Does Medullary Versus Cortical Invasion of the Mandible Affect Prognosis in Patients With Oral Squamous Cell Carcinoma?
Whether mandibular involvement by oral squamous cell carcinoma (OSCC) could be identified as a factor for cancer staging and prognosis prediction remains a subject of debate. In addition, the influence of different types of mandibular invasion (cortical or medullary invasion) on patients' progn...
Saved in:
| Published in: | Journal of oral and maxillofacial surgery Vol. 75; no. 2; p. 403 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
01.02.2017
|
| Subjects: | |
| ISSN: | 1531-5053, 1531-5053 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Whether mandibular involvement by oral squamous cell carcinoma (OSCC) could be identified as a factor for cancer staging and prognosis prediction remains a subject of debate. In addition, the influence of different types of mandibular invasion (cortical or medullary invasion) on patients' prognosis remains unclear. The aim of this systematic review was to establish whether mandibular invasion or its subset should be considered an independent prognostic factor for patients with OSCC.
The search for eligible studies was performed according to the predesigned inclusion criteria for a systematic review. Mandibular invasion and invasion depth were considered the primary and secondary predictor variables, respectively. The electronic search was performed using 12 databases. Manual searching covered 14 related journals and references of the included studies were scanned. The risk of bias assessment was evaluated by 2 reviewers using risk-of-bias assessment tools recommended by Saltaji et al (Angle Orthod 82:1115, 2012). Two reviewers extracted the data in duplicate. RevMan 5.2 was used for meta-analysis to assess the primary outcomes (disease-free survival and overall survival) and the secondary outcomes (2- and 5-year survival rate and local control).
Eighteen studies (total, 3,756 participants) were included and used as the study sample. Among these included studies, 7 had an unclear risk of bias and the remaining showed a high risk. The results of the meta-analyses showed a significant relation between mandibular invasion and overall survival (P = .04) and, most importantly, that medullary involvement (P = .0001), but not cortical involvement (P = .66), could decrease overall survival. When focusing on disease-specific survival, mandibular medullary involvement predicted a poor disease-specific survival (P < .0001), but cortical involvement showed no effect (P = .66).
This review showed that OSCC mandibular medullary invasion, and not mandibular invasion or mandibular cortical invasion, could be an independent prognostic factor for patients. |
|---|---|
| AbstractList | Whether mandibular involvement by oral squamous cell carcinoma (OSCC) could be identified as a factor for cancer staging and prognosis prediction remains a subject of debate. In addition, the influence of different types of mandibular invasion (cortical or medullary invasion) on patients' prognosis remains unclear. The aim of this systematic review was to establish whether mandibular invasion or its subset should be considered an independent prognostic factor for patients with OSCC.
The search for eligible studies was performed according to the predesigned inclusion criteria for a systematic review. Mandibular invasion and invasion depth were considered the primary and secondary predictor variables, respectively. The electronic search was performed using 12 databases. Manual searching covered 14 related journals and references of the included studies were scanned. The risk of bias assessment was evaluated by 2 reviewers using risk-of-bias assessment tools recommended by Saltaji et al (Angle Orthod 82:1115, 2012). Two reviewers extracted the data in duplicate. RevMan 5.2 was used for meta-analysis to assess the primary outcomes (disease-free survival and overall survival) and the secondary outcomes (2- and 5-year survival rate and local control).
Eighteen studies (total, 3,756 participants) were included and used as the study sample. Among these included studies, 7 had an unclear risk of bias and the remaining showed a high risk. The results of the meta-analyses showed a significant relation between mandibular invasion and overall survival (P = .04) and, most importantly, that medullary involvement (P = .0001), but not cortical involvement (P = .66), could decrease overall survival. When focusing on disease-specific survival, mandibular medullary involvement predicted a poor disease-specific survival (P < .0001), but cortical involvement showed no effect (P = .66).
