Measles

Measles is an infectious disease in humans caused by the measles virus (MeV). Before the introduction of an effective measles vaccine, virtually everyone experienced measles during childhood. Symptoms of measles include fever and maculopapular skin rash accompanied by cough, coryza and/or conjunctiv...

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Bibliographic Details
Published in:Nature reviews. Disease primers Vol. 2; no. 1; p. 16049
Main Authors: Rota, Paul A., Moss, William J., Takeda, Makoto, de Swart, Rik L., Thompson, Kimberly M., Goodson, James L.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 14.07.2016
Nature Publishing Group
Subjects:
631/326/590
631/326/596/1631
692/699/255/2514
692/700/478
Age Factors
Cancer Research
Epidemics - history
Epidemiology
History, 20th Century
History, 21st Century
Humans
Immunization
Incidence
Infectious diseases
Internal Medicine
Measles
Measles - diagnosis
Measles - epidemiology
Measles - physiopathology
Measles virus - immunology
Measles virus - pathogenicity
Medical Microbiology
Medicine
Medicine & Public Health
Nutritional Status - immunology
primer
Quality of Life Research
Respiratory Tract Infections - complications
Respiratory Tract Infections - transmission
Risk Factors
Vaccination - methods
Vaccines
ISSN:2056-676X, 2056-676X
Online Access:Get full text
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Description
Summary:Measles is an infectious disease in humans caused by the measles virus (MeV). Before the introduction of an effective measles vaccine, virtually everyone experienced measles during childhood. Symptoms of measles include fever and maculopapular skin rash accompanied by cough, coryza and/or conjunctivitis. MeV causes immunosuppression, and severe sequelae of measles include pneumonia, gastroenteritis, blindness, measles inclusion body encephalitis and subacute sclerosing panencephalitis. Case confirmation depends on clinical presentation and results of laboratory tests, including the detection of anti-MeV IgM antibodies and/or viral RNA. All current measles vaccines contain a live attenuated strain of MeV, and great progress has been made to increase global vaccination coverage to drive down the incidence of measles. However, endemic transmission continues in many parts of the world. Measles remains a considerable cause of childhood mortality worldwide, with estimates that >100,000 fatal cases occur each year. Case fatality ratio estimates vary from <0.01% in industrialized countries to >5% in developing countries. All six WHO regions have set goals to eliminate endemic transmission of MeV by achieving and maintaining high levels of vaccination coverage accompanied by a sensitive surveillance system. Because of the availability of a highly effective and relatively inexpensive vaccine, the monotypic nature of the virus and the lack of an animal reservoir, measles is considered a candidate for eradication. Measles is an infectious disease caused by the measles virus. In this Primer, Rota et al. cover the pathophysiology and management options, with a focus on the strategies to eliminate endemic transmission of the measles virus by achieving a high level of vaccination coverage
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ISSN:2056-676X
2056-676X
DOI:10.1038/nrdp.2016.49