Hypercoagulopathy and Adipose Tissue Exacerbated Inflammation May Explain Higher Mortality in COVID-19 Patients With Obesity

COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Frontiers in endocrinology (Lausanne) Jg. 11; S. 530
Hauptverfasser:	Pasquarelli-do-Nascimento, Gabriel, Braz-de-Melo, Heloísa Antoniella, Faria, Sara Socorro, Santos, Igor de Oliveira, Kobinger, Gary P., Magalhães, Kelly Grace
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 28.07.2020
Schlagworte:	ACE-2 adipose tissue Adipose Tissue - physiopathology Betacoronavirus - isolation & purification Coronavirus Infections - complications Coronavirus Infections - epidemiology Coronavirus Infections - mortality Coronavirus Infections - virology COVID-19 Endocrinology Humans hypercoagulopathy Inflammation - physiopathology Obesity Obesity - complications Pandemics Pneumonia, Viral - complications Pneumonia, Viral - epidemiology Pneumonia, Viral - mortality Pneumonia, Viral - virology Prognosis SARS-CoV-2 Survival Rate Thrombophilia - physiopathology COVID-19 adipose tissue Obesity SARS-CoV-2 ACE-2 hypercoagulopathy
ISSN:	1664-2392, 1664-2392
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Abstract	COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreover, countries with greater obesity prevalence have a higher morbidity and mortality risk of developing serious outcomes from COVID-19. The understanding of how this increased susceptibility of the people with obesity to develop severe forms of the SARS-CoV-2 infection occurs is crucial for implementing appropriate public health and therapeutic strategies to avoid COVID-19 severe symptoms and complications in people living with obesity. We hypothesize here that increased ACE2 expression in adipose tissue displayed by people with obesity may increase SARS-CoV-2 infection and accessibility to this tissue. Individuals with obesity have increased white adipose tissue, which may act as a reservoir for a more extensive viral spread with increased shedding, immune activation and pro-inflammatory cytokine amplification. Here we discuss how obesity is related to a pro-inflammatory and metabolic dysregulation, increased SARS-CoV-2 host cell entry in adipose tissue and induction of hypercoagulopathy, leading people with obesity to develop severe forms of COVID-19 and also death. Taken together, it may be crucial to better explore the role of visceral adipose tissue in the inflammatory response to SARS-CoV-2 infection and investigate the potential therapeutic effect of using specific target anti-inflammatories (canakinumab or anakinra for IL-1β inhibition; anti-IL-6 antibodies for IL-6 inhibition), anticoagulant or anti-diabetic drugs in COVID-19 treatment of people with obesity. Defining the immunopathological changes in COVID-19 patients with obesity can provide prominent targets for drug discovery and clinical management improvement.
AbstractList	COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreover, countries with greater obesity prevalence have a higher morbidity and mortality risk of developing serious outcomes from COVID-19. The understanding of how this increased susceptibility of the people with obesity to develop severe forms of the SARS-CoV-2 infection occurs is crucial for implementing appropriate public health and therapeutic strategies to avoid COVID-19 severe symptoms and complications in people living with obesity. We hypothesize here that increased ACE2 expression in adipose tissue displayed by people with obesity may increase SARS-CoV-2 infection and accessibility to this tissue. Individuals with obesity have increased white adipose tissue, which may act as a reservoir for a more extensive viral spread with increased shedding, immune activation and pro-inflammatory cytokine amplification. Here we discuss how obesity is related to a pro-inflammatory and metabolic dysregulation, increased SARS-CoV-2 host cell entry in adipose tissue and induction of hypercoagulopathy, leading people with obesity to develop severe forms of COVID-19 and also death. Taken together, it may be crucial to better explore the role of visceral adipose tissue in the inflammatory response to SARS-CoV-2 infection and investigate the potential therapeutic effect of using specific target anti-inflammatories (canakinumab or anakinra for IL-1β inhibition; anti-IL-6 antibodies for IL-6 inhibition), anticoagulant or anti-diabetic drugs in COVID-19 treatment of people with obesity. Defining the immunopathological changes in COVID-19 patients with obesity can provide prominent targets for drug discovery and clinical management improvement. COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreover, countries with greater obesity prevalence have a higher morbidity and mortality risk of developing serious outcomes from COVID-19. The understanding of how this increased susceptibility of the people with obesity to develop severe forms of the SARS-CoV-2 infection occurs is crucial for implementing appropriate public health and therapeutic strategies to avoid COVID-19 severe symptoms and complications in people living with obesity. We hypothesize here that increased ACE2 expression in adipose tissue displayed by people with obesity may increase SARS-CoV-2 infection and accessibility to this tissue. Individuals with obesity have increased white adipose tissue, which may act as a reservoir for a more extensive viral spread with increased shedding, immune activation and pro-inflammatory cytokine amplification. Here we discuss how obesity is related to a pro-inflammatory and metabolic dysregulation, increased SARS-CoV-2 host cell entry in adipose tissue and induction of hypercoagulopathy, leading people with obesity to develop severe forms of COVID-19 and also death. Taken together, it may be crucial to better explore the role of visceral adipose tissue in the inflammatory response to SARS-CoV-2 infection and investigate the potential therapeutic effect of using specific target anti-inflammatories (canakinumab or anakinra for IL-1β inhibition; anti-IL-6 antibodies for IL-6 inhibition), anticoagulant or anti-diabetic drugs in COVID-19 treatment of people with obesity. Defining the immunopathological changes in COVID-19 patients with obesity can provide prominent targets for drug discovery and clinical management improvement.COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world have identified obesity and severe obesity as one of the strongest risk factors for COVID-19 hospitalization and mechanical ventilation. Moreover, countries with greater obesity prevalence have a higher morbidity and mortality risk of developing serious outcomes from COVID-19. The understanding of how this increased susceptibility of the people with obesity to develop severe forms of the SARS-CoV-2 infection occurs is crucial for implementing appropriate public health and therapeutic strategies to avoid COVID-19 severe symptoms and complications in people living with obesity. We hypothesize here that increased ACE2 expression in adipose tissue displayed by people with obesity may increase SARS-CoV-2 infection and accessibility to this tissue. Individuals with obesity have increased white adipose tissue, which may act as a reservoir for a more extensive viral spread with increased shedding, immune activation and pro-inflammatory cytokine amplification. Here we discuss how obesity is related to a pro-inflammatory and metabolic dysregulation, increased SARS-CoV-2 host cell entry in adipose tissue and induction of hypercoagulopathy, leading people with obesity to develop severe forms of COVID-19 and also death. Taken together, it may be crucial to better explore the role of visceral adipose tissue in the inflammatory response to SARS-CoV-2 infection and investigate the potential therapeutic effect of using specific target anti-inflammatories (canakinumab or anakinra for IL-1β inhibition; anti-IL-6 antibodies for IL-6 inhibition), anticoagulant or anti-diabetic drugs in COVID-19 treatment of people with obesity. Defining the immunopathological changes in COVID-19 patients with obesity can provide prominent targets for drug discovery and clinical management improvement.
Author	Faria, Sara Socorro Pasquarelli-do-Nascimento, Gabriel Magalhães, Kelly Grace Santos, Igor de Oliveira Braz-de-Melo, Heloísa Antoniella Kobinger, Gary P.
