Morphology of mouse seminiferous tubules
We developed a technique to analyze the high-resolution three-dimensional (3D) structure of seminiferous tubules. It consists of segmentation of tubules in serial paraffin sections of the testis by marking the basement membrane with periodic acid–Schiff or a fluorescent anti-laminin antibody followe...
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| Veröffentlicht in: | Anatomical science international Jg. 94; H. 1; S. 1 - 10 |
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| Abstract | We developed a technique to analyze the high-resolution three-dimensional (3D) structure of seminiferous tubules. It consists of segmentation of tubules in serial paraffin sections of the testis by marking the basement membrane with periodic acid–Schiff or a fluorescent anti-laminin antibody followed by 3D reconstruction of tubules with high-performance software. Using this method, we analyzed testes from mice at different ages and accurately elucidated the 3D structure of seminiferous tubules, including the number and length of tubules as well as the numbers of connections with the rete testis, branching points, and blind ends. We also developed a technique to identify the precise spermatogenic stage and cellular composition of the seminiferous epithelium. It consists of the combination of lectin histochemistry for acrosomes and immunohistochemistry for specific cell markers visualized with fluorescence. Using this method, we examined seminiferous tubules from normal mice and counted the number of each cell type at each stage, and thereby established a quantitative standard for the cellular composition of the seminiferous epithelium. We then investigated seminiferous epithelia from genetically modified infertile mice deficient in certain cell adhesion molecules and revealed characteristic abnormalities in the cellular composition. We also analyzed the distribution and direction of spermatogenic waves along the length of adult seminiferous tubules as well as the site of the first onset of spermatogenesis in postnatal seminiferous tubules. These methods will be useful for investigating the structure and function of seminiferous tubules in mice and humans under normal and pathological conditions. |
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| AbstractList | We developed a technique to analyze the high-resolution three-dimensional (3D) structure of seminiferous tubules. It consists of segmentation of tubules in serial paraffin sections of the testis by marking the basement membrane with periodic acid–Schiff or a fluorescent anti-laminin antibody followed by 3D reconstruction of tubules with high-performance software. Using this method, we analyzed testes from mice at different ages and accurately elucidated the 3D structure of seminiferous tubules, including the number and length of tubules as well as the numbers of connections with the rete testis, branching points, and blind ends. We also developed a technique to identify the precise spermatogenic stage and cellular composition of the seminiferous epithelium. It consists of the combination of lectin histochemistry for acrosomes and immunohistochemistry for specific cell markers visualized with fluorescence. Using this method, we examined seminiferous tubules from normal mice and counted the number of each cell type at each stage, and thereby established a quantitative standard for the cellular composition of the seminiferous epithelium. We then investigated seminiferous epithelia from genetically modified infertile mice deficient in certain cell adhesion molecules and revealed characteristic abnormalities in the cellular composition. We also analyzed the distribution and direction of spermatogenic waves along the length of adult seminiferous tubules as well as the site of the first onset of spermatogenesis in postnatal seminiferous tubules. These methods will be useful for investigating the structure and function of seminiferous tubules in mice and humans under normal and pathological conditions. We developed a technique to analyze the high-resolution three-dimensional (3D) structure of seminiferous tubules. It consists of segmentation of tubules in serial paraffin sections of the testis by marking the basement membrane with periodic acid-Schiff or a fluorescent anti-laminin antibody followed by 3D reconstruction of tubules with high-performance software. Using this method, we analyzed testes from mice at different ages and accurately elucidated the 3D structure of seminiferous tubules, including the number and length of tubules as well as the numbers of connections with the rete testis, branching points, and blind ends. We also developed a technique to identify the precise spermatogenic stage and cellular composition of the seminiferous epithelium. It