Excessive folic acid intake and relation to adverse health outcome
The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 W...
Uložené v:
| Vydané v: | Biochimie Ročník 126; s. 71 - 78 |
|---|---|
| Hlavní autori: | , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
France
Elsevier B.V
01.07.2016
|
| Predmet: | |
| ISSN: | 0300-9084, 1638-6183, 1638-6183 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 WHO statement that “high folic acid intake has not reliably been shown to be associated with negative healeffects”. In the folic acid post-fortification era, we have shown that in elderly participants in NHANES 1999–2002, high plasma folate level is associated with exacerbation of both clinical (anemia and cognitive impairment) and biochemical (high MMA and high Hcy plasma levels) signs of vitamin B12 deficiency. Adverse clinical outcomes in association with high folate intake were also seen among elderly with low plasma B12 levels from the Framingham Original Cohort and in a study from Australia which combined three elderly cohorts. Relation between high folate and adverse biochemical outcomes were also seen in the Sacramento Area Latino Study on Aging (High Hcy, high MMA and lower TC2) and at an outpatient clinic at Yale University where high folate is associated with higher MMA in the elderly but not in the young.
Potential detrimental effects of high folic acid intake may not be limited to the elderly nor to those with B12 deficiency. A study from India linked maternal high RBC folate to increased insulin resistance in offspring. Our study suggested that excessive folic acid intake is associated with lower natural killer cells activity in elderly women. In a recent study we found that the risk for unilateral retinoblastoma in offspring is 4 fold higher in women that are homozygotes for the 19 bp deletion in the DHFR gene and took folic acid supplement during pregnancy. In the elderly this polymorphism is associated with lower memory and executive scores, both being significantly worse in those with high plasma folate. These and other data strongly imply that excessive intake of folic acid is not always safe in certain populations of different age and ethnical/genetic background.
•This is a review article which was written in response to the 2015 guidelines from the World Health Organization that: “high folic acid intake has not reliably been shown to be associated with negative health effects”.•It describes peer reviewed publication showing that excessive folic acid intake is not always safe.•In particular excessive intake of folic acid could have adverse health outcome in elderly with vitamin B12 deficiency, particularly with respect to cognitive function and anemia.•Other studies show diverse adverse effects, including lower natural killer cell activity in elderly women, increase in insulin resistance in offspring of mothers from India with high folic acid intake and increase in incident of breast cancer and other cancers in women with polymorphism of the dihydrofolate gene (19 bp deletion). |
|---|---|
| AbstractList | The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 WHO statement that "high folic acid intake has not reliably been shown to be associated with negative healeffects". In the folic acid post-fortification era, we have shown that in elderly participants in NHANES 1999-2002, high plasma folate level is associated with exacerbation of both clinical (anemia and cognitive impairment) and biochemical (high MMA and high Hcy plasma levels) signs of vitamin B12 deficiency. Adverse clinical outcomes in association with high folate intake were also seen among elderly with low plasma B12 levels from the Framingham Original Cohort and in a study from Australia which combined three elderly cohorts. Relation between high folate and adverse biochemical outcomes were also seen in the Sacramento Area Latino Study on Aging (High Hcy, high MMA and lower TC2) and at an outpatient clinic at Yale University where high folate is associated with higher MMA in the elderly but not in the