AuthorAffiliation	1 Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia , Brasilia , Brazil 2 Département de Microbiologie-Infectiologie et d'Immunologie, Université Laval , Quebec City, QC , Canada 3 Centre de Recherche en Infectiologie du CHU de Québec - Université Laval , Quebec City, QC , Canada
AuthorAffiliation_xml	– name: 2 Département de Microbiologie-Infectiologie et d'Immunologie, Université Laval , Quebec City, QC , Canada – name: 1 Laboratory of Immunology and Inflammation, Department of Cell Biology, University of Brasilia , Brasilia , Brazil – name: 3 Centre de Recherche en Infectiologie du CHU de Québec - Université Laval , Quebec City, QC , Canada
Author_xml	– sequence: 1 givenname: Gabriel surname: Pasquarelli-do-Nascimento fullname: Pasquarelli-do-Nascimento, Gabriel – sequence: 2 givenname: Heloísa Antoniella surname: Braz-de-Melo fullname: Braz-de-Melo, Heloísa Antoniella – sequence: 3 givenname: Sara Socorro surname: Faria fullname: Faria, Sara Socorro – sequence: 4 givenname: Igor de Oliveira surname: Santos fullname: Santos, Igor de Oliveira – sequence: 5 givenname: Gary P. surname: Kobinger fullname: Kobinger, Gary P. – sequence: 6 givenname: Kelly Grace surname: Magalhães fullname: Magalhães, Kelly Grace
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32849309$$D View this record in MEDLINE/PubMed
BookMark	eNp1UktvEzEQXqEiWkrvnJCPXBK8tvfhC1KVFhKpVTgUOFqz9jhxtVkvtoOIxI_HSVrUIuGLrZnvMdZ8r4uTwQ9YFG9LOuW8lR8sDsZPGWV0SmnF6YvirKxrMWFcspMn79PiIsZ7mo-gpZTtq-KUs1ZITuVZ8Xu-GzFoD6tt70dI6x2BwZBL40Yfkdy5GLdIrn-BxtBBQkMWg-1hs4Hk_EBuYZebYw9uIHO3WmMgtz4k6F3akVybLb8trialJF8yHocUyXeX1mTZYcyIN8VLC33Ei4f7vPj66fpuNp_cLD8vZpc3Ey1qliZdaZkRmlaybLWuGRoLXKLlXSt1bTRIRJRUNqbWLTStbWq0GkUFUFVSN_y8WBx1jYd7NQa3gbBTHpw6FHxYKQjJ6R6VoJJZ0TLRNZXoWC0bVtEWKOdl2VjDstbHo9a47TZodP5UgP6Z6PPO4NZq5X-qhktJm_0w7x8Egv-xxZjUxkWNfQ8D-m1UTPCmFSz7Zui7p15_TR7XlwH1EaCDjzGgVdqlw2aytetVSdU-KuoQFbWPijpEJRPpP8RH7f9S_gDlT8Oh
CitedBy_id	crossref_primary_10_1186_s12879_021_06958_z crossref_primary_10_1016_j_compbiomed_2024_108264 crossref_primary_10_1007_s11695_021_05799_8 crossref_primary_10_3390_medicina57080805 crossref_primary_10_3390_ijms24021091 crossref_primary_10_1016_j_biopha_2022_113178 crossref_primary_10_3389_fmicb_2022_1037469 crossref_primary_10_1002_osp4_626 crossref_primary_10_3389_fnut_2021_784429 crossref_primary_10_2217_cer_2021_0237 crossref_primary_10_3390_biomedicines11082116 crossref_primary_10_1089_dna_2021_1198 crossref_primary_10_1007_s10072_021_05505_7 crossref_primary_10_1038_s41430_022_01197_0 crossref_primary_10_3390_cells10040933 crossref_primary_10_3390_nu13124193 crossref_primary_10_1007_s10096_021_04260_z crossref_primary_10_3389_fimmu_2021_732913 crossref_primary_10_1016_j_ejphar_2020_173629 crossref_primary_10_1177_15598276221111054 crossref_primary_10_1210_clinem_dgab629 crossref_primary_10_3389_fnut_2022_931313 crossref_primary_10_1016_j_jdiacomp_2020_107817 crossref_primary_10_3390_nu15020436 crossref_primary_10_3389_fendo_2020_582870 crossref_primary_10_1007_s11010_022_04356_w crossref_primary_10_1371_journal_pntd_0010658 crossref_primary_10_1016_j_nut_2022_111677 crossref_primary_10_69601_meandrosmdj_1607649 crossref_primary_10_1186_s12902_021_00912_5 crossref_primary_10_1371_journal_ppat_1012988 crossref_primary_10_12998_wjcc_v11_i13_2925 crossref_primary_10_1007_s11695_020_04998_z crossref_primary_10_3390_ijms22031213 crossref_primary_10_1007_s11154_021_09656_y crossref_primary_10_1007_s11154_021_09678_6 crossref_primary_10_3389_fimmu_2020_599736 crossref_primary_10_3748_wjg_v29_i6_908 crossref_primary_10_1016_j_clnesp_2021_04_001 crossref_primary_10_1111_ors_12734 crossref_primary_10_1007_s42770_021_00497_0 crossref_primary_10_1016_j_exger_2020_111147 crossref_primary_10_1016_j_numecd_2020_11_012 crossref_primary_10_3389_fendo_2021_726967 crossref_primary_10_1111_liv_14854 crossref_primary_10_1038_s41366_024_01464_z crossref_primary_10_3390_life12101617 crossref_primary_10_1128_spectrum_00010_23 crossref_primary_10_1007_s11154_022_09715_y crossref_primary_10_3390_v15040944 crossref_primary_10_1007_s40618_021_01628_y crossref_primary_10_1016_j_lana_2021_100167 crossref_primary_10_3390_ijms26136214 crossref_primary_10_1007_s40200_025_01706_5 crossref_primary_10_2478_jtim_2022_0020 crossref_primary_10_1038_s42003_022_03503_9 crossref_primary_10_1111_obr_13330
Cites_doi	10.1007/s00125-011-2158-9 10.1155/2018/3407306 10.3906/sag-2004-21 10.1016/S2213-26002030076-X 10.1038/s41422-020-0305-x 10.1002/ajh.25829 10.1097/MOL.0b013e32814e6d29 10.1002/oby.22867 10.3892/etm.2016.3667 10.1038/s41586-020-2180-5 10.1111/bjh.16725 10.1016/S2213-2600(20)30116-8 10.4172/2161-1017.1000113 10.1016/S1096-71920200140-3 10.1001/jama.2009.1536 10.1016/j.diabres.2020.108146 10.1016/S2468-12532030118-7 10.1148/ryct.2020200067 10.1016/j.metabol.2020.154224 10.1007/s00592-020-01522-8 10.1016/j.tcm.2015.12.001 10.1016/j.redox.2017.04.012 10.2147/DMSO.S67400 10.1093/infdis/jir731 10.2337/dc20-0643 10.1155/2014/603409 10.1002/jmv.25767 10.1007/s13679-015-0157-8 10.2337/db15-0399 10.14336/AD.2020.0228 10.1016/j.thromres.2015.07.015 10.1055/s-0032-1305782 10.1001/jama.2020.4326 10.5694/mja2.50577 10.1111/obr.12320 10.1038/s41591-020-0868-6 10.1073/pnas.0711241105 10.1002/14651858.CD003747.pub4 10.1161/CIRCRESAHA.120.317134 10.1155/2012/476380 10.1016/j.virol.2017.11.012 10.1038/sj.ijo.0802778 10.1016/j.cca.2020.03.022 10.1080/22221751.2020.1746200 10.1007/s00441-016-2515-6 10.1101/2020.04.20.20061861 10.1155/2015/507151 10.1016/j.jaut.2020.102452 10.3389/fimmu.2016.00609 10.31744/einstein_journal/2020ed5758 10.1038/sj.ijo.0800435 10.1183/13993003.00857-2019 10.1101/2020.04.28.066761 10.1186/s13054-020-02902-w 10.20944/preprints202002.0221.v1 10.1093/jn/137.5.1236 10.1016/j.physbeh.2017.03.040 10.1146/annurev-nutr-081810-160812 10.1016/j.coph.2004.10.003 10.1186/s13054-019-2395-8 10.1161/CIRCULATIONAHA.118.032780 10.1002/biof.6 10.1093/eurheartj/ehaa471 10.1128/jvi.02677-05 10.1016/j.stem.2020.06.015 10.1038/s41577-020-0331-4 10.3332/ecancer.2020.1023 10.1016/j.antiviral.2020.104791 10.1111/jth.14975 10.1111/jth.14850 10.1016/j.accpm.2020.04.001 10.1016/j.atherosclerosis.2018.12.023 10.3390/jcm8060855 10.1371/journal.pone.0132626 10.3346/JKMS.2020.35.E142 10.1074/jbc.M200581200 10.2741/4474 10.1164/rccm.202003-0821OC 10.1016/S0140-6736(20)30566-3 10.1016/j.vaccine.2015.06.101.The 10.1016/S0140-6736(20)30183-5 10.1002/1521-4141(200109)31:9<2566::aid-immu2566>3.0.co;2-l 10.1007/s11684-020-0754-0 10.1111/jth.14854 10.1096/fj.202000782 10.1155/2014/689360 10.1007/s10753-016-0452-x 10.1016/S1473-3099(20)30293-0 10.1038/nature07203 10.1016/j.nut.2012.04.019 10.1016/j.cell.2020.02.052 10.1007/s00109-006-0094-9 10.1101/2020.03.11.20031096 10.1007/s15010-020-01432-5 10.1128/JVI.01387-16 10.1210/clinem/dgaa346 10.1084/jem.20140116 10.1007/s00125-010-1865-y 10.1086/653842 10.1378/chest.10-1971 10.1183/09031936.00039214 10.1084/jem.20200678 10.1016/j.mce.2012.03.005 10.3201/eid1002.030482 10.1016/j.medmal.2020.04.002 10.1073/pnas.93.22.12490 10.1136/thx.2007.086801 10.1016/j.cmet.2016.07.009 10.1152/physrev.00033.2011 10.1183/13993003.01009-2020 10.1001/jama.2020.6775 10.1038/s41586-020-2012-7 10.1016/j.bcp.2014.11.013 10.1002/oby.22856 10.1001/jama.2020.4683 10.1093/infdis/jiy370 10.1371/journal.pone.0121971 10.31525/ct1-nct04275414 10.1152/ajpendo.00311.2019 10.1136/bmj.m1185 10.1007/s00109-008-0336-0 10.1210/en.2014-1685 10.1194/jlr.M500294-JLR200 10.3390/ijms21020623 10.1148/radiol.2020201544 10.7326/AWED202001070 10.1111/jth.14817 10.1164/rccm.201712-2371ED 10.1016/j.mcna.2017.08.004 10.1172/JCI29881.both 10.1056/NEJMsr1606602 10.1038/s41368-020-0074-x 10.1161/CIRCRESAHA.116.307708 10.1016/S2213-2600(20)30158-2 10.1002/path.2162 10.1136/bmj.f6041 10.1016/S0140-67361360900-9 10.1160/TH14-05-0457 10.1001/jama.2020.1585 10.1038/s41422-020-0318-5 10.1182/blood.2020006000 10.4161/hv.28332 10.1126/scitranslmed.aaf9194.Influenza 10.1038/s41440-018-0166-6 10.1038/ijo.2011.208 10.1007/BF03346544 10.1111/cob.12365 10.1128/jvi.01262-19 10.1016/j.atherosclerosis.2012.06.062 10.1161/circulationaha.120.047549 10.1172/JCI137244 10.1101/2020.04.08.20058073 10.7554/eLife.57278 10.1093/cvr/cvx086 10.1038/nature05485 10.1016/j.rmed.2020.105941 10.1038/s41569-018-0110-0 10.1055/s-0040-1710018 10.1016/j.redox.2017.03.012 10.1371/journal.ppat.1004651 10.2174/1389450117666160727142401 10.1056/NEJMoa2020283 10.1093/cid/ciq152 10.1016/S0140-6736(20)31024-2 10.1101/2020.03.11.987016 10.1016/j.numecd.2009.01.006 10.3892/mmr.2020.11127 10.1038/nature03712 10.1016/S0140-67362030858-8 10.1016/j.thromres.2020.04.013 10.1016/S0140-67360314482-0 10.1016/j.cell.2020.02.058 10.1155/2013/678159 10.1056/NEJMsr2005760 10.1161/01.RES.87.5.e1 10.1016/S2213-26002030216-2 10.1016/S2213-8587(20)30156-X 10.1016/S0140-6736(20)30628-0 10.1001/jama.2020.6019 10.1172/JCI92035 10.1160/TH14-02-0156 10.1152/japplphysiol.00781.2009 10.1093/cid/ciaa415 10.1172/JCI26498DS1 10.2147/DMSO.S146339 10.1111/jth.14768 10.1016/j.metabol.2020.154244 10.1016/j.coph.2017.08.006 10.1159/000453002 10.2450/2013.0152-13 10.1074/jbc.M002615200 10.1002/oby.22831 10.1038/nrendo.2015.58
