Clinical impact and direct costs of nosocomial respiratory syncytial virus infections in the neonatal intensive care unit
•Nosocomial viral infections are frequently overlooked in neonatology units.•Nosocomial respiratory syncytial virus infection resulted in longer hospitalizations.•Health-care interventions increased in infants with nosocomial infection.•Hospital costs were higher in infants with respiratory syncytia...
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| Vydáno v: | American journal of infection control Ročník 48; číslo 9; s. 982 - 986 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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Elsevier Inc
01.09.2020
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| ISSN: | 0196-6553, 1527-3296, 1527-3296 |
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| Abstract | •Nosocomial viral infections are frequently overlooked in neonatology units.•Nosocomial respiratory syncytial virus infection resulted in longer hospitalizations.•Health-care interventions increased in infants with nosocomial infection.•Hospital costs were higher in infants with respiratory syncytial virus infection.•Interventions to reduce nosocomial respiratory syncytial virus infections are needed.
Nosocomial infections are a leading cause of morbidity, costs, and mortality in preterm newborns. Most reports regarding nosocomial infections in neonatal intensive care units (NICU) are focused on bacterial infections and there is limited information regarding the impact of nosocomial viruses. The objective of this study was to assess the impact of nosocomial respiratory syncytial virus (RSV) infections in a NICU.
This was a retrospective cohort design from a NICU in a general hospital in Mexico. We included 24 newborn infants with nosocomial RSV infection and 24 infants without RSV matched by gestational age, birth weight, and the period of time of hospitalization.
Infants with nosocomial RSV infection had longer hospitalization duration (median 24 days vs. 13 days; P = .05), increased antibiotic use (45.8% vs. 8.3%; P = .003), more mechanical ventilation requirement (54.2% vs. 0.4%; P <.001), more frequent nosocomial infections (45.8% vs. 0%; P <.001), and higher hospitalization direct costs (median 3,587.20 USD vs. 1,123.60 USD; P = .001) after nosocomial RSV detection.
Nosocomial RSV infections are associated to a significant increase of costs in infants hospitalized in the NICU. Evaluation of interventions that may reduce the incidence of nosocomial RSV infections in this setting is warranted. |
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| AbstractList | Nosocomial infections are a leading cause of morbidity, costs, and mortality in preterm newborns. Most reports regarding nosocomial infections in neonatal intensive care units (NICU) are focused on bacterial infections and there is limited information regarding the impact of nosocomial viruses. The objective of this study was to assess the impact of nosocomial respiratory syncytial virus (RSV) infections in a NICU.BACKGROUNDNosocomial infections are a leading cause of morbidity, costs, and mortality in preterm newborns. Most reports regarding nosocomial infections in neonatal intensive care units (NICU) are focused on bacterial infections and there is limited information regarding the impact of nosocomial viruses. The objective of this study was to assess the impact of nosocomial respiratory syncytial virus (RSV) infections in a NICU.This was a retrospective cohort design from a NICU in a general hospital in Mexico. We included 24 newborn infants with nosocomial RSV infection and 24 infants without RSV matched by gestational age, birth weight, and the period of time of hospitalization.METHODSThis was a retrospective cohort design from a NICU in a general hospital in Mexico. We included 24 newborn infants with nosocomial RSV infection and 24 infants without RSV matched by gestational age, birth weight, and the period of time of hospitalization.Infants with nosocomial RSV infection had longer hospitalization duration (median 24 days vs. 13 days; P = .05), increased antibiotic use (45.8% vs. 8.3%; P = .003), more mechanical ventilation requirement (54.2% vs. 0.4%; P <.001), more frequent nosocomial infections (45.8% vs. 0%; P <.001), and higher hospitalization direct costs (median 3,587.20 USD vs. 1,123.60 USD; P = .001) after nosocomial RSV detection.RESULTSInfants with nosocomial RSV infection had longer hospitalization duration (median 24 days vs. 13 days; P = .05), increased antibiotic use (45.8% vs. 8.3%; P = .003), more mechanical ventilation requirement (54.2% vs. 0.4%; P <.001), more frequent nosocomial infections (45.8% vs. 0%; P <.001), and higher hospitalization direct costs (median 3,587.20 USD vs. 1,123.60 USD; P = .001) after nosocomial RSV detection.Nosocomial RSV infections are associated to a significant increase of costs in infants hospitalized in the NICU. Evaluation of interventions that may reduce the incidence of nosocomial RSV infections in this setting is warranted.CONCLUSIONSNosocomial RSV infections are associated to a significant increase of costs in infants hospitalized in the NICU. Evaluation of interventions that may reduce the incidence of nosocomial RSV infections in this setting is warranted. •Nosocomial viral infections are frequently overlooked in neonatology units.•Nosocomial respiratory syncytial virus infection resulted in longer hospitalizations.•Health-care interventions increased in infants with nosocomial infection.•Hospital costs were higher in infants with respiratory syncytial virus infection.