Incidence, presentation and outcome of toxoplasmosis in HIV infected in the combination antiretroviral therapy era

HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years. From the Danish HIV Cohort Study, we identified 6325 HIV-infected individuals. We assessed incidence, mortality, predictive and prognostic factors of CTX during the pre-combination anti...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	The Journal of infection Ročník 75; číslo 3; s. 263 - 273
Hlavní autori:	Martin-Iguacel, Raquel, Ahlström, Magnus Glindvad, Touma, Madeleine, Engsig, Frederik Neess, Stærke, Nina Breinholt, Stærkind, Mette, Obel, Niels, Rasmussen, Line D.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Elsevier Ltd 01.09.2017
Predmet:	Adult AIDS-Related Opportunistic Infections - diagnosis AIDS-Related Opportunistic Infections - epidemiology AIDS-Related Opportunistic Infections - mortality AIDS-Related Opportunistic Infections - parasitology Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active Cerebral toxoplasmosis Cohort Studies Combination antiretroviral therapy Denmark - epidemiology Drug Therapy, Combination Female HIV HIV Infections - complications HIV Infections - drug therapy Humans Incidence Infectious Disease Male Middle Aged Opportunistic infections Poisson Distribution Prognosis Risk Factors Toxoplasmosis, Cerebral - diagnosis Toxoplasmosis, Cerebral - epidemiology Toxoplasmosis, Cerebral - mortality Toxoplasmosis, Cerebral - parasitology Opportunistic infections Combination antiretroviral therapy HIV Cerebral toxoplasmosis
ISSN:	0163-4453, 1532-2742, 1532-2742
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years. From the Danish HIV Cohort Study, we identified 6325 HIV-infected individuals. We assessed incidence, mortality, predictive and prognostic factors of CTX during the pre-combination antiretroviral therapy (pre-cART; 1995–1996) and cART-era (1997–2014). Adjusted incidence rate ratios (aIRR), mortality rate ratios (aMRR) and 95% confidence intervals (CI) were assessed using Poisson regression analysis. CTX IR was 1.17/1000 PYR (95% CI 0.93–1.47). We observed no change in CTX-risk in the first year after HIV-diagnosis, but a substantial reduction in mortality in the first 3 months after CTX diagnosis when comparing the cART-era to the pre-cART-era; {(aIRR: 0.79; 95% CI: 0.37–1.72) (aMRR: 0.15; 95% CI: 0.06–0.38)}. For individuals surviving the first year after HIV-diagnosis or the first 3 months after CTX-diagnosis, IRR and MRR had declined to minimal levels {(aIRR: 0.06; 95% CI: 0.03–0.10); (aMRR: 0.02; 95% CI: 0.01–0.05)}. Three years after CTX-diagnosis 30% of the patients still had neurological deficits. Although, CTX remains an important cause of morbidity and mortality in the cART-era, with high prevalence of neurological sequelae, incidence and mortality has largely declined, especially among those surviving the first year after diagnosis. •Data from the Danish HIV Cohort Study – a nationwide population-based cohort study.•Declining incidence of CTX in the cART-era after surviving the 1st year.•Declining CTX mortality in the cART-era, specially after surviving the first 3 months.•CTX remains an important cause of morbidity and mortality in late presenters.•CTX has an important impact in the patient's later well being and quality of life.
AbstractList	HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years.BACKGROUNDHIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years.From the Danish HIV Cohort Study, we identified 6325 HIV-infected individuals. We assessed incidence, mortality, predictive and prognostic factors of CTX during the pre-combination antiretroviral therapy (pre-cART; 1995-1996) and cART-era (1997-2014). Adjusted incidence rate ratios (aIRR), mortality rate ratios (aMRR) and 95% confidence intervals (CI) were assessed using Poisson regression analysis.METHODSFrom the Danish HIV Cohort Study, we identified 6325 HIV-infected individuals. We assessed incidence, mortality, predictive and prognostic factors of CTX during the pre-combination antiretroviral therapy (pre-cART; 1995-1996) and cART-era (1997-2014). Adjusted incidence rate ratios (aIRR), mortality rate ratios (aMRR) and 95% confidence intervals (CI) were assessed using Poisson regression analysis.CTX IR was 1.17/1000 PYR (95% CI 0.93-1.47). We observed no change in CTX-risk in the first year after HIV-diagnosis, but a substantial reduction in mortality in the first 3 months after CTX diagnosis when comparing the cART-era to the pre-cART-era; {(aIRR: 0.79; 95% CI: 0.37-1.72) (aMRR: 0.15; 95% CI: 0.06-0.38)}. For individuals surviving the first year after HIV-diagnosis or the first 3 months after CTX-diagnosis, IRR and MRR had declined to minimal levels {(aIRR: 0.06; 95% CI: 0.03-0.10); (aMRR: 0.02; 95% CI: 0.01-0.05)}. Three years after CTX-diagnosis 30% of the patients still had neurological deficits.RESULTSCTX IR was 1.17/1000 PYR (95% CI 0.93-1.47). We observed no change in CTX-risk in the first year after HIV-diagnosis, but a substantial reduction in mortality in the first 3 months after CTX diagnosis when comparing the cART-era to the pre-cART-era; {(aIRR: 0.79; 95% CI: 0.37-1.72) (aMRR: 0.15; 95% CI: 