ContentType	Journal Article
Copyright	Copyright © 2020 Pasquarelli-do-Nascimento, Braz-de-Melo, Faria, Santos, Kobinger and Magalhães. Copyright © 2020 Pasquarelli-do-Nascimento, Braz-de-Melo, Faria, Santos, Kobinger and Magalhães. 2020 Pasquarelli-do-Nascimento, Braz-de-Melo, Faria, Santos, Kobinger and Magalhães
Copyright_xml	– notice: Copyright © 2020 Pasquarelli-do-Nascimento, Braz-de-Melo, Faria, Santos, Kobinger and Magalhães. – notice: Copyright © 2020 Pasquarelli-do-Nascimento, Braz-de-Melo, Faria, Santos, Kobinger and Magalhães. 2020 Pasquarelli-do-Nascimento, Braz-de-Melo, Faria, Santos, Kobinger and Magalhães
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM DOA
DOI	10.3389/fendo.2020.00530
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine
EISSN	1664-2392
ExternalDocumentID	oai_doaj_org_article_4092f4824b754b26972508a033117fd2 PMC7399077 32849309 10_3389_fendo_2020_00530
Genre	Journal Article Review
GroupedDBID	53G 5VS 9T4 AAFWJ AAKDD AAYXX ACGFO ACGFS ADBBV ADRAZ AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV CITATION DIK EMOBN GROUPED_DOAJ GX1 HYE KQ8 M48 M~E OK1 PGMZT RPM ACXDI CGR CUY CVF ECM EIF IAO IEA IHR IHW IPNFZ NPM RIG 7X8 5PM
ID	FETCH-LOGICAL-c462t-b1f2d4c05918cc62edfa39ef3b89c6dca9eee9097d6c8a78f76efce45aa559c73
IEDL.DBID	DOA
ISICitedReferencesCount	71
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000561365400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1664-2392
IngestDate	Fri Oct 03 12:51:32 EDT 2025 Thu Aug 21 13:59:10 EDT 2025 Thu Sep 04 18:44:12 EDT 2025 Thu Jan 02 22:58:57 EST 2025 Sat Nov 29 06:38:00 EST 2025 Tue Nov 18 21:30:58 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Keywords	COVID-19 adipose tissue Obesity SARS-CoV-2 ACE-2 hypercoagulopathy
Language	English
License	Copyright © 2020 Pasquarelli-do-Nascimento, Braz-de-Melo, Faria, Santos, Kobinger and Magalhães. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c462t-b1f2d4c05918cc62edfa39ef3b89c6dca9eee9097d6c8a78f76efce45aa559c73
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Reviewed by: Luca Spiezia, University of Padova, Italy; Erik Albert Karlsson, Institut Pasteur du Cambodge, Cambodia Edited by: Jeff M. P. Holly, University of Bristol, United Kingdom This article was submitted to Obesity, a section of the journal Frontiers in Endocrinology
OpenAccessLink	https://doaj.org/article/4092f4824b754b26972508a033117fd2
PMID	32849309
PQID	2437842725
PQPubID	23479
ParticipantIDs	doaj_primary_oai_doaj_org_article_4092f4824b754b26972508a033117fd2 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7399077 proquest_miscellaneous_2437842725 pubmed_primary_32849309 crossref_citationtrail_10_3389_fendo_2020_00530 crossref_primary_10_3389_fendo_2020_00530
PublicationCentury	2000
PublicationDate	2020-07-28
PublicationDateYYYYMMDD	2020-07-28
PublicationDate_xml	– month: 07 year: 2020 text: 2020-07-28 day: 28
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland
PublicationTitle	Frontiers in endocrinology (Lausanne)
PublicationTitleAlternate	Front Endocrinol (Lausanne)
PublicationYear	2020
Publisher	Frontiers Media S.A
Publisher_xml	– name: Frontiers Media S.A
References	Jose (B167) 2019; 2019 Wan (B4) 2020; 5 Gordon-Larsen (B15) 2018; 137 Qu (B159) 2020 Anfossi (B132) 2009; 19 Kanda (B101) 2006; 116 Shirato (B50) 2017; 91 Shimizu (B58) 2015; 4 Yang (B66) 2020; 27 Elliot (B83) 2019; 54 Fensterl (B113) 2009; 35 Hotamisligil (B95) 2006; 444 Liumbruno (B146) 2013; 11 Barrasa (B31) 2020 Hoffmann (B37) 2020; 181 Van der Meijden (B139) 2018; 16 Leng (B88) 2020; 11 Terán-Cabanillas (B112) 2017; 40 Milner (B111) 2016; 176 Liu (B177) 2020; 111 Lumeng (B102) 2007; 117 Vickers (B46) 2002; 277 Skurk (B143) 2004; 28 Sheridan (B18) 2012; 36 Vardhana (B140) 2020; 217 Luzi (B116) 2020; 57 Barrachina (B141) 2019; 281 Borghi (B64) 2016; 366 Peters (B176) 2020; 202 Deng (B25) 2020; 24 Walls (B48) 2020; 181 Malavazos (B82) 2020; 41 Tchernof (B130) 2013; 93 Cinti (B97) 2005; 46 Lippi (B129) 2020; 506 Zhang (B17) 2008; 454 Yuan (B61) 2010; 33 Lan (B52) 2020; 581 De Pergola (B142) 1997; 21 Petrakis (B70) 2020; 22 Jing (B63) 2013; 378 Yao (B77) 2020; 30 Mehta (B90) 2020; 395 Tipnis (B39) 2000; 275 Sencan (B3) 2020; 50 Levi (B134) 2012; 38 Huang (B1) 2020; 395 Hamming (B43) 2007; 212 Ellinghaus (B147) 2020 Matthews (B98) 2010; 53 Hensley (B185) 2004; 10 Flint (B11) 2020; 8 Bello-Chavolla (B29) 2020; 105 Schmidt (B105) 2015; 10 Kim (B120) 2012; 205 Tang (B193) 2020; 18 Frantzeskaki (B154) 2017; 93 Sallard (B186) 2020; 178 Grillet (B187) 2020 Roumier (B178) 2020 Gardner (B119) 2019; 31 Zhao (B79) 2020 Boini (B12) 2018; 22 Jaganjac (B13) 2017; 12 Alikhan (B190) 2014; 2014 Brown (B162) 2020; 8 Luther (B62) 2011; 54 Vilahur (B137) 2017; 113 Ye (B118) 2019; 93 Merad (B92) 2020; 20 Yang (B53) 2007; 57 Park (B115) 2014; 10 Hemalatha Rajkumar (B19) 2013; 2 Iacobellis (B81) 2015; 11 Csige (B131) 2018; 2018 Kass (B26) 2020; 6736 Painter (B121) 2015; 33 Little (B170) 2020; 368 Louie (B74) 2011; 52 Bader (B45) 2008; 86 Meng (B163) 2020; 9 Barale (B133) 2020; 21 Matsuyama (B175) 2020 Rodríguez-Hernández (B96) 2013; 2013 Zhou (B9) 2020; 395 B94 Hui (B171) 2018; 197 Xu (B93) 2020; 8 Tsatsanis (B110) 2010; 202 Russell (B164) 2020; 14 Alessi (B144) 2007; 18 Raiko (B145) 2012; 224 Klonoff (B23) 2020; 108 Maier (B76) 2018; 218 Lauby-Secretan (B21) 2016; 375 Mancuso (B166) 2010; 108 Patel (B40) 2016; 118 Xia (B49) 2020; 30 Boros (B86) 2002; 77 Wagner (B84) 2015; 45 Dhurandhar (B22) 2015; 16 Little (B169) 2013; 347 Xydakis (B6) 2020 Panigada (B125) 2020; 18 Valencak (B14) 2017; 12 McClean (B104) 2008; 63 Mycroft-west (B194) 2020 Sungnak (B56) 2020; 26 Kruger (B85) 2015; 11 Cinatl (B184) 2003; 362 Simonnet (B30) 2020; 28 Kawano (B103) 2016; 24 Kawabe (B65) 2019; 317 Yan (B47) 2020; 34 Mirsoian (B72) 2014; 211 Jiang (B107) 2016; 12 Dominguez-Cherit (B109) 2009; 302 Ulhaq (B91) 2020; 50 Nieuwdorp (B16) 2005; 5 (B161) 2020 Witkowski (B136) 2016; 26 Zhang (B67) 2014; 2014 Pal (B200) 2020; 163 Patel (B80) 2016; 65 Kuba (B42) 2006; 84 Zietz (B149) 2020 Pacurari (B59) 2014; 2014 Feldmann (B181) 2020; 395 Al-Goblan (B106) 2014; 7 Zhao (B148) 2020 (B160) 2020 Lighter (B28) 2020 Sanders (B165) 2020; 323 (B2) 2020 Arentz (B122) 2020; 323 B188 Beavers (B138) 2015; 136 Zhang (B198) 2020; 126 Saltiel (B99) 2017; 127 (B179) 2020 Kruglikov (B57) 2020; 28 B180 Rao (B156) 2020; 43 Gentile (B89) 2019; 8 Luo (B44) 2019; 42 Faloia (B71) 2012; 2012 Klok (B152) 2020; 191 Romaní-Pérez (B68) 2015; 156 Athale (B117) 2017; 9 Tikoo (B69) 2015; 93 Smith (B75) 2007; 137 Zheng (B24) 2020; 108 Onder (B32) 2020; 2019 Shirato (B51) 2018; 517 Campello (B135) 2015; 113 Rubin (B7) 2020; 172 Chen (B34) 2020; 2019 Stolarczyk (B100) 2017; 37 Connors (B123) 2020; 135 Ranucci (B158) 2020; 18 Kim (B35) 2020; 35 Katz (B153) 2011; 139 Franchini (B150) 2014; 112 Chen (B155) 2020; 130 Teran-Cabanillas (B73) 2013; 29 Upadhyay (B20) 2018; 102 Zou (B54) 2020; 14 Imai (B41) 2005; 436 Velloso (B60) 1996; 93 Hussell (B183) 2001; 31 Liu (B128) 2020; 142 Tang (B126) 2020; 18 Lippi (B10) 2020; 167 Halpin (B173) 2020; 55 Richardson (B27) 2020; 10022 Terpos (B124) 2020; 95 Murira (B114) 2016; 7 Xie (B189) 2020; 2 Xu (B55) 2020; 12 Fang (B195) 2020; 8 Iba (B157) 2020 Donoghue (B38) 2000; 87 Finer (B33) 2020; 10 Baigent (B168) 2013; 382 Mousavi (B191) 2015; 2015 Rossi (B197) 2020; 9 Sarwar (B108) 2018; 11 Zhu (B87) 2020 Wang (B5) 2020; 323 Rodrigues Prestes (B199) 2017; 18 Ibricevic (B78) 2006; 80 Zhou (B36) 2020; 579 Haga (B182) 2008; 105 Spiezia (B127) 2020; 120 Savioli (B192) 2020; 18 Song (B151) 2016; 10 Xiong (B8) 2020; 189 Zha (B174) 2020; 2019 Ni (B172) 2019; 23 Mcmurray (B196) 2020; 382