•Interventions to reduce nosocomial respiratory syncytial virus infections are needed. Nosocomial infections are a leading cause of morbidity, costs, and mortality in preterm newborns. Most reports regarding nosocomial infections in neonatal intensive care units (NICU) are focused on bacterial infections and there is limited information regarding the impact of nosocomial viruses. The objective of this study was to assess the impact of nosocomial respiratory syncytial virus (RSV) infections in a NICU. This was a retrospective cohort design from a NICU in a general hospital in Mexico. We included 24 newborn infants with nosocomial RSV infection and 24 infants without RSV matched by gestational age, birth weight, and the period of time of hospitalization. Infants with nosocomial RSV infection had longer hospitalization duration (median 24 days vs. 13 days; P = .05), increased antibiotic use (45.8% vs. 8.3%; P = .003), more mechanical ventilation requirement (54.2% vs. 0.4%; P <.001), more frequent nosocomial infections (45.8% vs. 0%; P <.001), and higher hospitalization direct costs (median 3,587.20 USD vs. 1,123.60 USD; P = .001) after nosocomial RSV detection. Nosocomial RSV infections are associated to a significant increase of costs in infants hospitalized in the NICU. Evaluation of interventions that may reduce the incidence of nosocomial RSV infections in this setting is warranted. Highlights•Nosocomial viral infections are frequently overlooked in neonatology units. •Nosocomial respiratory syncytial virus infection resulted in longer hospitalizations. •Health-care interventions increased in infants with nosocomial infection. •Hospital costs were higher in infants with respiratory syncytial virus infection. •Interventions to reduce nosocomial respiratory syncytial virus infections are needed. Nosocomial infections are a leading cause of morbidity, costs, and mortality in preterm newborns. Most reports regarding nosocomial infections in neonatal intensive care units (NICU) are focused on bacterial infections and there is limited information regarding the impact of nosocomial viruses. The objective of this study was to assess the impact of nosocomial respiratory syncytial virus (RSV) infections in a NICU. This was a retrospective cohort design from a NICU in a general hospital in Mexico. We included 24 newborn infants with nosocomial RSV infection and 24 infants without RSV matched by gestational age, birth weight, and the period of time of hospitalization. Infants with nosocomial RSV infection had longer hospitalization duration (median 24 days vs. 13 days; P = .05), increased antibiotic use (45.8% vs. 8.3%; P = .003), more mechanical ventilation requirement (54.2% vs. 0.4%; P <.001), more frequent nosocomial infections (45.8% vs. 0%; P <.001), and higher hospitalization direct costs (median 3,587.20 USD vs. 1,123.60 USD; P = .001) after nosocomial RSV detection. Nosocomial RSV infections are associated to a significant increase of costs in infants hospitalized in the NICU. Evaluation of interventions that may reduce the incidence of nosocomial RSV infections in this setting is warranted. |
| Author | Gutierrez-Mendoza, Luis M. Comas-García, Andreu Noyola, Daniel E. Lima-Rogel, Victoria Aguilera-Martínez, José I. Escalante-Padrón, Francisco J. |
| Author_xml | – sequence: 1 givenname: Andreu surname: Comas-García fullname: Comas-García, Andreu organization: Microbiology Department, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico – sequence: 2 givenname: José I. surname: Aguilera-Martínez fullname: Aguilera-Martínez, José I. organization: Neonatology Department, Hospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí, Mexico – sequence: 3 givenname: Francisco J. surname: Escalante-Padrón fullname: Escalante-Padrón, Francisco J. organization: Neonatology Department, Hospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí, Mexico – sequence: 4 givenname: Victoria surname: Lima-Rogel fullname: Lima-Rogel, Victoria organization: Neonatology Department, Hospital Central “Dr. Ignacio Morones Prieto”, San Luis Potosí, Mexico – sequence: 5 givenname: Luis M. surname: Gutierrez-Mendoza fullname: Gutierrez-Mendoza, Luis M. organization: Public Health Department, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico – sequence: 6 givenname: Daniel E. surname: Noyola fullname: Noyola, Daniel E. email: dnoyola@uaslp.mx organization: Microbiology Department, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico |
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| Cites_doi | 10.3389/fped.2019.00168 10.1016/S0140-6736(12)61901-1 10.1542/peds.106.3.520 10.1016/j.ajic.2013.01.026 10.1016/S0140-6736(10)60206-1 10.1038/sj.jp.7211120 10.1056/NEJM197512252932604 10.3389/fmicb.2018.02484 10.1086/588000 10.3109/14767058.2015.1079614 10.1016/j.jpeds.2012.05.001 10.1053/jhin.2000.0852 10.1097/01.inf.0000190027.59795.ac 10.1542/peds.2014-1665 10.1016/S0378-3782(14)70018-0 |
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| Copyright | 2020 Association for Professionals in Infection Control and Epidemiology, Inc. Association for Professionals in Infection Control and Epidemiology, Inc. Copyright © 2020 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. |
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| Keywords | Economics Premature Health-care associated infection Pneumonia Newborn |
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| Snippet | •Nosocomial viral infections are frequently overlooked in neonatology units.•Nosocomial respiratory syncytial virus infection resulted in longer... Highlights•Nosocomial viral infections are frequently overlooked in neonatology units. •Nosocomial respiratory syncytial virus infection resulted in longer... Nosocomial infections are a leading cause of morbidity, costs, and mortality in preterm newborns. Most reports regarding nosocomial infections in neonatal... |
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| SubjectTerms | Economics Health-care associated infection Infectious Disease Newborn Pneumonia Premature |
| Title | Clinical impact and direct costs of nosocomial respiratory syncytial virus infections in the neonatal intensive care unit |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S019665532030211X https://www.clinicalkey.es/playcontent/1-s2.0-S019665532030211X https://dx.doi.org/10.1016/j.ajic.2020.04.009 https://www.ncbi.nlm.nih.gov/pubmed/32305431 https://www.proquest.com/docview/2392477029 |
| Volume | 48 |
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