The Environment and Cyanophage Diversity: Insights From Environmental Sequencing of DNA Polymerase
Globally distributed and abundant cyanophages in the family Myoviridae have dsDNA genomes with variable gene content, including host-derived auxiliary metabolic genes (AMGs) that potentially can facilitate viral replication. However, it is not well understood how this variation in gene content inter...
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| Vydáno v: | Frontiers in microbiology Ročník 10; s. 167 |
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Frontiers Media S.A
08.02.2019
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| ISSN: | 1664-302X, 1664-302X |
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| Abstract | Globally distributed and abundant cyanophages in the family Myoviridae have dsDNA genomes with variable gene content, including host-derived auxiliary metabolic genes (AMGs) that potentially can facilitate viral replication. However, it is not well understood how this variation in gene content interacts with environmental variables to shape cyanomyovirus communities. This project correlated the genetic repertoire of cyanomyoviruses with their phyologeny, and investigated cyanomyovirus ecotype distribution as a function of environmental conditions across locations and seasons. Reference cyanomyovirus genomes were compared for their overlap in gene content to infer phyologenetic distances, and these distances were compared to distances calculated based on DNA polymerase (gp43) gene sequences. In turn, gp43 partial gene sequences amplified from natural cyanophage communities were used to describe cyanomyovirus community composition and to assess the relationship between environmental variables. The results showed the following: (1) DNA polymerase gene phylogeny generally correlated with the similarity in gene content among reference cyanomyoviruses, and thus can be used to describe environmental cyanomyovirus communities; (2) spatial and seasonal patterns in cyanomyovirus communities were related to environmental variables; (3) salinity and temperature, combined with nutrient concentration were predictors of cyanomyovirus richness, diversity and community composition. This study shows that environmental variables shape viral communities by drawing on a diverse seed bank of viral genotypes. From these results it is evident that that viral ecotypes with their corresponding genetic repertoires underlie selection pressures. However, the mechanisms involved in selecting for specific viral genotypes remain to be fully understood. |
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| AbstractList | Globally distributed and abundant cyanophages in the family Myoviridae have dsDNA genomes with variable gene content, including host-derived auxiliary metabolic genes (AMGs) that potentially can facilitate viral replication. However, it is not well understood how this variation in gene content interacts with environmental variables to shape cyanomyovirus communities. This project correlated the genetic repertoire of cyanomyoviruses with their phyologeny, and investigated cyanomyovirus ecotype distribution as a function of environmental conditions across locations and seasons. Reference cyanomyovirus genomes were compared for their overlap in gene content to infer phyologenetic distances, and these distances were compared to distances calculated based on DNA polymerase (gp43) gene sequences. In turn, gp43 partial gene sequences amplified from natural cyanophage communities were used to describe cyanomyovirus community composition and to assess the relationship between environmental variables. The results showed the following: (1) DNA polymerase gene phylogeny generally correlated with the similarity in gene content among reference cyanomyoviruses, and thus can be used to describe environmental cyanomyovirus communities; (2) spatial and seasonal patterns in cyanomyovirus communities were related to environmental variables; (3) salinity and temperature, combined with nutrient concentration were predictors of cyanomyovirus richness, diversity and community composition. This study shows that environmental variables shape viral communities by drawing on a diverse seed bank of viral genotypes. From these results it is evident that that viral ecotypes with their corresponding genetic repertoires underlie selection pressures. However, the mechanisms involved in selecting for specific viral genotypes