References_xml	– volume: 54 start-page: 2152 year: 2011 ident: B62 article-title: Aldosterone decreases glucose-stimulated insulin secretion in vivo in mice and in murine islets publication-title: Diabetologia. doi: 10.1007/s00125-011-2158-9 – volume: 2018 start-page: 3407306 year: 2018 ident: B131 article-title: The impact of obesity on the cardiovascular system publication-title: J Diabetes Res. doi: 10.1155/2018/3407306 – volume: 50 start-page: 534 year: 2020 ident: B3 article-title: Global threat of COVID 19 and evacuation of the citizens of different countries publication-title: TURKISH J Med Sci. doi: 10.3906/sag-2004-21 – volume: 8 start-page: 420 year: 2020 ident: B93 article-title: Pathological findings of COVID-19 associated with acute respiratory distress syndrome publication-title: Lancet Respir Med. doi: 10.1016/S2213-26002030076-X – volume: 30 start-page: 343 year: 2020 ident: B49 article-title: Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion publication-title: Cell Res. doi: 10.1038/s41422-020-0305-x – volume: 95 start-page: 834 year: 2020 ident: B124 article-title: Hematological findings and complications of COVID-19 publication-title: Am J Hematol. doi: 10.1002/ajh.25829 – volume: 18 start-page: 240 year: 2007 ident: B144 article-title: Plasminogen activator inhibitor-1, adipose tissue and insulin resistance publication-title: Curr Opin Lipidol. doi: 10.1097/MOL.0b013e32814e6d29 – year: 2020 ident: B79 article-title: Obesity accompanying COVID-19: the role of epicardial fat publication-title: Obesity. doi: 10.1002/oby.22867 – volume: 12 start-page: 2395 year: 2016 ident: B107 article-title: Obesity and hypertension publication-title: Exp Ther Med. doi: 10.3892/etm.2016.3667 – volume: 581 start-page: 215 year: 2020 ident: B52 article-title: Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor publication-title: Nature. doi: 10.1038/s41586-020-2180-5 – volume: 189 start-page: 1050 year: 2020 ident: B8 article-title: Changes in blood coagulation in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis publication-title: Br J Haematol. doi: 10.1111/bjh.16725 – volume: 8 start-page: e21 year: 2020 ident: B195 article-title: Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? publication-title: Lancet Respir. doi: 10.1016/S2213-2600(20)30116-8 – start-page: 5 year: 2020 ident: B161 publication-title: Coronavirus (COVID-19) & Obesity – volume: 2 start-page: 113 year: 2013 ident: B19 article-title: The impact of obesity on immune response to infection and vaccine: an insight into plausible mechanisms publication-title: Endocrinol Metab Syndr. doi: 10.4172/2161-1017.1000113 – volume: 77 start-page: 230 year: 2002 ident: B86 article-title: Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts publication-title: Mol Genet Metab. doi: 10.1016/S1096-71920200140-3 – volume: 302 start-page: 1880 year: 2009 ident: B109 article-title: Critically Ill patients with 2009 influenza A(H1N1) in Mexico publication-title: JAMA. doi: 10.1001/jama.2009.1536 – volume: 163 start-page: 108146 year: 2020 ident: B200 article-title: Should anti-diabetic medications be reconsidered amid COVID-19 pandemic? publication-title: Diabetes Res Clin Pract. doi: 10.1016/j.diabres.2020.108146 – volume: 5 start-page: 534 year: 2020 ident: B4 article-title: Enteric involvement in hospitalised patients with COVID-19 outside Wuhan publication-title: Lancet Gastroenterol Hepatol. doi: 10.1016/S2468-12532030118-7 – volume: 2 start-page: e200067 year: 2020 ident: B189 article-title: COVID-19 complicated by acute pulmonary embolism publication-title: Radiol Cardiothorac Imaging. doi: 10.1148/ryct.2020200067 – volume: 108 start-page: 154224 year: 2020 ident: B23 article-title: COVID-19 in patients with diabetes: risk factors that increase morbidity publication-title: Metabolism. doi: 10.1016/j.metabol.2020.154224 – volume: 57 start-page: 759 year: 2020 ident: B116 article-title: Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic publication-title: Acta Diabetol doi: 10.1007/s00592-020-01522-8 – volume: 26 start-page: 297 year: 2016 ident: B136 article-title: Tissue factor as a link between inflammation and coagulation publication-title: Trends Cardiovasc Med. doi: 10.1016/j.tcm.2015.12.001 – volume: 12 start-page: 806 year: 2017 ident: B14 article-title: Sex matters: the effects of biological sex on adipose tissue biology and energy metabolism publication-title: Redox Biol. doi: 10.1016/j.redox.2017.04.012 – volume: 7 start-page: 587 year: 2014 ident: B106 article-title: Mechanism linking diabetes mellitus and obesity publication-title: Diabetes Metab Syndr Obes Targets Ther. doi: 10.2147/DMSO.S67400 – volume: 205 start-page: 244 year: 2012 ident: B120 article-title: Diet-induced obesity dramatically reduces the efficacy of a 2009 pandemic H1N1 vaccine in a mouse model publication-title: J Infect Dis. doi: 10.1093/infdis/jir731 – volume: 43 start-page: 1 year: 2020 ident: B156 article-title: Exploring diseases / traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2 : a mendelian randomization analysis highlights tentative relevance of diabetes-related traits publication-title: Diabetes Care. doi: 10.2337/dc20-0643 – volume: 2014 start-page: 1 year: 2014 ident: B67 article-title: Pioglitazone upregulates angiotensin converting enzyme 2 expression in insulin-sensitive tissues in rats with high-fat diet-induced nonalcoholic steatohepatitis publication-title: Sci World J. doi: 10.1155/2014/603409 – year: 2020 ident: B159 article-title: Platelet-to-lymphocyte ratio is associated with prognosis in patients with CoronaVirus disease-19 publication-title: J Med Virol. doi: 10.1002/jmv.25767 – volume: 4 start-page: 224 year: 2015 ident: B58 article-title: The whitening of brown fat and its implications for weight management in obesity publication-title: Curr Obes Rep. doi: 10.1007/s13679-015-0157-8 – ident: B94 – volume: 65 start-page: 85 year: 2016 ident: B80 article-title: ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity publication-title: Diabetes. doi: 10.2337/db15-0399 – volume: 11 start-page: 216 year: 2020 ident: B88 article-title: Transplantation of ACE2- Mesenchymal stem cells improves the outcome of patients with covid-19 pneumonia publication-title: Aging Dis. doi: 10.14336/AD.2020.0228 – volume: 136 start-page: 712 year: 2015 ident: B138 article-title: Obesity and antiplatelets-does one size fit all? publication-title: Thromb Res. doi: 10.1016/j.thromres.2015.07.015 – ident: B188 – volume: 38 start-page: 506 year: 2012 ident: B134 article-title: Infection and inflammation as risk factors for thrombosis and atherosclerosis publication-title: Semin Thromb Hemost. doi: 10.1055/s-0032-1305782 – volume: 323 start-page: 1612 year: 2020 ident: B122 article-title: Characteristics and outcomes of 21 critically Ill patients with COVID-19 in Washington state publication-title: JAMA. doi: 10.1001/jama.2020.4326 – volume: 2019 start-page: 1 year: 2020 ident: B174 article-title: Corticosteroid treatment of patients with coronavirus disease 2019 (COVID-19) publication-title: Med J Aust. doi: 10.5694/mja2.50577 – volume: 16 start-page: 1017 year: 2015 ident: B22 article-title: Interaction of obesity and infections publication-title: Obes Rev. doi: 10.1111/obr.12320 – volume: 26 start-page: 681 year: 2020 ident: B56 article-title: SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes publication-title: Nat. Med. doi: 10.1038/s41591-020-0868-6 – volume: 105 start-page: 7809 year: 2008 ident: B182 article-title: Modulation of TNF-α-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-α production and facilitates viral entry publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.0711241105 – volume: 2014 start-page: CD003747 year: 2014 ident: B190 article-title: Heparin for the prevention of venous thromboembolism in acutely ill medical patients (excluding stroke and myocardial infarction) publication-title: Cochrane Database Syst Rev doi: 10.1002/14651858.CD003747.pub4 – volume: 126 start-page: 1671 year: 2020 ident: B198 article-title: Association of inpatient use of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers with mortality among patients with hypertension hospitalized with COVID-19 publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.120.317134 – volume: 2012 start-page: 7 year: 2012 ident: B71 article-title: Inflammation as a link between obesity and metabolic syndrome publication-title: J Nutr Metab. doi: 10.1155/2012/476380 – volume: 517 start-page: 9 year: 2018 ident: B51 article-title: Wild-type human coronaviruses prefer cell-surface TMPRSS2 to endosomal cathepsins for cell entry publication-title: Virology. doi: 10.1016/j.virol.2017.11.012 – volume: 28 start-page: 1357 year: 2004 ident: B143 article-title: Obesity and impaired fibrinolysis: role of adipose production of plasminogen activator inhibitor-1 publication-title: Int J Obes. doi: 10.1038/sj.ijo.0802778 – volume: 506 start-page: 145 year: 2020 ident: B129 article-title: Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: a meta-analysis publication-title: Clin Chim Acta. doi: 10.1016/j.cca.2020.03.022 – volume: 9 start-page: 757 year: 2020 ident: B163 article-title: Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension publication-title: Emerg Microbes Infect. doi: 10.1080/22221751.2020.1746200 – volume: 366 start-page: 543 year: 2016 ident: B64 article-title: The adipose tissue and the involvement of the renin–angiotensin–aldosterone system in cardiometabolic syndrome publication-title: Cell Tissue Res. doi: 10.1007/s00441-016-2515-6 – year: 2020 ident: B178 article-title: Interleukin-6 blockade for severe COVID-19 publication-title: Br Med J doi: 10.1101/2020.04.20.20061861 – volume: 2015 start-page: 507151 year: 2015 ident: B191 article-title: Anti-inflammatory effects of heparin and its derivatives: a systematic review publication-title: Adv Pharmacol Sci. doi: 10.1155/2015/507151 – volume: 111 start-page: 102452 year: 2020 ident: B177 article-title: Can we use interleukin-6 (IL-6) blockade for coronavirus disease 2019 (COVID-19)-induced cytokine release syndrome (CRS)? publication-title: J. Autoimmun doi: 10.1016/j.jaut.2020.102452 – volume: 7 start-page: 609 year: 2016 ident: B114 article-title: Type-I interferon responses: from friend to foe in the battle against chronic viral infection publication-title: Front Immunol. doi: 10.3389/fimmu.2016.00609 – volume: 18 start-page: eED5758 year: 2020 ident: B192 article-title: Is there a rationale for heparin use among severe COVID-19 patients? publication-title: Einstein doi: 10.31744/einstein_journal/2020ed5758 – volume: 21 start-page: 527 year: 1997 ident: B142 article-title: Increase in both pro-thrombotic and anti-thrombotic factors in obese premenopausal women: relationship with body fat distribution publication-title: Int J Obes. doi: 10.1038/sj.ijo.0800435 – volume: 54 start-page: 1900857 year: 2019 ident: B83 article-title: Fatty airways: implications for obstructive disease publication-title: Eur Respir J. doi: 10.1183/13993003.00857-2019 – start-page: 1 year: 2020 ident: B194 article-title: Heparin inhibits cellular invasion by SARS-CoV-2: structural dependence of the interaction of the surface protein (spike) S1 receptor binding domain with heparin publication-title: Immunol Netw doi: 10.1101/2020.04.28.066761 – volume: 24 start-page: 179 year: 2020 ident: B25 article-title: Clinical determinants for fatality of 44, 672 patients with COVID-19 publication-title: Crit Care. doi: 10.1186/s13054-020-02902-w – start-page: 1 year: 2020 ident: B87 article-title: Single cell analysis of ace2 expression reveals the potential targets for 2019-nCoV publication-title: Preprints doi: 10.20944/preprints202002.0221.v1 – volume: 137 start-page: 1236 year: 2007 ident: B75 article-title: Diet-induced obese mice have increased mortality and altered immune responses when infected with influenza virus publication-title: J Nutr. doi: 10.1093/jn/137.5.1236 – volume: 176 start-page: 139 year: 2016 ident: B111 article-title: Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice publication-title: Physiol Behav. doi: 10.1016/j.physbeh.2017.03.040 – volume: 31 start-page: 353 year: 2019 ident: B119 article-title: Energy intake and response to infection with influenza publication-title: Annu Rev Nutr doi: 10.1146/annurev-nutr-081810-160812 – volume: 5 start-page: 155 year: 2005 ident: B16 article-title: Hypercoagulability in the metabolic syndrome publication-title: Curr Opin Pharmacol. doi: 10.1016/j.coph.2004.10.003 – volume: 23 start-page: 1 year: 2019 ident: B172 article-title: The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis publication-title: Crit Care. doi: 10.1186/s13054-019-2395-8 – volume: 137 start-page: 1543 year: 2018 ident: B15 article-title: Obesity as a disease, not a behavior publication-title: Circulation. doi: 10.1161/CIRCULATIONAHA.118.032780 – volume: 35 start-page: 14 year: 2009 ident: B113 article-title: Interferons and viral infections publication-title: Biofactors. doi: 10.1002/biof.6 – volume: 41 start-page: 2333 year: 2020 ident: B82 article-title: Does epicardial fat contribute to COVID-19 myocardial inflammation? publication-title: Eur Heart J. doi: 10.1093/eurheartj/ehaa471 – volume: 80 start-page: 7469 year: 2006 ident: B78 article-title: Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells publication-title: J Virol. doi: 10.1128/jvi.02677-05 – volume: 27 start-page: 125 year: 2020 ident: B66 article-title: A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids publication-title: Cell Stem Cell. doi: 10.1016/j.stem.2020.06.015 – ident: B180 – volume: 20 start-page: 355 year: 2020 ident: B92 article-title: Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages publication-title: Nat Rev Immunol. doi: 10.1038/s41577-020-0331-4 – volume: 14 start-page: 1 year: 2020 ident: B164 article-title: COVID-19 and treatment with NSAIDs and corticosteroids: should we be limiting their use in the clinical setting? publication-title: Ecancermedicalscience. doi: 10.3332/ecancer.2020.1023 – volume: 178 start-page: 104791 year: 2020 ident: B186 article-title: Type 1 interferons as a potential treatment against COVID-19 publication-title: Antiviral Res. doi: 10.1016/j.antiviral.2020.104791 – year: 2020 ident: B157 article-title: Coagulopathy in COVID-19 publication-title: J Thromb Haemost. doi: 10.1111/jth.14975 – volume: 18 start-page: 1738 year: 2020 ident: B125 article-title: Hypercoagulability of COVID-19 patients in intensive care unit: a report of thromboelastography findings and other parameters of hemostasis publication-title: J Thromb Haemost. doi: 10.1111/jth.14850 – year: 2020 ident: B31 article-title: SARS-Cov-2 in Spanish intensive care: early experience with 15-day survival in Vitoria publication-title: Anaesth Crit Care Pain Med. doi: 10.1016/j.accpm.2020.04.001 – volume: 281 start-page: 62 year: 2019 ident: B141 article-title: GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2018.12.023 – volume: 8 start-page: 855 year: 2019 ident: B89 article-title: Concise review: adipose-derived stem cells (ASCs) and adipocyte-secreted exosomal microRNA (A-SE-miR) modulate cancer growth and promote wound repair publication-title: J Clin Med. doi: 10.3390/jcm8060855 – volume: 10 start-page: e0132626 year: 2016 ident: B151 article-title: Quantitative Influence of ABO Blood Groups on Factor VIII and Its Ratio to von Willebrand Factor, Novel Observations from an ARIC Study of 11, 673 Subjects publication-title: PLoS ONE. doi: 10.1371/journal.pone.0132626 – volume: 35 start-page: 1 year: 2020 ident: B35 article-title: Clinical course and outcomes of patients with severe acute respiratory syndrome coronavirus 2 infection: a preliminary report of the first 28 patients from the korean cohort study on COVID-19 publication-title: J Korean Med Sci. doi: 10.3346/JKMS.2020.35.E142 – volume: 277 start-page: 14838 year: 2002 ident: B46 article-title: Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase publication-title: J Biol Chem. doi: 10.1074/jbc.M200581200 – volume: 22 start-page: 96 year: 2018 ident: B12 article-title: Sphingolipids in obesity and related complications publication-title: Front Biosci doi: 10.2741/4474 – volume: 202 start-page: 83 year: 2020 ident: B176 article-title: COVID-19 related genes in sputum cells in asthma: relationship to demographic features and corticosteroids publication-title: Am J Respir Crit Care Med. doi: 10.1164/rccm.202003-0821OC – volume: 395 start-page: 1054 year: 2020 ident: B9 article-title: Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study publication-title: Lancet. doi: 10.1016/S0140-6736(20)30566-3 – volume: 33 start-page: 4422 year: 2015 ident: B121 article-title: The weight of obesity on the human immune response to vaccination publication-title: Vaccine. doi: 10.1016/j.vaccine.2015.06.101.The – volume: 395 start-page: 497 year: 2020 ident: B1 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet. doi: 10.1016/S0140-6736(20)30183-5 – volume: 31 start-page: 2566 year: 2001 ident: B183 article-title: Inhibition of tumor necrosis factor reduces the severity of virus-specific lung immunopathology publication-title: Eur J Immunol doi: 10.1002/1521-4141(200109)31:9<2566::aid-immu2566>3.0.co;2-l – volume: 14 start-page: 185 year: 2020 ident: B54 article-title: Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection publication-title: Front. Med. doi: 10.1007/s11684-020-0754-0 – volume: 57 