Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure

Adverse remodeling of the extracellular matrix (ECM) is a significant characteristic of heart failure. Reverse remodeling of the fibrillar ECM secondary to mechanical unloading of the left ventricle (LV) by left ventricular assist device (LVAD) has been subject of intense investigation; however, lit...

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Bibliographic Details
Published in:	Translational research : the journal of laboratory and clinical medicine Vol. 172; pp. 30 - 44
Main Authors:	Sakamuri, Siva S.V.P., Takawale, Abhijit, Basu, Ratnadeep, Fedak, Paul W.M., Freed, Darren, Sergi, Consolato, Oudit, Gavin Y., Kassiri, Zamaneh
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2016
Subjects:	ADAMTS Proteins - metabolism Adult Basement Membrane - metabolism Biomechanical Phenomena Collagen - metabolism Extracellular Matrix - chemistry Extracellular Matrix - metabolism Female Fibrosis Heart Failure - physiopathology Heart Ventricles - pathology Heart Ventricles - physiopathology Heart-Assist Devices Humans Integrin beta1 - metabolism Internal Medicine Male Models, Biological Myocardium - metabolism Osteonectin - metabolism Osteopontin - metabolism Proteolysis RNA, Messenger - genetics RNA, Messenger - metabolism Solubility Tissue Inhibitor of Metalloproteinases - genetics Tissue Inhibitor of Metalloproteinases - metabolism BiVAD OCT SPARC LV IQR EDTA OPN ECM LVAD PSR DCM MMP ADAMTS2 MT1-MMP RT-PCR ACEi TGFβ HF biventricular assist device left ventricle transforming growth factor beta secreted protein acidic and rich in cysteine angiotensin-converting-enzyme inhibitor interquartile range picrosirius red ethylenediaminetetraacetic acid dilated cardiomyopathy heart failure osteopontin A disintegrin and metalloproteinase with thrombospondin motifs 2 membrane type 1-matrix metalloproteinase optimal cutting temperature reverse transcription polymerase chain reaction matrix metalloproteinase left ventricular assist device extracellular matrix
ISSN:	1931-5244, 1878-1810
Online Access:	Get full text
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