remain to be fully understood. Globally distributed and abundant cyanophages in the family Myoviridae have dsDNA genomes with variable gene content, including host-derived auxiliary metabolic genes (AMGs) that potentially can facilitate viral replication. However, it is not well understood how this variation in gene content interacts with environmental variables to shape cyanomyovirus communities. This project correlated the genetic repertoire of cyanomyoviruses with their phyologeny, and investigated cyanomyovirus ecotype distribution as a function of environmental conditions across locations and seasons. Reference cyanomyovirus genomes were compared for their overlap in gene content to infer phyologenetic distances, and these distances were compared to distances calculated based on DNA polymerase (gp43) gene sequences. In turn, gp43 partial gene sequences amplified from natural cyanophage communities were used to describe cyanomyovirus community composition and to assess the relationship between environmental variables. The results showed the following: (1) DNA polymerase gene phylogeny generally correlated with the similarity in gene content among reference cyanomyoviruses, and thus can be used to describe environmental cyanomyovirus communities; (2) spatial and seasonal patterns in cyanomyovirus communities were related to environmental variables; (3) salinity and temperature, combined with nutrient concentration were predictors of cyanomyovirus richness, diversity and community composition. This study shows that environmental variables shape viral communities by drawing on a diverse seed bank of viral genotypes. From these results it is evident that that viral ecotypes with their corresponding genetic repertoires underlie selection pressures. However, the mechanisms involved in selecting for specific viral genotypes remain to be fully understood.Globally distributed and abundant cyanophages in the family Myoviridae have dsDNA genomes with variable gene content, including host-derived auxiliary metabolic genes (AMGs) that potentially can facilitate viral replication. However, it is not well understood how this variation in gene content interacts with environmental variables to shape cyanomyovirus communities. This project correlated the genetic repertoire of cyanomyoviruses with their phyologeny, and investigated cyanomyovirus ecotype distribution as a function of environmental conditions across locations and seasons. Reference cyanomyovirus genomes were compared for their overlap in gene content to infer phyologenetic distances, and these distances were compared to distances calculated based on DNA polymerase (gp43) gene sequences. In turn, gp43 partial gene sequences amplified from natural cyanophage communities were used to describe cyanomyovirus community composition and to assess the relationship between environmental variables. The results showed the following: (1) DNA polymerase gene phylogeny generally correlated with the similarity in gene content among reference cyanomyoviruses, and thus can be used to describe environmental cyanomyovirus communities; (2) spatial and seasonal patterns in cyanomyovirus communities were related to environmental variables; (3) salinity and temperature, combined with nutrient concentration were predictors of cyanomyovirus richness, diversity and community composition. This study shows that environmental variables shape viral communities by drawing on a diverse seed bank of viral genotypes. From these results it is evident that that viral ecotypes with their corresponding genetic repertoires underlie selection pressures. However, the mechanisms involved in selecting for specific viral genotypes remain to be fully understood. |
| Author | Finke, Jan F. Suttle, Curtis A. |
| AuthorAffiliation | 1 Department of Earth, Ocean and Atmospheric Sciences, The University of British Columbia , Vancouver, BC , Canada 2 Department of Microbiology and Immunology, The University of British Columbia , Vancouver, BC , Canada 3 Department of Botany, The University of British Columbia , Vancouver, BC , Canada 4 Institute for the Oceans and Fisheries, The University of British Columbia , Vancouver, BC , Canada |
| AuthorAffiliation_xml | – name: 2 Department of Microbiology and Immunology, The University of British Columbia , Vancouver, BC , Canada – name: 4 Institute for the Oceans and Fisheries, The University of British Columbia , Vancouver, BC , Canada – name: 3 Department of Botany, The University of British Columbia , Vancouver, BC , Canada – name: 1 Department of Earth, Ocean and Atmospheric Sciences, The University of British Columbia , Vancouver, BC , Canada |