start-page: 450 year: 2007 ident: B53 article-title: Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection publication-title: Comp Med. – volume: 18 start-page: 1747 year: 2020 ident: B158 article-title: The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome publication-title: J. Thromb. Haemost. doi: 10.1111/jth.14854 – volume: 34 start-page: 6017 year: 2020 ident: B47 article-title: Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: a double-edged sword? publication-title: FASEB J. doi: 10.1096/fj.202000782 – volume: 2014 start-page: 689360 year: 2014 ident: B59 article-title: The renin-angiotensin-aldosterone system in vascular inflammation and remodeling publication-title: Int J Inflam. doi: 10.1155/2014/689360 – volume: 40 start-page: 58 year: 2017 ident: B112 article-title: Role of leptin and SOCS3 in inhibiting the type I interferon response during obesity publication-title: Inflammation. doi: 10.1007/s10753-016-0452-x – year: 2020 ident: B6 article-title: Smell and taste dysfunction in patients with COVID-19 publication-title: Lancet Infect Dis. doi: 10.1016/S1473-3099(20)30293-0 – volume: 454 start-page: 455 year: 2008 ident: B17 article-title: From endoplasmic-reticulum stress to the inflammatory response publication-title: Nature. doi: 10.1038/nature07203 – volume: 29 start-page: 207 year: 2013 ident: B73 article-title: Decreased interferon-α and interferon-β production in obesity and expression of suppressor of cytokine signaling publication-title: Nutrition. doi: 10.1016/j.nut.2012.04.019 – volume: 181 start-page: 271 year: 2020 ident: B37 article-title: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor publication-title: Cell. doi: 10.1016/j.cell.2020.02.052 – volume: 84 start-page: 814 year: 2006 ident: B42 article-title: Lessons from SARS: control of acute lung failure by the SARS receptor ACE2 publication-title: J Mol Med. doi: 10.1007/s00109-006-0094-9 – year: 2020 ident: B148 article-title: Relationship between the ABO blood group and the COVID-19 susceptibility publication-title: medRxiv [Preprint]. doi: 10.1101/2020.03.11.20031096 – volume: 2019 start-page: 1 year: 2020 ident: B34 article-title: Clinical characteristics of 145 patients with corona virus disease 2019 (COVID-19) in Taizhou, Zhejiang, China publication-title: Infection. doi: 10.1007/s15010-020-01432-5 – volume: 91 start-page: e01387 year: 2017 ident: B50 article-title: Clinical isolates of human coronavirus 229E bypass the endosome for cell entry publication-title: J Virol. doi: 10.1128/JVI.01387-16 – volume: 105 start-page: dgaa346 year: 2020 ident: B29 article-title: Predicting mortality due to SARS-CoV-2: a mechanistic score relating obesity and diabetes to COVID-19 outcomes in Mexico publication-title: J Clin Endocrinol Metab. doi: 10.1210/clinem/dgaa346 – volume: 211 start-page: 2373 year: 2014 ident: B72 article-title: Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice publication-title: J Exp Med. doi: 10.1084/jem.20140116 – volume: 53 start-page: 2431 year: 2010 ident: B98 article-title: Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance publication-title: Diabetologia. doi: 10.1007/s00125-010-1865-y – volume: 202 start-page: 459 year: 2010 ident: B110 article-title: Association between H1N1 infection severity and obesity—adiponectin as a potential etiologic factor publication-title: J Infect Dis. doi: 10.1086/653842 – volume: 139 start-page: 658 year: 2011 ident: B153 article-title: Beyond thrombosis: the versatile platelet in critical illness publication-title: Chest doi: 10.1378/chest.10-1971 – volume: 45 start-page: 227 year: 2015 ident: B84 article-title: The physiological basis of pulmonary gas exchange: implications for clinical interpretation of arterial blood gases publication-title: Eur Respir J. doi: 10.1183/09031936.00039214 – volume: 217 start-page: e20200678 year: 2020 ident: B140 article-title: The many faces of the anti-COVID immune response publication-title: J Exp Med. doi: 10.1084/jem.20200678 – start-page: 4 year: 2020 ident: B160 publication-title: People Who Are at Higher Risk for Severe Illness – volume: 378 start-page: 23 year: 2013 ident: B63 article-title: Role of renin-angiotensin-aldosterone system in adipose tissue dysfunction publication-title: Mol Cell Endocrinol. doi: 10.1016/j.mce.2012.03.005 – volume: 10 start-page: 317 year: 2004 ident: B185 article-title: Interferon- β 1a and SARS coronavirus replication publication-title: Emerg Infect Dis. doi: 10.3201/eid1002.030482 – volume: 50 start-page: 382 year: 2020 ident: B91 article-title: Interleukin-6 as a potential biomarker of COVID-19 progression publication-title: Méd Mal Infect. doi: 10.1016/j.medmal.2020.04.002 – volume: 93 start-page: 12490 year: 1996 ident: B60 article-title: Cross-talk between the insulin and angiotensin signaling systems publication-title: Proc Natl Acad Sci USA. doi: 10.1073/pnas.93.22.12490 – volume: 63 start-page: 649 year: 2008 ident: B104 article-title: Obesity and the lung: 1 Epidemiology publication-title: Thorax. doi: 10.1136/thx.2007.086801 – volume: 24 start-page: 295 year: 2016 ident: B103 article-title: Colonic pro-inflammatory macrophages cause insulin resistance in an intestinal Ccl2/Ccr2-dependent manner publication-title: Cell Metab. doi: 10.1016/j.cmet.2016.07.009 – volume: 93 start-page: 359 year: 2013 ident: B130 article-title: Pathophysiology of human visceral obesity: an update publication-title: Physiol Rev. doi: 10.1152/physrev.00033.2011 – volume: 55 start-page: 2001009 year: 2020 ident: B173 article-title: Inhaled corticosteroids and COVID-19: a systematic review and clinical perspective publication-title: Eur Respir J. doi: 10.1183/13993003.01009-2020 – volume: 10022 start-page: 1 year: 2020 ident: B27 article-title: Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City Area publication-title: JAMA. doi: 10.1001/jama.2020.6775 – volume: 579 start-page: 270 year: 2020 ident: B36 article-title: A Pneumonia outbreak associated with a new coronavirus of probable bat origin publication-title: Nature. doi: 10.1038/s41586-020-2012-7 – volume: 93 start-page: 343 year: 2015 ident: B69 article-title: Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications publication-title: Biochem Pharmacol. doi: 10.1016/j.bcp.2014.11.013 – volume: 28 start-page: 1187 year: 2020 ident: B57 article-title: The role of adipocytes and adipocyte-like cells in the severity of COVID-19 infections publication-title: Obesity. doi: 10.1002/oby.22856 – volume: 2019 start-page: 2019 year: 2020 ident: B32 article-title: Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy publication-title: J Am Med Assoc. doi: 10.1001/jama.2020.4683 – volume: 218 start-page: 1378 year: 2018 ident: B76 article-title: Obesity increases the duration of influenza a virus shedding in adults publication-title: J Infect Dis. doi: 10.1093/infdis/jiy370 – volume: 10 start-page: e0121971 year: 2015 ident: B105 article-title: Inflammatory cytokines in general and central obesity and modulating effects of physical activity publication-title: PLoS ONE. doi: 10.1371/journal.pone.0121971 – start-page: 1 year: 2020 ident: B2 publication-title: Rational Use of Personal Protective Equipment for Coronavirus Disease 2019 (COVID-19). – start-page: 1 year: 2020 ident: B179 publication-title: Bevacizumab in Severe or Critical Patients With COVID-19 Pneumonia (BEST-CP). doi: 10.31525/ct1-nct04275414 – volume: 317 start-page: E1140 year: 2019 ident: B65 article-title: ACE2 exerts anti-obesity effect via stimulating brown adipose tissue and induction of browning in white adipose tissue publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00311.2019 – volume: 368 start-page: 1 year: 2020 ident: B170 article-title: Non-steroidal anti-inflammatory drugs and covid-19 publication-title: BMJ. doi: 10.1136/bmj.m1185 – volume: 86 start-page: 615 year: 2008 ident: B45 article-title: Update on tissue renin–angiotensin systems publication-title: J Mol Med. doi: 10.1007/s00109-008-0336-0 – volume: 156 start-page: 3559 year: 2015 ident: B68 article-title: Activation of the GLP-1 receptor by liraglutide increases ACE2 expression, reversing right ventricle hypertrophy, and improving the production of SP-A and SP-B in the lungs of type 1 diabetes rats publication-title: Endocrinology. doi: 10.1210/en.2014-1685 – volume: 46 start-page: 2347 year: 2005 ident: B97 article-title: Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans publication-title: J Lipid Res. doi: 10.1194/jlr.M500294-JLR200 – volume: 21 start-page: 1 year: 2020 ident: B133 article-title: