Interleukin-6 Signaling Pathway and Its Role in Kidney Disease: An Update

Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by...

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Published in:Frontiers in immunology Vol. 8; p. 405
Main Authors: Su, Hua, Lei, Chun-Tao, Zhang, Chun
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 21.04.2017
Subjects:
endothelial cells
IL-6 classic signaling
IL-6 trans-signaling
Immunology
mesangial cells
podocyte
tubular epithelial cells
endothelial cells
IL-6 classic signaling
tubular epithelial cells
podocyte
IL-6 trans-signaling
mesangial cells
renal disease
ISSN:1664-3224, 1664-3224
Online Access:Get full text
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Summary:Interleukin-6 (IL-6) is a pleiotropic cytokine that not only regulates the immune and inflammatory response but also affects hematopoiesis, metabolism, and organ development. IL-6 can simultaneously elicit distinct or even contradictory physiopathological processes, which is likely discriminated by the cascades of signaling pathway, termed classic and trans-signaling. Besides playing several important physiological roles, dysregulated IL-6 has been demonstrated to underlie a number of autoimmune and inflammatory diseases, metabolic abnormalities, and malignancies. This review provides an overview of basic concept of IL-6 signaling pathway as well as the interplay between IL-6 and renal-resident cells, including podocytes, mesangial cells, endothelial cells, and tubular epithelial cells. Additionally, we summarize the roles of IL-6 in several renal diseases, such as IgA nephropathy, lupus nephritis, diabetic nephropathy, acute kidney injury, and chronic kidney disease.
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Specialty section: This article was submitted to Inflammation, a section of the journal Frontiers in Immunology
Reviewed by: Behdad Afzali, King’s College London, UK; National Institutes of Health, USA; James R. Whiteford, Queen Mary University of London, UK
Edited by: Massimo Gadina, National Institute of Arthritis and Musculoskeletal and Skin Diseases, USA
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.00405