| Author_xml | – sequence: 1 givenname: Jan F. surname: Finke fullname: Finke, Jan F. – sequence: 2 givenname: Curtis A. surname: Suttle fullname: Suttle, Curtis A. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30800109$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1126/science.1120250 10.1093/nar/gkq747 10.1016/j.virol.2016.09.016 10.1038/ismej.2011.54 10.1111/j.1462-2920.2007.01285.x 10.1093/plankt/23.10.1147 10.1016/j.cub.2008.02.067 10.1073/pnas.0503404102 10.1038/ismej.2011.41 10.2307/1313569 10.1111/j.1574-6968.2010.02054.x 10.1038/nmicrobiol.2015.24 10.1093/molbev/msn080 10.1016/S0967-0645(98)00073-3 10.1111/1462-2920.12629 10.1007/s00248-003-1010-2 10.1073/pnas.1102164108 10.1128/AEM.65.1.45-52.1999 10.1016/S0003-2670(00)88444-5 10.1038/ismej.2010.1 10.3354/ame017111 10.1128/AEM.71.8.4276-4279.2005 10.1111/j.1574-6941.2002.tb00930.x 10.1038/424741a 10.1371/journal.pone.0001456 10.1128/JB.183.1.358 10.1111/j.1462-2920.2004.00713.x 10.1038/ismej.2013.19 10.1146/annurev-virology-031413-085540 10.1016/j.femsec.2004.04.002 10.1038/ismej.2014.143 10.1128/AEM.67.7.3285 10.1038/ismej.2017.29 10.1128/MMBR.63.1.106-127.1999 10.1890/08-1823.1 10.1111/1462-2920.14273 10.1128/AEM.05531-11 10.1073/pnas.0401526101 10.4319/mave.2010.978-0-9845591-0-7.102 10.18637/jss.v025.i01 10.1038/nrmicro3289 10.1093/bioinformatics/btu170 10.4319/lo.1994.39.1.0169 10.1111/j.1758-2229.2008.00007.x 10.1093/bioinformatics/btr088 10.1111/j.0022-3646.1996.00506.x 10.1093/nar/gkw290 10.1371/journal.pbio.0030144 10.1111/j.1574-6968.2010.02025.x 10.1038/ismej.2015.130 10.1128/AEM.02483-14 10.1073/pnas.1510795112 10.3354/meps092099 10.1038/ismej.2013.58 10.1016/j.virol.2014.07.016 10.1093/bioinformatics/btg412 10.1128/AEM.02480-07 10.1038/msb.2011.75 10.7717/peerj.997 10.1017/S0025315406013427 10.1371/journal.pone.0003550 10.1093/bioinformatics/btu033 10.1111/j.1462-2920.2006.01171.x 10.1093/gbe/evv064 10.1093/bioinformatics/btq461 10.3410/B4-17 10.1128/AEM.58.11.3721-3729.1992 10.1128/AEM.69.8.4639 10.3354/ame012039 10.18637/jss.v022.i04 10.3390/v9050116 10.3389/fmicb.2016.00983 10.1038/nature01929 10.1016/B978-012362675-2/50007-0 10.1111/j.1462-2920.2009.02037.x 10.1038/nmeth.2604 10.1111/1462-2920.13556 10.1111/j.1462-2920.2009.01866.x 10.1128/AEM.00168-06 10.1111/1462-2920.12062 10.1046/j.1462-2920.2003.00539.x 10.1128/AEM.71.1.480 10.1128/AEM.70.3.1506-1513.2004 10.3354/ame01768 10.1126/science.281.5374.237 10.3354/ame034105 10.1111/j.1462-2920.2010.02280.x 10.1111/j.1462-2920.2012.02744.x 10.1016/j.virol.2014.06.032 10.1186/1743-422X-7-291 10.1128/AEM.63.1.77-83.1997 10.1111/1574-6941.12343 |
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| Keywords | gp43 gene content DNA polymerase selection ecotypes cyanomyovirus |
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| References | Partensky (B69); 63 Tetart (B84) 2001; 183 Suttle (B82) 1993; 92 Weigele (B88) 2007; 9 Edgar (B24) 2013; 10 Letunic (B47) 2016; 44 Herlemann (B36) 2011; 5 Stamatakis (B77) 2014; 30 Bolger (B4) 2014; 30 Clokie (B14) 2006; 8 Crummett (B17) 2016; 499 Liu (B50) 1997; 12 Breitbart (B6) 2007; 20 Mann (B52) 2003; 424 Goldsmith (B31); 76 McDaniel (B58) 2006; 86 Brussaard (B7) 2004; 70 Wilson (B97) 1996; 32 Lindell (B48) 2004; 101 Le (B45) 2008; 25 Suttle (B83) 1992; 58 Chow (B12) 2015; 2 Goldsmith (B32); 3 Wang (B87) 2004; 34 Edgar (B23) 2010; 26 Hurwitz (B38) 2014; 9 Noble (B65) 1997; 63 Sandaa (B73) 2006; 72 William (B95) 1994; 39 Estrada (B26) 2004; 49 Field (B27) 1998; 281 Sullivan (B78) 2005; 3 Bragg (B5) 2008; 3 Muhling (B61) 2005; 7 Thompson (B85) 2011; 108 Clokie (B15) 2010; 7 De Caceres (B20) 2009; 90 Wilson (B98) Clerissi (B13) 2014 Marston (B54) 2009; 11 Mojica (B60) 2016; 10 Dammeyer (B18) 2008; 18 Legendre (B46) 2015; 112 Rodrigues-Brito (B72) 2010; 4 Wigington (B93) 2016; 1 Partensky (B68); 19 Short (B75) 2005; 71 Murphey (B62) 1962; 27 Butina (B9) 2010; 309 Hanson (B34) 2016; 7 Marston (B57) 2013; 15 Scanlan (B74) 2002; 40 Lu (B51) 2001; 67 Needham (B64) 2017; 11 Wilhelm (B94) 1999; 49 Goldsmith (B33) 2011; 77 Jover (B41) 2014; 12 Jia (B40) 2010; 310 Yutin (B100) 2014 Weithoff (B91) 2001; 23 Kelly (B43) 2013; 7 Finke (B29) 2017; 9 Weinbauer (B89) 2004; 6 Kukkaro (B44) 2009; 1 Darriba (B19) 2011; 27 Marie (B53) 1999; 65 Brussaard (B8) 2010 Frederickson (B30) 2003; 46 