Detection and characterization of a divergent avian reovirus strain from a broiler chicken with central nervous system disease

Avian orthoreoviruses have been associated with a variety of diseases in chickens, including tenosynovitis, runting-stunting syndrome, hepatitis, myocarditis, osteoporosis, respiratory diseases, and central nervous system disease. The primary objective of our study was the molecular characterization...

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Vydané v:	Archives of virology Ročník 158; číslo 12; s. 2583 - 2588
Hlavní autori:	Dandár, Eszter, Bálint, Ádám, Kecskeméti, Sándor, Szentpáli-Gavallér, Katalin, Kisfali, Péter, Melegh, Béla, Farkas, Szilvia L, Bányai, Krisztián
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Vienna Springer-Verlag 01.12.2013 Springer Vienna Springer Nature B.V
Predmet:	Animals Avian orthoreovirus Avian reovirus Biomedical and Life Sciences Biomedicine Brief Report broiler chickens cell culture central nervous system Central Nervous System Infections Central Nervous System Infections - veterinary Central Nervous System Infections - virology Chickens Cluster Analysis Food chains Genes genetic background genetics Genome, Viral Genomes Hepatitis Hungary Infectious Diseases isolation & purification Medical Microbiology Myocarditis Nervous system Neurological disorders nucleic acids nucleotide sequences Orthoreovirus, Avian Orthoreovirus, Avian - genetics Orthoreovirus, Avian - isolation & purification Osteoporosis Phylogenetics Phylogeny Poultry Poultry Diseases Poultry Diseases - virology Reoviridae Infections Reoviridae Infections - veterinary Reoviridae Infections - virology Reovirus Respiratory diseases respiratory tract diseases RNA, Viral RNA, Viral - genetics sequence analysis Sequence Analysis, DNA Sequence Homology, Nucleic Acid tenosynovitis veterinary Virology Hungary Phylogenetic analysis Genome sequencing Hungary
ISSN:	0304-8608, 1432-8798, 1432-8798
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Shrnutí:	Avian orthoreoviruses have been associated with a variety of diseases in chickens, including tenosynovitis, runting-stunting syndrome, hepatitis, myocarditis, osteoporosis, respiratory diseases, and central nervous system disease. The primary objective of our study was the molecular characterization of an avian reovirus strain, T1781, which was isolated from a broiler chicken with a central nervous system disorder in Hungary during 2012. The complete genome sequence was determined using a traditional sequencing method after cell culture adaptation of the strain. Sequence and phylogenetic analyses showed that T1781 shared only moderate nucleic acid sequence identity in several genes to previously analyzed reovirus strains from chickens, and each gene formed separate branches in the corresponding phylogenetic trees. The maximum nucleotide sequence identities of strain T1781 genes to reference avian reovirus strains ranged from 79 % to 90 %. Collectively, our analyses indicated that T1781 is a divergent chicken reovirus strain. The genetic background of this and other avian reoviruses associated with various disease manifestations needs further investigation.
Bibliografia:	http://dx.doi.org/10.1007/s00705-013-1739-y ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-8608 1432-8798 1432-8798
DOI:	10.1007/s00705-013-1739-y