consists of the combination of lectin histochemistry for acrosomes and immunohistochemistry for specific cell markers visualized with fluorescence. Using this method, we examined seminiferous tubules from normal mice and counted the number of each cell type at each stage, and thereby established a quantitative standard for the cellular composition of the seminiferous epithelium. We then investigated seminiferous epithelia from genetically modified infertile mice deficient in certain cell adhesion molecules and revealed characteristic abnormalities in the cellular composition. We also analyzed the distribution and direction of spermatogenic waves along the length of adult seminiferous tubules as well as the site of the first onset of spermatogenesis in postnatal seminiferous tubules. These methods will be useful for investigating the structure and function of seminiferous tubules in mice and humans under normal and pathological conditions.We developed a technique to analyze the high-resolution three-dimensional (3D) structure of seminiferous tubules. It consists of segmentation of tubules in serial paraffin sections of the testis by marking the basement membrane with periodic acid-Schiff or a fluorescent anti-laminin antibody followed by 3D reconstruction of tubules with high-performance software. Using this method, we analyzed testes from mice at different ages and accurately elucidated the 3D structure of seminiferous tubules, including the number and length of tubules as well as the numbers of connections with the rete testis, branching points, and blind ends. We also developed a technique to identify the precise spermatogenic stage and cellular composition of the seminiferous epithelium. It consists of the combination of lectin histochemistry for acrosomes and immunohistochemistry for specific cell markers visualized with fluorescence. Using this method, we examined seminiferous tubules from normal mice and counted the number of each cell type at each stage, and thereby established a quantitative standard for the cellular composition of the seminiferous epithelium. We then investigated seminiferous epithelia from genetically modified infertile mice deficient in certain cell adhesion molecules and revealed characteristic abnormalities in the cellular composition. We also analyzed the distribution and direction of spermatogenic waves along the length of adult seminiferous tubules as well as the site of the first onset of spermatogenesis in postnatal seminiferous tubules. These methods will be useful for investigating the structure and function of seminiferous tubules in mice and humans under normal and pathological conditions. |
| Author | Nakata, Hiroki |
| Author_xml | – sequence: 1 givenname: Hiroki orcidid: 0000-0002-5532-7356 surname: Nakata fullname: Nakata, Hiroki email: hnakata@staff.kanazawa-u.ac.jp organization: Department of Histology and Cell Biology, Graduate School of Medical Sciences, Kanazawa University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30128978$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1369/0022155414564870 10.1007/978-1-60761-103-5_16 10.1093/biolreprod/9.5.500 10.1038/ng1366 10.1002/dvdy.21925 10.1530/REP-10-0431 10.1002/jmor.1051440208 10.1095/biolreprod.116.141770 10.1152/physrev.1972.52.1.198 10.1083/jcb.84.2.340 10.1369/0022155414562045 10.1073/pnas.81.13.4174 10.1007/s00418-016-1478-8 10.1002/aja.1000990307 10.1002/ar.1090070605 10.1210/endo-76-1-80 10.1242/dev.118695 10.1530/REP-12-0043 10.1002/aja.1000990303 10.1002/aja.1000030202 10.1002/ar.1091550210 10.1002/aja.1000900202 10.1111/j.1749-6632.1952.tb26576.x 10.1002/aja.1000870102 10.1128/MCB.14.2.1137 10.1111/j.1469-185X.1962.tb01616.x 10.1002/dvdy.21954 10.1002/aja.1000240303 10.1016/j.mce.2003.10.065 10.1007/978-1-62703-038-0_27 10.1002/aja.1000110403 10.1016/j.celrep.2015.07.015 10.1002/aja.1001080105 10.1530/REP-17-0391 10.1002/aja.1000760305 10.1016/B978-012647751-1/50004-0 10.1002/ar.1091500407 10.1111/j.1365-2605.1981.tb00732.x 10.1002/aja.1001080106 10.1002/ar.1090940210 10.1111/joa.12375 10.1093/oso/9780195062694.003.0014 |
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| SubjectTerms | Acrosomes Anatomy Animal Anatomy Animal Physiology Animals Basement Membrane - anatomy & histology Cell adhesion & migration Cell adhesion molecules Cell Biology Epithelium Histology Human Physiology Immunohistochemistry Laminin Male Medicine Medicine & Public Health Mice - anatomy & histology Models, Anatomic Morphology Neurosciences Paraffin Rete Testis - anatomy & histology Review Article Segmentation Seminiferous Tubules - anatomy & histology Seminiferous Tubules - physiology Spermatogenesis Structure-function relationships Testes Tubules |
| Title | Morphology of mouse seminiferous tubules |
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