.1902/jop.2009.080385
10.1126/science.282.5392.1281
10.1016/j.atherosclerosis.2004.06.018
10.1002/art.38061
10.1177/096120339600500603
10.1182/blood.V92.6.1957
10.1152/ajprenal.00597.2009
10.1007/BF02253829
10.1038/82763
10.1016/j.jdiacomp.2013.06.006
10.1042/BST20130267
10.18632/oncotarget.4334
10.1074/jbc.M210584200
10.1038/leu.2009.230
10.1111/j.1365-3083.1994.tb03448.x
10.4049/jimmunol.0801217
10.1038/ki.2012.192
10.1159/000097667
10.1016/j.ccr.2011.03.009
10.1161/ATVBAHA.107.153080
10.1093/intimm/dxm037
10.1089/gtmb.2013.0357
10.1074/jbc.272.50.31764
10.1097/01.ASN.0000101180.96787.02
10.1681/ASN.2004111006
10.1152/ajprenal.00319.2012
10.1016/j.bbrc.2004.11.098
10.1002/j.1460-2075.1996.tb00500.x
10.1177/0961203313512882
10.1038/clpt.2009.313
10.1681/ASN.2004110917
10.1038/324073a0
10.1016/j.atherosclerosis.2015.04.014
10.3892/etm.2012.454
10.1084/jem.20020619
10.1016/j.intimp.2010.10.004
10.4049/jimmunol.172.9.5149
10.1081/JDI-100100878
10.1002/art.20727
10.1007/s00281-009-0194-z
10.1191/096120398678919949
10.1002/jcla.20151
10.1161/01.ATV.19.10.2364
10.1016/1043-4666(92)90043-Q
10.1182/blood.V82.4.1120.1120
10.1681/ASN.2003090757
10.1016/j.bbamcr.2009.12.001
10.1161/01.ATV.20.10.2175
10.1016/0014-5793(93)80507-Q
10.1016/j.cyto.2012.12.025
10.1152/ajprenal.00090.2011
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Keywords endothelial cells
IL-6 classic signaling
tubular epithelial cells
podocyte
IL-6 trans-signaling
mesangial cells
renal disease
Language English
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Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Behdad Afzali, King’s College London, UK; National Institutes of Health, USA; James R. Whiteford, Queen Mary University of London, UK
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References Chodorowska (B9) 2004; 59
Hirano (B2) 1998; 16
Ball (B123) 2014; 23
Lu (B90) 2009; 76
Franchimont (B38) 2005; 52
Matthews (B36) 2003; 278
Kaur (B141) 2012; 303
Moreno Velasquez (B47) 2015; 240
Wassmann (B94) 2004; 94
Srivastava (B101) 2013; 7
Garaud (B127) 2009; 182
Huber (B153) 1999; 19
Tanaka (B43) 2000; 106
Coletta (B87) 2000; 8
Lagathu (B137) 2003; 311
Tamouza (B118) 2012; 82
Bruun (B152) 2003; 285
Oberg (B16) 2006; 18
Lamas (B32) 2013; 61
Mccarthy (B155) 2010; 5
Chomarat (B79) 2000; 1
Dalla Vestra (B139) 2005; 16
Lust (B30) 1992; 4
Tilg (B52) 1997; 18
Rotter (B138) 2003; 278
Solus (B125) 2015; 34
Ranganathan (B96) 2013; 304
Matsumoto (B57) 2010; 184
Kaplanski (B62) 2003; 24
Gomez-Guerrero (B116) 1994; 153
Peterson (B121) 1996; 5
Wang (B126) 2015; 8
Nishimoto (B154) 2010; 87
Abdel Galil (B124) 2015; 76
Rothaug (B29) 2016; 1863
Kielar (B97) 2005; 16
Lemay (B147) 2000; 69
Papaoikonomou (B144) 2013; 27
Fantini (B68) 2004; 172
Navarro (B140) 2006; 26
Chalaris (B35) 2010; 1803
Sanchez-Nino (B105) 2012; 302
Lesina (B59) 2011; 19
Peters (B8) 1997; 159
Jasiewicz (B61) 2015; 76
Mangan (B64) 2006; 441
Dimitrov (B33) 2006; 20
Cash (B122) 2010; 37
Lee (B99) 2012; 121
Kuravi (B108) 2014; 193
Greenhill (B58) 2011; 186
Nakajima (B82) 1996; 15
Takahashi (B150) 2000; 22
Caglar (B151) 2002; 62
Reddy (B19) 2000; 275
Mullberg (B45) 1993; 332
Rincon (B73) 1997; 185
Kim (B100) 2013; 435
Abkhezr (B102) 2014; 86
Scheller (B49) 2005; 326
Matsumoto (B104) 2010; 299
Garbers (B6) 2012; 23
Lee (B130) 2012; 21
Andriankaja (B136) 2009; 80
Mullberg (B31) 1993; 23
Jostock (B46) 2001; 268
Chen (B67) 2003; 198
Sironi (B113) 1989; 142
Rose-John (B23) 2007; 11
Pecoits-Filho (B149) 2003; 41
Rose-John (B26) 1994; 300
Herrera-Esparza (B133) 1998; 7
Atsumi (B21) 2002; 196
Li (B24) 2015; 6
Dominitzki (B69) 2007; 179
Smith (B143) 2009; 20
Harrison (B76) 2003; 91
Tanaka (B85) 1995; 80
Linker-Israeli (B120) 1991; 147
Peschon (B18) 1998; 282
Griendling (B75) 2000; 20
Moutabarrik (B15) 1994; 40
Biswas (B81) 1998; 91
Dai (B91) 2013; 84
Vahdat (B39) 2010; 24
Walev (B37) 1996; 93
Lo (B60) 2011; 71
Fujimoto (B70) 2011; 186
Grigoryev (B146) 2008; 19
Bettelli (B63) 2006; 441
Lu (B93) 2008; 28
Schumacher (B40) 2015; 290
Tamura (B10) 1993; 90
Richards (B11) 2000; 12
Xing (B103) 2006; 70
Ohtani (B13) 2000; 12
Malchow (B28) 2011; 1812
Atreya (B53) 2000; 6
Liu (B142) 2012; 3
Fukada (B12) 1996; 5
Hirano (B1) 1986; 324
Mitsuyama (B54) 2006; 55
Costa-Pereira (B5) 2014; 42
Huang (B128) 2006; 20
Yoshino (B148) 2003; 14
Kopf (B84) 1994; 368
Arakawa (B107) 2008; 23
Harcourt (B98) 2012; 17
Zhang (B119) 2014; 28
Zhuang (B25) 2015; 15
Yamanaka (B83) 1996; 15
Scheller (B4) 2006; 6
Scheller (B22) 2006; 195
Waetzig (B50) 2012; 16
Orlando (B17) 1997; 272
Romano (B114) 1997; 6
Teague (B71) 1997; 158
Tsai (B132) 2000; 85
Gurr (B135) 2002; 51
Santos (B129) 2011; 30
Vardam (B44) 2007; 39
Iwano (B131) 1993; 40
Hui (B48) 2000; 12
Nechemia-Arbely (B88) 2008; 19
Karadeniz (B145) 2014; 18
Feng (B89) 2009; 20
Zhang (B42) 1998; 273
Mitani (B77) 2000; 109
Scheller (B51) 2011; 1813
Heinrich (B3) 2003; 374
Ebihara (B27) 2011; 52
Schmitt (B111) 2014; 193
Kimura (B66) 2011; 11
Anderson (B106) 2014; 229
Gohda (B92) 2001; 24
Krishnaraju (B78) 1998; 92
Dorner (B7) 1997; 8
Novick (B20) 1989; 170
Tsantikos (B134) 2013; 65
Ji (B112) 2016; 11
Linterman (B74) 2010; 32
Yoshida (B72) 2010; 634
Pfafflin (B110) 2006; 18
Kamimura (B14) 2003; 149
Chalaris (B34) 2007; 110
Moura (B117) 2005; 16
Song (B109) 2004; 177
Tanaka (B80) 2000; 95
Narazaki (B41) 1993; 82
Finotto (B55) 2007; 19
Schrader (B95) 2007; 27
Akira (B86) 1996; 3
Rabe (B56) 2008; 111
Yung (B115) 2005; 16
Veldhoen (B65) 2006; 24
16146075 - Ann Univ Mariae Curie Sklodowska Med. 2004;59(2):189-93
19186972 - J Periodontol. 2009 Feb;80(2):307-16
9414293 - Blood. 1998 Jan 1;91(1):258-65
8002928 - Biochem J. 1994 Jun 1;300 ( Pt 2):281-90
22004976 - Lupus. 2012 Jan;21(1):60-7
12687404 - Rev Physiol Biochem Pharmacol. 2003;149:1-38
10666199 - Blood. 2000 Feb 15;95(4):1264-73
9293158 - Immunol Today. 1997 Sep;18(9):428-32
21481788 - Cancer Cell. 2011 Apr 12;19(4):456-69
20184875 - Eur J Pharmacol. 2010 May 25;634(1-3):178-83
19038572 - Cytokine Growth Factor Rev. 2009 Feb;20(1):43-59
11031201 - Arterioscler Thromb Vasc Biol. 2000 Oct;20(10):2175-83
17465721 - Expert Opin Ther Targets. 2007 May;11(5):613-24
24344329 - FASEB J. 2014 Mar;28(3):1511-25
22969947 - Exp Ther Med. 2012 Apr;3(4):655-664
11812740 - Diabetes. 2002 Feb;51(2):339-46
25910182 - Atherosclerosis. 2015 Jun;240(2):477-81
26525581 - BMC Cancer. 2015 Nov 02;15:830
16648837 - Nature. 2006 May 11;441(7090):231-4
9607638 - Lupus. 1998;7(3):154-8
8436181 - Eur J Immunol. 1993 Feb;23(2):473-80
23234871 - Nephron Exp Nephrol. 2012;121(3-4):e86-96
10867535 - Nephron. 2000 Jul;85(3):207-14
22169009 - Am J Physiol Renal Physiol. 2012 Mar 15;302(6):F647-57
27583546 - PLoS One. 2016 Sep 01;11(9):e0161867
20966123 - Clin J Am Soc Nephrol. 2010 Nov;5(11):2115-21