This review showed that OSCC mandibular medullary invasion, and not mandibular invasion or mandibular cortical invasion, could be an independent prognostic factor for patients. Whether mandibular involvement by oral squamous cell carcinoma (OSCC) could be identified as a factor for cancer staging and prognosis prediction remains a subject of debate. In addition, the influence of different types of mandibular invasion (cortical or medullary invasion) on patients' prognosis remains unclear. The aim of this systematic review was to establish whether mandibular invasion or its subset should be considered an independent prognostic factor for patients with OSCC.PURPOSEWhether mandibular involvement by oral squamous cell carcinoma (OSCC) could be identified as a factor for cancer staging and prognosis prediction remains a subject of debate. In addition, the influence of different types of mandibular invasion (cortical or medullary invasion) on patients' prognosis remains unclear. The aim of this systematic review was to establish whether mandibular invasion or its subset should be considered an independent prognostic factor for patients with OSCC.The search for eligible studies was performed according to the predesigned inclusion criteria for a systematic review. Mandibular invasion and invasion depth were considered the primary and secondary predictor variables, respectively. The electronic search was performed using 12 databases. Manual searching covered 14 related journals and references of the included studies were scanned. The risk of bias assessment was evaluated by 2 reviewers using risk-of-bias assessment tools recommended by Saltaji et al (Angle Orthod 82:1115, 2012). Two reviewers extracted the data in duplicate. RevMan 5.2 was used for meta-analysis to assess the primary outcomes (disease-free survival and overall survival) and the secondary outcomes (2- and 5-year survival rate and local control).MATERIALS AND METHODSThe search for eligible studies was performed according to the predesigned inclusion criteria for a systematic review. Mandibular invasion and invasion depth were considered the primary and secondary predictor variables, respectively. The electronic search was performed using 12 databases. Manual searching covered 14 related journals and references of the included studies were scanned. The risk of bias assessment was evaluated by 2 reviewers using risk-of-bias assessment tools recommended by Saltaji et al (Angle Orthod 82:1115, 2012). Two reviewers extracted the data in duplicate. RevMan 5.2 was used for meta-analysis to assess the primary outcomes (disease-free survival and overall survival) and the secondary outcomes (2- and 5-year survival rate and local control).Eighteen studies (total, 3,756 participants) were included and used as the study sample. Among these included studies, 7 had an unclear risk of bias and the remaining showed a high risk. The results of the meta-analyses showed a significant relation between mandibular invasion and overall survival (P = .04) and, most importantly, that medullary involvement (P = .0001), but not cortical involvement (P = .66), could decrease overall survival. When focusing on disease-specific survival, mandibular medullary involvement predicted a poor disease-specific survival (P < .0001), but cortical involvement showed no effect (P = .66).RESULTSEighteen studies (total, 3,756 participants) were included and used as the study sample. Among these included studies, 7 had an unclear risk of bias and the remaining showed a high risk. The results of the meta-analyses showed a significant relation between mandibular invasion and overall survival (P = .04) and, most importantly, that medullary involvement (P = .0001), but not cortical involvement (P = .66), could decrease overall survival. When focusing on disease-specific survival, mandibular medullary involvement predicted a poor disease-specific survival (P < .0001), but cortical involvement showed no effect (P = .66).This review showed that OSCC mandibular medullary invasion, and not mandibular invasion or mandibular cortical invasion, could be an independent prognostic factor for patients.CONCLUSIONThis review showed that OSCC mandibular medullary invasion, and not mandibular invasion or mandibular cortical invasion, could be an independent prognostic factor for patients. |