Suttle (B81) 2000 Dray (B22) 2007; 22 Jameson (B39) 2011; 5 Huang (B37) 2015; 81 Sullivan (B80) 2003; 424 Williamson (B96) 2008; 3 Hellweger (B35) 2009; 11 Needham (B63) 2013; 7 Kao (B42) 2005; 71 Armstrong (B1) 1967; 14 Liu (B49) 1998; 45 Chow (B11) 2012; 14 Vaulot (B86) 1989; 2 Wilson (B99); 19 Oksanen (B66) 2016 El-Swais (B25) 2015; 17 Chénard (B10) 2008; 74 Paradis (B67) 2004; 20 (B70) 2015 Weinbauer (B90) 1999; 17 Marston (B56) 2003; 69 Marston (B55) 2016; 18 Rho (B71) 2010; 38 Bachy (B2) 2018; 20 Sullivan (B79) 2010; 12 Comeau (B16) 2008; 25 Filée (B28) 2005; 102 Weitz (B92) 2012; 4 Battye (B3) 2015 DeLong (B21) 2006; 311 Mojica (B59) 2014; 89 Sievers (B76) 2011; 7 |
| References_xml | – volume: 311 start-page: 496 year: 2006 ident: B21 article-title: Community genomics among stratified microbial assemblages in the ocean’s interior. publication-title: Science doi: 10.1126/science.1120250 – volume: 2 year: 1989 ident: B86 article-title: CYTOPC: processing software for flow cytometric data. publication-title: Signal. Noise – volume: 38 year: 2010 ident: B71 article-title: FragGeneScan: predicting genes in short and error-prone reads. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq747 – volume: 499 start-page: 219 year: 2016 ident: B17 article-title: The genomic content and context of auxiliary metabolic genes in marine cyanomyoviruses. publication-title: Virology doi: 10.1016/j.virol.2016.09.016 – volume: 5 start-page: 1713 year: 2011 ident: B39 article-title: The diversity of cyanomyovirus populations along a North-South Atlantic Ocean transect. publication-title: ISME J. doi: 10.1038/ismej.2011.54 – volume: 9 start-page: 1675 year: 2007 ident: B88 article-title: Genomic and structural analysis of Syn9, a cyanophage infecting marine Prochlorococcus and Synechococcus. publication-title: Environ. Microbiol. doi: 10.1111/j.1462-2920.2007.01285.x – volume: 23 start-page: 1147 year: 2001 ident: B91 article-title: The intermediate disturbance hypothesis — species diversity or functional diversity? publication-title: J. Plankton Res. doi: 10.1093/plankt/23.10.1147 – volume: 18 start-page: 442 year: 2008 ident: B18 article-title: Efficient phage-mediated pigment biosynthesis in oceanic cyanobacteria. publication-title: Curr. Biol. doi: 10.1016/j.cub.2008.02.067 – volume: 102 start-page: 12471 year: 2005 ident: B28 article-title: Marine T4-type bacteriophages, a ubiquitous component of the dark matter of the biosphere. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0503404102 – volume: 5 start-page: 1571 year: 2011 ident: B36 article-title: Transitions in bacterial communities along the 2000 Km salinity gradient of the Baltic Sea. publication-title: ISME J. doi: 10.1038/ismej.2011.41 – volume: 49 start-page: 781 year: 1999 ident: B94 article-title: Viruses and Nutrient Cycles in the Sea: viruses play critical roles in the structure and function of aquatic food webs. publication-title: Bioscience doi: 10.2307/1313569 – volume: 310 start-page: 120 year: 2010 ident: B40 article-title: Light-dependent adsorption of photosynthetic cyanophages to Synechococcus Sp. WH7803. publication-title: FEMS Microbiol. Lett. doi: 10.1111/j.1574-6968.2010.02054.x – volume: 1 year: 2016 ident: B93 article-title: Re-examination of the Relationship between marine virus and microbial cell abundances. publication-title: Nat. Microbiol. doi: 10.1038/nmicrobiol.2015.24 – volume: 25 start-page: 1321 year: 2008 ident: B16 article-title: The capsid of the T4 phage superfamily: the evolution, diversity, and structure of some of the most prevalent proteins in the biosphere. publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msn080 – volume: 45 start-page: 2327 year: 1998 ident: B49 article-title: Prochlorococcus and Synechococcus growth rates and contributions to production in the Arabian Sea during the 1995 southwest and northeast monsoons. publication-title: Deep Sea Res. Part II doi: 10.1016/S0967-0645(98)00073-3 – volume: 17 start-page: 3642 year: 2015 ident: B25 article-title: Seasonal assemblages and short-lived blooms in coastal north-west Atlantic Ocean bacterioplankton. publication-title: Environ. Microbiol. doi: 10.1111/1462-2920.12629 – volume: 46 start-page: 348 year: 2003 ident: B30 article-title: The physical environment affects cyanophage communities in British Columbia inlets. publication-title: Microb. Ecol. doi: 10.1007/s00248-003-1010-2 – volume: 108 start-page: E757 year: 2011 ident: B85 article-title: Phage auxiliary metabolic genes and the redirection of cyanobacterial host carbon metabolism. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1102164108 – volume: 65 start-page: 45 year: 1999 ident: B53 article-title: Enumeration of marine viruses in culture and natural samples by flow cytometry enumeration of marine viruses in culture and natural samples by flow cytometry. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.65.1.45-52.1999 – volume: 27 start-page: 31 year: 1962 ident: B62 article-title: A modified single solution method for the determination of phosphate in natural waters. publication-title: Anal. Chem. Acta doi: 10.1016/S0003-2670(00)88444-5 – volume: 4 start-page: 739 year: 2010 ident: B72 article-title: Viral and microbial community dynamics in four aquatic environments. publication-title: ISME J. doi: 10.1038/ismej.2010.1 – volume: 17 start-page: 111 year: 1999 ident: B90 article-title: Sunlight-induced DNA damage and resistance in natural viral communities. publication-title: Aquat. Microb. Ecol. doi: 10.3354/ame017111 – volume: 71 start-page: 4276 year: 2005 ident: B42 article-title: Diel infection of a cyanobacterium by a contractile bacteriophage. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.71.8.4276-4279.2005 – volume: 40 start-page: 1 year: 2002 ident: B74 article-title: Molecular ecology of the marine cyanobacterial genera Prochlorococcus and Synechococcus. publication-title: FEMS Microbiol. Ecol. doi: 10.1111/j.1574-6941.2002.tb00930.x – volume: 424 year: 2003 ident: B52 article-title: Bacterial photosynthesis genes in a virus. publication-title: Nature doi: 10.1038/424741a – volume: 3 year: 2008 ident: B96 article-title: The sorcerer II global ocean sampling expedition: metagenomic characterization of viruses within aquatic microbial samples. publication-title: PLoS One doi: 10.1371/journal.pone.0001456 – volume: 183 start-page: 358 year: 2001 ident: B84 article-title: Phylogeny of the major head and tail genes of the wide-ranging T4-type bacteriophages. publication-title: J. Bacteriol. doi: 10.1128/JB.183.1.358 – volume: 7 start-page: 499 year: 2005 ident: B61 article-title: Genetic diversity of marine Synechococcus and co-occurring cyanophage communities: evidence for viral control of phytoplankton. publication-title: Environ. Microbiol. doi: 10.1111/j.1462-2920.2004.00713.x – volume: 7 start-page: 1274 year: 2013 ident: B63 article-title: Short-term observations of marine bacterial and viral communities: patterns, connections and resilience. publication-title: ISME J. doi: 10.1038/ismej.2013.19 – ident: B98 article-title: “Analysis of cyanophage diversity in the marine environment using denaturing gradient gel electrophoresis,” in publication-title: Proceedings of the 8th International Symposium on Microbial Ecology – volume: 2 start-page: 41 year: 2015 ident: B12 article-title: Biogeography of viruses in the sea. publication-title: Annu. Rev. Virol. doi: 10.1146/annurev-virology-031413-085540 – volume: 49 start-page: 281 year: 2004 ident: B26 article-title: Diversity of planktonic photoautotrophic microorganisms along a salinity gradient as depicted by microscopy, flow cytometry, pigment analysis and DNA-based methods. publication-title: FEMS Microbiol. Ecol. doi: 10.1016/j.femsec.2004.04.002 – volume: 9 start-page: 472 year: 2014 ident: B38 article-title: Depth-stratified functional and taxonomic niche specialization in the ‘Core’ and ‘Flexible’ pacific ocean virome. publication-title: ISME J. doi: 10.1038/ismej.2014.143 – volume: 67 start-page: 3285 year: 2001 ident: B51 article-title: Distribution, isolation, host specificity, and diversity of cyanophages infecting marine Synechococcus Spp. in river estuaries. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.67.7.3285 – volume: 11 start-page: 1614 year: 2017 ident: B64 article-title: Ecological dynamics and co-occurrence among marine phytoplankton, bacteria and myoviruses shows microdiversity matters. publication-title: ISME J. doi: 10.1038/ismej.2017.29 – volume: 63 start-page: 106 ident: B69 article-title: Prochlorococcus, a marine photosynthetic prokaryote of global significance. publication-title: Microbiol. Mol. Biol. Rev. doi: 10.1128/MMBR.63.1.106-127.1999 – volume: 90 start-page: 3566 year: 2009 ident: B20 article-title: Associations between species and groups of sites: indices and statistical inference. publication-title: Ecology doi: 10.1890/08-1823.1 – volume: 20 start-page: 2898 year: 2018 ident: B2 article-title: Transcriptional responses of the marine green alga Micromonas pusilla and an infecting prasinovirus under different phosphate conditions. publication-title: Environ. Microbiol. doi: 10.1111/1462-2920.14273 – volume: 77 start-page: 7730 year: 2011 ident: B33 article-title: Development of PhoH as a novel signature gene for assessing marine phage diversity. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.05531-11 – volume: 101 start-page: 11013 year: 2004 ident: B48 article-title: Transfer of photosynthesis genes to and from Prochlorococcus viruses. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.0401526101 – start-page: 102 year: 2010 ident: B8 article-title: “Quantification of aquatic viruses by flow cytometry,” in publication-title: Manual of Aquatic Viral Ecology doi: 10.4319/mave.2010.978-0-9845591-0-7.102 – volume: 25 start-page: 1 year: 2008 ident: B45 article-title: FactoMineR: an R package for multivariate analysis. publication-title: J. Stat. Softw. doi: 10.18637/jss.v025.i01 – volume: 12 start-page: 519 year: 2014 ident: B41 article-title: The elemental composition of virus particles: implications for marine biogeochemical cycles. publication-title: Nat. Rev. Microbiol. doi: 10.1038/nrmicro3289 – volume: 30 start-page: 2114 year: 2014 ident: B4 article-title: Trimmomatic: a flexible trimmer for Illumina sequence data. publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 – volume: 39 start-page: 169 year: 1994 ident: B95 article-title: Primary production of prochlorophytes, cyanobacteria, and eucaryotic ultrphytoplankton: measurements vrom flow cytometric sorting. publication-title: Limnol. Oceanogr. doi: 10.4319/lo.1994.39.1.0169 – volume: 1 start-page: 71 year: 2009 ident: B44 article-title: Virus – host interactions in environments with a wide range of ionic strengths. publication-title: Environ. Microbiol. Rep. doi: 10.1111/j.1758-2229.2008.00007.x – volume: 27 start-page: 1164 year: 2011 ident: B19 article-title: ProtTest 3: fast selection of best-fit models of protein evolution. publication-title: Bioinformatics doi: 10.1093/bioinformatics/btr088 – volume: 32 start-page: 506 year: 1996 ident: B97 article-title: The effect of phosphate status on the kinetics of cyanophage infection in the oceanic cyanobacterium Synechococcus SP. WH7803. publication-title: J. Phycol. doi: 10.1111/j.0022-3646.1996.00506.x – volume: 44 start-page: W242 year: 2016 ident: B47 article-title: Interactive tree of life (ITOL) v3: an online tool for the display and annotation of phylogenetic and other trees. publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkw290 – volume: 3 year: 2005 ident: B78 article-title: Three Prochlorococcus cyanophage genomes: signature features and ecological interpretations. publication-title: PLoS Biol. doi: 10.1371/journal.pbio.0030144 – volume: 309 start-page: 122 year: 2010 ident: B9 article-title: Phylogenetic diversity of T4-like bacteriophages in Lake Baikal, East Siberia. publication-title: FEMS Microbiol. Lett. doi: 10.1111/j.1574-6968.2010.02025.x – volume: 10 start-page: 500 year: 2016 ident: B60 article-title: Latitudinal variation in virus-induced mortality of phytoplankton across the north Atlantic ocean. publication-title: ISME J. doi: 10.1038/ismej.2015.130 – volume: 81 start-page: 441 year: 2015 ident: B37 article-title: Marine cyanophages demonstrate biogeographic patterns throughout the global ocean. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.02483-14 – volume: 112 start-page: E5327 year: 2015 ident: B46 article-title: In-depth study of Mollivirus sibericum, a new 30,000-y- old giant virus infecting Acanthamoeba. publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1510795112 – volume: 92 start-page: 99 year: 1993 ident: B82 article-title: Marine cyanophages infecting oceanic and coastal strains of Synechococcus: abundance, morphology, cross-infectivity and growth characteristics. publication-title: Mar. Ecol. Prog. Ser. doi: 10.3354/meps092099 – volume: 7 start-page: 1827 year: 2013 ident: B43 article-title: Genetic diversity in cultured and wild marine cyanomyoviruses reveals phosphorus stress as a strong selective agent. publication-title: ISME J. doi: 10.1038/ismej.2013.58 – start-page: 146 year: 2014 ident: B13 article-title: Prasinovirus distribution in the northwest Mediterranean Sea s affected by the environment and particularly by phosphate availability. publication-title: Virology doi: 10.1016/j.virol.2014.07.016 – volume: 20 start-page: 289 year: 2004 ident: B67 article-title: APE: analyses of phylogenetics and evolution in R language. publication-title: Bioinformatics doi: 10.1093/bioinformatics/btg412 – volume: 74 start-page: 5317 year: 2008 ident: B10 article-title: Phylogenetic diversity of sequences of cyanophage photosynthetic gene PsbA in marine and freshwaters. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.02480-07 – year: 2015 ident: B3 publication-title: Weasel. – volume: 7 year: 2011 ident: B76 article-title: Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega. publication-title: Mol. Syst. Biol. doi: 10.1038/msb.2011.75 – volume: 3 ident: B32 article-title: Deep sequencing of the viral PhoH gene reveals temporal variation, depth-specific composition, and persistent dominance of the same viral PhoH genes in the Sargasso Sea. publication-title: PeerJ doi: 10.7717/peerj.997 – volume: 86 start-page: 517 year: 2006 ident: B58 article-title: Temperate and lytic cyanophages from the gulf of Mexico. publication-title: J. Mar. Biol. Assoc. UK doi: 10.1017/S0025315406013427 – volume: 3 year: 2008 ident: B5 article-title: Modeling the fitness consequences of a cyanophage-encoded photosynthesis gene. publication-title: PLoS One doi: 10.1371/journal.pone.0003550 – volume: 30 start-page: 1312 year: 2014 ident: B77 article-title: RAxML version 8 a tool for phylogenetic analysis and post-analysis of large phylogenies. publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu033 – year: 2016 ident: B66 publication-title: Vegan: Community Ecology Package. R Package Version 2.3-3. – volume: 8 start-page: 2074 year: 2006 ident: B14 article-title: Marine cyanophages and light. publication-title: Environ. Microbiol. doi: 10.1111/j.1462-2920.2006.01171.x – volume: 20 start-page: 135 year: 2007 ident: B6 article-title: Exploring the vast diversity of marine viruses. publication-title: Oceanography doi: 10.1093/gbe/evv064 – volume: 26 start-page: 2460 year: 2010 ident: B23 article-title: Search and clustering orders of magnitude faster than BLAST. publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq461 – volume: 4 year: 2012 ident: B92 article-title: Ocean viruses and their effects on microbial communities and biogeochemical cycles. publication-title: F1000 Biol. Rep. doi: 10.3410/B4-17 – volume: 58 start-page: 3721 year: 1992 ident: B83 article-title: Mechanisms and rates of decay of marine viruses in seawater. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.58.11.3721-3729.1992 – volume: 19 start-page: 431 ident: B68 article-title: Differential distribution and ecology of Prochlorococcus and Synechococcus in oceanic waters: a review. publication-title: Bull. Inst. Oceanogr. Monaco – volume: 19 start-page: 209 ident: B99 article-title: Analysis of cyanophage diversity and population structure in a south-north transect of the Atlantic ocean. publication-title: Bull. Inst. Oceanogr. Monaco – volume: 69 start-page: 4639 year: 2003 ident: B56 article-title: Genetic diversity and temporal variation in the cyanophage community infecting marine Synechococcus species in rhode island’s coastal waters. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.69.8.4639 – volume: 12 start-page: 39 year: 1997 ident: B50 article-title: Prochlorococcus growth rate and contribution to primary production in the equatorial and subtropical north pacific ocean. publication-title: Aquat. Microb. Ecol. doi: 10.3354/ame012039 – year: 2015 ident: B70 publication-title: R: A Language and Environment for Statistical Computing. – volume: 22 start-page: 1 year: 2007 ident: B22 article-title: The Ade4 package: implementing the duality diagram for ecologists. publication-title: J. Stat. Softw. doi: 10.18637/jss.v022.i04 – volume: 9 start-page: 1 year: 2017 ident: B29 article-title: Variation in the genetic repertoire of viruses infecting Micromonas pusilla reflects horizontal gene transfer and links to their environmental distribution. publication-title: Viruses doi: 10.3390/v9050116 – volume: 7 year: 2016 ident: B34 article-title: Biogeographic variation in host range phenotypes and taxonomic composition of marine cyanophage isolates. publication-title: Front. Microbiol. doi: 10.3389/fmicb.2016.00983 – volume: 424 start-page: 1047 year: 2003 ident: B80 article-title: Cyanophages infecting the oceanic cyanobacterium Prochlorococcus. publication-title: Nature doi: 10.1038/nature01929 – start-page: 247 year: 2000 ident: B81 article-title: “Ecology, evolutionary, and geochemical