TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children

Purpose Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports of germline TP53 variants in childhood hypodiploid acute lymphoblastic leukemia (ALL) suggest that this type of leukemia is another manifestation of Li-Fra...

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Veröffentlicht in:	Journal of clinical oncology Jg. 36; H. 6; S. 591
Hauptverfasser:	Qian, Maoxiang, Cao, Xueyuan, Devidas, Meenakshi, Yang, Wenjian, Cheng, Cheng, Dai, Yunfeng, Carroll, Andrew, Heerema, Nyla A, Zhang, Hui, Moriyama, Takaya, Gastier-Foster, Julie M, Xu, Heng, Raetz, Elizabeth, Larsen, Eric, Winick, Naomi, Bowman, W Paul, Martin, Paul L, Mardis, Elaine R, Fulton, Robert, Zambetti, Gerard, Borowitz, Michael, Wood, Brent, Nichols, Kim E, Carroll, William L, Pui, Ching-Hon, Mullighan, Charles G, Evans, William E, Hunger, Stephen P, Relling, Mary V, Loh, Mignon L, Yang, Jun J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 20.02.2018
ISSN:	1527-7755, 1527-7755
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