Long Non-Coding RNAs: The Regulatory Mechanisms, Research Strategies, and Future Directions in Cancers

The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irrep...

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Vydáno v:Frontiers in oncology Ročník 10; s. 598817
Hlavní autoři: Gao, Na, Li, Yueheng, Li, Jing, Gao, Zhengfan, Yang, Zhenzhen, Li, Yong, Liu, Hongtao, Fan, Tianli
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland Frontiers Media S.A 18.12.2020
Témata:
cancer
long non-coding RNA
mechanism of action
Oncology
research strategies
therapeutic targets
mechanism of action
cancer
long non-coding RNA
therapeutic targets
research strategies
ISSN:2234-943X, 2234-943X
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Shrnutí:The development and application of whole genome sequencing technology has greatly broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs are more than 200 nucleotides in length and lack protein-coding potential. Increasing evidence indicates that lncRNAs exert an irreplaceable role in tumor initiation, progression, as well as metastasis, and are novel molecular biomarkers for diagnosis and prognosis of cancer patients. Furthermore, lncRNAs and the pathways they influence might represent promising therapeutic targets for a number of tumors. Here, we discuss the recent advances in understanding of the specific regulatory mechanisms of lncRNAs. We focused on the signal, decoy, guide, and scaffold functions of lncRNAs at the epigenetic, transcription, and post-transcription levels in cancer cells. Additionally, we summarize the research strategies used to investigate the roles of lncRNAs in tumors, including lncRNAs screening, lncRNAs characteristic analyses, functional studies, and molecular mechanisms of lncRNAs. This review will provide a short but comprehensive description of the lncRNA functions in tumor development and progression, thus accelerating the clinical implementation of lncRNAs as tumor biomarkers and therapeutic targets.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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Edited by: Lorenzo Gerratana, University of Udine, Italy
Reviewed by: Anup Kumar Singh, Beckman Research Institute, City of Hope, United States; Young-Jun Jeon, Sungkyunkwan University, South Korea
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.598817