15607729 - Biochem Biophys Res Commun. 2005 Jan 28;326(4):724-8
2051017 - J Immunol. 1991 Jul 1;147(1):117-23
21106853 - J Immunol. 2011 Jan 1;186(1):32-40
24850720 - J Immunol. 2014 Jul 1;193(1):317-26
9053446 - J Exp Med. 1997 Feb 3;185(3):461-9
7530603 - Cell. 1995 Jan 27;80(2):353-61
26163998 - Cytokine. 2015 Dec;76(2):187-92
24102240 - Genet Test Mol Biomarkers. 2014 Jan;18(1):62-5
21153673 - Clin Rheumatol. 2011 Mar;30(3):409-13
1633265 - Cytokine. 1992 Mar;4(2):96-100
16682432 - Gut. 2006 Sep;55(9):1263-9
24243775 - Lupus. 2014;23 (1):46-56
18556750 - Nephrol Dial Transplant. 2008 Nov;23(11):3418-26
12736161 - Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E527-33
17962626 - Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2576-81
20026129 - Biochim Biophys Acta. 2010 Feb;1803(2):234-45
22951891 - Kidney Int. 2012 Dec;82(12):1284-96
16540526 - Int Immunol. 2006 Apr;18(4):555-63
18031104 - BioDrugs. 1997 Dec;8(6):418-29
21296109 - Biochim Biophys Acta. 2011 May;1813(5):878-88
12495721 - Trends Immunol. 2003 Jan;24(1):25-9
12776273 - Am J Kidney Dis. 2003 Jun;41(6):1212-8
10843736 - Cytokine. 2000 Jun;12 (6):613-21
9731053 - Blood. 1998 Sep 15;92(6):1957-66
9190930 - J Immunol. 1997 Jun 15;158(12):5791-6
19380809 - J Immunol. 2009 May 1;182(9):5623-32
21035432 - Int Immunopharmacol. 2011 Mar;11(3):319-22
15987753 - J Am Soc Nephrol. 2005 Sep;16(9):2667-76
15641051 - Arthritis Rheum. 2005 Jan;52(1):84-93
16192422 - J Am Soc Nephrol. 2005 Nov;16(11):3281-94
14638908 - J Am Soc Nephrol. 2003 Dec;14(12):3090-101
9233646 - J Immunol. 1997 Aug 1;159(3):1474-81
17903700 - Cytokine. 2007 Jul;39(1):84-96
17167242 - Am J Nephrol. 2006;26(6):562-70
9116699 - Lupus. 1996 Dec;5(6):571-5
20630940 - Am J Physiol Renal Physiol. 2010 Oct;299(4):F776-84
21989726 - Invest Ophthalmol Vis Sci. 2011 Nov 01;52(12):8549-57
17567983 - Blood. 2007 Sep 15;110(6):1748-55
16741736 - Med Microbiol Immunol. 2006 Dec;195(4):173-83
22128916 - Nephrology (Carlton). 2012 Mar;17(3):257-62
19357722 - Kidney Int. 2009 Jul;76(1):63-71
9075932 - Immunity. 1997 Mar;6(3):315-25
16837924 - Kidney Int. 2006 Sep;70(6):1038-45
10843245 - Ren Fail. 2000 May;22(3):345-54
10848814 - Br J Haematol. 2000 May;109(2):288-95
9505191 - Int Rev Immunol. 1998;16(3-4):249-84
12370259 - J Exp Med. 2002 Oct 7;196(7):979-90
14676299 - J Exp Med. 2003 Dec 15;198(12):1875-86
9372056 - Curr Opin Hematol. 1996 Jan;3(1):87-93
10755557 - Transplantation. 2000 Mar 15;69(5):959-63
8612579 - EMBO J. 1996 Apr 1;15(7):1557-65
3491322 - Nature. 1986 Nov 6-12;324(6092):73-6
24872191 - J Immunol. 2014 Jul 1;193(1):234-43
12645638 - Am J Cardiol. 2003 Feb 6;91(3A):7A-11A
26073684 - Cytokine. 2015 Dec;76(2):280-7
21130161 - Biochim Biophys Acta. 2011 Mar;1812(3):290-301
8670868 - EMBO J. 1996 Jul 15;15(14):3651-8
19608706 - J Am Soc Nephrol. 2009 Oct;20(10):2138-46
23375120 - Cytokine. 2013 Mar;61(3):720-3
17496315 - Int Immunol. 2007 Jun;19(6):685-93
24037962 - J Cell Physiol. 2014 Apr;229(4):434-42
12952969 - J Biol Chem. 2003 Nov 14;278(46):45777-84
14592424 - Biochem Biophys Res Commun. 2003 Nov 14;311(2):372-9
26359498 - J Biol Chem. 2015 Oct 23;290(43):26059-71
8405437 - FEBS Lett. 1993 Oct 11;332(1-2):174-8
15938041 - J Am Soc Nephrol. 2005 Mar;16 Suppl 1:S78-82
8358870 - Clin Nephrol. 1993 Jul;40(1):16-21
23842188 - Kidney Int. 2013 Nov;84(5):950-61
17675459 - J Immunol. 2007 Aug 15;179(4):2041-5
8353278 - Blood. 1993 Aug 15;82(4):1120-6
26629199 - Int J Clin Exp Med. 2015 Sep 15;8(9):16658-63
8755571 - Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7882-7
2783442 - J Immunol. 1989 Jan 15;142(2):549-53
18235097 - J Am Soc Nephrol. 2008 Mar;19(3):547-58
10661409 - Immunity. 2000 Jan;12(1):95-105
8127368 - Nature. 1994 Mar 24;368(6469):339-42
26091352 - Oncotarget. 2015 Jun 10;6(16):14026-32
19955044 - J Rheumatol. 2010 Jan;37(1):60-70
9812885 - Science. 1998 Nov 13;282(5392):1281-4
17989316 - Blood. 2008 Feb 1;111(3):1021-8
12773095 - Biochem J. 2003 Aug 15;374(Pt 1):1-20
15488864 - Atherosclerosis. 2004 Nov;177(1):43-51
10521365 - Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2364-7
16473830 - Immunity. 2006 Feb;24(2):179-89
27016501 - Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1218-27
12234313 - Kidney Int. 2002 Oct;62(4):1408-16
18563316 - J Huazhong Univ Sci Technolog Med Sci. 2008 Jun;28(3):247-50
11121117 - Eur J Biochem. 2001 Jan;268(1):160-7
20107805 - Semin Immunopathol. 2010 Jun;32(2):183-96
22874765 - Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1145-50
23161414 - J Cell Commun Signal. 2013 Mar;7(1):49-60
2529343 - J Exp Med. 1989 Oct 1;170(4):1409-14
20182422 - Clin Pharmacol Ther. 2010 Apr;87(4):483-7
10880057 - J Clin Invest. 2000 Jul;106(1):137-44
10644881 - Exp Nephrol. 2000 Jan-Feb;8(1):37-43
20042582 - J Immunol. 2010 Feb 1;184(3):1543-51
10671300 - Cytokine. 2000 Feb;12(2):151-5
9395521 - J Biol Chem. 1997 Dec 12;272(50):31764-9
7963578 - J Immunol. 1994 Dec 1;153(11):5247-55
11174004 - Kidney Blood Press Res. 2001;24(1):33-8
9553147 - J Biol Chem. 1998 Apr 24;273(17):10798-805
23818297 - Arthritis Rheum. 2013 Oct;65(10):2691-702
21148800 - J Immunol. 2011 Jan 15;186(2):1199-208
8265649 - Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11924-8
19890373 - Leukemia. 2010 Jan;24(1):51-7
15100250 - J Immunol. 2004 May 1;172(9):5149-53
8047839 - Scand J Immunol. 1994 Aug;40(2):181-6
11101873 - Nat Immunol. 2000 Dec;1(6):510-4
24850910 - Mol Pharmacol. 2014 Aug;86(2):150-8
24450628 - Biochem Soc Trans. 2014 Feb;42(1):59-62
22324903 - Expert Opin Ther Targets. 2012 Feb;16(2):225-36
12832423 - J Biol Chem. 2003 Oct 3;278(40):38829-39
10799547 - J Biol Chem. 2000 May 12;275(19):14608-14
23408169 - Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1054-65
22595692 - Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97
16648838 - Nature. 2006 May 11;441(7090):235-8
8934572 - Immunity. 1996 Nov;5(5):449-60
17167225 - Cell Physiol Biochem. 2006;18(4-5):199-210
25652333 - Clin Rheumatol. 2015 Aug;34(8):1375-82
10802717 - Nat Med. 2000 May;6(5):583-8
23871133 - J Diabetes Complications. 2013 Nov-Dec;27(6):576-9
18337485 - J Am Soc Nephrol. 2008 Jun;19(6):1106-15
14699015 - Circ Res. 2004 Mar 5;94(4):534-41
16912152 - FASEB J. 2006 Oct;20(12):2174-6
23692924 - Biochem Biophys Res Commun. 2013 Jun 14;435(4):702-7
17115422 - J Clin Lab Anal. 2006;20(6):255-9
16192425 - J Am Soc Nephrol. 2005 Nov;16(11):3315-25
21123455 - Cancer Res. 2011 Jan 15;71(2):424-34
References_xml – volume: 121
  start-page: e86
  year: 2012
  ident: B99
  article-title: Podocytes express IL-6 and lipocalin 2/ neutrophil gelatinase-associated lipocalin in lipopolysaccharide-induced acute glomerular injury
  publication-title: Nephron Exp Nephrol
  doi: 10.1159/000345151
– volume: 7