young. Potential detrimental effects of high folic acid intake may not be limited to the elderly nor to those with B12 deficiency. A study from India linked maternal high RBC folate to increased insulin resistance in offspring. Our study suggested that excessive folic acid intake is associated with lower natural killer cells activity in elderly women. In a recent study we found that the risk for unilateral retinoblastoma in offspring is 4 fold higher in women that are homozygotes for the 19 bp deletion in the DHFR gene and took folic acid supplement during pregnancy. In the elderly this polymorphism is associated with lower memory and executive scores, both being significantly worse in those with high plasma folate. These and other data strongly imply that excessive intake of folic acid is not always safe in certain populations of different age and ethnical/genetic background.The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 WHO statement that "high folic acid intake has not reliably been shown to be associated with negative healeffects". In the folic acid post-fortification era, we have shown that in elderly participants in NHANES 1999-2002, high plasma folate level is associated with exacerbation of both clinical (anemia and cognitive impairment) and biochemical (high MMA and high Hcy plasma levels) signs of vitamin B12 deficiency. Adverse clinical outcomes in association with high folate intake were also seen among elderly with low plasma B12 levels from the Framingham Original Cohort and in a study from Australia which combined three elderly cohorts. Relation between high folate and adverse biochemical outcomes were also seen in the Sacramento Area Latino Study on Aging (High Hcy, high MMA and lower TC2) and at an outpatient clinic at Yale University where high folate is associated with higher MMA in the elderly but not in the young. Potential detrimental effects of high folic acid intake may not be limited to the elderly nor to those with B12 deficiency. A study from India linked maternal high RBC folate to increased insulin resistance in offspring. Our study suggested that excessive folic acid intake is associated with lower natural killer cells activity in elderly women. In a recent study we found that the risk for unilateral retinoblastoma in offspring is 4 fold higher in women that are homozygotes for the 19 bp deletion in the DHFR gene and took folic acid supplement during pregnancy. In the elderly this polymorphism is associated with lower memory and executive scores, both being significantly worse in those with high plasma folate. These and other data strongly imply that excessive intake of folic acid is not always safe in certain populations of different age and ethnical/genetic background. The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 WHO statement that “high folic acid intake has not reliably been shown to be associated with negative healeffects”. In the folic acid post-fortification era, we have shown that in elderly participants in NHANES 1999–2002, high plasma folate level is associated with exacerbation of both clinical (anemia and cognitive impairment) and biochemical (high MMA and high Hcy plasma levels) signs of vitamin B12 deficiency. Adverse clinical outcomes in association with high folate intake were also seen among elderly with low plasma B12 levels from the Framingham Original Cohort and in a study from Australia which combined three elderly cohorts. Relation between high folate and adverse biochemical outcomes were also seen in the Sacramento Area Latino Study on Aging (High Hcy, high MMA and lower TC2) and at an outpatient clinic at Yale University where high folate is associated with higher MMA in the elderly but not in the young.Potential detrimental effects of high folic acid intake may not be limited to the elderly nor to those with B12 deficiency. A study from India linked maternal high RBC folate to increased insulin resistance in offspring. Our study suggested that excessive folic acid intake is associated with lower natural killer cells