Influence of cardiometabolic risk factors on platelet function publication-title: Int J Mol Sci. doi: 10.3390/ijms21020623 – year: 2020 ident: B187 article-title: Acute pulmonary embolism associated with COVID-19 pneumonia detected by pulmonary CT angiography publication-title: Radiology. doi: 10.1148/radiol.2020201544 – volume: 172 start-page: ITC1 year: 2020 ident: B7 article-title: Histopathologic changes and SARS–CoV-2 immunostaining in the lung of a patient with COVID-19 publication-title: Ann Intern Med. doi: 10.7326/AWED202001070 – volume: 18 start-page: 1094 year: 2020 ident: B193 article-title: Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy publication-title: J Thromb Haemost. doi: 10.1111/jth.14817 – volume: 197 start-page: 700 year: 2018 ident: B171 article-title: Systemic corticosteroid therapy may delay viral clearance in patients with middle east respiratory syndrome coronavirus infection publication-title: Am J Respir Crit Care Med. doi: 10.1164/rccm.201712-2371ED – volume: 102 start-page: 13 year: 2018 ident: B20 article-title: Obesity as a disease publication-title: Med Clin North Am. doi: 10.1016/j.mcna.2017.08.004 – volume: 117 start-page: 175 year: 2007 ident: B102 article-title: Obesity induces a phenotypic switch in adipose tissue macrophage polarization Find the latest version : obesity induces a phenotypic switch in adipose tissue macrophage polarization publication-title: J Clin Invest. doi: 10.1172/JCI29881.both – volume: 375 start-page: 794 year: 2016 ident: B21 article-title: Body fatness and cancer — Viewpoint of the IARC Working Group publication-title: N Engl J Med. doi: 10.1056/NEJMsr1606602 – volume: 12 start-page: 8 year: 2020 ident: B55 article-title: High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa publication-title: Int J Oral Sci. doi: 10.1038/s41368-020-0074-x – volume: 118 start-page: 1313 year: 2016 ident: B40 article-title: Role of the ACE2/Angiotensin 1–7 axis of the renin–angiotensin system in heart failure publication-title: Circ Res. doi: 10.1161/CIRCRESAHA.116.307708 – volume: 8 start-page: e28 year: 2020 ident: B162 article-title: Antihypertensive drugs and risk of COVID-19? publication-title: Lancet Respir Med. doi: 10.1016/S2213-2600(20)30158-2 – volume: 212 start-page: 1 year: 2007 ident: B43 article-title: The emerging role of ACE2 in physiology and disease publication-title: J Pathol. doi: 10.1002/path.2162 – volume: 347 start-page: f6041 year: 2013 ident: B169 article-title: Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial publication-title: BMJ. doi: 10.1136/bmj.f6041 – volume: 382 start-page: 769 year: 2013 ident: B168 article-title: Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials publication-title: Lancet. doi: 10.1016/S0140-67361360900-9 – volume: 112 start-page: 1103 year: 2014 ident: B150 article-title: ABO blood group and thrombotic vascular disease publication-title: Thromb. Haemost doi: 10.1160/TH14-05-0457 – volume: 323 start-page: 1061 year: 2020 ident: B5 article-title: Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected Pneumonia in Wuhan, China publication-title: JAMA. doi: 10.1001/jama.2020.1585 – volume: 30 start-page: 541 year: 2020 ident: B77 article-title: Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient publication-title: Cell Res. doi: 10.1038/s41422-020-0318-5 – volume: 135 start-page: 2033 year: 2020 ident: B123 article-title: COVID-19 and its implications for thrombosis and anticoagulation publication-title: Blood. doi: 10.1182/blood.2020006000 – volume: 10 start-page: 1181 year: 2014 ident: B115 article-title: Obesity-induced chronic inflammation is associated with the reduced efficacy of influenza vaccine publication-title: Hum Vaccin Immunother. doi: 10.4161/hv.28332 – volume: 9 start-page: eaaf9194 year: 2017 ident: B117 article-title: Influenza vaccines differentially regulate the interferon response in human dendritic cell subsets publication-title: Sci Transl Med. doi: 10.1126/scitranslmed.aaf9194.Influenza – volume: 42 start-page: 681 year: 2019 ident: B44 article-title: Association of ACE2 genetic polymorphisms with hypertension-related target organ damages in south Xinjiang publication-title: Hypertens Res. doi: 10.1038/s41440-018-0166-6 – volume: 36 start-page: 1072 year: 2012 ident: B18 article-title: Obesity is associated with impaired immune response to influenza vaccination in humans publication-title: Int J Obes. doi: 10.1038/ijo.2011.208 – volume: 33 start-page: 13 year: 2010 ident: B61 article-title: Effects of renin-angiotensin system blockade on islet function in diabetic rats publication-title: J Endocrinol Invest. doi: 10.1007/BF03346544 – volume: 10 start-page: 1 year: 2020 ident: B33 article-title: COVID-19 and obesity publication-title: Clin Obes. doi: 10.1111/cob.12365 – volume: 93 start-page: 1 year: 2019 ident: B118 article-title: Type I and Type III interferons differ in their adjuvant activities for influenza vaccines publication-title: J Virol. doi: 10.1128/jvi.01262-19 – volume: 224 start-page: 208 year: 2012 ident: B145 article-title: Plasminogen activator inhitor-1 associates with cardiovascular risk factors in healthy young adults in the Cardiovascular Risk in Young Finns Study publication-title: Atherosclerosis. doi: 10.1016/j.atherosclerosis.2012.06.062 – volume: 142 start-page: 68 year: 2020 ident: B128 article-title: The science underlying COVID- 19: implications for the cardiovascular system publication-title: Circulation doi: 10.1161/circulationaha.120.047549 – volume: 130 start-page: 2620 year: 2020 ident: B155 article-title: Clinical and immunological features of severe and moderate coronavirus disease 2019 publication-title: J Clin Invest doi: 10.1172/JCI137244 – year: 2020 ident: B149 article-title: Testing the association between blood type and COVID-19 infection, intubation, and death publication-title: medRxiv [Preprint]. doi: 10.1101/2020.04.08.20058073 – volume: 9 start-page: 1 year: 2020 ident: B197 article-title: Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients publication-title: Elife. doi: 10.7554/eLife.57278 – volume: 113 start-page: 1046 year: 2017 ident: B137 article-title: New insights into the role of adipose tissue in thrombosis publication-title: Cardiovasc Res. doi: 10.1093/cvr/cvx086 – volume: 444 start-page: 860 year: 2006 ident: B95 article-title: Inflammation and metabolic disorders 1 publication-title: Nature. doi: 10.1038/nature05485 – volume: 167 start-page: 105941 year: 2020 ident: B10 article-title: Chronic obstructive pulmonary disease is associated with severe coronavirus disease 2019 (COVID-19) publication-title: Respir Med. doi: 10.1016/j.rmed.2020.105941 – volume: 16 start-page: 166 year: 2018 ident: B139 article-title: Platelet biology and functions: new concepts and clinical perspectives publication-title: Nat. Rev. Cardiol. doi: 10.1038/s41569-018-0110-0 – volume: 120 start-page: 998 year: 2020 ident: B127 article-title: COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure publication-title: Thromb Haemost. doi: 10.1055/s-0040-1710018 – volume: 12 start-page: 483 year: 2017 ident: B13 article-title: Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients publication-title: Redox Biol. doi: 10.1016/j.redox.2017.03.012 – volume: 11 start-page: e1004651 year: 2015 ident: B85 article-title: Neutrophils: between host defence, immune modulation, and tissue injury publication-title: PLoS Pathog. doi: 10.1371/journal.ppat.1004651 – volume: 18 start-page: 1301 year: 2017 ident: B199 article-title: The anti-inflammatory potential of receptor axis : evidence from basic and clinical research publication-title: Curr Drug Targets. doi: 10.2174/1389450117666160727142401 – year: 2020 ident: B147 article-title: Genomewide association study of severe Covid-19 with respiratory failure publication-title: N Engl J Med. doi: 10.1056/NEJMoa2020283 – volume: 52 start-page: 301 year: 2011 ident: B74 article-title: A novel risk factor for a novel virus: obesity and 2009 pandemic influenza a (H1N1) publication-title: Clin Infect Dis. doi: 10.1093/cid/ciq152 – volume: 6736 start-page: 19 year: 2020 ident: B26 article-title: Correspondence severe COVID-19 disease publication-title: Lancet. doi: 10.1016/S0140-6736(20)31024-2 – year: 2020 ident: B175 article-title: The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15 publication-title: bioRxiv [Preprint]. doi: 10.1101/2020.03.11.987016 – volume: 19 start-page: 440 year: 2009 ident: B132 article-title: Platelet dysfunction in central obesity publication-title: Nutr Metab Cardiovasc