  start-page: 49
  year: 2013
  ident: B101
  article-title: LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile
  publication-title: J Cell Commun Signal
  doi: 10.1007/s12079-012-0184-0
– volume: 62
  start-page: 1408
  year: 2002
  ident: B151
  article-title: Inflammatory signals associated with hemodialysis
  publication-title: Kidney Int
  doi: 10.1111/j.1523-1755.2002.kid556.x
– volume: 290
  start-page: 26059
  year: 2015
  ident: B40
  article-title: Shedding of endogenous interleukin-6 receptor (IL-6R) is governed by a disintegrin and metalloproteinase (ADAM) proteases while a full-length IL-6R isoform localizes to circulating microvesicles
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M115.649509
– volume: 16
  start-page: 249
  year: 1998
  ident: B2
  article-title: Interleukin 6 and its receptor: ten years later
  publication-title: Int Rev Immunol
  doi: 10.3109/08830189809042997
– volume: 34
  start-page: 1375
  year: 2015
  ident: B125
  article-title: Genetics of serum concentration of IL-6 and TNFalpha in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis
  publication-title: Clin Rheumatol
  doi: 10.1007/s10067-015-2881-6
– volume: 16
  start-page: 225
  year: 2012
  ident: B50
  article-title: Hitting a complex target: an update on interleukin-6 trans-signalling
  publication-title: Expert Opin Ther Targets
  doi: 10.1517/14728222.2012.660307
– volume: 30
  start-page: 409
  year: 2011
  ident: B129
  article-title: Interleukin-6 promoter polymorphism -174 G/C is associated with nephritis in Portuguese Caucasian systemic lupus erythematosus patients
  publication-title: Clin Rheumatol
  doi: 10.1007/s10067-010-1640-y
– volume: 55
  start-page: 1263
  year: 2006
  ident: B54
  article-title: STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
  publication-title: Gut
  doi: 10.1136/gut.2005.079343
– volume: 142
  start-page: 549
  year: 1989
  ident: B113
  article-title: IL-1 stimulates IL-6 production in endothelial cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.142.2.549
– volume: 1863
  start-page: 1218
  year: 2016
  ident: B29
  article-title: The role of interleukin-6 signaling in nervous tissue
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbamcr.2016.03.018
– volume: 106
  start-page: 137
  year: 2000
  ident: B43
  article-title: Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis
  publication-title: J Clin Invest
  doi: 10.1172/JCI7479
– volume: 441
  start-page: 235
  year: 2006
  ident: B63
  article-title: Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
  publication-title: Nature
  doi: 10.1038/nature04753
– volume: 1813
  start-page: 878
  year: 2011
  ident: B51
  article-title: The pro- and anti-inflammatory properties of the cytokine interleukin-6
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbamcr.2011.01.034
– volume: 91
  start-page: 7A
  year: 2003
  ident: B76
  article-title: Role of oxidative stress in atherosclerosis
  publication-title: Am J Cardiol
  doi: 10.1016/S0002-9149(02)03144-2
– volume: 70
  start-page: 1038
  year: 2006
  ident: B103
  article-title: Direct effects of dexamethasone on human podocytes
  publication-title: Kidney Int
  doi: 10.1038/sj.ki.5001655
– volume: 111
  start-page: 1021
  year: 2008
  ident: B56
  article-title: Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
  publication-title: Blood
  doi: 10.1182/blood-2007-07-102137
– volume: 8
  start-page: 37
  year: 2000
  ident: B87
  article-title: Selective induction of MCP-1 in human mesangial cells by the IL-6/sIL-6R complex
  publication-title: Exp Nephrol
  doi: 10.1159/000059327
– volume: 28
  start-page: 247
  year: 2008
  ident: B93
  article-title: HBV X gene transfection upregulates IL-1beta and IL-6 gene expression and induces rat glomerular mesangial cell proliferation
  publication-title: J Huazhong Univ Sci Technolog Med Sci
  doi: 10.1007/s11596-008-0304-5
– volume: 110
  start-page: 1748
  year: 2007
  ident: B34
  article-title: Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
  publication-title: Blood
  doi: 10.1182/blood-2007-01-067918
– volume: 109
  start-page: 288
  year: 2000
  ident: B77
  article-title: Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells
  publication-title: Br J Haematol
  doi: 10.1046/j.1365-2141.2000.02020.x
– volume: 186
  start-page: 32
  year: 2011
  ident: B70
  article-title: The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0903314
– volume: 198
  start-page: 1875
  year: 2003
  ident: B67
  article-title: Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
  publication-title: J Exp Med
  doi: 10.1084/jem.20030152
– volume: 159
  start-page: 1474
  year: 1997
  ident: B8
  article-title: Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice
  publication-title: J Immunol
  doi: 10.4049/jimmunol.159.3.1474
– volume: 15
  start-page: 3651
  year: 1996
  ident: B82
  article-title: A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1996.tb00734.x
– volume: 147
  start-page: 117
  year: 1991
  ident: B120
  article-title: Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.147.1.117
– volume: 273
  start-page: 10798
  year: 1998
  ident: B42
  article-title: Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma
  publication-title: J Biol Chem
  doi: 10.1074/jbc.273.17.10798
– volume: 12
  start-page: 151
  year: 2000
  ident: B48
  article-title: Soluble glycoprotein 130 (gp130) attenuates OSM- and LIF-induced cartilage proteoglycan catabolism
  publication-title: Cytokine
  doi: 10.1006/cyto.1999.0550
– volume: 20
  start-page: 2174
  year: 2006
  ident: B33
  article-title: Sleep enhances IL-6 trans-signaling in humans
  publication-title: FASEB J
  doi: 10.1096/fj.06-5754fje
– volume: 186
  start-page: 1199
  year: 2011
  ident: B58
  article-title: IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1002971
– volume: 1812
  start-page: 290
  year: 2011
  ident: B28
  article-title: Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbadis.2010.11.009
– volume: 149
  start-page: 1
  year: 2003
  ident: B14
  article-title: IL-6 signal transduction and its physiological roles: the signal orchestration model
  publication-title: Rev Physiol Biochem Pharmacol
  doi: 10.1007/s10254-003-0012-2
– volume: 193
  start-page: 234
  year: 2014
  ident: B108
  article-title: Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1300229
– volume: 18
  start-page: 428
  year: 1997
  ident: B52
  article-title: IL-6 and APPs: anti-inflammatory and immunosuppressive mediators
  publication-title: Immunol Today
  doi: 10.1016/S0167-5699(97)01103-1
– volume: 19
  start-page: 547
  year: 2008
  ident: B146
  article-title: The local and systemic inflammatory transcriptome after acute kidney injury
