Mutating for Good: DNA Damage Responses During Somatic Hypermutation

Somatic hypermutation (SHM) of immunoglobulin ( ) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies. In this way SHM is key in optimizing antibody dependent immune responses. SHM is initiated by targeting the Activ...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 10; p. 438
Main Authors:	Pilzecker, Bas, Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 12.03.2019
Subjects:	abasic site B-Lymphocytes - immunology base excision repair Cytidine Deaminase - genetics Cytidine Deaminase - metabolism cytosine deamination Deamination - physiology DNA - genetics DNA Damage - genetics DNA damage tolerance (DDT) DNA Repair - genetics Humans Immunology non-canonical mismatch repair (ncMMR) Somatic Hypermutation, Immunoglobulin - genetics translesion synthesis (TLS) VDJ Exons - genetics base excision repair non-canonical mismatch repair (ncMMR) abasic site translesion synthesis (TLS) DNA damage tolerance (DDT) cytosine deamination
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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