0.06-0.38)}. For individuals surviving the first year after HIV-diagnosis or the first 3 months after CTX-diagnosis, IRR and MRR had declined to minimal levels {(aIRR: 0.06; 95% CI: 0.03-0.10); (aMRR: 0.02; 95% CI: 0.01-0.05)}. Three years after CTX-diagnosis 30% of the patients still had neurological deficits.Although, CTX remains an important cause of morbidity and mortality in the cART-era, with high prevalence of neurological sequelae, incidence and mortality has largely declined, especially among those surviving the first year after diagnosis.CONCLUSIONAlthough, CTX remains an important cause of morbidity and mortality in the cART-era, with high prevalence of neurological sequelae, incidence and mortality has largely declined, especially among those surviving the first year after diagnosis. HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years. From the Danish HIV Cohort Study, we identified 6325 HIV-infected individuals. We assessed incidence, mortality, predictive and prognostic factors of CTX during the pre-combination antiretroviral therapy (pre-cART; 1995–1996) and cART-era (1997–2014). Adjusted incidence rate ratios (aIRR), mortality rate ratios (aMRR) and 95% confidence intervals (CI) were assessed using Poisson regression analysis. CTX IR was 1.17/1000 PYR (95% CI 0.93–1.47). We observed no change in CTX-risk in the first year after HIV-diagnosis, but a substantial reduction in mortality in the first 3 months after CTX diagnosis when comparing the cART-era to the pre-cART-era; {(aIRR: 0.79; 95% CI: 0.37–1.72) (aMRR: 0.15; 95% CI: 0.06–0.38)}. For individuals surviving the first year after HIV-diagnosis or the first 3 months after CTX-diagnosis, IRR and MRR had declined to minimal levels {(aIRR: 0.06; 95% CI: 0.03–0.10); (aMRR: 0.02; 95% CI: 0.01–0.05)}. Three years after CTX-diagnosis 30% of the patients still had neurological deficits. Although, CTX remains an important cause of morbidity and mortality in the cART-era, with high prevalence of neurological sequelae, incidence and mortality has largely declined, especially among those surviving the first year after diagnosis. •Data from the Danish HIV Cohort Study – a nationwide population-based cohort study.•Declining incidence of CTX in the cART-era after surviving the 1st year.•Declining CTX mortality in the cART-era, specially after surviving the first 3 months.•CTX remains an important cause of morbidity and mortality in late presenters.•CTX has an important impact in the patient's later well being and quality of life. Summary Background HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years. Methods From the Danish HIV Cohort Study, we identified 6325 HIV-infected individuals. We assessed incidence, mortality, predictive and prognostic factors of CTX during the pre-combination antiretroviral therapy (pre-cART; 1995–1996) and cART-era (1997–2014). Adjusted incidence rate ratios (aIRR), mortality rate ratios (aMRR) and 95% confidence intervals (CI) were assessed using Poisson regression analysis. Results CTX IR was 1.17/1000 PYR (95% CI 0.93–1.47). We observed no change in CTX-risk in the first year after HIV-diagnosis, but a substantial reduction in mortality in the first 3 months after CTX diagnosis when comparing the cART-era to the pre-cART-era; {(aIRR: 0.79; 95% CI: 0.37–1.72) (aMRR: 0.15; 95% CI: 0.06–0.38)}. For individuals surviving the first year after HIV-diagnosis or the first 3 months after CTX-diagnosis, IRR and MRR had declined to minimal levels {(aIRR: 0.06; 95% CI: 0.03–0.10); (aMRR: 0.02; 95% CI: 0.01–0.05)}. Three years after CTX-diagnosis 30% of the patients still had neurological deficits. Conclusion Although, CTX remains an important cause of morbidity and mortality in the cART-era, with high prevalence of neurological sequelae, incidence and mortality has largely declined, especially among those surviving the first year after diagnosis. HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years. From the Danish HIV Cohort Study, we identified 6325 HIV-infected individuals. We assessed incidence, mortality, predictive and prognostic factors of CTX during the pre-combination antiretroviral therapy (pre-cART; 1995-1996) and cART-era (1997-2014). Adjusted incidence rate ratios (aIRR), mortality rate ratios (aMRR) and 95% confidence intervals (CI) were assessed using Poisson regression analysis. CTX IR was 1.17/1000 PYR (95% CI 0.93-1.47). We observed no change in CTX-risk in the first year after HIV-diagnosis, but a substantial reduction in mortality in the first 3 months after CTX diagnosis when comparing the cART-era to the pre-cART-era; {(aIRR: 0.79; 95% CI: 0.37-1.72) (aMRR: 0.15; 95% CI: 0.06-0.38)}. For individuals surviving the first year after HIV-diagnosis or the first 3 months after CTX-diagnosis, IRR and MRR had declined to minimal levels {(aIRR: 0.06; 95% CI: 0.03-0.10); (aMRR: 0.02; 95% CI: 0.01-0.05)}. Three years after CTX-diagnosis 30% of the patients still had neurological deficits. Although, CTX remains an important cause of morbidity and mortality in the cART-era, with high prevalence of neurological sequelae, incidence and mortality has largely declined, especially among those surviving the first year after diagnosis.