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2007040469
– volume: 5
  start-page: 2115
  year: 2010
  ident: B155
  article-title: Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis
  publication-title: Clin J Am Soc Nephrol
  doi: 10.2215/CJN.03800609
– volume: 6
  start-page: 315
  year: 1997
  ident: B114
  article-title: Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80334-9
– volume: 285
  start-page: E527
  year: 2003
  ident: B152
  article-title: Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
  publication-title: Am J Physiol Endocrinol Metab
  doi: 10.1152/ajpendo.00110.2003
– volume: 18
  start-page: 555
  year: 2006
  ident: B16
  article-title: Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25- and CD25high regulatory T cells
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxh396
– volume: 28
  start-page: 1511
  year: 2014
  ident: B119
  article-title: Sublytic C5b-9 induces IL-6 and TGF-beta1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPbeta acetylation
  publication-title: FASEB J
  doi: 10.1096/fj.13-242693
– volume: 8
  start-page: 16658
  year: 2015
  ident: B126
  article-title: Role of IL-1beta, IL-6, IL-8 and IFN-gamma in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous
  publication-title: Int J Clin Exp Med
– volume: 158
  start-page: 5791
  year: 1997
  ident: B71
  article-title: IL-6 rescues resting mouse T cells from apoptosis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.158.12.5791
– volume: 26
  start-page: 562
  year: 2006
  ident: B140
  article-title: Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration
  publication-title: Am J Nephrol
  doi: 10.1159/000098004
– volume: 170
  start-page: 1409
  year: 1989
  ident: B20
  article-title: Soluble cytokine receptors are present in normal human urine
  publication-title: J Exp Med
  doi: 10.1084/jem.170.4.1409
– volume: 441
  start-page: 231
  year: 2006
  ident: B64
  article-title: Transforming growth factor-beta induces development of the T(H)17 lineage
  publication-title: Nature
  doi: 10.1038/nature04754
– volume: 20
  start-page: 43
  year: 2009
  ident: B143
  article-title: Cytokine and cytokine receptor gene polymorphisms and their functionality
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2008.11.006
– volume: 12
  start-page: 613
  year: 2000
  ident: B11
  article-title: Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: synergy with dexamethasone
  publication-title: Cytokine
  doi: 10.1006/cyto.1999.0635
– volume: 195
  start-page: 173
  year: 2006
  ident: B22
  article-title: Interleukin-6 and its receptor: from bench to bedside
  publication-title: Med Microbiol Immunol
  doi: 10.1007/s00430-006-0019-9
– volume: 52
  start-page: 8549
  year: 2011
  ident: B27
  article-title: Role of the IL-6 classic- and trans-signaling pathways in corneal sterile inflammation and wound healing
  publication-title: Invest Ophthalmol Vis Sci
  doi: 10.1167/iovs.11-7956
– volume: 435
  start-page: 702
  year: 2013
  ident: B100
  article-title: Sequential signaling cascade of IL-6 and PGC-1alpha is involved in high glucose-induced podocyte loss and growth arrest
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2013.05.046
– volume: 179
  start-page: 2041
  year: 2007
  ident: B69
  article-title: Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.179.4.2041
– volume: 182
  start-page: 5623
  year: 2009
  ident: B127
  article-title: IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0802412
– volume: 19
  start-page: 1106
  year: 2008
  ident: B88
  article-title: IL-6/IL-6R axis plays a critical role in acute kidney injury
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2007070744
– volume: 21
  start-page: 60
  year: 2012
  ident: B130
  article-title: The association between interleukin-6 polymorphisms and systemic lupus erythematosus: a meta-analysis
  publication-title: Lupus
  doi: 10.1177/0961203311422711
– volume: 23
  start-page: 473
  year: 1993
  ident: B31
  article-title: The soluble interleukin-6 receptor is generated by shedding
  publication-title: Eur J Immunol
  doi: 10.1002/eji.1830230226
– volume: 94
  start-page: 534
  year: 2004
  ident: B94
  article-title: Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000115557.25127.8D
– volume: 193
  start-page: 317
  year: 2014
  ident: B111
  article-title: The combined role of galactose-deficient IgA1 and streptococcal IgA-binding M protein in inducing IL-6 and C3 secretion from human mesangial cells: implications for IgA nephropathy
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1302249
– volume: 69
  start-page: 959
  year: 2000
  ident: B147
  article-title: Prominent and sustained up-regulation of gp130-signaling cytokines and the chemokine MIP-2 in murine renal ischemia-reperfusion injury
  publication-title: Transplantation
  doi: 10.1097/00007890-200003150-00049
– volume: 24
  start-page: 33
  year: 2001
  ident: B92
  article-title: Dilazep hydrochloride, an antiplatelet drug, inhibits lipopolysaccharide-induced mouse mesangial cell IL-6 secretion and proliferation
  publication-title: Kidney Blood Press Res
  doi: 10.1159/000054203
– volume: 374
  start-page: 1
  year: 2003
  ident: B3
  article-title: Principles of interleukin (IL)-6-type cytokine signalling and its regulation
  publication-title: Biochem J
  doi: 10.1042/BJ20030407
– volume: 90
  start-page: 11924
  year: 1993
  ident: B10
  article-title: Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.90.24.11924
– volume: 39
  start-page: 84
  year: 2007
  ident: B44
  article-title: Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2007.07.184
– volume: 11
  start-page: e0161867
  year: 2016
  ident: B112
  article-title: C5a induces the synthesis of IL-6 and TNF-alpha in rat glomerular mesangial cells through MAPK signaling pathways
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0161867
– volume: 23
  start-page: 85
  year: 2012
  ident: B6
  article-title: Plasticity and cross-talk of interleukin 6-type cytokines
  publication-title: Cytokine Growth Factor Rev
  doi: 10.1016/j.cytogfr.2012.04.001
– volume: 8
  start-page: 418
  year: 1997
  ident: B7
  article-title: Interleukin-11
  publication-title: BioDrugs
  doi: 10.2165/00063030-199708060-00002
– volume: 3
  start-page: 87
  year: 1996
  ident: B86
  article-title: Role of interleukin-6 in macrophage function
  publication-title: Curr Opin Hematol
  doi: 10.1097/00062752-199603010-00013
– volume: 24
  start-page: 179
  year: 2006
  ident: B65
  article-title: TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2006.01.001
– volume: 16
  start-page: S78
  year: 2005
  ident: B139
  article-title: Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2004110961
– volume: 12
