Device-detected atrial fibrillation and risk for stroke: an analysis of >10,000 patients from the SOS AF project (Stroke preventiOn Strategies based on Atrial Fibrillation information from implanted devices)

The aim of this study was to assess the association between maximum daily atrial fibrillation (AF) burden and risk of ischaemic stroke. Cardiac implanted electronic devices (CIEDs) enhance detection of AF, providing a comprehensive measure of AF burden. A pooled analysis of individual patient data f...

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Vydáno v:European heart journal Ročník 35; číslo 8; s. 508
Hlavní autoři: Boriani, Giuseppe, Glotzer, Taya V, Santini, Massimo, West, Teena M, De Melis, Mirko, Sepsi, Milan, Gasparini, Maurizio, Lewalter, Thorsten, Camm, John A, Singer, Daniel E
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 01.02.2014
Témata:
Aged
Anticoagulants - therapeutic use
Atrial Fibrillation - diagnosis
Atrial Fibrillation - therapy
Cost of Illness
Defibrillators, Implantable
Female
Humans
Ischemic Attack, Transient - prevention & control
Kaplan-Meier Estimate
Male
Middle Aged
Observational Studies as Topic
Prospective Studies
Risk Factors
Stroke - prevention & control
Stroke
Anticoagulation
Implantable defibrillator
Pacemaker
Atrial fibrillation
ISSN:1522-9645, 1522-9645
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Shrnutí:The aim of this study was to assess the association between maximum daily atrial fibrillation (AF) burden and risk of ischaemic stroke. Cardiac implanted electronic devices (CIEDs) enhance detection of AF, providing a comprehensive measure of AF burden. A pooled analysis of individual patient data from five prospective studies was performed. Patients without permanent AF, previously implanted with CIEDs, were included if they had at least 3 months of follow-up. A total of 10 016 patients (median age 70 years) met these criteria. The risk of ischaemic stroke associated with pre-specified cut-off points of AF burden (5 min, 1, 6, 12, and 23 h, respectively) was assessed. During a median follow-up of 24 months, 43% of 10 016 patients experienced at least 1 day with at least 5 min of AF burden and for them the median time to the maximum AF burden was 6 months (inter-quartile range: 1.3-14). A Cox regression analysis adjusted for the CHADS2 score and anticoagulants at baseline demonstrated that AF burden was an independent predictor of ischaemic stroke. Among the thresholds of AF burden that we evaluated, 1 h was associated with the highest hazard ratio (HR) for ischaemic stroke, i.e. 2.11 (95% CI: 1.22-3.64, P = 0.008). Device-detected AF burden is associated with an increased risk of ischaemic stroke in a relatively unselected population of CIEDs patients. This finding may add to the basis for timely and clinically appropriate decision-making on anticoagulation treatment.
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ISSN:1522-9645
1522-9645
DOI:10.1093/eurheartj/eht491