activity in elderly women. In a recent study we found that the risk for unilateral retinoblastoma in offspring is 4 fold higher in women that are homozygotes for the 19 bp deletion in the DHFR gene and took folic acid supplement during pregnancy. In the elderly this polymorphism is associated with lower memory and executive scores, both being significantly worse in those with high plasma folate. These and other data strongly imply that excessive intake of folic acid is not always safe in certain populations of different age and ethnical/genetic background. The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 WHO statement that “high folic acid intake has not reliably been shown to be associated with negative healeffects”. In the folic acid post-fortification era, we have shown that in elderly participants in NHANES 1999–2002, high plasma folate level is associated with exacerbation of both clinical (anemia and cognitive impairment) and biochemical (high MMA and high Hcy plasma levels) signs of vitamin B12 deficiency. Adverse clinical outcomes in association with high folate intake were also seen among elderly with low plasma B12 levels from the Framingham Original Cohort and in a study from Australia which combined three elderly cohorts. Relation between high folate and adverse biochemical outcomes were also seen in the Sacramento Area Latino Study on Aging (High Hcy, high MMA and lower TC2) and at an outpatient clinic at Yale University where high folate is associated with higher MMA in the elderly but not in the young. Potential detrimental effects of high folic acid intake may not be limited to the elderly nor to those with B12 deficiency. A study from India linked maternal high RBC folate to increased insulin resistance in offspring. Our study suggested that excessive folic acid intake is associated with lower natural killer cells activity in elderly women. In a recent study we found that the risk for unilateral retinoblastoma in offspring is 4 fold higher in women that are homozygotes for the 19 bp deletion in the DHFR gene and took folic acid supplement during pregnancy. In the elderly this polymorphism is associated with lower memory and executive scores, both being significantly worse in those with high plasma folate. These and other data strongly imply that excessive intake of folic acid is not always safe in certain populations of different age and ethnical/genetic background. •This is a review article which was written in response to the 2015 guidelines from the World Health Organization that: “high folic acid intake has not reliably been shown to be associated with negative health effects”.•It describes peer reviewed publication showing that excessive folic acid intake is not always safe.•In particular excessive intake of folic acid could have adverse health outcome in elderly with vitamin B12 deficiency, particularly with respect to cognitive function and anemia.•Other studies show diverse adverse effects, including lower natural killer cell activity in elderly women, increase in insulin resistance in offspring of mothers from India with high folic acid intake and increase in incident of breast cancer and other cancers in women with polymorphism of the dihydrofolate gene (19 bp deletion). The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports of adverse health outcome in elderly with low B12 status who took high doses of folic acid. These safety concerns are contrary to the 2015 WHO statement that "high folic acid intake has not reliably been shown to be associated with negative healeffects". In the folic acid post-fortification era, we have shown that in elderly participants in NHANES 1999-2002, high plasma folate level is associated with exacerbation of both clinical (anemia and cognitive impairment) and biochemical (high MMA and high Hcy plasma levels) signs of vitamin B12 deficiency. Adverse clinical outcomes in association with high folate intake were also seen among elderly with low plasma B12 levels from the Framingham Original Cohort and in a study from Australia which