  start-page: 95
  year: 2000
  ident: B13
  article-title: Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80162-4
– volume: 634
  start-page: 178
  year: 2010
  ident: B72
  article-title: Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells
  publication-title: Eur J Pharmacol
  doi: 10.1016/j.ejphar.2010.02.026
– volume: 304
  start-page: F1054
  year: 2013
  ident: B96
  article-title: Proximal tubule-specific overexpression of netrin-1 suppresses acute kidney injury-induced interstitial fibrosis and glomerulosclerosis through suppression of IL-6/STAT3 signaling
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00650.2012
– volume: 20
  start-page: 2138
  year: 2009
  ident: B89
  article-title: Reduction of Stat3 activity attenuates HIV-induced kidney injury
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2008080879
– volume: 268
  start-page: 160
  year: 2001
  ident: B46
  article-title: Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
  publication-title: Eur J Biochem
  doi: 10.1046/j.1432-1327.2001.01867.x
– volume: 6
  start-page: 240
  year: 2006
  ident: B4
  article-title: Updating interleukin-6 classic- and trans-signaling
  publication-title: Signal Transduct
  doi: 10.1002/sita.200600086
– volume: 311
  start-page: 372
  year: 2003
  ident: B137
  article-title: Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2003.10.013
– volume: 229
  start-page: 434
  year: 2014
  ident: B106
  article-title: Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species
  publication-title: J Cell Physiol
  doi: 10.1002/jcp.24461
– volume: 76
  start-page: 63
  year: 2009
  ident: B90
  article-title: Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy
  publication-title: Kidney Int
  doi: 10.1038/ki.2009.98
– volume: 86
  start-page: 150
  year: 2014
  ident: B102
  article-title: Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.114.092536
– volume: 278
  start-page: 45777
  year: 2003
  ident: B138
  article-title: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M301977200
– volume: 40
  start-page: 16
  year: 1993
  ident: B131
  article-title: Urinary levels of IL-6 in patients with active lupus nephritis
  publication-title: Clin Nephrol
– volume: 153
  start-page: 5247
  year: 1994
  ident: B116
  article-title: Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation
  publication-title: J Immunol
  doi: 10.4049/jimmunol.153.11.5247
– volume: 95
  start-page: 1264
  year: 2000
  ident: B80
  article-title: GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1
  publication-title: Blood
  doi: 10.1182/blood.V95.4.1264.004k09_1264_1273
– volume: 368
  start-page: 339
  year: 1994
  ident: B84
  article-title: Impaired immune and acute-phase responses in interleukin-6-deficient mice
  publication-title: Nature
  doi: 10.1038/368339a0
– volume: 84
  start-page: 950
  year: 2013
  ident: B91
  article-title: Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum-induced glomerulonephritis
  publication-title: Kidney Int
  doi: 10.1038/ki.2013.197
– volume: 41
  start-page: 1212
  year: 2003
  ident: B149
  article-title: Associations between circulating inflammatory markers and residual renal function in CRF patients
  publication-title: Am J Kidney Dis
  doi: 10.1016/S0272-6386(03)00353-6
– volume: 91
  start-page: 258
  year: 1998
  ident: B81
  article-title: Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line
  publication-title: Blood
  doi: 10.1182/blood.V91.1.258
– volume: 6
  start-page: 583
  year: 2000
  ident: B53
  article-title: Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo
  publication-title: Nat Med
  doi: 10.1038/75068
– volume: 23
  start-page: 3418
  year: 2008
  ident: B107
  article-title: Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis
  publication-title: Nephrol Dial Transplant
  doi: 10.1093/ndt/gfn314
– volume: 76
  start-page: 187
  year: 2015
  ident: B61
  article-title: Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2015.06.018
– volume: 185
  start-page: 461
  year: 1997
  ident: B73
  article-title: Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells
  publication-title: J Exp Med
  doi: 10.1084/jem.185.3.461
– volume: 5
  start-page: 449
  year: 1996
  ident: B12
  article-title: Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80501-4
– volume: 85
  start-page: 207
  year: 2000
  ident: B132
  article-title: Increased excretions of beta2-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritis
  publication-title: Nephron
  doi: 10.1159/000045663
– volume: 24
  start-page: 25
  year: 2003
  ident: B62
  article-title: IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation
  publication-title: Trends Immunol
  doi: 10.1016/S1471-4906(02)00013-3
– volume: 11
  start-page: 613
  year: 2007
  ident: B23
  article-title: The IL-6/sIL-6R complex as a novel target for therapeutic approaches
  publication-title: Expert Opin Ther Targets
  doi: 10.1517/14728222.11.5.613
– volume: 17
  start-page: 257
  year: 2012
  ident: B98
  article-title: Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice
  publication-title: Nephrology (Carlton)
  doi: 10.1111/j.1440-1797.2011.01547.x
– volume: 37
  start-page: 60
  year: 2010
  ident: B122
  article-title: Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.090194
– volume: 15
  start-page: 830
  year: 2015
  ident: B25
  article-title: Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma
  publication-title: BMC Cancer
  doi: 10.1186/s12885-015-1763-2
– volume: 71
  start-page: 424
  year: 2011
  ident: B60
  article-title: IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer
  publication-title: Cancer Res
  doi: 10.1158/0008-5472
– volume: 275
  start-page: 14608
  year: 2000
  ident: B19
  article-title: Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme
  publication-title: J Biol Chem
  doi: 10.1074/jbc.275.19.14608
– volume: 51
  start-page: 339
  year: 2002
  ident: B135
  article-title: A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice
  publication-title: Diabetes
  doi: 10.2337/diabetes.51.2.339
– volume: 300
  start-page: 281
  year: 1994
  ident: B26
  article-title: Soluble receptors for cytokines and growth factors: generation and biological function
  publication-title: Biochem J
  doi: 10.1042/bj3000281
– volume: 80
  start-page: 353
  year: 1995
  ident: B85
  article-title: Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90418-2
– volume: 93
  start-page: 7882
  year: 1996
  ident: B37
  article-title: Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.93.15.7882
– volume: 80
  start-page: 307
  year: 2009
  ident: B136
  article-title: Levels of serum interleukin (IL)-6 and gingival crevicular fluid of IL-1beta and prostaglandin E(2) among non-smoking subjects with gingivitis and type 2 diabetes
