Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction
The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones. The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between...
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| Vydáno v: | American journal of obstetrics and gynecology Ročník 208; číslo 2; s. 130.e1 - 130.e6 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Mosby, Inc
01.02.2013
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| ISSN: | 0002-9378, 1097-6868, 1097-6868 |
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| Abstract | The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones.
The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications.
We included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4).
IUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children. |
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| AbstractList | The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones.
The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications.
We included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4).
IUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children. The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones.OBJECTIVEThe objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones.The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications.STUDY DESIGNThe outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications.We included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4).RESULTSWe included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4).IUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children.CONCLUSIONIUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children. Objective The objective of the study was to evaluate perinatal and long-term complications of fetuses with intrauterine growth restriction (IUGR) compared with constitutionally small for gestational age (SGA) ones. Study Design The outcome of infants with IUGR and SGA born at the Medical University Graz (Austria) between 2003 and 2009 was retrospectively analyzed. Group assignment was based on birthweight, Doppler ultrasound, and placental morphology. The primary outcome was neurodevelopmental delay at 2 years corrected age. The secondary outcomes were perinatal complications. Results We included 219 IUGR and 299 SGA infants for perinatal and 146 and 215 for long-term analysis. Fetuses with IUGR were delivered earlier (35 vs 38 weeks) and had higher rates of mortality (8% vs 1%; odds ratio [OR], 8.3) as well as perinatal complications (24.4% vs 1.0%; OR, 31.6). The long-term outcome was affected by increased risk for neurodevelopmental impairment (24.7% vs 5.6%; OR, 5.5) and growth delay (21.2% vs 7.4%; OR, 3.4). Conclusion IUGR infants are subject to an increased risk for adverse short- and long-term outcome compared with SGA children. |
| Author | von Beckerath, Anne-Karen Rotky-Fast, Christa Karpf, Eva Klaritsch, Philipp Lang, Uwe Kollmann, Martina |
| Author_xml | – sequence: 1 givenname: Anne-Karen surname: von Beckerath fullname: von Beckerath, Anne-Karen organization: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria – sequence: 2 givenname: Martina surname: Kollmann fullname: Kollmann, Martina organization: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria – sequence: 3 givenname: Christa surname: Rotky-Fast fullname: Rotky-Fast, Christa organization: Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria – sequence: 4 givenname: Eva surname: Karpf fullname: Karpf, Eva organization: Institute of Pathology, Medical University of Graz, Graz, Austria – sequence: 5 givenname: Uwe surname: Lang fullname: Lang, Uwe organization: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria – sequence: 6 givenname: Philipp surname: Klaritsch fullname: Klaritsch, Philipp email: philipp.klaritsch@medunigraz.at organization: Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23159694$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Adolescent Adult Austria - epidemiology Cesarean Section - statistics & numerical data Child, Preschool Cohort Studies Developmental Disabilities - epidemiology Developmental Disabilities - etiology Doppler ultrasound Female Fetal Growth Retardation - epidemiology Follow-Up Studies Humans Infant, Newborn Infant, Small for Gestational Age - growth & development intrauterine growth restriction Magnetic Resonance Imaging - methods Nervous System Diseases - epidemiology Nervous System Diseases - etiology neurodevelopmental impairment Obstetrics and Gynecology Peripartum Period Pregnancy Pregnancy Outcome - epidemiology Retrospective Studies Risk Assessment small for gestational age Ultrasonography, Doppler Young Adult |
| Title | Perinatal complications and long-term neurodevelopmental outcome of infants with intrauterine growth restriction |
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