combined three elderly cohorts. Relation between high folate and adverse biochemical outcomes were also seen in the Sacramento Area Latino Study on Aging (High Hcy, high MMA and lower TC2) and at an outpatient clinic at Yale University where high folate is associated with higher MMA in the elderly but not in the young. Potential detrimental effects of high folic acid intake may not be limited to the elderly nor to those with B12 deficiency. A study from India linked maternal high RBC folate to increased insulin resistance in offspring. Our study suggested that excessive folic acid intake is associated with lower natural killer cells activity in elderly women. In a recent study we found that the risk for unilateral retinoblastoma in offspring is 4 fold higher in women that are homozygotes for the 19 bp deletion in the DHFR gene and took folic acid supplement during pregnancy. In the elderly this polymorphism is associated with lower memory and executive scores, both being significantly worse in those with high plasma folate. These and other data strongly imply that excessive intake of folic acid is not always safe in certain populations of different age and ethnical/genetic background. |
| Author | Rosenberg, Irwin H. Selhub, Jacob |
| Author_xml | – sequence: 1 givenname: Jacob surname: Selhub fullname: Selhub, Jacob email: jacob.selhub@tufts.edu – sequence: 2 givenname: Irwin H. surname: Rosenberg fullname: Rosenberg, Irwin H. email: irwin.rosenberg@tufts.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27131640$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU1PGzEURa0KVELaf1AhL9nM8Dz-yLiLSjSiLRISG1hbjv2sOJ2MwXai8u8ZGth0UTZ-snTuXdxzSo7GNCIhXxi0DJi62LSrmNw6tt30a0G0wOADmTHF-0axnh-RGXCARkMvTshpKRsAkNDpj-SkWzDOlIAZ-X71x2EpcY80pCE6al30NI7V_kZqR08zDrbGNNKaqPV7zAXpGu1Q1zTtqktb_ESOgx0Kfn69c3L_4-pu-au5uf15vby8aZxQrDZ-ZS1zC8HVCpkUGhaKBSUC9rZzIXQhSNBMTojXfHod516LrpOe9dpr5HNyfuh9yOlxh6WabSwOh8GOmHbFsL6TggvJ4X10oWWvgGs5oWev6G61RW8ectza_GTeJpqArwfA5VRKxmBcrH8nqdnGwTAwLz7Mxhx8mBcfBoSZfExh8U_4rf-d2LdDDKc99xGzKS7i6NDHjK4an-L_C54B28iksg |
| CitedBy_id | crossref_primary_10_3390_nu15214699 crossref_primary_10_1016_j_heliyon_2024_e36980 crossref_primary_10_1039_C9FO02419K crossref_primary_10_1080_09637486_2017_1320536 crossref_primary_10_3389_fpubh_2025_1530380 crossref_primary_10_1038_s41598_023_31690_w crossref_primary_10_1016_j_cnd_2025_06_005 crossref_primary_10_1089_met_2023_0024 crossref_primary_10_3389_fpls_2018_00443 crossref_primary_10_3390_nu16183154 crossref_primary_10_1016_j_nutres_2023_09_008 crossref_primary_10_1017_S0029665117000404 crossref_primary_10_1016_j_cdnut_2025_107531 crossref_primary_10_1093_advances_nmy120 crossref_primary_10_3390_nu10060795 crossref_primary_10_1016_j_biochi_2020_04_019 crossref_primary_10_1016_j_clnu_2020_05_032 crossref_primary_10_1016_j_bbadis_2021_166231 crossref_primary_10_1158_1055_9965_EPI_25_0154 crossref_primary_10_1016_j_bios_2025_117906 crossref_primary_10_1016_j_clnesp_2021_06_004 crossref_primary_10_1016_j_ijbiomac_2018_06_058 crossref_primary_10_1016_j_mam_2016_11_001 crossref_primary_10_3390_ijms26167703 crossref_primary_10_1136_bmjopen_2024_086825 crossref_primary_10_3389_fvets_2021_720851 crossref_primary_10_1016_j_jff_2022_105317 crossref_primary_10_1080_10408444_2020_1727842 crossref_primary_10_1016_j_fufo_2025_100674 crossref_primary_10_3390_nu12010247 crossref_primary_10_1038_s41538_025_00396_w crossref_primary_10_1016_j_clinbiochem_2018_04_011 crossref_primary_10_3390_jpm8030026 crossref_primary_10_1111_cga_12231 crossref_primary_10_1371_journal_ppat_1008521 crossref_primary_10_1016_j_ecoenv_2019_109380 crossref_primary_10_3390_ph11020052 crossref_primary_10_3389_fnut_2025_1547844 crossref_primary_10_1186_s12263_017_0560_8 crossref_primary_10_1017_S1368980019000193 crossref_primary_10_3390_jpm8010010 crossref_primary_10_3390_genes10090634 crossref_primary_10_3389_fnut_2023_1179807 crossref_primary_10_1016_j_tjnut_2023_05_020 crossref_primary_10_1093_jn_nxy163 crossref_primary_10_3389_fnut_2023_1191610 crossref_primary_10_1177_25158414241240687 