Diabetes, heart failure, and renal dysfunction: The vicious circles
The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. T...
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| Veröffentlicht in: | Progress in cardiovascular diseases Jg. 62; H. 4; S. 298 - 302 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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United States
Elsevier Inc
01.07.2019
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| ISSN: | 0033-0620, 1873-1740, 1532-8643, 1873-1740 |
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| Abstract | The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represents important therapeutic goals. |
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| AbstractList | The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represents important therapeutic goals. The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represents important therapeutic goals.The prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represents important therapeutic goals. AbstractThe prevalence of Type 2 diabetes mellitus (T2DM) has reached pandemic proportions. T2DM frequently causes macrovascular and/or microvascular pathologic changes and thereby increases the risks for the development of myocardial infarction, heart failure, stroke, renal failure, and reduced survival. This article describes the important interactions between T2DM, heart failure, and renal dysfunction, forming vicious circles. The interruption of these circles represents important therapeutic goals. |
| Author | Braunwald, Eugene |
| Author_xml | – sequence: 1 givenname: Eugene surname: Braunwald fullname: Braunwald, Eugene email: ebraunwald@partners.org organization: TIMI Study Group, Cardiovascular Division, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31377223$$D View this record in MEDLINE/PubMed |
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| Copyright | 2019 Elsevier Inc. Elsevier Inc. Copyright © 2019 Elsevier Inc. All rights reserved. |
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| Keywords | Heart failure T2DM Diabetes mellitus RAAS Cardiovascular disease Chronic kidney disease HFpEF Type 2 diabetes mellitus HFrEF DCM CVD ROS U.S DKD HF AGE Diabetic kidney disease Heart failure with preserved ejection fraction Renin-angiotensin -aldosterone system United States Heart failure with reduced ejection fraction Advanced glycation end products Diabetic cardiomyopathy Reactive O 2 species |
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| SubjectTerms | Cardiovascular Cardiovascular disease Chronic kidney disease Comorbidity Diabetes mellitus Diabetes Mellitus, Type 2 - diagnosis Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - therapy Diabetic Cardiomyopathies - diagnosis Diabetic Cardiomyopathies - epidemiology Diabetic Cardiomyopathies - therapy Diabetic kidney disease Diabetic Nephropathies - diagnosis Diabetic Nephropathies - epidemiology Diabetic Nephropathies - therapy Female Heart failure Heart Failure - diagnosis Heart Failure - epidemiology Heart Failure - therapy Humans Male Prevalence Prognosis Renal Insufficiency, Chronic - diagnosis Renal Insufficiency, Chronic - epidemiology Renal Insufficiency, Chronic - therapy Severity of Illness Index Survival Analysis Type 2 diabetes mellitus United States - epidemiology |
| Title | Diabetes, heart failure, and renal dysfunction: The vicious circles |
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