  publication-title: J Periodontol
  doi: 10.1902/jop.2009.080385
– volume: 282
  start-page: 1281
  year: 1998
  ident: B18
  article-title: An essential role for ectodomain shedding in mammalian development
  publication-title: Science
  doi: 10.1126/science.282.5392.1281
– volume: 177
  start-page: 43
  year: 2004
  ident: B109
  article-title: IL-6 and the acute phase response in murine atherosclerosis
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2004.06.018
– volume: 65
  start-page: 2691
  year: 2013
  ident: B134
  article-title: Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice
  publication-title: Arthritis Rheum
  doi: 10.1002/art.38061
– volume: 5
  start-page: 571
  year: 1996
  ident: B121
  article-title: Serum and urinary interleukin-6 in systemic lupus erythematosus
  publication-title: Lupus
  doi: 10.1177/096120339600500603
– volume: 92
  start-page: 1957
  year: 1998
  ident: B78
  article-title: The zinc finger transcription factor Egr-1 activates macrophage differentiation in M1 myeloblastic leukemia cells
  publication-title: Blood
  doi: 10.1182/blood.V92.6.1957
– volume: 299
  start-page: F776
  year: 2010
  ident: B104
  article-title: Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00597.2009
– volume: 76
  start-page: 280
  year: 2015
  ident: B124
  article-title: The role of serum IL-17 and IL-6 as biomarkers of disease activity and predictors of remission in patients with lupus nephritis
  publication-title: Cytokine
  doi: 10.1007/BF02253829
– volume: 1
  start-page: 510
  year: 2000
  ident: B79
  article-title: IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
  publication-title: Nat Immunol
  doi: 10.1038/82763
– volume: 27
  start-page: 576
  year: 2013
  ident: B144
  article-title: The association of the 174G>C polymorphism of interleukin 6 gene with diabetic nephropathy in patients with type 2 diabetes mellitus
  publication-title: J Diabetes Complications
  doi: 10.1016/j.jdiacomp.2013.06.006
– volume: 42
  start-page: 59
  year: 2014
  ident: B5
  article-title: Regulation of IL-6-type cytokine responses by MAPKs
  publication-title: Biochem Soc Trans
  doi: 10.1042/BST20130267
– volume: 6
  start-page: 14026
  year: 2015
  ident: B24
  article-title: Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.4334
– volume: 278
  start-page: 38829
  year: 2003
  ident: B36
  article-title: Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M210584200
– volume: 24
  start-page: 51
  year: 2010
  ident: B39
  article-title: TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species
  publication-title: Leukemia
  doi: 10.1038/leu.2009.230
– volume: 40
  start-page: 181
  year: 1994
  ident: B15
  article-title: Interleukin-6 and interleukin-6 receptor are expressed by cultured glomerular epithelial cells
  publication-title: Scand J Immunol
  doi: 10.1111/j.1365-3083.1994.tb03448.x
– volume: 59
  start-page: 189
  year: 2004
  ident: B9
  article-title: Leukemia inhibitory factor (LIF) and its biological activity
  publication-title: Ann Univ Mariae Curie Sklodowska Med
– volume: 184
  start-page: 1543
  year: 2010
  ident: B57
  article-title: Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
  publication-title: J Immunol
  doi: 10.4049/jimmunol.0801217
– volume: 82
  start-page: 1284
  year: 2012
  ident: B118
  article-title: The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy
  publication-title: Kidney Int
  doi: 10.1038/ki.2012.192
– volume: 18
  start-page: 199
  year: 2006
  ident: B110
  article-title: Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha
  publication-title: Cell Physiol Biochem
  doi: 10.1159/000097667
– volume: 19
  start-page: 456
  year: 2011
  ident: B59
  article-title: Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.03.009
– volume: 27
  start-page: 2576
  year: 2007
  ident: B95
  article-title: IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/ATVBAHA.107.153080
– volume: 19
  start-page: 685
  year: 2007
  ident: B55
  article-title: Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
  publication-title: Int Immunol
  doi: 10.1093/intimm/dxm037
– volume: 18
  start-page: 62
  year: 2014
  ident: B145
  article-title: Association of interleukin-6 -174 G>C promoter polymorphism with increased risk of type 2 diabetes mellitus patients with diabetic nephropathy in Turkey
  publication-title: Genet Test Mol Biomarkers
  doi: 10.1089/gtmb.2013.0357
– volume: 272
  start-page: 31764
  year: 1997
  ident: B17
  article-title: Role of metalloproteases in the release of the IL-1 type II decoy receptor
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.50.31764
– volume: 14
  start-page: 3090
  year: 2003
  ident: B148
  article-title: Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure
  publication-title: J Am Soc Nephrol
  doi: 10.1097/01.ASN.0000101180.96787.02
– volume: 16
  start-page: 2667
  year: 2005
  ident: B117
  article-title: Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2004111006
– volume: 303
  start-page: F1145
  year: 2012
  ident: B141
  article-title: Hyperglycemia induces toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00319.2012
– volume: 326
  start-page: 724
  year: 2005
  ident: B49
  article-title: No inhibition of IL-27 signaling by soluble gp130
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2004.11.098
– volume: 15
  start-page: 1557
  year: 1996
  ident: B83
  article-title: Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation
  publication-title: EMBO J
  doi: 10.1002/j.1460-2075.1996.tb00500.x
– volume: 23
  start-page: 46
  year: 2014
  ident: B123
  article-title: Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus
  publication-title: Lupus
  doi: 10.1177/0961203313512882
– volume: 87
  start-page: 483
  year: 2010
  ident: B154
  article-title: Interleukin-6 as a therapeutic target in candidate inflammatory diseases
  publication-title: Clin Pharmacol Ther
  doi: 10.1038/clpt.2009.313
– volume: 16
  start-page: 3281
  year: 2005
  ident: B115
  article-title: Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2004110917
– volume: 324
  start-page: 73
  year: 1986
  ident: B1
  article-title: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
  publication-title: Nature
  doi: 10.1038/324073a0
– volume: 240
  start-page: 477
  year: 2015
  ident: B47
  article-title: Circulating levels of interleukin 6 soluble receptor and its natural antagonist, sgp130, and the risk of myocardial infarction
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2015.04.014
– volume: 3
  start-page: 655
  year: 2012
  ident: B142
  article-title: Association between IL6 -174G/C and cancer: a meta-analysis of 105,482 individuals
