The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects

Metabotropic glutamate receptor 5 (mGlu5) has been shown to modulate nociception in animals, but no mGlu5 antagonists have been developed commercially as analgesics. The mGlu5 antagonist fenobam [N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazole-2-yl)urea] was originally evaluated...

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Bibliographic Details
Published in:	Pain (Amsterdam) Vol. 161; no. 1; p. 135
Main Authors:	Cavallone, Laura F, Montana, Michael C, Frey, Karen, Kallogjeri, Dorina, Wages, James M, Rodebaugh, Thomas L, Doshi, Tina, Kharasch, Evan D, Gereau, 4th, Robert W
Format:	Journal Article
Language:	English
Published:	United States 01.01.2020
Subjects:	Adult Analgesics - pharmacokinetics Analgesics - pharmacology Analgesics - therapeutic use Double-Blind Method Excitatory Amino Acid Antagonists - pharmacokinetics Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acid Antagonists - therapeutic use Female Healthy Volunteers Humans Hyperalgesia - drug therapy Imidazoles - pharmacokinetics Imidazoles - pharmacology Imidazoles - therapeutic use Male Middle Aged Pain - drug therapy Pain Measurement Receptor, Metabotropic Glutamate 5 - antagonists & inhibitors Treatment Outcome Young Adult
ISSN:	1872-6623, 1872-6623
Online Access:	Get more information
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