crossref_primary_10_1016_j_brainresbull_2018_12_015 crossref_primary_10_3389_fped_2022_828300 crossref_primary_10_3390_nu13020327 crossref_primary_10_3945_an_117_015610 crossref_primary_10_1016_j_copbio_2016_12_003 crossref_primary_10_1093_jn_nxab280 crossref_primary_10_1016_j_aca_2025_344678 crossref_primary_10_3390_nu12051335 crossref_primary_10_3390_nu9030234 crossref_primary_10_3390_molecules27206868 crossref_primary_10_1002_epd2_70097 crossref_primary_10_1002_bdr2_1004 crossref_primary_10_1007_s00467_023_06132_4 crossref_primary_10_4239_wjd_v13_i3_185 crossref_primary_10_1016_j_jaip_2019_06_017 crossref_primary_10_1016_j_clnesp_2024_09_018 crossref_primary_10_3390_ijms20051100 crossref_primary_10_1038_s41421_022_00512_0 crossref_primary_10_1017_S000711451600307X crossref_primary_10_1016_j_jnutbio_2023_109536 crossref_primary_10_3390_biology10100959 crossref_primary_10_1093_nutrit_nuy026 crossref_primary_10_1016_j_jnutbio_2018_06_008 crossref_primary_10_1093_nutrit_nuy025 crossref_primary_10_1134_S207905702101046X crossref_primary_10_1111_joim_13279 crossref_primary_10_1016_j_biochi_2016_05_008 crossref_primary_10_1038_ejcn_2016_194 crossref_primary_10_1038_s41598_018_20175_w crossref_primary_10_1016_j_mehy_2020_110374 crossref_primary_10_1016_j_ijdevneu_2018_10_001 crossref_primary_10_1080_13685538_2024_2336625 crossref_primary_10_1002_alz_13115 crossref_primary_10_1016_j_chroma_2019_02_037 crossref_primary_10_1096_fj_201701503RR crossref_primary_10_1186_s40662_020_00199_y crossref_primary_10_3390_nu14193944 crossref_primary_10_1016_j_plefa_2020_102057 crossref_primary_10_1002_jdn_10132 crossref_primary_10_1017_S136898002200194X crossref_primary_10_1111_nyas_13972 crossref_primary_10_1039_D0RA04922K crossref_primary_10_1007_s10067_025_07337_8 crossref_primary_10_1093_ajcn_nqaa259 crossref_primary_10_3389_fimmu_2022_946713 crossref_primary_10_3389_fnut_2025_1504441 crossref_primary_10_1371_journal_pone_0217403 crossref_primary_10_3390_cells13231968 crossref_primary_10_3390_nu13061790 crossref_primary_10_1055_a_1952_1946 crossref_primary_10_1136_jclinpath_2018_205048 crossref_primary_10_1177_03000605231223064 crossref_primary_10_1093_jncics_pkz096 crossref_primary_10_1017_S1368980018003610 crossref_primary_10_1016_j_ijfoodmicro_2024_110895 crossref_primary_10_1021_acsomega_5c00251 crossref_primary_10_1136_bmjopen_2019_031076 crossref_primary_10_1007_s10620_020_06525_7 crossref_primary_10_1016_j_scitotenv_2019_134390 crossref_primary_10_3390_biomedicines10050965 crossref_primary_10_1155_2022_7043883 crossref_primary_10_1016_j_clnu_2017_07_008 crossref_primary_10_1080_10641963_2017_1306540 crossref_primary_10_1016_j_saa_2021_120661 crossref_primary_10_1093_inthealth_ihy097 crossref_primary_10_3390_nu16152503 crossref_primary_10_4103_njcp_njcp_381_20 crossref_primary_10_1212_WNL_0000000000003909 crossref_primary_10_4178_epih_e2022046 crossref_primary_10_1007_s00394_017_1588_7 crossref_primary_10_1016_j_mehy_2024_111323 |
| Cites_doi | 10.1093/ajcn/80.5.1123 10.1017/S0007114575000463 10.3945/ajcn.115.116509 10.1093/ajcn/86.1.265 10.1161/CIRCULATIONAHA.105.570846 10.3945/ajcn.111.013433 10.3390/nu5124836 10.1126/science.107.2781.396 10.1093/ajcn/65.6.1889 10.3945/ajcn.2009.28671 10.1007/s00125-007-0793-y 10.1016/S0140-6736(05)78966-2 10.1073/pnas.0902072106 10.1001/archneur.1993.00540070055015 10.1007/s00253-001-0902-7 10.1056/NEJM199905133401901 10.1371/journal.pone.0143738 10.1016/0065-2571(82)90012-7 10.1093/ajcn/87.3.517 10.1203/PDR.0b013e31815b8ec5 10.1093/ajcn/65.6.1790 10.1111/j.1532-5415.2012.04076.x 10.3233/JAD-131265 10.1001/jama.1993.03510220049033 10.1093/ajcn/82.2.442 10.1002/cncr.27621 10.3945/ajcn.2009.27514 10.1136/bmj.311.7010.949a 10.3945/jn.108.096404 10.1093/jn/132.9.2792 10.1093/ajcn/85.1.193 10.1002/bdra.20468 10.1016/j.jnutbio.2015.12.006 10.3389/fgene.2014.00289 10.1177/15648265080292S110 10.1111/jgs.12155 10.3945/ajcn.2008.26947C 10.1093/jn/136.1.189 10.1126/science.102.2644.227 10.1073/pnas.0709487104 10.1002/bdra.23092 10.1093/ajcn/85.4.1098 |
| ContentType | Journal Article |