  publication-title: Exp Ther Med
  doi: 10.3892/etm.2012.454
– volume: 196
  start-page: 979
  year: 2002
  ident: B21
  article-title: A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
  publication-title: J Exp Med
  doi: 10.1084/jem.20020619
– volume: 11
  start-page: 319
  year: 2011
  ident: B66
  article-title: Th17 cells in inflammation
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2010.10.004
– volume: 172
  start-page: 5149
  year: 2004
  ident: B68
  article-title: Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.9.5149
– volume: 22
  start-page: 345
  year: 2000
  ident: B150
  article-title: Interleukin-6 gene expression in peripheral blood mononuclear cells from patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis
  publication-title: Ren Fail
  doi: 10.1081/JDI-100100878
– volume: 52
  start-page: 84
  year: 2005
  ident: B38
  article-title: Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells
  publication-title: Arthritis Rheum
  doi: 10.1002/art.20727
– volume: 32
  start-page: 183
  year: 2010
  ident: B74
  article-title: Signals that influence T follicular helper cell differentiation and function
  publication-title: Semin Immunopathol
  doi: 10.1007/s00281-009-0194-z
– volume: 7
  start-page: 154
  year: 1998
  ident: B133
  article-title: Renal expression of IL-6 and TNFalpha genes in lupus nephritis
  publication-title: Lupus
  doi: 10.1191/096120398678919949
– volume: 20
  start-page: 255
  year: 2006
  ident: B128
  article-title: Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus
  publication-title: J Clin Lab Anal
  doi: 10.1002/jcla.20151
– volume: 19
  start-page: 2364
  year: 1999
  ident: B153
  article-title: Interleukin-6 exacerbates early atherosclerosis in mice
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.19.10.2364
– volume: 4
  start-page: 96
  year: 1992
  ident: B30
  article-title: Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
  publication-title: Cytokine
  doi: 10.1016/1043-4666(92)90043-Q
– volume: 82
  start-page: 1120
  year: 1993
  ident: B41
  article-title: Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
  publication-title: Blood
  doi: 10.1182/blood.V82.4.1120.1120
– volume: 16
  start-page: 3315
  year: 2005
  ident: B97
  article-title: Maladaptive role of IL-6 in ischemic acute renal failure
  publication-title: J Am Soc Nephrol
  doi: 10.1681/ASN.2003090757
– volume: 1803
  start-page: 234
  year: 2010
  ident: B35
  article-title: ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase
  publication-title: Biochim Biophys Acta
  doi: 10.1016/j.bbamcr.2009.12.001
– volume: 20
  start-page: 2175
  year: 2000
  ident: B75
  article-title: Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.20.10.2175
– volume: 332
  start-page: 174
  year: 1993
  ident: B45
  article-title: Differential shedding of the two subunits of the interleukin-6 receptor
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(93)80507-Q
– volume: 61
  start-page: 720
  year: 2013
  ident: B32
  article-title: Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis
  publication-title: Cytokine
  doi: 10.1016/j.cyto.2012.12.025
– volume: 302
  start-page: F647
  year: 2012
  ident: B105
  article-title: Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00090.2011
– reference: 19380809 - J Immunol. 2009 May 1;182(9):5623-32
– reference: 16741736 - Med Microbiol Immunol. 2006 Dec;195(4):173-83
– reference: 20107805 - Semin Immunopathol. 2010 Jun;32(2):183-96
– reference: 19955044 - J Rheumatol. 2010 Jan;37(1):60-70
– reference: 10880057 - J Clin Invest. 2000 Jul;106(1):137-44
– reference: 16648838 - Nature. 2006 May 11;441(7090):235-8
– reference: 22951891 - Kidney Int. 2012 Dec;82(12):1284-96
– reference: 10661409 - Immunity. 2000 Jan;12(1):95-105
– reference: 15488864 - Atherosclerosis. 2004 Nov;177(1):43-51
– reference: 12773095 - Biochem J. 2003 Aug 15;374(Pt 1):1-20
– reference: 17567983 - Blood. 2007 Sep 15;110(6):1748-55
– reference: 27016501 - Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1218-27
– reference: 22595692 - Cytokine Growth Factor Rev. 2012 Jun;23(3):85-97
– reference: 14638908 - J Am Soc Nephrol. 2003 Dec;14(12):3090-101
– reference: 17989316 - Blood. 2008 Feb 1;111(3):1021-8
– reference: 25652333 - Clin Rheumatol. 2015 Aug;34(8):1375-82
– reference: 9372056 - Curr Opin Hematol. 1996 Jan;3(1):87-93
– reference: 9053446 - J Exp Med. 1997 Feb 3;185(3):461-9
– reference: 10848814 - Br J Haematol. 2000 May;109(2):288-95
– reference: 9116699 - Lupus. 1996 Dec;5(6):571-5
– reference: 8755571 - Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7882-7
– reference: 7530603 - Cell. 1995 Jan 27;80(2):353-61
– reference: 24450628 - Biochem Soc Trans. 2014 Feb;42(1):59-62
– reference: 12687404 - Rev Physiol Biochem Pharmacol. 2003;149:1-38
– reference: 24872191 - J Immunol. 2014 Jul 1;193(1):234-43
– reference: 20966123 - Clin J Am Soc Nephrol. 2010 Nov;5(11):2115-21
– reference: 8934572 - Immunity. 1996 Nov;5(5):449-60
– reference: 12370259 - J Exp Med. 2002 Oct 7;196(7):979-90
– reference: 11121117 - Eur J Biochem. 2001 Jan;268(1):160-7
– reference: 15987753 - J Am Soc Nephrol. 2005 Sep;16(9):2667-76
– reference: 12952969 - J Biol Chem. 2003 Nov 14;278(46):45777-84
– reference: 21148800 - J Immunol. 2011 Jan 15;186(2):1199-208
– reference: 11031201 - Arterioscler Thromb Vasc Biol. 2000 Oct;20(10):2175-83
– reference: 21106853 - J Immunol. 2011 Jan 1;186(1):32-40
– reference: 10755557 - Transplantation. 2000 Mar 15;69(5):959-63
– reference: 18337485 - J Am Soc Nephrol. 2008 Jun;19(6):1106-15
– reference: 16837924 - Kidney Int. 2006 Sep;70(6):1038-45
– reference: 23818297 - Arthritis Rheum. 2013 Oct;65(10):2691-702
– reference: 8002928 - Biochem J. 1994 Jun 1;300 ( Pt 2):281-90
– reference: 17675459 - J Immunol. 2007 Aug 15;179(4):2041-5
– reference: 17962626 - Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2576-81
– reference: 17115422 - J Clin Lab Anal. 2006;20(6):255-9
– reference: 20630940 - Am J Physiol Renal Physiol. 2010 Oct;299(4):F776-84
– reference: 26073684 - Cytokine. 2015 Dec;76(2):280-7
– reference: 9395521 - J Biol Chem. 1997 Dec 12;272(50):31764-9
– reference: 19186972 - J Periodontol. 2009 Feb;80(2):307-16
– reference: 23692924 - Biochem Biophys Res Commun. 2013 Jun 14;435(4):702-7
– reference: 14699015 - Circ Res. 2004 Mar 5;94(4):534-41
– reference: 8670868 - EMBO J. 1996 Jul 15;15(14):3651-8
– reference: 20042582 - J Immunol. 2010 Feb 1;184(3):1543-51
– reference: 21123455 - Cancer Res. 2011 Jan 15;71(2):424-34
– reference: 22969947 - Exp Ther Med. 2012 Apr;3(4):655-664
– reference: 12495721 - Trends Immunol. 2003 Jan;24(1):25-9
– reference: 19890373 - Leukemia. 2010 Jan;24(1):51-7
– reference: 17167225 - Cell Physiol Biochem. 2006;18(4-5):199-210
