The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery

Inflammasome-mediated activation of caspase-1 regulates inflammatory responses and pyroptosis. We analyzed possible associations between inflammasome-related genes and immune reconstitution in HIV-infected antiretroviral therapy (ART)-treated patients. Cross-sectional, case-control study. HIV-infect...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 9; p. 214
Main Authors:	Bandera, Alessandra, Masetti, Michela, Fabbiani, Massimiliano, Biasin, Mara, Muscatello, Antonio, Squillace, Nicola, Clerici, Mario, Gori, Andrea, Trabattoni, Daria
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 12.02.2018
Subjects:	Adult Aged Animals Anti-HIV Agents - therapeutic use Case-Control Studies caspase Caspase 1 - immunology Caspase 1 - metabolism Cross-Sectional Studies Female HIV HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - genetics HIV-1 - immunology HIV-1 - isolation & purification Humans immune reconstitution Immune Reconstitution - immunology Immunology inflammasome Inflammasomes - immunology Inflammasomes - metabolism Leukocytes, Mononuclear Male Mice Middle Aged NLR Family, Pyrin Domain-Containing 3 Protein - immunology NLR Family, Pyrin Domain-Containing 3 Protein - metabolism pyroptosis RNA, Viral - isolation & purification Treatment Outcome Up-Regulation pyroptosis immune reconstitution HIV inflammasome caspase
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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