Detection of Bleeding Events in Electronic Health Record Notes Using Convolutional Neural Network Models Enhanced With Recurrent Neural Network Autoencoders: Deep Learning Approach

Bleeding events are common and critical and may cause significant morbidity and mortality. High incidences of bleeding events are associated with cardiovascular disease in patients on anticoagulant therapy. Prompt and accurate detection of bleeding events is essential to prevent serious consequences...

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Bibliographic Details
Published in:JMIR medical informatics Vol. 7; no. 1; p. e10788
Main Authors: Li, Rumeng, Hu, Baotian, Liu, Feifan, Liu, Weisong, Cunningham, Francesca, McManus, David D, Yu, Hong
Format: Journal Article
Language:English
Published: Canada JMIR Publications 08.02.2019
Subjects:
Anticoagulants
Automation
Classification
Data collection
Deep learning
Electronic health records
Machine translation
Neural networks
Original Paper
Support vector machines
autoencoder
bleeding
convolutional neural networks
BiLSTM
electronic health record
ISSN:2291-9694, 2291-9694
Online Access:Get full text
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Summary:Bleeding events are common and critical and may cause significant morbidity and mortality. High incidences of bleeding events are associated with cardiovascular disease in patients on anticoagulant therapy. Prompt and accurate detection of bleeding events is essential to prevent serious consequences. As bleeding events are often described in clinical notes, automatic detection of bleeding events from electronic health record (EHR) notes may improve drug-safety surveillance and pharmacovigilance. We aimed to develop a natural language processing (NLP) system to automatically classify whether an EHR note sentence contains a bleeding event. We expert annotated 878 EHR notes (76,577 sentences and 562,630 word-tokens) to identify bleeding events at the sentence level. This annotated corpus was used to train and validate our NLP systems. We developed an innovative hybrid convolutional neural network (CNN) and long short-term memory (LSTM) autoencoder (HCLA) model that integrates a CNN architecture with a bidirectional LSTM (BiLSTM) autoencoder model to leverage large unlabeled EHR data. HCLA achieved the best area under the receiver operating characteristic curve (0.957) and F1 score (0.938) to identify whether a sentence contains a bleeding event, thereby surpassing the strong baseline support vector machines and other CNN and autoencoder models. By incorporating a supervised CNN model and a pretrained unsupervised BiLSTM autoencoder, the HCLA achieved high performance in detecting bleeding events.
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ISSN:2291-9694
2291-9694
DOI:10.2196/10788