Targeting VEGF/VEGFR to Modulate Antitumor Immunity

In addition to the crucial role in promoting the growth of tumor vessels, vascular endothelial growth factor (VEGF) is also immunosuppressive. VEGF can inhibit the function of T cells, increase the recruitment of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and hinder the...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 9; p. 978
Main Authors:	Yang, Ju, Yan, Jing, Liu, Baorui
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 03.05.2018
Subjects:	angiogenesis Angiogenesis Inhibitors - pharmacology Animals Cell Differentiation - immunology Dendritic Cells - immunology Humans immune Immunologic Factors - pharmacology Immunology Mice Myeloid-Derived Suppressor Cells - immunology Neoplasms - immunology Neovascularization, Pathologic Receptors, Vascular Endothelial Growth Factor - immunology T cells T-Lymphocytes, Regulatory - immunology tumor vascular endothelial growth factor Vascular Endothelial Growth Factors - immunology immune T cells angiogenesis tumor vascular endothelial growth factor
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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