Author	Ahlström, Magnus Glindvad Martin-Iguacel, Raquel Touma, Madeleine Stærke, Nina Breinholt Rasmussen, Line D. Stærkind, Mette Obel, Niels Engsig, Frederik Neess
Author_xml	– sequence: 1 givenname: Raquel surname: Martin-Iguacel fullname: Martin-Iguacel, Raquel email: raquel@bisaurin.org organization: Department of Infectious Diseases, Odense University Hospital, Søndre Boulevard 29, 5000 Odense C, Denmark – sequence: 2 givenname: Magnus Glindvad surname: Ahlström fullname: Ahlström, Magnus Glindvad organization: Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark – sequence: 3 givenname: Madeleine surname: Touma fullname: Touma, Madeleine organization: Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark – sequence: 4 givenname: Frederik Neess surname: Engsig fullname: Engsig, Frederik Neess organization: Department of Infectious Diseases, Copenhagen University Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark – sequence: 5 givenname: Nina Breinholt surname: Stærke fullname: Stærke, Nina Breinholt organization: Department of Infectious Diseases, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus, Denmark – sequence: 6 givenname: Mette surname: Stærkind fullname: Stærkind, Mette organization: Department of Infectious Diseases, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, Denmark – sequence: 7 givenname: Niels surname: Obel fullname: Obel, Niels organization: Department of Infectious Diseases, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark – sequence: 8 givenname: Line D. surname: Rasmussen fullname: Rasmussen, Line D. organization: Department of Infectious Diseases, Odense University Hospital, Søndre Boulevard 29, 5000 Odense C, Denmark
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/28579301$$D View this record in MEDLINE/PubMed
BookMark	eNqFUstu1DAUtVARnRZ-gAXKkgUJfsVJEKqEqkJHqsSCx9Zy7BvhkNjB9lTM3_At_TIcTWdTibK5V1c-59g-556hE-cdIPSS4IpgIt6O1WjdUFFMmgrXFSbtE7QhNaMlbTg9QZsMYiXnNTtFZzGOGOOOdeIZOqVt3XQMkw2KW6etAafhTbEEiOCSSta7QjlT-F3SfobCD3d_kv_tl0nF2UcbC-uK6-333AbQCcw6px9QZHRv3VEg2QAp-Fsb1LQeB7Xsi1yfo6eDmiK8uO_n6NvHq6-X1-XN50_byw83peaCpjK_T4uBDYIy3oLBnea9rkU3MNxrYzjveqoEawTFfdPwDsjQmoH3vK8Z5pyxc_T6oLsE_2sHMcnZRg3TpBz4XZSkw4LwuuE4Q1_dQ3f9DEYuwc4q7OXRqAxoDwAdfIwBBqntwakUlJ0kwXLNRI5yzUSumUhcy5xJptIH1KP6o6T3BxJkg24tBBm1XWMy2VSdpPH2cfrFA7qerLNaTT9hD3H0u-Cy9ZLISCWWX9ZNWReFNPmzQvAs8O7fAv-7_S-828-W
CitedBy_id	crossref_primary_10_3389_fmed_2022_759091 crossref_primary_10_1007_s00436_020_07007_5 crossref_primary_10_1097_QCO_0000000000001014 crossref_primary_10_1097_ID9_0000000000000105 crossref_primary_10_1128_CMR_00057_17 crossref_primary_10_1128_CMR_00115_19 crossref_primary_10_3390_diseases5040035 crossref_primary_10_1093_cid_ciz890 crossref_primary_10_1186_s12879_025_11231_8 crossref_primary_10_1093_ofid_ofad208 crossref_primary_10_1016_j_pt_2020_08_005 crossref_primary_10_1097_QAD_0000000000003723 crossref_primary_10_1097_QAD_0000000000001796 crossref_primary_10_1177_2325958219867315 crossref_primary_10_1177_23259582211043863 crossref_primary_10_1186_s12889_025_21317_2 crossref_primary_10_3390_microorganisms9122531 crossref_primary_10_3390_pathogens13050375
Cites_doi	10.1086/597468 10.1186/1743-8454-6-2 10.1371/journal.pone.0098666 10.1186/1471-2334-14-278 10.1086/424877 10.1128/JCM.43.10.5044-5047.2005 10.1093/cid/cir990 10.1002/ana.10827 10.1212/WNL.56.2.257 10.1089/apc.2005.19.626 10.1097/QAD.0b013e32835b0fa2 10.1093/ije/dyu153 10.1007/s11908-000-0016-x 10.1007/s10096-011-1254-6 10.1111/j.1468-1293.2012.01033.x 10.1016/j.bjid.2013.10.003 10.1111/j.1469-0691.2007.01683.x 10.1093/cid/ciw125 10.1056/NEJMoa1506816 10.1097/QAD.0b013e32833a3967 10.3171/jns.1985.62.4.0475 10.1016/S0140-6736(03)13802-0 10.1086/595299 10.1177/1403494810387965 10.1086/506366 10.1371/journal.pone.0005575 10.1111/j.1365-2125.2011.03935.x 10.1590/S1413-86702009000100006
ContentType	Journal Article
Copyright	2017 Copyright © 2017. Published by Elsevier Ltd.
Copyright_xml	– notice: 2017 – notice: Copyright © 2017. Published by Elsevier Ltd.
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1016/j.jinf.2017.05.018
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Medicine Public Health
EISSN	1532-2742
EndPage	273
ExternalDocumentID	28579301 10_1016_j_jinf_2017_05_018 S0163445317301664 1_s2_0_S0163445317301664
Genre	Journal Article
GroupedDBID	--- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 3O- 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AATTM AAWTL AAXKI AAXUO AAYWO ABBQC ABFNM ABFRF ABGAM ABJNI ABMAC ABMZM ABWVN ABXDB ACDAQ ACGFO ACGFS ACIEU ACLOT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADMUD ADNMO ADVLN AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFFNX AFJKZ AFPUW AFRHN AFTJW AFXIZ AGEKW AGHFR AGQPQ AGUBO AGYEJ AHHHB AI. AIEXJ AIGII AIIUN AIKHN AITUG AJRQY AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU ANZVX APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG CJTIS COF CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEJ HMK HMO HVGLF HZ~ IHE J1W J5H KOM L7B LUGTX M27 M41 MO0 N9A O-L O9- OAUVE OD- OO. OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SAE SDF SDG SDP SEL SES SEW SPCBC SSH SSI SSZ T5K UHS VH1 WUQ YHZ Z5R ZGI ~G- ~HD AACTN AFCTW AFKWA AJOXV AMFUW RIG 0SF AAIAV ABLVK ABYKQ AJBFU LCYCR 9DU AAYXX CITATION GROUPED_DOAJ CGR CUY CVF ECM EIF NPM 7X8
