Liposphere mediated topical delivery of thymoquinone in the treatment of psoriasis

Thymoquinone (TMQ) is reported with good anti-psoriatic activity; however, the hydrophobicity, poor aqueous solubility, light and pH sensitive nature of TMQ hinder its delivery to target site. To address these delivery challenges of TMQ, lipospheres were explored. The topical use of lipospheres offe...

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Veröffentlicht in:	Nanomedicine Jg. 13; H. 7; S. 2251 - 2262
Hauptverfasser:	Jain, Anjali, Pooladanda, Venkatesh, Bulbake, Upendra, Doppalapudi, Sindhu, Rafeeqi, Towseef Amin, Godugu, Chandraiah, Khan, Wahid
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.10.2017
Schlagworte:	Administration, Topical Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacokinetics Anti-Inflammatory Agents - therapeutic use Benzoquinones - administration & dosage Benzoquinones - pharmacokinetics Benzoquinones - therapeutic use Imiquimod induced psoriatic plaque model Inflammation Interleukin-17 - analysis Interleukin-2 - analysis Interleukin-6 - analysis Internal Medicine Liposomes Lipospheres Male Mice Mice, Inbred BALB C Psoriasis Psoriasis - drug therapy RAW 264.7 Cells Skin - drug effects Skin - pathology Skin Absorption Thymoquinone Tumor Necrosis Factor-alpha - analysis Inflammation Psoriasis Lipospheres Thymoquinone Imiquimod induced psoriatic plaque model Imiquimod induced psoriatic mice model
ISSN:	1549-9634, 1549-9642, 1549-9642
Online-Zugang:	Volltext
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