Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers

The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irrep...

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Veröffentlicht in:	Frontiers in oncology Jg. 10; S. 598817
Hauptverfasser:	Gao, Na, Li, Yueheng, Li, Jing, Gao, Zhengfan, Yang, Zhenzhen, Li, Yong, Liu, Hongtao, Fan, Tianli
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland Frontiers Media S.A 18.12.2020
Schlagworte:	cancer long non-coding RNA mechanism of action Oncology research strategies therapeutic targets mechanism of action cancer long non-coding RNA therapeutic targets research strategies
ISSN:	2234-943X, 2234-943X
Online-Zugang:	Volltext
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Abstract	The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irreplaceable role in tumor initiation, progression, as well as metastasis, and are novel molecular biomarkers for diagnosis and prognosis of cancer patients. Furthermore, lncRNAs and the pathways they influence might represent promising therapeutic targets for a number of tumors. Here, we discuss the recent advances in understanding of the specific regulatory mechanisms of lncRNAs. We focused on the signal, decoy, guide, and scaffold functions of lncRNAs at the epigenetic, transcription, and post-transcription levels in cancer cells. Additionally, we summarize the research strategies used to investigate the roles of lncRNAs in tumors, including lncRNAs screening, lncRNAs characteristic analyses, functional studies, and molecular mechanisms of lncRNAs. This review will provide a short but comprehensive description of the lncRNA functions in tumor development and progression, thus accelerating the clinical implementation of lncRNAs as tumor biomarkers and therapeutic targets.
AbstractList	The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irreplaceable role in tumor initiation, progression, as well as metastasis, and are novel molecular biomarkers for diagnosis and prognosis of cancer patients. Furthermore, lncRNAs and the pathways they influence might represent promising therapeutic targets for a number of tumors. Here, we discuss the recent advances in understanding of the specific regulatory mechanisms of lncRNAs. We focused on the signal, decoy, guide, and scaffold functions of lncRNAs at the epigenetic, transcription, and post-transcription levels in cancer cells. Additionally, we summarize the research strategies used to investigate the roles of lncRNAs in tumors, including lncRNAs screening, lncRNAs characteristic analyses, functional studies, and molecular mechanisms of lncRNAs. This review will provide a short but comprehensive description of the lncRNA functions in tumor development and progression, thus accelerating the clinical implementation of lncRNAs as tumor biomarkers and therapeutic targets. The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irreplaceable role in tumor initiation, progression, as well as metastasis, and are novel molecular biomarkers for diagnosis and prognosis of cancer patients. Furthermore, lncRNAs and the pathways they influence might represent promising therapeutic targets for a number of tumors. Here, we discuss the recent advances in understanding of the specific regulatory mechanisms of lncRNAs. We focused on the signal, decoy, guide, and scaffold functions of lncRNAs at the epigenetic, transcription, and post-transcription levels in cancer cells. Additionally, we summarize the research strategies used to investigate the roles of lncRNAs in tumors, including lncRNAs screening, lncRNAs characteristic analyses, functional studies, and molecular mechanisms of lncRNAs. This review will provide a short but comprehensive description of the lncRNA functions in tumor development and progression, thus accelerating the clinical implementation of lncRNAs as tumor biomarkers and therapeutic targets.The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irreplaceable role in tumor initiation, progression, as well as metastasis, and are novel molecular biomarkers for diagnosis and prognosis of cancer patients. Furthermore, lncRNAs and the pathways they influence might represent promising therapeutic targets for a number of tumors. Here, we discuss the recent advances in understanding of the specific regulatory mechanisms of lncRNAs. We focused on the signal, decoy, guide, and scaffold functions of lncRNAs at the epigenetic, transcription, and post-transcription levels in cancer cells. Additionally, we summarize the research strategies used to investigate the roles of lncRNAs in tumors, including lncRNAs screening, lncRNAs characteristic analyses, functional studies, and molecular mechanisms of lncRNAs. This review will provide a short but comprehensive description of the lncRNA functions in tumor development and progression, thus accelerating the clinical implementation of lncRNAs as tumor biomarkers and therapeutic targets.
Author	Li, Yueheng Li, Yong Li, Jing Yang, Zhenzhen Fan, Tianli Gao, Zhengfan Liu, Hongtao Gao, Na
AuthorAffiliation	4 Laboratory for Cell Biology, College of Life Sciences of Zhengzhou University , Zhengzhou , China 2 Translational Medicine Research Center, People’s Hospital of Zhengzhou , Zhengzhou , China 1 Department of Pharmacology, School of Basic Medicine, Zhengzhou University , Zhengzhou , China 3 Faculty of Medicine, St George and Sutherland Clinical School, St George Hospital, The University of New South Wales (UNSW) Sydney , Kensington, NSW , Australia
AuthorAffiliation_xml	– name: 1 Department of Pharmacology, School of Basic Medicine, Zhengzhou University , Zhengzhou , China – name: 2 Translational Medicine Research Center, People’s Hospital of Zhengzhou , Zhengzhou , China – name: 3 Faculty of Medicine, St George and Sutherland Clinical School, St George Hospital, The University of New South Wales (UNSW) Sydney , Kensington, NSW , Australia – name: 4 Laboratory for Cell Biology, College of Life Sciences of Zhengzhou University , Zhengzhou , China
Author_xml	– sequence: 1 givenname: Na surname: Gao fullname: Gao, Na – sequence: 2 givenname: Yueheng surname: Li fullname: Li, Yueheng – sequence: 3 givenname: Jing surname: Li fullname: Li, Jing – sequence: 4 givenname: Zhengfan surname: Gao fullname: Gao, Zhengfan – sequence: 5 givenname: Zhenzhen surname: Yang fullname: Yang, Zhenzhen – sequence: 6 givenname: Yong surname: Li fullname: Li, Yong – sequence: 7 givenname: Hongtao surname: Liu fullname: Liu, Hongtao – sequence: 8 givenname: Tianli surname: Fan fullname: Fan, Tianli
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33392092$$D View this record in MEDLINE/PubMed
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Keywords	mechanism of action cancer long non-coding RNA therapeutic targets research strategies
Language	English
License	Copyright © 2020 Gao, Li, Li, Gao, Yang, Li, Liu and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Edited by: Lorenzo Gerratana, University of Udine, Italy Reviewed by: Anup Kumar Singh, Beckman Research Institute, City of Hope, United States; Young-Jun Jeon, Sungkyunkwan University, South Korea This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology
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PublicationDate	2020-12-18
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PublicationDate_xml	– month: 12 year: 2020 text: 2020-12-18 day: 18
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PublicationTitle	Frontiers in oncology
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PublicationYear	2020
Publisher	Frontiers Media S.A
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Snippet	The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs)....
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SubjectTerms	cancer long non-coding RNA mechanism of action Oncology research strategies therapeutic targets
Title	Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers
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