Mitochondria as new therapeutic targets for eradicating cancer stem cells: Quantitative proteomics and functional validation via MCT1/2 inhibition

Here, we used quantitative proteomics analysis to identify novel therapeutic targets in cancer stem cells and/or progenitor cells. For this purpose, mammospheres from two ER-positive breast cancer cell lines (MCF7 and T47D) were grown in suspension using low-attachment plates and directly compared t...

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Veröffentlicht in:	Oncotarget Jg. 5; H. 22; S. 11029
Hauptverfasser:	Lamb, Rebecca, Harrison, Hannah, Hulit, James, Smith, Duncan L, Lisanti, Michael P, Sotgia, Federica
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 30.11.2014
Schlagworte:	Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Female Humans MCF-7 Cells Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Proteins - antagonists & inhibitors Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Molecular Targeted Therapy Monocarboxylic Acid Transporters - antagonists & inhibitors Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Proteomics - methods Symporters - antagonists & inhibitors Thiophenes - pharmacology Uracil - analogs & derivatives Uracil - pharmacology
ISSN:	1949-2553, 1949-2553
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