Sleep and wakefulness disturbances in Parkinson's disease: A meta-analysis on prevalence and clinical aspects of REM sleep behavior disorder, excessive daytime sleepiness and insomnia

Sleep disorders (SDs) are common non-motor symptoms of Parkinson's disease (PD) with wide variability in their prevalence rates. The etiology of SDs in PD is multifactorial because the degenerative processes underlying the disease and their interaction with drugs and clinical features may promo...

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Vydané v:Sleep medicine reviews Ročník 68; s. 101759
Hlavní autori: Maggi, Gianpaolo, Vitale, Carmine, Cerciello, Francesco, Santangelo, Gabriella
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Elsevier Ltd 01.04.2023
Predmet:
Disorders of Excessive Somnolence - diagnosis
Disorders of Excessive Somnolence - epidemiology
Excessive daytime sleepiness
Humans
Insomnia
Neurology
Parkinson Disease - complications
Parkinson Disease - drug therapy
Parkinson Disease - epidemiology
Parkinson's disease
Prevalence
Quality of Life
REM sleep Behavior disorder
REM Sleep Behavior Disorder - complications
REM Sleep Behavior Disorder - etiology
Sleep
Sleep disorders
Sleep Initiation and Maintenance Disorders - complications
Sleep Initiation and Maintenance Disorders - epidemiology
Sleep Medicine
Sleep Wake Disorders
Wakefulness
Sleep disorders
Excessive daytime sleepiness
Parkinson's disease
Prevalence
REM sleep Behavior disorder
Insomnia
ISSN:1087-0792, 1532-2955, 1532-2955
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Shrnutí:Sleep disorders (SDs) are common non-motor symptoms of Parkinson's disease (PD) with wide variability in their prevalence rates. The etiology of SDs in PD is multifactorial because the degenerative processes underlying the disease and their interaction with drugs and clinical features may promote REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS) and insomnia. Therefore, we designed a meta-analytic study to provide a reliable estimate of the prevalence and associated clinical and neuropsychiatric aspects of SDs in PD. A systematic literature search was performed up to February 2022. Pooled RBD prevalence was 46%, and its occurrence was associated with older age, lower education, longer disease duration, higher levodopa equivalent daily dose (LEDD), worse motor and autonomic manifestations, poorer quality of life and autonomy, and more severe neuropsychiatric symptoms. The pooled prevalence of EDS was 35% and was associated with older age, longer disease duration, worse motor and autonomic symptoms, higher LEDD, reduced autonomy, and more severe neuropsychiatric symptoms. Insomnia was reported in 44% of PD patients and was related to longer disease duration, higher LEDD, and more severe depression. SDs are associated with a more severe PD clinical phenotype; further studies should explore the pathophysiological mechanisms underlying SDs and develop targeted therapeutic strategies.
Bibliografia:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ISSN:1087-0792
1532-2955
1532-2955
DOI:10.1016/j.smrv.2023.101759