Radiolabeled Monoclonal Antibody Against Colony-Stimulating Factor 1 Receptor Specifically Distributes to the Spleen and Liver in Immunocompetent Mice

Macrophages can promote tumor development. Preclinically, targeting macrophages by colony-stimulating factor 1 (CSF1)/CSF1 receptor (CSF1R) monoclonal antibodies (mAbs) enhances conventional therapeutics in combination treatments. The physiological distribution and tumor uptake of CSF1R mAbs are unk...

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Bibliographic Details

Published in:	Frontiers in oncology Vol. 11; p. 786191
Main Authors:	Waaijer, Stijn J. H., Suurs, Frans V., Hau, Cheei-Sing, Vrijland, Kim, de Visser, Karin E., de Groot, Derk Jan A., de Vries, Elisabeth G. E., Lub-de Hooge, Marjolijn N., Schröder, Carolina P.
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 16.12.2021
Subjects:	antibody immunotherapy noninvasive imaging in animal models Oncology pharmacokinetics/pharmacodynamics (PKPD) positron emission tomography (PET) tumor-associated macrophage (TAM) antibody immunotherapy noninvasive imaging in animal models positron emission tomography (PET) pharmacokinetics/pharmacodynamics (PKPD) tumor-associated macrophage (TAM)
ISSN:	2234-943X, 2234-943X
Online Access:	Get full text
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