Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment

MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immu...

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Vydané v:Frontiers in pediatrics Ročník 8; s. 626182
Hlavní autori: McMurray, Jeremy C., May, Joseph W., Cunningham, Madeleine W., Jones, Olcay Y.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland Frontiers Media S.A 16.12.2020
Predmet:
coronary artery aneurysm
IL-1 (interleukin-1)
MIS-C
myocarditis
Pediatrics
vasculitis
coronary artery aneurysm
MIS-C
vasculitis
IL-1 (interleukin-1)
myocarditis
ISSN:2296-2360, 2296-2360
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Abstract MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.
AbstractList MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.
MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature on diagnosis, parameters of disease severity, and current treatment regimens. The clinical perspective was analyzed in light of potential immunopathogenesis and compared to other post-infectious and inflammatory illnesses of children affecting the heart. In this paradigm, the evidence supports the importance of endothelial injury and activation of the IL-1 pathway as a common determinant among MIS-C, Kawasaki disease, and Acute Rheumatic fever.
Author McMurray, Jeremy C.
Jones, Olcay Y.
May, Joseph W.
Cunningham, Madeleine W.
AuthorAffiliation 3 Department of Pediatrics, Uniformed Services University of the Health Sciences , Bethesda, MD , United States
2 Division of Pediatric Cardiology, Walter Reed National Military Medical Center (WRNMMC) , Bethesda, MD , United States
4 Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK , United States
5 Division of Pediatric Rheumatology, WRNMMC , Bethesda, MD , United States
1 Department of Pediatrics, Walter Reed National Military Medical Center (WRNMMC) , Bethesda , MD , United States
AuthorAffiliation_xml – name: 4 Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, OK , United States
– name: 1 Department of Pediatrics, Walter Reed National Military Medical Center (WRNMMC) , Bethesda , MD , United States
– name: 2 Division of Pediatric Cardiology, Walter Reed National Military Medical Center (WRNMMC) , Bethesda, MD , United States
– name: 3 Department of Pediatrics, Uniformed Services University of the Health Sciences , Bethesda, MD , United States
– name: 5 Division of Pediatric Rheumatology, WRNMMC , Bethesda, MD , United States
Author_xml – sequence: 1
  givenname: Jeremy C.
  surname: McMurray
  fullname: McMurray, Jeremy C.
– sequence: 2
  givenname: Joseph W.
  surname: May
  fullname: May, Joseph W.
– sequence: 3
  givenname: Madeleine W.
  surname: Cunningham
  fullname: Cunningham, Madeleine W.
– sequence: 4
  givenname: Olcay Y.
  surname: Jones
  fullname: Jones, Olcay Y.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33425823$$D View this record in MEDLINE/PubMed
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Keywords coronary artery aneurysm
MIS-C
vasculitis
IL-1 (interleukin-1)
myocarditis
Language English
License Copyright © 2020 McMurray, May, Cunningham and Jones.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Edited by: Erkan Demirkaya, Western University, Canada
Reviewed by: David Piskin, Lawson Health Research Institute, Canada; Ozgur Kasapcopur, Istanbul University-Cerrahpasa, Turkey
This article was submitted to Pediatric Rheumatology, a section of the journal Frontiers in Pediatrics
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  publication-title: Indian Heart J.
  doi: 10.1016/j.ihj.2020.10.001
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Snippet MIS-C is a newly defined post-viral myocarditis and inflammatory vasculopathy of children following COVID-19 infection. This review summarizes the literature...
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SubjectTerms coronary artery aneurysm
IL-1 (interleukin-1)
MIS-C
myocarditis
Pediatrics
vasculitis
Title Multisystem Inflammatory Syndrome in Children (MIS-C), a Post-viral Myocarditis and Systemic Vasculitis—A Critical Review of Its Pathogenesis and Treatment
URI https://www.ncbi.nlm.nih.gov/pubmed/33425823
https://www.proquest.com/docview/2476850346
https://pubmed.ncbi.nlm.nih.gov/PMC7793714
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