consequences of viral infection of cyanobacteria and eukaryotic algae,” in publication-title: In Viral Ecology doi: 10.1016/B978-012362675-2/50007-0 – volume: 11 start-page: 2893 year: 2009 ident: B54 article-title: Recombination and microdiversity in coastal marine cyanophages. publication-title: Environ. Microbiol. doi: 10.1111/j.1462-2920.2009.02037.x – volume: 10 start-page: 996 year: 2013 ident: B24 article-title: UPARSE: highly accurate OTU sequences from microbial amplicon reads. publication-title: Nat. Methods doi: 10.1038/nmeth.2604 – volume: 18 start-page: 4240 year: 2016 ident: B55 article-title: Genomic diversification of marine cyanophages into stable ecotypes. publication-title: Environ. Microbiol. doi: 10.1111/1462-2920.13556 – volume: 11 start-page: 1386 year: 2009 ident: B35 article-title: Carrying photosynthesis genes increases ecological fitness of cyanophage in silico. publication-title: Environ. Microbiol. doi: 10.1111/j.1462-2920.2009.01866.x – volume: 72 start-page: 4610 year: 2006 ident: B73 article-title: Seasonal variations in virus-host populations in norwegian coastal waters: focusing on the cyanophage community infecting marine Synechococcus Spp. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.00168-06 – volume: 14 start-page: 381 year: 1967 ident: B1 article-title: The measurement of upwelling and subsequent biological processes by means of the technicon autoanalyzer and associated equipment. publication-title: Deep Sea Res. – volume: 15 start-page: 1452 year: 2013 ident: B57 article-title: Marine cyanophages exhibit local and regional biogeography. publication-title: Environ. Microbiol. doi: 10.1111/1462-2920.12062 – volume: 6 start-page: 1 year: 2004 ident: B89 article-title: Are viruses driving microbial diversification and diversity? publication-title: Environ. Microbiol. doi: 10.1046/j.1462-2920.2003.00539.x – volume: 71 start-page: 480 year: 2005 ident: B75 article-title: Nearly identical bacteriophage structural gene sequences are widely distributed in both marine and freshwater environments. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.71.1.480 – volume: 70 start-page: 1506 year: 2004 ident: B7 article-title: Optimization of procedures for counting viruses by flow cytometry. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.70.3.1506-1513.2004 – volume: 76 start-page: 85 ident: B31 article-title: Water column stratification structures viral community composition in the Sargasso Sea. publication-title: Aquat. Microb. Ecol. doi: 10.3354/ame01768 – volume: 281 start-page: 237 year: 1998 ident: B27 article-title: Primary production of the biosphere: integrating terrestrial and oceanic components. publication-title: Science doi: 10.1126/science.281.5374.237 – volume: 34 start-page: 105 year: 2004 ident: B87 article-title: Genetic diversity and population dynamics of cyanophage communities in the Chesapeake bay. publication-title: Aquat. Microb. Ecol. doi: 10.3354/ame034105 – volume: 12 start-page: 3035 year: 2010 ident: B79 article-title: Genomic analysis of oceanic cyanobacterial myoviruses compared with T4-like myoviruses from diverse hosts and environments. publication-title: Environ. Microbiol. doi: 10.1111/j.1462-2920.2010.02280.x – volume: 14 start-page: 2171 year: 2012 ident: B11 article-title: Seasonality and monthly dynamics of marine myovirus communities. publication-title: Environ. Microbiol. doi: 10.1111/j.1462-2920.2012.02744.x – start-page: 38 year: 2014 ident: B100 article-title: Origin of giant viruses from smaller DNA viruses not from a fourth domain of cellular life. publication-title: Virology doi: 10.1016/j.virol.2014.06.032 – volume: 7 year: 2010 ident: B15 article-title: T4 genes in the marine ecosystem: studies of the T4-like cyanophages and their role in marine ecology. publication-title: Virol. J. doi: 10.1186/1743-422X-7-291 – volume: 63 start-page: 77 year: 1997 ident: B65 article-title: Virus decay and its causes in coastal waters. publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.63.1.77-83.1997 – volume: 89 start-page: 495 year: 2014 ident: B59 article-title: Factors affecting virus dynamics and microbial host-virus interactions in marine environments. publication-title: FEMS Microbiol. Ecol. doi: 10.1111/1574-6941.12343 |
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| Title | The Environment and Cyanophage Diversity: Insights From Environmental Sequencing of DNA Polymerase |
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