ID	FETCH-LOGICAL-c462t-301c6f3f62348ed09c4bc569f30bcdd449b2a637620b7749e1f8df4b4b5304433
ISICitedReferencesCount	23
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000408022800010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0163-4453 1532-2742
IngestDate	Sun Sep 28 08:55:15 EDT 2025 Wed Feb 19 02:43:01 EST 2025 Sat Nov 29 07:25:10 EST 2025 Tue Nov 18 22:30:39 EST 2025 Fri Feb 23 02:17:19 EST 2024 Tue Feb 25 20:04:45 EST 2025 Tue Oct 14 19:31:01 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Issue	3
Keywords	Opportunistic infections Combination antiretroviral therapy HIV Cerebral toxoplasmosis
Language	English
License	Copyright © 2017. Published by Elsevier Ltd.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c462t-301c6f3f62348ed09c4bc569f30bcdd449b2a637620b7749e1f8df4b4b5304433
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	28579301
PQID	1906145740
PQPubID	23479
PageCount	11
ParticipantIDs	proquest_miscellaneous_1906145740 pubmed_primary_28579301 crossref_citationtrail_10_1016_j_jinf_2017_05_018 crossref_primary_10_1016_j_jinf_2017_05_018 elsevier_sciencedirect_doi_10_1016_j_jinf_2017_05_018 elsevier_clinicalkeyesjournals_1_s2_0_S0163445317301664 elsevier_clinicalkey_doi_10_1016_j_jinf_2017_05_018
PublicationCentury	2000
PublicationDate	2017-09-01
PublicationDateYYYYMMDD	2017-09-01
PublicationDate_xml	– month: 09 year: 2017 text: 2017-09-01 day: 01
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	The Journal of infection
PublicationTitleAlternate	J Infect
PublicationYear	2017
Publisher	Elsevier Ltd
Publisher_xml	– name: Elsevier Ltd
References	Riveiro-Barciela, Falcó, Burgos, Curran, Van den Eynde, Navarro (bib20) 2012 Jun 25; 14 Pedersen (bib16) 2011 Jul 20; 39 Hoffmann, Ernst, Meyer, Wolf, Rosenkranz, Plettenberg (bib33) 2007 May; 13 Schwarcz, Chen, Vittinghoff, Hsu, Schwarcz (bib5) 2013 Feb; 27 Populations and elections: population in Denmark. 2015. Available at Podlekareva, Mocroft, Dragsted, Ledergerber, Beniowski, Lazzarin (bib22) 2006 Sep 1; 194 Colombo, Vidal, Oliveira, Hernandez, Bonasser-Filho, Nogueira (bib34) 2005 Oct 5; 43 Coelho, Cardoso, Amancio, Moreira, Campos, Veloso (bib3) 2014 Jun 5; 9 Low, Gavriilidis, Larke, B-Lajoie, Drouin, Stover (bib6) 2016 May 30; 62 Mocroft, Ledergerber, Katlama, Kirk, Reiss, d'Arminio Monforte (bib7) 2003 Jul 5; 362 Omland, Ahlstrom, Obel (bib15) 2014 Dec 23; 43 2015. (bib17) 1992 Dec 18; 41 (bib25) 2015 Aug 27; 373 [Accessed 1 January 2015]. 2016 Feb 17; 1–12. Antinori, Larussa, Cingolani, Lorenzini, Bossolasco, Finazzi (bib24) 2004 Dec 1; 39 Luft, Chua (bib31) 2000 Aug; 2 Coelho, Veloso, Grinsztejn, Luz (bib10) 2014 Mar 24; 18 (bib12) 2009 Apr 15; 48 d'Arminio Monforte, Cinque, Mocroft, Goebel, Antunes, Katlama (bib8) 2004 Mar; 55 Engsig, Hansen, Omland, Kronborg, Gerstoft, Laursen (bib9) 2009 Jan; 199 Luz, Bruyand, Ribeiro, Bonnet, Moreira, Hessamfar (bib11) 2014 May 21; 14 Nogui, Mattas, Turcato Júnior, Lewi (bib29) 2009 Feb; 13 Buchacz, Baker, Palella, Chmiel, Lichtenstein, Novak (bib4) 2010 Jun; 24 Kiderlen, Liesenfeld, Schürmann, Schneider (bib23) 2011 Apr 15; 30 Alfonso, Fraga, Fonseca, Jiménez, Pinillos, Dorta-Contreras (bib28) 2009; 6 Julander, Martin, Lappalainen (bib30) 2009 Jul 8; 33 Jones, Roberts (bib21) 2012 Mar 8; 54 . Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. Available from Zolopa, Andersen, Komarow, Sanne, Sanchez, Hogg (bib26) 2009 May 18; 4 Vidal, Hernandez, de Oliveira, Dauar, Barbosa, Focaccia (bib27) 2005 Oct; 19 Eurosida list of definitions on clinical events. 2015 Dec 9; 1–4. Available from Levy, Bredesen, Rosenblum (bib32) 1985 Apr; 62 (bib2) 2010 Dec 15; 18 Sacktor, Lyles, Skolasky, Kleeberger, Selnes, Miller (bib1) 2001 Jan 23; 56 Petersen, Andersen, Gerstoft, Thorsteinsson, Larsen, Pedersen (bib14) 2011 Jun 9; 72 Buchacz (10.1016/j.jinf.2017.05.018_bib4) 2010; 24 10.1016/j.jinf.2017.05.018_bib13 Antinori (10.1016/j.jinf.2017.05.018_bib24) 2004; 39 Petersen (10.1016/j.jinf.2017.05.018_bib14) 2011; 72 (10.1016/j.jinf.2017.05.018_bib17) 1992; 41 Kiderlen (10.1016/j.jinf.2017.05.018_bib23) 2011; 30 Vidal (10.1016/j.jinf.2017.05.018_bib27) 2005; 19 Sacktor (10.1016/j.jinf.2017.05.018_bib1) 2001; 56 Riveiro-Barciela (10.1016/j.jinf.2017.05.018_bib20) 2012; 14 Omland (10.1016/j.jinf.2017.05.018_bib15) 2014; 43 Schwarcz (10.1016/j.jinf.2017.05.018_bib5) 2013; 27 Coelho (10.1016/j.jinf.2017.05.018_bib3) 2014; 9 Pedersen (10.1016/j.jinf.2017.05.018_bib16) 2011; 39 d'Arminio Monforte (10.1016/j.jinf.2017.05.018_bib8) 2004; 55 Luft (10.1016/j.jinf.2017.05.018_bib31) 2000; 2 Mocroft (10.1016/j.jinf.2017.05.018_bib7) 2003; 362 (10.1016/j.jinf.2017.05.018_bib12) 2009; 48 Colombo (10.1016/j.jinf.2017.05.018_bib34) 2005; 43 (10.1016/j.jinf.2017.05.018_bib2) 2010; 18 Low (10.1016/j.jinf.2017.05.018_bib6) 2016; 62 Jones (10.1016/j.jinf.2017.05.018_bib21) 2012; 54 Luz (10.1016/j.jinf.2017.05.018_bib11) 2014; 14 (10.1016/j.jinf.2017.05.018_bib25) 2015; 373 Podlekareva (10.1016/j.jinf.2017.05.018_bib22) 2006; 194 Engsig (10.1016/j.jinf.2017.05.018_bib9) 2009; 199 Zolopa (10.1016/j.jinf.2017.05.018_bib26) 2009; 4 Alfonso (10.1016/j.jinf.2017.05.018_bib28) 2009; 6 Nogui (10.1016/j.jinf.2017.05.018_bib29) 2009; 13 10.1016/j.jinf.2017.05.018_bib19 10.1016/j.jinf.2017.05.018_bib18 Julander (10.1016/j.jinf.2017.05.018_bib30) 2009; 33 Levy (10.1016/j.jinf.2017.05.018_bib32) 1985; 62 Hoffmann (10.1016/j.jinf.2017.05.018_bib33) 2007; 13 Coelho (10.1016/j.jinf.2017.05.018_bib10) 2014; 18