| Author | Yang, Wenbin Men, Yi Lin, Jie Li, Longjiang Li, Chunjie Mi, Fanglin |
| Author_xml | – sequence: 1 givenname: Chunjie surname: Li fullname: Li, Chunjie organization: Associate Professor, Departments of Head and Neck Oncology and Evidence-Based Dentistry, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China – sequence: 2 givenname: Jie surname: Lin fullname: Lin, Jie organization: Attending Physician, Department of Dental Anesthesiology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China – sequence: 3 givenname: Yi surname: Men fullname: Men, Yi organization: Attending Physician and Lecturer, Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China – sequence: 4 givenname: Wenbin surname: Yang fullname: Yang, Wenbin organization: PhD Candidate, Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China – sequence: 5 givenname: Fanglin surname: Mi fullname: Mi, Fanglin organization: Professor and Department Head, Department of Stomatology, North Sichuan Medical College, Nanchong, Sichuan, China – sequence: 6 givenname: Longjiang surname: Li fullname: Li, Longjiang email: muzili63@163.com organization: Professor and Department Director, Department of Head and Neck Oncology, West China Hospital of Stomatology, State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China. Electronic address: muzili63@163.com |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27621147$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkD1PwzAYhC1URGnhDzAgjywJthsn8YSq8lWpVSvxNUaO84a6SuzWdkD8e4IoEtM9w93pdCM0MNYAQheUxJTQ9Hobb23rY9ZzTPKYEH6ETimf0IgTPhn84yEaeb8lhFKepSdoyLKUUZpkp-jz1oLHS6i6ppHuC7-C853HM-uCVrLBc_MhvbYG2xqHDeClNJUuG8DTugYV8NrZd2O99lgbvJZBgwkev-mwwSvX55_2nWztTyM0DZ5Jp7Sxrbw5Q8e1bDycH3SMXu7vnmeP0WL1MJ9NF5FKUhYiQWSay1wIoUrIBZRMQpmUTOW0koLnPFGpgBRILRktSaIUE0AqzjmjGQPBxujqt3fn7L4DH4pWe9VvkQb6WQXNucholuW8t14erF3ZQlXsnG77S4q_s9g3pjxviA |
| CitedBy_id | crossref_primary_10_1016_j_jcms_2020_10_006 crossref_primary_10_1007_s12070_025_05321_x crossref_primary_10_1007_s12105_024_01642_5 crossref_primary_10_1177_2057178X17738912 crossref_primary_10_4103_jiaomr_jiaomr_10_21 crossref_primary_10_1016_j_jbo_2025_100712 crossref_primary_10_1186_s12903_024_03920_8 crossref_primary_10_1002_hed_26360 crossref_primary_10_1016_j_joms_2019_12_011 crossref_primary_10_1016_j_otorri_2020_04_006 crossref_primary_10_1007_s00405_023_08050_5 crossref_primary_10_1016_j_ejso_2025_110308 crossref_primary_10_1111_odi_15035 crossref_primary_10_14639_0392_100X_suppl_1_45_2025_N1141 crossref_primary_10_3389_froh_2021_806477 crossref_primary_10_3390_cmtr18030030 crossref_primary_10_1007_s00432_023_04963_0 crossref_primary_10_1097_SAP_0000000000003217 crossref_primary_10_1002_hed_26475 crossref_primary_10_1016_j_otoeng_2020_04_007 crossref_primary_10_3390_diagnostics15010104 crossref_primary_10_1016_j_bprint_2021_e00132 crossref_primary_10_1016_j_cden_2025_03_004 crossref_primary_10_1016_j_oraloncology_2019_01_008 crossref_primary_10_1016_j_amjoto_2021_103303 crossref_primary_10_1016_j_oraloncology_2019_04_012 crossref_primary_10_1007_s12105_019_01014_4 crossref_primary_10_3389_fonc_2021_752018 |
| ContentType | Journal Article |
| Copyright | Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. |
| Copyright_xml | – notice: Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1016/j.joms.2016.08.005 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Dentistry |
| EISSN | 1531-5053 |
| ExternalDocumentID | 27621147 |
