Identification of vitamin B1 metabolism as a tumor-specific radiosensitizing pathway using a high-throughput colony formation screen

Colony formation is the gold standard assay for determining reproductive cell death after radiation treatment, since effects on proliferation often do not reflect survival. We have developed a high-throughput radiosensitivity screening method based on clonogenicity and screened a siRNA library again...

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Vydáno v:	Oncotarget Ročník 6; číslo 8; s. 5978
Hlavní autoři:	Tiwana, Gaganpreet S, Prevo, Remko, Buffa, Francesca M, Yu, Sheng, Ebner, Daniel V, Howarth, Alison, Folkes, Lisa K, Budwal, Balam, Chu, Kwun-Ye, Durrant, Lisa, Muschel, Ruth J, McKenna, W Gillies, Higgins, Geoff S
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 20.03.2015
Témata:	Cell Line, Tumor Colony-Forming Units Assay DNA Damage HCT116 Cells HeLa Cells High-Throughput Screening Assays Humans Neoplasms - metabolism Neoplasms - radiotherapy Pyrithiamine - pharmacology Radiation Tolerance Radiation-Sensitizing Agents - pharmacology Thiamin Pyrophosphokinase - metabolism Thiamine - metabolism Transfection thiamine tumor radiosensitivity TPK1 high-throughput screening
ISSN:	1949-2553, 1949-2553
On-line přístup:	Zjistit podrobnosti o přístupu
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