References_xml	– reference: . [Accessed 1 January 2015]. 2016 Feb 17; 1–12. – volume: 43 start-page: 1769 year: 2014 Dec 23 ident: bib15 article-title: Cohort profile update: the Danish HIV cohort study (DHCS) publication-title: Int J Epidemiol – volume: 19 start-page: 626 year: 2005 Oct end-page: 634 ident: bib27 article-title: Cerebral toxoplasmosis in HIV-positive patients in Brazil: clinical features and predictors of treatment response in the HAART era publication-title: AIDS Patient Care STDS – volume: 62 start-page: 1595 year: 2016 May 30 end-page: 1603 ident: bib6 article-title: Incidence of opportunistic infections and the impact of antiretroviral therapy among HIV-infected adults in low- and middle-income countries: a systematic review and meta-analysis publication-title: Clin Infect Dis – volume: 362 start-page: 22 year: 2003 Jul 5 end-page: 29 ident: bib7 article-title: Decline in the AIDS and death rates in the EuroSIDA study: an observational study publication-title: Lancet – reference: Populations and elections: population in Denmark. 2015. Available at: – volume: 14 start-page: 21 year: 2012 Jun 25 end-page: 30 ident: bib20 article-title: Neurological opportunistic infections and neurological immune reconstitution syndrome: impact of one decade of highly active antiretroviral treatment in a tertiary hospital publication-title: HIV Med – volume: 199 start-page: 77 year: 2009 Jan end-page: 83 ident: bib9 article-title: Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study publication-title: J Infect Dis – volume: 18 start-page: 196 year: 2014 Mar 24 end-page: 210 ident: bib10 article-title: Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review publication-title: Braz J Infect Dis – volume: 6 start-page: 2 year: 2009 ident: bib28 article-title: Molecular diagnosis of Toxoplasma gondii infection in cerebrospinal fluid from AIDS patients publication-title: Cerebrospinal Fluid Res – volume: 27 start-page: 597 year: 2013 Feb end-page: 605 ident: bib5 article-title: Declining incidence of AIDS-defining opportunistic illnesses publication-title: AIDS – volume: 24 start-page: 1549 year: 2010 Jun end-page: 1559 ident: bib4 article-title: AIDS-defining opportunistic illnesses in US patients, 1994–2007: a cohort study publication-title: AIDS – volume: 41 start-page: 1 year: 1992 Dec 18 end-page: 19 ident: bib17 article-title: 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults publication-title: MMWR Recomm Rep – volume: 9 start-page: e98666 year: 2014 Jun 5 ident: bib3 article-title: Trends in AIDS-Defining opportunistic illnesses incidence over 25 years in Rio de Janeiro, Brazil publication-title: PLoS One – volume: 62 start-page: 475 year: 1985 Apr end-page: 495 ident: bib32 article-title: Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature publication-title: J Neurosurg – volume: 18 start-page: 527 year: 2010 Dec 15 end-page: 534 ident: bib2 article-title: HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era publication-title: Eur J Neurol – reference: Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. Available from: – volume: 33 start-page: 538 year: 2009 Jul 8 end-page: 541 ident: bib30 article-title: Polymerase chain reaction for diagnosis of cerebral toxoplasmosis in cerebrospinal fluid in HIV-positive patients publication-title: Scand J Infect Dis – volume: 13 start-page: 18 year: 2009 Feb end-page: 23 ident: bib29 article-title: Neurotoxoplasmosis diagnosis for HIV-1 patients by real-time PCR of cerebrospinal fluid publication-title: Braz J Infect Dis – volume: 56 start-page: 257 year: 2001 Jan 23 end-page: 260 ident: bib1 article-title: HIV-associated neurologic disease incidence changes:: multicenter AIDS Cohort Study, 1990–1998 publication-title: Neurology – volume: 48 start-page: 1138 year: 2009 Apr 15 end-page: 1151 ident: bib12 article-title: Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy: not all AIDS-defining conditions are created equal publication-title: Clin Infect Dis – volume: 43 start-page: 5044 year: 2005 Oct 5 end-page: 5047 ident: bib34 article-title: Diagnosis of cerebral toxoplasmosis in AIDS patients in Brazil: importance of molecular and immunological methods using peripheral blood samples publication-title: J Clin Microbiol – volume: 13 start-page: 510 year: 2007 May end-page: 515 ident: bib33 article-title: Evolving characteristics of toxoplasmosis in patients infected with human immunodeficiency virus-1: clinical course and Toxoplasma gondii-specific immune responses publication-title: Clin Microbiol Infect – reference: . 