Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment

MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immu...

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Bibliographic Details
Published in:Frontiers in pediatrics Vol. 8; p. 626182
Main Authors: McMurray, Jeremy C., May, Joseph W., Cunningham, Madeleine W., Jones, Olcay Y.
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 16.12.2020
Subjects:
coronary artery aneurysm
IL-1 (interleukin-1)
MIS-C
myocarditis
Pediatrics
vasculitis
coronary artery aneurysm
MIS-C
vasculitis
IL-1 (interleukin-1)
myocarditis
ISSN:2296-2360, 2296-2360
Online Access:Get full text
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Summary:MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.
Bibliography:ObjectType-Article-1
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ObjectType-Review-3
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Edited by: Erkan Demirkaya, Western University, Canada
Reviewed by: David Piskin, Lawson Health Research Institute, Canada; Ozgur Kasapcopur, Istanbul University-Cerrahpasa, Turkey
This article was submitted to Pediatric Rheumatology, a section of the journal Frontiers in Pediatrics
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2020.626182