| Genre | Systematic Review Journal Article Comparative Study |
| GroupedDBID | --- --K .1- .55 .FO 0R~ 1B1 1CY 1P~ 1RT 1~5 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 AAEDT AAEDW AAGKA AALRI AAQFI AAQQT AAQXK AAXUO AAYWO ABJNI ABLJU ABMAC ABOCM ABWVN ACGFS ACRPL ACVFH ADBBV ADCNI ADMUD ADNMO AENEX AEVXI AFCTW AFFNX AFJKZ AFRHN AFTJW AGCQF AGQPQ AHHHB AIGII AITUG AJUYK AKRWK ALMA_UNASSIGNED_HOLDINGS AMRAJ APXCP ASPBG AVWKF AZFZN BELOY CAG CGR COF CS3 CUY CVF DU5 EBS ECM EFKBS EIF EJD EO8 F5P FDB FEDTE FGOYB FIRID G-2 G-Q GBLVA HDX HMK HMO HVGLF HZ~ IHE J1W K-O L7B M41 N4W N9A NPM NQ- O9- OF. OQ0 P2P R2- RIG ROL RPZ SAE SDG SDP SEL SES SEW SJN SSZ UHS UV1 X7M XH2 Z5R ZGI ZXP 7X8 |
| ID | FETCH-LOGICAL-c462t-90a68a8999cbe89eb2aeb4b2c81da95854c69e6e0fa21b04cc29e0d5552172e92 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 31 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000399221600035&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1531-5053 |
| IngestDate | Sat Sep 27 23:48:14 EDT 2025 Mon Jul 21 05:55:23 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | Copyright © 2016 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c462t-90a68a8999cbe89eb2aeb4b2c81da95854c69e6e0fa21b04cc29e0d5552172e92 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Undefined-4 |
| PMID | 27621147 |
| PQID | 1859717785 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1859717785 pubmed_primary_27621147 |
| PublicationCentury | 2000 |
| PublicationDate | 2017-02-01 |
| PublicationDateYYYYMMDD | 2017-02-01 |
| PublicationDate_xml | – month: 02 year: 2017 text: 2017-02-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of oral and maxillofacial surgery |
| PublicationTitleAlternate | J Oral Maxillofac Surg |
| PublicationYear | 2017 |
| SSID | ssj0011576 |
| Score | 2.3506255 |
| SecondaryResourceType | review_article |
| Snippet | Whether mandibular involvement by oral squamous cell carcinoma (OSCC) could be identified as a factor for cancer staging and prognosis prediction remains a... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 403 |
| SubjectTerms | Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Humans Mandibular Neoplasms - secondary Mouth Neoplasms - diagnosis Mouth Neoplasms - pathology Neoplasm Invasiveness - diagnosis Neoplasm Invasiveness - pathology Prognosis |
| Title | Does Medullary Versus Cortical Invasion of the Mandible Affect Prognosis in Patients With Oral Squamous Cell Carcinoma? |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27621147 https://www.proquest.com/docview/1859717785 |
| Volume | 75 |
| WOSCitedRecordID | wos000399221600035&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8QwEA6-QC--H-uLEbwW22z6yElkVRTcdUHFvS1JmuLKbqutq_jvnUkrngTBSw-BQEhnMq9v5mPsmGZ6GaG1lxjre6JtfNS5WHpZEKUS17kMXKPwTdzrJYOB7DcJt6qBVX6_ie6hTgtDOfITtCsSQ484CU9fXj1ijaLqakOhMcvm2-jKEKQrHvxUEYLQkcuhUgceWvp20zRT47ueiwmN6w4iN8LTD393MZ2puVz57yFX2XLjZMJZLRVrbMbm62zxnIBBxO22wT7OC1tBF80MSkH5CZQ1m1bQKUqX2obr_F1RGg2KDNBDhC41v-ixhTMH_4B-WRBAb1TBKId-PZq1gsfR2xPclrj_7nWqKKcAHTseQ4f4ivJiok432cPlxX3nymsoGDwjIv7mSV9FicKYTBptE4lhuLJaaG7QzVUSQw1hImkj62eKB9oXxnBp_TQMQyK-spJvsbm8yO0OgxA9oaAthBYShYPTLEYe6zSzcaDC1M9a7Oj7Toco4lS3ULnFow5_brXFtusfM3ypZ3EMOT7mGNLFu3_YvceWOBllh7neZ_MZKrg9YAvmHW-_PHSyg99ev_sFsZfPKA |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Does+Medullary+Versus+Cortical+Invasion+of+the+Mandible+Affect+Prognosis+in+Patients+With+Oral+Squamous+Cell+Carcinoma%3F&rft.jtitle=Journal+of+oral+and+maxillofacial+surgery&rft.au=Li%2C+Chunjie&rft.au=Lin%2C+Jie&rft.au=Men%2C+Yi&rft.au=Yang%2C+Wenbin&rft.date=2017-02-01&rft.issn=1531-5053&rft.eissn=1531-5053&rft.volume=75&rft.issue=2&rft.spage=403&rft_id=info:doi/10.1016%2Fj.joms.2016.08.005&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1531-5053&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1531-5053&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1531-5053&client=summon |