2015. – volume: 39 start-page: 1681 year: 2004 Dec 1 end-page: 1691 ident: bib24 article-title: Prevalence, associated factors, and prognostic determinants of AIDS-related toxoplasmic encephalitis in the era of advanced highly active antiretroviral therapy publication-title: Clin Infect Dis – volume: 54 start-page: e58 year: 2012 Mar 8 end-page: e61 ident: bib21 article-title: Toxoplasmosis hospitalizations in the United States, 2008, and trends, 1993–2008 publication-title: Clin Infect Dis – reference: . – volume: 2 start-page: 358 year: 2000 Aug end-page: 362 ident: bib31 article-title: Central nervous system toxoplasmosis in HIV pathogenesis, diagnosis, and therapy publication-title: Curr Infect Dis Rep – volume: 30 start-page: 1521 year: 2011 Apr 15 end-page: 1525 ident: bib23 article-title: Toxoplasmic encephalitis in AIDS-patients before and after the introduction of highly active antiretroviral therapy (HAART) publication-title: Eur J Clin Microbiol Infect Dis [Internet] – reference: Eurosida list of definitions on clinical events. 2015 Dec 9; 1–4. Available from: – volume: 55 start-page: 320 year: 2004 Mar end-page: 328 ident: bib8 article-title: Changing incidence of central nervous system diseases in the EuroSIDA cohort publication-title: Ann Neurol – volume: 72 start-page: 116 year: 2011 Jun 9 end-page: 124 ident: bib14 article-title: Adherence to national guidelines for initiation of antiretroviral regimens in HIV patients: a Danish nationwide study publication-title: Br J Clin Pharmacol – volume: 4 start-page: e5575 year: 2009 May 18 ident: bib26 article-title: Early antiretroviral therapy reduces AIDS progression/death in individuals with acute opportunistic infections: a multicenter randomized strategy trial publication-title: PLoS One – volume: 39 start-page: 22 year: 2011 Jul 20 end-page: 25 ident: bib16 article-title: The Danish civil registration system publication-title: Scand J Public Health – volume: 194 start-page: 633 year: 2006 Sep 1 end-page: 641 ident: bib22 article-title: Factors associated with the development of opportunistic infections in HIV-1-infected adults with high CD4+ cell counts: a EuroSIDA study publication-title: J Infect Dis – volume: 373 start-page: 795 year: 2015 Aug 27 end-page: 807 ident: bib25 article-title: Initiation of antiretroviral therapy in early asymptomatic HIV infection publication-title: N Engl J Med – volume: 14 start-page: 1 year: 2014 May 21 end-page: 13 ident: bib11 article-title: AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000–2008: hospital-based cohort studies publication-title: BMC Infect Dis – volume: 18 start-page: 527 issue: 3 year: 2010 ident: 10.1016/j.jinf.2017.05.018_bib2 article-title: HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era publication-title: Eur J Neurol – volume: 48 start-page: 1138 issue: 8 year: 2009 ident: 10.1016/j.jinf.2017.05.018_bib12 article-title: Variable impact on mortality of AIDS-defining events diagnosed during combination antiretroviral therapy: not all AIDS-defining conditions are created equal publication-title: Clin Infect Dis doi: 10.1086/597468 – volume: 6 start-page: 2 issue: 1 year: 2009 ident: 10.1016/j.jinf.2017.05.018_bib28 article-title: Molecular diagnosis of Toxoplasma gondii infection in cerebrospinal fluid from AIDS patients publication-title: Cerebrospinal Fluid Res doi: 10.1186/1743-8454-6-2 – volume: 9 start-page: e98666 issue: 6 year: 2014 ident: 10.1016/j.jinf.2017.05.018_bib3 article-title: Trends in AIDS-Defining opportunistic illnesses incidence over 25 years in Rio de Janeiro, Brazil publication-title: PLoS One doi: 10.1371/journal.pone.0098666 – volume: 14 start-page: 1 issue: 1 year: 2014 ident: 10.1016/j.jinf.2017.05.018_bib11 article-title: AIDS and non-AIDS severe morbidity associated with hospitalizations among HIV-infected patients in two regions with universal access to care and antiretroviral therapy, France and Brazil, 2000–2008: hospital-based cohort studies publication-title: BMC Infect Dis doi: 10.1186/1471-2334-14-278 – volume: 39 start-page: 1681 issue: 11 year: 2004 ident: 10.1016/j.jinf.2017.05.018_bib24 article-title: Prevalence, associated factors, and prognostic determinants of AIDS-related toxoplasmic encephalitis in the era of advanced highly active antiretroviral therapy publication-title: Clin Infect Dis doi: 10.1086/424877 – volume: 43 start-page: 5044 issue: 10 year: 2005 ident: 10.1016/j.jinf.2017.05.018_bib34 article-title: Diagnosis of cerebral toxoplasmosis in AIDS patients in Brazil: importance of molecular and immunological methods using peripheral blood samples publication-title: J Clin Microbiol doi: 10.1128/JCM.43.10.5044-5047.2005 – volume: 54 start-page: e58 issue: 7 year: 2012 ident: 10.1016/j.jinf.2017.05.018_bib21 