Beyond Fmoc: a review of aromatic peptide capping groups

Self-assembling short peptides have attracted widespread interest due to their tuneable, biocompatible nature and have potential applications in energy materials, tissue engineering, sensing and drug delivery. The hierarchical self-assembly of these peptides is highly dependent on the selection of n...

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Veröffentlicht in:Journal of materials chemistry. B, Materials for biology and medicine Jg. 8; H. 5; S. 863
Hauptverfasser: Martin, Adam D, Thordarson, Pall
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 07.02.2020
Schlagworte:
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Hydrocarbons, Aromatic - chemistry
Materials Testing
Molecular Structure
Particle Size
Peptides - chemical synthesis
Peptides - chemistry
Surface Properties
ISSN:2050-7518, 2050-7518
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Zusammenfassung:Self-assembling short peptides have attracted widespread interest due to their tuneable, biocompatible nature and have potential applications in energy materials, tissue engineering, sensing and drug delivery. The hierarchical self-assembly of these peptides is highly dependent on the selection of not only amino acid sequence, but also the capping group which is often employed at the N-terminus of the peptide to drive self-assembly. Although the Fmoc (9H-fluorenylmethyloxycarbonyl) group is commonly used due to its utility in solid phase peptide synthesis, many other aromatic capping groups have been reported which yield functional, responsive materials. This review explores recent developments in the utilisation of functional, aromatic capping groups beyond the Fmoc group for the creation of redox-responsive, fluorescent and drug delivering hydrogel scaffolds.
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:2050-7518
2050-7518
DOI:10.1039/c9tb02539a