Excessive folic acid intake and relation to adverse health outcome

The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 W...

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Bibliographic Details
Published in:	Biochimie Vol. 126; pp. 71 - 78
Main Authors:	Selhub, Jacob, Rosenberg, Irwin H.
Format:	Journal Article
Language:	English
Published:	France Elsevier B.V 01.07.2016
Subjects:	Aging - genetics Aging - immunology Aging - pathology anemia Australia Base Sequence Breast Neoplasms - chemically induced Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - pathology central nervous system diseases cohort studies elderly erythrocytes Female Folate Folic acid Folic Acid - adverse effects Folic Acid - therapeutic use fortified foods genes genetic background Homocysteine homozygosity Humans India insulin resistance Killer Cells, Natural - immunology Killer Cells, Natural - pathology Latinos memory Methylmalonic acid National Health and Nutrition Examination Survey natural killer cells Neoplasm Proteins - genetics Neoplasm Proteins - immunology Polymorphism, Genetic pregnancy progeny risk Sequence Deletion Tetrahydrofolate Dehydrogenase - genetics Tetrahydrofolate Dehydrogenase - immunology Vitamin B12 women World Health Organization Australia India Methylmalonic acid Vitamin B12 Homocysteine Folic acid Folate
ISSN:	0300-9084, 1638-6183, 1638-6183
Online Access:	Get full text
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