– reference: 2529343 - J Exp Med. 1989 Oct 1;170(4):1409-14
– reference: 21989726 - Invest Ophthalmol Vis Sci. 2011 Nov 01;52(12):8549-57
– reference: 24850910 - Mol Pharmacol. 2014 Aug;86(2):150-8
– reference: 10671300 - Cytokine. 2000 Feb;12(2):151-5
– reference: 10644881 - Exp Nephrol. 2000 Jan-Feb;8(1):37-43
– reference: 23842188 - Kidney Int. 2013 Nov;84(5):950-61
– reference: 21153673 - Clin Rheumatol. 2011 Mar;30(3):409-13
– reference: 18235097 - J Am Soc Nephrol. 2008 Mar;19(3):547-58
– reference: 19038572 - Cytokine Growth Factor Rev. 2009 Feb;20(1):43-59
– reference: 9233646 - J Immunol. 1997 Aug 1;159(3):1474-81
– reference: 9075932 - Immunity. 1997 Mar;6(3):315-25
– reference: 9293158 - Immunol Today. 1997 Sep;18(9):428-32
– reference: 7963578 - J Immunol. 1994 Dec 1;153(11):5247-55
– reference: 9414293 - Blood. 1998 Jan 1;91(1):258-65
– reference: 17903700 - Cytokine. 2007 Jul;39(1):84-96
– reference: 23871133 - J Diabetes Complications. 2013 Nov-Dec;27(6):576-9
– reference: 9607638 - Lupus. 1998;7(3):154-8
– reference: 15641051 - Arthritis Rheum. 2005 Jan;52(1):84-93
– reference: 12234313 - Kidney Int. 2002 Oct;62(4):1408-16
– reference: 19357722 - Kidney Int. 2009 Jul;76(1):63-71
– reference: 10843736 - Cytokine. 2000 Jun;12 (6):613-21
– reference: 24037962 - J Cell Physiol. 2014 Apr;229(4):434-42
– reference: 16473830 - Immunity. 2006 Feb;24(2):179-89
– reference: 25910182 - Atherosclerosis. 2015 Jun;240(2):477-81
– reference: 9190930 - J Immunol. 1997 Jun 15;158(12):5791-6
– reference: 20184875 - Eur J Pharmacol. 2010 May 25;634(1-3):178-83
– reference: 22004976 - Lupus. 2012 Jan;21(1):60-7
– reference: 14676299 - J Exp Med. 2003 Dec 15;198(12):1875-86
– reference: 1633265 - Cytokine. 1992 Mar;4(2):96-100
– reference: 22169009 - Am J Physiol Renal Physiol. 2012 Mar 15;302(6):F647-57
– reference: 15100250 - J Immunol. 2004 May 1;172(9):5149-53
– reference: 16682432 - Gut. 2006 Sep;55(9):1263-9
– reference: 11101873 - Nat Immunol. 2000 Dec;1(6):510-4
– reference: 22324903 - Expert Opin Ther Targets. 2012 Feb;16(2):225-36
– reference: 26629199 - Int J Clin Exp Med. 2015 Sep 15;8(9):16658-63
– reference: 16648837 - Nature. 2006 May 11;441(7090):231-4
– reference: 14592424 - Biochem Biophys Res Commun. 2003 Nov 14;311(2):372-9
– reference: 17167242 - Am J Nephrol. 2006;26(6):562-70
– reference: 10867535 - Nephron. 2000 Jul;85(3):207-14
– reference: 16192425 - J Am Soc Nephrol. 2005 Nov;16(11):3315-25
– reference: 20182422 - Clin Pharmacol Ther. 2010 Apr;87(4):483-7
– reference: 12645638 - Am J Cardiol. 2003 Feb 6;91(3A):7A-11A
– reference: 10666199 - Blood. 2000 Feb 15;95(4):1264-73
– reference: 24102240 - Genet Test Mol Biomarkers. 2014 Jan;18(1):62-5
– reference: 10799547 - J Biol Chem. 2000 May 12;275(19):14608-14
– reference: 12776273 - Am J Kidney Dis. 2003 Jun;41(6):1212-8
– reference: 9505191 - Int Rev Immunol. 1998;16(3-4):249-84
– reference: 22128916 - Nephrology (Carlton). 2012 Mar;17(3):257-62
– reference: 16540526 - Int Immunol. 2006 Apr;18(4):555-63
– reference: 3491322 - Nature. 1986 Nov 6-12;324(6092):73-6
– reference: 2783442 - J Immunol. 1989 Jan 15;142(2):549-53
– reference: 8358870 - Clin Nephrol. 1993 Jul;40(1):16-21
– reference: 9812885 - Science. 1998 Nov 13;282(5392):1281-4
– reference: 24344329 - FASEB J. 2014 Mar;28(3):1511-25
– reference: 24850720 - J Immunol. 2014 Jul 1;193(1):317-26
– reference: 12736161 - Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E527-33
– reference: 17496315 - Int Immunol. 2007 Jun;19(6):685-93
– reference: 26163998 - Cytokine. 2015 Dec;76(2):187-92
– reference: 21035432 - Int Immunopharmacol. 2011 Mar;11(3):319-22
– reference: 8405437 - FEBS Lett. 1993 Oct 11;332(1-2):174-8
– reference: 26525581 - BMC Cancer. 2015 Nov 02;15:830
– reference: 18556750 - Nephrol Dial Transplant. 2008 Nov;23(11):3418-26
– reference: 17465721 - Expert Opin Ther Targets. 2007 May;11(5):613-24
– reference: 2051017 - J Immunol. 1991 Jul 1;147(1):117-23
– reference: 12832423 - J Biol Chem. 2003 Oct 3;278(40):38829-39
– reference: 16192422 - J Am Soc Nephrol. 2005 Nov;16(11):3281-94
– reference: 11174004 - Kidney Blood Press Res. 2001;24(1):33-8
– reference: 9731053 - Blood. 1998 Sep 15;92(6):1957-66
– reference: 19608706 - J Am Soc Nephrol. 2009 Oct;20(10):2138-46
– reference: 8353278 - Blood. 1993 Aug 15;82(4):1120-6
– reference: 23375120 - Cytokine. 2013 Mar;61(3):720-3
– reference: 15607729 - Biochem Biophys Res Commun. 2005 Jan 28;326(4):724-8
– reference: 10802717 - Nat Med. 2000 May;6(5):583-8
– reference: 26091352 - Oncotarget. 2015 Jun 10;6(16):14026-32
– reference: 21481788 - Cancer Cell. 2011 Apr 12;19(4):456-69
– reference: 22874765 - Am J Physiol Renal Physiol. 2012 Oct 15;303(8):F1145-50
– reference: 23161414 - J Cell Commun Signal. 2013 Mar;7(1):49-60
– reference: 24243775 - Lupus. 2014;23 (1):46-56
– reference: 8047839 - Scand J Immunol. 1994 Aug;40(2):181-6
– reference: 18563316 - J Huazhong Univ Sci Technolog Med Sci. 2008 Jun;28(3):247-50
– reference: 8612579 - EMBO J. 1996 Apr 1;15(7):1557-65
– reference: 21296109 - Biochim Biophys Acta. 2011 May;1813(5):878-88
– reference: 16146075 - Ann Univ Mariae Curie Sklodowska Med. 2004;59(2):189-93
– reference: 23234871 - Nephron Exp Nephrol. 2012;121(3-4):e86-96
– reference: 16912152 - FASEB J. 2006 Oct;20(12):2174-6
– reference: 11812740 - Diabetes. 2002 Feb;51(2):339-46
– reference: 8265649 - Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11924-8
– reference: 8127368 - Nature. 1994 Mar 24;368(6469):339-42
– reference: 21130161 - Biochim Biophys Acta. 2011 Mar;1812(3):290-301
– reference: 9553147 - J Biol Chem. 1998 Apr 24;273(17):10798-805
– reference: 10843245 - Ren Fail. 2000 May;22(3):345-54
– reference: 23408169 - Am J Physiol Renal Physiol. 2013 Apr 15;304(8):F1054-65
– reference: 27583546 - PLoS One. 2016 Sep 01;11(9):e0161867
– reference: 15938041 - J Am Soc Nephrol. 2005 Mar;16 Suppl 1:S78-82
– reference: 20026129 - Biochim Biophys Acta. 2010 Feb;1803(2):234-45
– reference: 8436181 - Eur J Immunol. 1993 Feb;23(2):473-80
– reference: 26359498 - J Biol Chem. 2015 Oct 23;290(43):26059-71
– reference: 10521365 - Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2364-7
– reference: 18031104 - BioDrugs. 1997 Dec;8(6):418-29
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Snippet Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and...
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SubjectTerms endothelial cells
IL-6 classic signaling
IL-6 trans-signaling
Immunology
mesangial cells
podocyte
tubular epithelial cells
Title Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update
URI https://www.ncbi.nlm.nih.gov/pubmed/28484449
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