article-title: Toxoplasmosis hospitalizations in the United States, 2008, and trends, 1993–2008 publication-title: Clin Infect Dis doi: 10.1093/cid/cir990 – volume: 55 start-page: 320 issue: 3 year: 2004 ident: 10.1016/j.jinf.2017.05.018_bib8 article-title: Changing incidence of central nervous system diseases in the EuroSIDA cohort publication-title: Ann Neurol doi: 10.1002/ana.10827 – volume: 56 start-page: 257 issue: 2 year: 2001 ident: 10.1016/j.jinf.2017.05.018_bib1 article-title: HIV-associated neurologic disease incidence changes:: multicenter AIDS Cohort Study, 1990–1998 publication-title: Neurology doi: 10.1212/WNL.56.2.257 – volume: 19 start-page: 626 issue: 10 year: 2005 ident: 10.1016/j.jinf.2017.05.018_bib27 article-title: Cerebral toxoplasmosis in HIV-positive patients in Brazil: clinical features and predictors of treatment response in the HAART era publication-title: AIDS Patient Care STDS doi: 10.1089/apc.2005.19.626 – volume: 27 start-page: 597 issue: 4 year: 2013 ident: 10.1016/j.jinf.2017.05.018_bib5 article-title: Declining incidence of AIDS-defining opportunistic illnesses publication-title: AIDS doi: 10.1097/QAD.0b013e32835b0fa2 – volume: 43 start-page: 1769 issue: 6 year: 2014 ident: 10.1016/j.jinf.2017.05.018_bib15 article-title: Cohort profile update: the Danish HIV cohort study (DHCS) publication-title: Int J Epidemiol doi: 10.1093/ije/dyu153 – ident: 10.1016/j.jinf.2017.05.018_bib18 – volume: 2 start-page: 358 issue: 4 year: 2000 ident: 10.1016/j.jinf.2017.05.018_bib31 article-title: Central nervous system toxoplasmosis in HIV pathogenesis, diagnosis, and therapy publication-title: Curr Infect Dis Rep doi: 10.1007/s11908-000-0016-x – volume: 30 start-page: 1521 issue: 12 year: 2011 ident: 10.1016/j.jinf.2017.05.018_bib23 article-title: Toxoplasmic encephalitis in AIDS-patients before and after the introduction of highly active antiretroviral therapy (HAART) publication-title: Eur J Clin Microbiol Infect Dis [Internet] doi: 10.1007/s10096-011-1254-6 – volume: 14 start-page: 21 issue: 1 year: 2012 ident: 10.1016/j.jinf.2017.05.018_bib20 article-title: Neurological opportunistic infections and neurological immune reconstitution syndrome: impact of one decade of highly active antiretroviral treatment in a tertiary hospital publication-title: HIV Med doi: 10.1111/j.1468-1293.2012.01033.x – volume: 18 start-page: 196 issue: 2 year: 2014 ident: 10.1016/j.jinf.2017.05.018_bib10 article-title: Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review publication-title: Braz J Infect Dis doi: 10.1016/j.bjid.2013.10.003 – volume: 13 start-page: 510 issue: 5 year: 2007 ident: 10.1016/j.jinf.2017.05.018_bib33 article-title: Evolving characteristics of toxoplasmosis in patients infected with human immunodeficiency virus-1: clinical course and Toxoplasma gondii-specific immune responses publication-title: Clin Microbiol Infect doi: 10.1111/j.1469-0691.2007.01683.x – volume: 62 start-page: 1595 issue: 12 year: 2016 ident: 10.1016/j.jinf.2017.05.018_bib6 article-title: Incidence of opportunistic infections and the impact of antiretroviral therapy among HIV-infected adults in low- and middle-income countries: a systematic review and meta-analysis publication-title: Clin Infect Dis doi: 10.1093/cid/ciw125 – volume: 373 start-page: 795 issue: 9 year: 2015 ident: 10.1016/j.jinf.2017.05.018_bib25 article-title: Initiation of antiretroviral therapy in early asymptomatic HIV infection publication-title: N Engl J Med doi: 10.1056/NEJMoa1506816 – volume: 24 start-page: 1549 issue: 10 year: 2010 ident: 10.1016/j.jinf.2017.05.018_bib4 article-title: AIDS-defining opportunistic illnesses in US patients, 1994–2007: a cohort study publication-title: AIDS doi: 10.1097/QAD.0b013e32833a3967 – volume: 62 start-page: 475 issue: 4 year: 1985 ident: 10.1016/j.jinf.2017.05.018_bib32 article-title: Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature publication-title: J Neurosurg doi: 10.3171/jns.1985.62.4.0475 – volume: 41 start-page: 1 issue: RR-17 year: 1992 ident: 10.1016/j.jinf.2017.05.018_bib17 article-title: 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults publication-title: MMWR Recomm Rep – volume: 362 start-page: 22 issue: 9377 year: 2003 ident: 10.1016/j.jinf.2017.05.018_bib7 article-title: Decline in the AIDS and death rates in the EuroSIDA study: an observational study publication-title: Lancet doi: 10.1016/S0140-6736(03)13802-0 – volume: 199 start-page: 77 issue: 1 year: 2009 ident: 10.1016/j.jinf.2017.05.018_bib9 article-title: Incidence, clinical presentation, and outcome of progressive multifocal leukoencephalopathy in HIV-infected patients during the highly active antiretroviral therapy era: a nationwide cohort study publication-title: J Infect Dis doi: 10.1086/595299 – ident: 10.1016/j.jinf.2017.05.018_bib13 – volume: 33 start-page: 538 issue: 7 year: 2009 ident: 10.1016/j.jinf.2017.05.018_bib30 article-title: Polymerase chain reaction for diagnosis of cerebral toxoplasmosis in cerebrospinal fluid in HIV-positive patients publication-title: Scand J Infect Dis – volume: 39 start-page: 22 issue: 7 Suppl year: 2011 ident: 10.1016/j.jinf.2017.05.018_bib16 article-title: The Danish civil registration system publication-title: Scand J Public Health doi: 10.1177/1403494810387965 – volume: 194 start-page: 633 issue: 5 year: 2006 ident: 10.1016/j.jinf.2017.05.018_bib22 article-title: Factors associated with the development of opportunistic infections in HIV-1-infected adults with high CD4+ cell counts: a EuroSIDA study publication-title: J Infect Dis doi: 10.1086/506366 – volume: 4 start-page: e5575 issue: 5 year: 2009 ident: 10.1016/j.jinf.2017.05.018_bib26 article-title: Early antiretroviral therapy reduces AIDS progression/death in individuals with acute opportunistic infections: a multicenter randomized strategy trial publication-title: PLoS One doi: 10.1371/journal.pone.0005575 – volume: 72 start-page: 116 issue: 1 year: 2011 ident: 10.1016/j.jinf.2017.05.018_bib14 article-title: Adherence to national guidelines for initiation of antiretroviral regimens in HIV patients: a Danish nationwide study publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.2011.03935.x – ident: 10.1016/j.jinf.2017.05.018_bib19 – volume: 13 start-page: 18 issue: 1 year: 2009 ident: 10.1016/j.jinf.2017.05.018_bib29 article-title: Neurotoxoplasmosis diagnosis for HIV-1 patients by real-time PCR of cerebrospinal fluid publication-title: Braz J Infect Dis doi: 10.1590/S1413-86702009000100006
SSID	ssj0009396
Score	2.3054996
Snippet	HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years. From the Danish HIV Cohort Study, we... Summary Background HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years. Methods From the Danish... HIV-associated incidence and prognosis of cerebral toxoplasmosis (CTX) is not well established during later years.BACKGROUNDHIV-associated incidence and...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	263
SubjectTerms	Adult AIDS-Related Opportunistic Infections - diagnosis AIDS-Related Opportunistic Infections - epidemiology AIDS-Related Opportunistic Infections - mortality AIDS-Related Opportunistic Infections - parasitology Anti-HIV Agents - adverse effects Anti-HIV Agents - therapeutic use Antiretroviral Therapy, Highly Active Cerebral toxoplasmosis Cohort Studies Combination antiretroviral therapy Denmark - epidemiology Drug Therapy, Combination Female HIV HIV Infections - complications HIV Infections - drug therapy Humans Incidence Infectious Disease Male Middle Aged Opportunistic infections Poisson Distribution Prognosis Risk Factors Toxoplasmosis, Cerebral - diagnosis Toxoplasmosis, Cerebral - epidemiology Toxoplasmosis, Cerebral - mortality Toxoplasmosis, Cerebral - parasitology
Title	Incidence, presentation and outcome of toxoplasmosis in HIV infected in the combination antiretroviral therapy era
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0163445317301664 https://www.clinicalkey.es/playcontent/1-s2.0-S0163445317301664 https://dx.doi.org/10.1016/j.jinf.2017.05.018 https://www.ncbi.nlm.nih.gov/pubmed/28579301 https://www.proquest.com/docview/1906145740
Volume	75
WOSCitedRecordID	wos000408022800010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: ScienceDirect database customDbUrl: eissn: 1532-2742 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0009396 issn: 0163-4453 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6DSEkhGAwKJfJSOxpZMrFufixVAXGZUIwpL5ZjuOUVl1SNUlV_g3_gP_AL-O4dpJuo-Mi8RK1aeykOV98jk--8xmhZ4FPpStoZPmhG1skdoVFvUTJ3cXSc6RH03Qlmf8uPDmJhkP6odP5XtfCLKZhlkXLJZ39V1PDPjC2Kp39C3M3ncIO-AxGhy2YHbZ_ZHh44vVCoeruzdrqIs06zqsSTqoSBQd996Bnl_kyn0EEfZYrZRIlfAXzQc3QkklNgoQWMIGuOylhlCxVJkLV9uv6ra-Hcs7X49y24syIUmjKV4NErV5gHY8qLjRP4CMHD9XQPXpfpkW5eov_ItBJWz7KquLwFUTFyYInbXK8OuP6d7WizxpJYJCNivFIx-ZKMGOsSjpquolJc4DrrHlcTeYz8CxCtLLwpXFfpyAmRxPYq_h6Ro41ar1c_WZ_0H_rWIV7ZFufVJeqR0eNcoEWU78gvu2wwmU2u3ToFtpxQ5_CMLrTOx4M37Q6z95qSbjmak2dlqYUXry6TbHQprnOKuY5vY1uGQPingbZHdSR2S66_t7QMXbRTZ30xbqW7S4qGuw9x-vIw4A8bJCH8_THt3Oow-MMA-pwjTr1HWCF11CHz6MOG9Rh2N5Dn18OTvuvLbOqhyVI4JYW3EARpF4KcTeJZGJTQWLhBzT17FgkCSE0dnkAfs-1Y5ibUOmkUZKSmMS-ZxPieXtoO8sz-QBhiP5dTkREIh5AkEWiIEgFlzHlIlaJjy5y6vvLhJG8VyuvTFnNbZwwZROmbMJsn4FNuuiwaTPTgi9XHu3VZmN1KTM4Xwa4vLJV-KtWsjDDSME24a6L_KalCZF16PvbMz6tMcXAf6iXgjyTeQVnoion5IfE7qL7GmzN_3YjH9y37Tz85-t9hG60D_NjtF3OK_kEXROLclzM99FWOIz2zSP0E11G9c4
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Incidence%2C+presentation+and+outcome+of%C2%A0toxoplasmosis+in+HIV+infected+in+the+combination+antiretroviral+therapy+era&rft.jtitle=The+Journal+of+infection&rft.au=Martin-Iguacel%2C+Raquel&rft.au=Ahlstr%C3%B6m%2C+Magnus+Glindvad&rft.au=Touma%2C+Madeleine&rft.au=Engsig%2C+Frederik+Neess&rft.date=2017-09-01&rft.issn=0163-4453&rft_id=info:doi/10.1016%2Fj.jinf.2017.05.018&rft.externalDBID=ECK1-s2.0-S0163445317301664&rft.externalDocID=1_s2_0_S0163445317301664
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0163-4453&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0163-4453&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0163-4453&client=summon