Dis. doi: 10.1016/j.numecd.2009.01.006 – volume: 22 start-page: 9 year: 2020 ident: B70 article-title: Obesity - a risk factor for increased COVID-19 prevalence, severity and lethality (Review) publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2020.11127 – volume: 436 start-page: 112 year: 2005 ident: B41 article-title: Angiotensin-converting enzyme 2 protects from severe acute lung failure publication-title: Nature. doi: 10.1038/nature03712 – volume: 395 start-page: 1407 year: 2020 ident: B181 article-title: Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed publication-title: Lancet. doi: 10.1016/S0140-67362030858-8 – volume: 191 start-page: 145 year: 2020 ident: B152 article-title: Incidence of thrombotic complications in critically ill ICU patients with COVID-19 publication-title: Thromb. Res. doi: 10.1016/j.thromres.2020.04.013 – volume: 362 start-page: 293 year: 2003 ident: B184 article-title: Treatment of SARS with human interferons publication-title: Lancet. doi: 10.1016/S0140-67360314482-0 – volume: 181 start-page: 281 year: 2020 ident: B48 article-title: Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein publication-title: Cell. doi: 10.1016/j.cell.2020.02.058 – volume: 2013 start-page: 678159 year: 2013 ident: B96 article-title: Obesity and inflammation: epidemiology, risk factors, and markers of inflammation publication-title: Int J Endocrinol. doi: 10.1155/2013/678159 – volume: 382 start-page: 1653 year: 2020 ident: B196 article-title: Renin – angiotensin – aldosterone system inhibitors in patients with Covid-19 publication-title: N Engl J Med. doi: 10.1056/NEJMsr2005760 – volume: 87 start-page: E1 year: 2000 ident: B38 article-title: A novel angiotensin-converting enzyme–related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 publication-title: Circ Res. doi: 10.1161/01.RES.87.5.e1 – volume: 2019 start-page: 2019 year: 2019 ident: B167 article-title: COVID-19 cytokine storm: the interplay between inflammation and coagulation publication-title: Lancet Respir. doi: 10.1016/S2213-26002030216-2 – volume: 8 start-page: 474 year: 2020 ident: B11 article-title: COVID-19 and obesity—lack of clarity, guidance, and implications for care publication-title: Lancet Diabetes Endocrinol. doi: 10.1016/S2213-8587(20)30156-X – volume: 395 start-page: 1033 year: 2020 ident: B90 article-title: COVID-19: consider cytokine storm syndromes and immunosuppression publication-title: Lancet. doi: 10.1016/S0140-6736(20)30628-0 – volume: 323 start-page: 1824 year: 2020 ident: B165 article-title: Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review publication-title: JAMA. doi: 10.1001/jama.2020.6019 – volume: 127 start-page: 1 year: 2017 ident: B99 article-title: Inflammatory linking obesity and metabolic disease and metabolic disease publication-title: J Clin Invest. doi: 10.1172/JCI92035 – volume: 113 start-page: 85 year: 2015 ident: B135 article-title: Hypercoagulability in overweight and obese subjects who are asymptomatic for thrombotic events publication-title: Thromb Haemost. doi: 10.1160/TH14-02-0156 – volume: 108 start-page: 722 year: 2010 ident: B166 article-title: Obesity and lung inflammation publication-title: J Appl Physiol. doi: 10.1152/japplphysiol.00781.2009 – year: 2020 ident: B28 article-title: Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission publication-title: Infect Dis Soc Am doi: 10.1093/cid/ciaa415 – volume: 116 start-page: 1494 year: 2006 ident: B101 article-title: MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity1 publication-title: J Clin Invest. doi: 10.1172/JCI26498DS1 – volume: 11 start-page: 533 year: 2018 ident: B108 article-title: Obesity and nonalcoholic fatty liver disease: current perspectives publication-title: Diabetes Metab Syndr Obes Targets Ther. doi: 10.2147/DMSO.S146339 – volume: 18 start-page: 844 year: 2020 ident: B126 article-title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia publication-title: J Thromb Haemost. doi: 10.1111/jth.14768 – volume: 108 start-page: 154244 year: 2020 ident: B24 article-title: Obesity as a risk factor for greater severity of COVID-19 in patients with metabolic associated fatty liver disease publication-title: Metabolism. doi: 10.1016/j.metabol.2020.154244 – volume: 37 start-page: 35 year: 2017 ident: B100 article-title: Adipose tissue inflammation in obesity: a metabolic or immune response? publication-title: Curr Opin Pharmacol. doi: 10.1016/j.coph.2017.08.006 – volume: 93 start-page: 212 year: 2017 ident: B154 article-title: Immunothrombosis in acute respiratory distress syndrome: cross talks between inflammation and coagulation publication-title: Respiration doi: 10.1159/000453002 – volume: 11 start-page: 491 year: 2013 ident: B146 article-title: Beyond immunohaematology: the role of the ABO blood group in human diseases publication-title: Blood Transfus. doi: 10.2450/2013.0152-13 – volume: 275 start-page: 33238 year: 2000 ident: B39 article-title: A human homolog of angiotensin-converting enzyme publication-title: J Biol Chem. doi: 10.1074/jbc.M002615200 – volume: 28 start-page: 1195 year: 2020 ident: B30 article-title: High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation publication-title: Obesity. doi: 10.1002/oby.22831 – volume: 11 start-page: 363 year: 2015 ident: B81 article-title: Local and systemic effects of the multifaceted epicardial adipose tissue depot publication-title: Nat Rev Endocrinol. doi: 10.1038/nrendo.2015.58
SSID	ssj0000401998
Score	2.4762151
SecondaryResourceType	review_article
Snippet	COVID-19, caused by SARS-CoV-2, is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Several reports from around the world...
SourceID	doaj pubmedcentral proquest pubmed crossref
SourceType	Open Website Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	530
SubjectTerms	ACE-2 adipose tissue Adipose Tissue - physiopathology Betacoronavirus - isolation & purification Coronavirus Infections - complications Coronavirus Infections - epidemiology Coronavirus Infections - mortality Coronavirus Infections - virology COVID-19 Endocrinology Humans hypercoagulopathy Inflammation - physiopathology Obesity Obesity - complications Pandemics Pneumonia, Viral - complications Pneumonia, Viral - epidemiology Pneumonia, Viral - mortality Pneumonia, Viral - virology Prognosis SARS-CoV-2 Survival Rate Thrombophilia - physiopathology
Title	Hypercoagulopathy and Adipose Tissue Exacerbated Inflammation May Explain Higher Mortality in COVID-19 Patients With Obesity
URI	https://www.ncbi.nlm.nih.gov/pubmed/32849309 https://www.proquest.com/docview/2437842725 https://pubmed.ncbi.nlm.nih.gov/PMC7399077 https://doaj.org/article/4092f4824b754b26972508a033117fd2
Volume	11
WOSCitedRecordID	wos000561365400001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1664-2392 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000401998 issn: 1664-2392 databaseCode: DOA dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1664-2392 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000401998 issn: 1664-2392 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagQogL4k14VEbiwiHaxHZi-1jKVu1hSw8F9mY5ftBIlVPtA1EJ8dsZ2-lqFyG4cMnBcRRrZpz5JjP-BqG3vq4tZfHcluG-ZA1nZeckLQnl2rNWxFRUajbBT0_FfC7Ptlp9xZqwTA-cBTeB-IN4JgjreMM60koOTlvoitK65t6mry-gnq1gKn2DIWyAQCLnJSEKkxPvgo2H_Ugs5Wpi0fOWH0p0_X_CmL-XSm75nqMH6P4IGvFBXuxDdMuFR-jubEyLP0Y_jiGaXJhBf11fDrHH8DXWweID218NS4fPk3Dx9Ls2IEQAlxafBA-mkI8t4pm-xrEWT_cB57oPPEuoHBA6hrHDj59PPpS1xGeZhHWJv_SrCzz2FHiCPh1Nzw-Py7GtQmlYS1ZlV3timQFcVQtjWuKs11Q6TzshTWuNls45WUluWyM0F563zhvHGq0h_DCcPkV7YQjuOcLOewAsnmrZeVbpyI6vmSZSNE3X1KIt0ORGyMqMnOOx9cWlgtgjqkUltaioFpXUUqB3myeuMt_GX-a-j3rbzItM2WkA7EeN9qP-ZT8FenOjdQU7K6ZLdHDDeqkiVaNgBOYX6Fm2gs2rKHh1SStZIL5jHztr2b0T-ovE3s0BElacv_gfi3-J7kVxxH_NRLxCe6vF2r1Gd8y3Vb9c7KPbfC7208aA6-zn9Bf2dRIo
linkProvider	Directory of Open Access Journals
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hypercoagulopathy+and+Adipose+Tissue+Exacerbated+Inflammation+May+Explain+Higher+Mortality+in+COVID-19+Patients+With+Obesity&rft.jtitle=Frontiers+in+endocrinology+%28Lausanne%29&rft.au=Pasquarelli-do-Nascimento%2C+Gabriel&rft.au=Braz-de-Melo%2C+Helo%C3%ADsa+Antoniella&rft.au=Faria%2C+Sara+Socorro&rft.au=Santos%2C+Igor+de+Oliveira&rft.date=2020-07-28&rft.pub=Frontiers+Media+S.A&rft.eissn=1664-2392&rft.volume=11&rft_id=info:doi/10.3389%2Ffendo.2020.00530&rft_id=info%3Apmid%2F32849309&rft.externalDocID=PMC7399077
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-2392&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-2392&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-2392&client=summon