Ectopic activation of germline and placental genes identifies aggressive metastasis-prone lung cancers

Activation of normally silent tissue-specific genes and the resulting cell "identity crisis" are the unexplored consequences of malignant epigenetic reprogramming. We designed a strategy for investigating this reprogramming, which consisted of identifying a large number of tissue-restricte...

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Bibliographic Details
Published in:	Science translational medicine Vol. 5; no. 186; p. 186ra66
Main Authors:	Rousseaux, Sophie, Debernardi, Alexandra, Jacquiau, Baptiste, Vitte, Anne-Laure, Vesin, Aurélien, Nagy-Mignotte, Hélène, Moro-Sibilot, Denis, Brichon, Pierre-Yves, Lantuejoul, Sylvie, Hainaut, Pierre, Laffaire, Julien, de Reyniès, Aurélien, Beer, David G, Timsit, Jean-François, Brambilla, Christian, Brambilla, Elisabeth, Khochbin, Saadi
Format:	Journal Article
Language:	English
Published:	United States 22.05.2013
Subjects:	Animals Cell Line, Tumor DNA Methylation - genetics Epigenesis, Genetic Female Gene Expression Regulation, Neoplastic Germ Cells - metabolism Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - pathology Neoplasm Invasiveness Neoplasm Metastasis - genetics Neoplasm Staging Organ Specificity Placenta - metabolism Pregnancy Prognosis Promoter Regions, Genetic - genetics Reproducibility of Results Transcriptome
ISSN:	1946-6242, 1946-6242
Online Access:	Get more information
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