Diabetes, heart failure, and renal dysfunction: The vicious circles

The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. T...

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Bibliographic Details
Published in:Progress in cardiovascular diseases Vol. 62; no. 4; pp. 298 - 302
Main Author: Braunwald, Eugene
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01.07.2019
Subjects:
Cardiovascular
Cardiovascular disease
Chronic kidney disease
Comorbidity
Diabetes mellitus
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - therapy
Diabetic Cardiomyopathies - diagnosis
Diabetic Cardiomyopathies - epidemiology
Diabetic Cardiomyopathies - therapy
Diabetic kidney disease
Diabetic Nephropathies - diagnosis
Diabetic Nephropathies - epidemiology
Diabetic Nephropathies - therapy
Female
Heart failure
Heart Failure - diagnosis
Heart Failure - epidemiology
Heart Failure - therapy
Humans
Male
Prevalence
Prognosis
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - therapy
Severity of Illness Index
Survival Analysis
Type 2 diabetes mellitus
United States - epidemiology
United States
Heart failure
T2DM
Diabetes mellitus
RAAS
Cardiovascular disease
Chronic kidney disease
HFpEF
Type 2 diabetes mellitus
HFrEF
DCM
CVD
ROS
U.S
DKD
HF
AGE
Diabetic kidney disease
Heart failure with preserved ejection fraction
Renin-angiotensin -aldosterone system
United States
Heart failure with reduced ejection fraction
Advanced glycation end products
Diabetic cardiomyopathy
Reactive O 2 species
ISSN:0033-0620, 1873-1740, 1532-8643, 1873-1740
Online Access:Get full text
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Summary:The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represents important therapeutic goals.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0033-0620
1873-1740
1532-8643
1873-1740
DOI:10.1016/j.pcad.2019.07.003