Panax notoginseng Saponins for Treating Coronary Artery Disease: A Functional and Mechanistic Overview

Coronary artery disease (CAD) is a major public health problem and the chief cause of morbidity and mortality worldwide. , a valuable herb in traditional Chinese medicine (TCM) with obvious efficacy and favorable safety, shows a great promise as a novel option for CAD and is increasingly recognized...

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Vydáno v:Frontiers in pharmacology Ročník 8; s. 702
Hlavní autoři: Duan, Lian, Xiong, Xingjiang, Hu, Junyuan, Liu, Yongmei, Li, Jun, Wang, Jie
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 17.10.2017
Témata:
coronary artery disease
Panax notoginseng
Pharmacology
PNS
review
traditional Chinese medicine
Panax notoginseng
coronary artery disease
traditional Chinese medicine
PNS
review
ISSN:1663-9812, 1663-9812
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Popis
Shrnutí:Coronary artery disease (CAD) is a major public health problem and the chief cause of morbidity and mortality worldwide. , a valuable herb in traditional Chinese medicine (TCM) with obvious efficacy and favorable safety, shows a great promise as a novel option for CAD and is increasingly recognized clinically. Firstly, this review introduced recent clinical trials on treatment with PNS either alone or in combination with conventional drugs as novel treatment strategies. Then we discussed the mechanisms of and saponins (PNS), which can regulate signaling pathways associated with inflammation, lipid metabolism, the coagulation system, apoptosis, angiogenesis, atherosclerosis, and myocardial ischaemia.
Bibliografie:ObjectType-Article-1
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ObjectType-Feature-2
ObjectType-Review-3
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This article was submitted to Ethnopharmacology, a section of the journal Frontiers in Pharmacology
Edited by: Aiping Lu, Hong Kong Baptist University, Hong Kong
Reviewed by: Zhenhua Dai, Guangdong Provincial Academy of Chinese Medical Sciences, China; Thomas Heinbockel, Howard University, United States
These authors have contributed equally to this work.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2017.00702