Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition

Here, we used quantitative proteomics analysis to identify novel therapeutic targets in cancer stem cells and/or progenitor cells. For this purpose, mammospheres from two ER-positive breast cancer cell lines (MCF7 and T47D) were grown in suspension using low-attachment plates and directly compared t...

Full description

Saved in:

Bibliographic Details
Published in:	Oncotarget Vol. 5; no. 22; p. 11029
Main Authors:	Lamb, Rebecca, Harrison, Hannah, Hulit, James, Smith, Duncan L, Lisanti, Michael P, Sotgia, Federica
Format:	Journal Article
Language:	English
Published:	United States 30.11.2014
Subjects:	Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Female Humans MCF-7 Cells Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Proteins - antagonists & inhibitors Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Molecular Targeted Therapy Monocarboxylic Acid Transporters - antagonists & inhibitors Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Proteomics - methods Symporters - antagonists & inhibitors Thiophenes - pharmacology Uracil - analogs & derivatives Uracil - pharmacology
ISSN:	1949-2553, 1949-2553
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!