The chameleon of neuroinflammation: magnetic resonance imaging characteristics of natalizumab-associated progressive multifocal leukoencephalopathy

Natalizumab is a monoclonal antibody against α4-integrin approved for the treatment of multiple sclerosis (MS) due to a positive effect on clinical and magnetic resonance imaging (MRI) outcome measures. However, one relatively rare but serious side effect of this drug is a higher risk of developing...

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Bibliographic Details
Published in:	Multiple sclerosis Vol. 19; no. 14; pp. 1826 - 1840
Main Authors:	Wattjes, Mike P, Richert, Nancy D, Killestein, Joep, de Vos, Marlieke, Sanchez, Esther, Snaebjornsson, Petur, Cadavid, Diego, Barkhof, Frederik
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01.12.2013 Sage Publications Sage Publications Ltd
Subjects:	Animals Antibodies, Monoclonal, Humanized - adverse effects Biological and medical sciences Brain - drug effects Brain - pathology Brain - virology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Demyelinating Diseases - pathology Diagnosis, Differential Early Diagnosis Human viral diseases Humans Immune Reconstitution Inflammatory Syndrome - chemically induced Immune Reconstitution Inflammatory Syndrome - pathology Immune Reconstitution Inflammatory Syndrome - virology Immunologic Factors - adverse effects Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Leukoencephalopathy, Progressive Multifocal - chemically induced Leukoencephalopathy, Progressive Multifocal - pathology Leukoencephalopathy, Progressive Multifocal - virology Magnetic Resonance Imaging Medical sciences Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Natalizumab Nervous system Neuroimaging - methods Neurology Predictive Value of Tests Radiodiagnosis. Nmr imagery. Nmr spectrometry Viral diseases Viral diseases of the nervous system Multiple sclerosis magnetic resonance imaging progressive multifocal leukoencephalopathy natalizumab Nervous system diseases Natalizumab Nuclear magnetic resonance imaging Inflammatory disease Cerebral disorder Progressive multifocal leukoencephalopathy Infection Virus Viral disease Central nervous system disease Medical imagery Degenerative disease Slow virus
ISSN:	1352-4585, 1477-0970, 1477-0970
Online Access:	Get full text
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