| Copyright | 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) Copyright © 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved. |
| Copyright_xml | – notice: 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM) – notice: Copyright © 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| DOI | 10.1016/j.biochi.2016.04.010 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE - Academic AGRICOLA MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering Anatomy & Physiology Chemistry |
| EISSN | 1638-6183 |
| EndPage | 78 |
| ExternalDocumentID | 27131640 10_1016_j_biochi_2016_04_010 S0300908416300530 |
| Genre | Journal Article Review |
| GeographicLocations | Australia India |
| GeographicLocations_xml | – name: Australia – name: India |
| GroupedDBID | --- --K --M -~X .GJ .~1 0R~ 1B1 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5VS 6J9 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAXUO ABFNM ABFRF ABGSF ABJNI ABMAC ABUDA ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEFWE AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AI. AIEXJ AIKHN AITUG AJBFU AJOXV ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLW HVGLF HZ~ H~9 IHE J1W KOM LX3 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SBG SCC SDF SDG SDP SES SEW SSU SSZ T5K TWZ VH1 WUQ Y6R ZGI ZXP ~02 ~G- ~KM 9DU AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACLOT ACRPL ACVFH ADCNI ADNMO AEIPS AEUPX AFJKZ AFPUW AGQPQ AIGII AIIUN AKBMS AKRWK AKYEP ANKPU CITATION EFKBS ~HD CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c461t-dbaa1c7436be15490761f64fe8a2cff2ff509151c7d931c7c33d94225d189d9e3 |
| ISICitedReferencesCount | 135 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000378963500012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0300-9084 1638-6183 |
| IngestDate | Sun Sep 28 08:46:22 EDT 2025 Sun Nov 09 14:40:46 EST 2025 Wed Feb 19 02:03:55 EST 2025 Sat Nov 29 01:38:12 EST 2025 Tue Nov 18 21:21:51 EST 2025 Fri Feb 23 02:11:04 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | Methylmalonic acid Vitamin B12 Homocysteine Folic acid Folate |
| Language | English |
| License | Copyright © 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c461t-dbaa1c7436be15490761f64fe8a2cff2ff509151c7d931c7c33d94225d189d9e3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 27131640 |
| PQID | 1795860395 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1825434530 proquest_miscellaneous_1795860395 pubmed_primary_27131640 crossref_citationtrail_10_1016_j_biochi_2016_04_010 crossref_primary_10_1016_j_biochi_2016_04_010 elsevier_sciencedirect_doi_10_1016_j_biochi_2016_04_010 |
| PublicationCentury | 2000 |
| PublicationDate | July 2016 2016-07-00 2016-Jul 20160701 |
| PublicationDateYYYYMMDD | 2016-07-01 |
| PublicationDate_xml | – month: 07 year: 2016 text: July 2016 |
| PublicationDecade | 2010 |
| PublicationPlace | France |
| PublicationPlace_xml | – name: France |
| PublicationTitle | Biochimie |
| PublicationTitleAlternate | Biochimie |
| PublicationYear | 2016 |
| Publisher | Elsevier B.V |
| Publisher_xml | – name: Elsevier B.V |
| References | Rickes, Brink, Koniuszy, Wood, Folkers (bib9) Apr 16 1948; 107 Kalmbach, Paul, Selhub (bib33) Jul 2011; 94 Martens, Barg, Warren, Jahn (bib10) Mar 2002; 58 Selhub, Morris, Jacques (bib49) Dec 11 2007; 104 Brito, Verdugo, Hertrampf (bib48) 2016 Jan; 103 Troen, Mitchell, Sorensen (bib37) Jan 2006; 136 Morris, Selhub, Jacques (bib31) Aug 2012; 60 Choumenkovitch, Selhub, Wilson, Rader, Rosenberg, Jacques (bib22) Sep 2002; 132 Johnston (bib43) Jan 2008; 63 Selhub, Jacques, Dallal, Choumenkovitch, Rogers (bib27) Jun 2008; 29 Sawangeri, Wang, Reginaldo (bib47) 2016 Apr; 30 Mikael, Deng, Paul, Selhub, Rozen (bib45) Jan 2013; 97 Selhub, Morris, Jacques, Rosenberg (bib28) Feb 2009; 89 Smith, Kim, Refsum (bib4) Mar 2008; 87 WHO (bib1) 2015 Yang, Botto, Erickson (bib19) Mar 14 2006; 113 Morris, Jacques, Rosenberg, Selhub (bib23) Jan 2007; 85 Wechsler (bib24) 1997 Pfeiffer, Caudill, Gunter, Osterloh, Sampson (bib25) Aug 2005; 82 Savage, Lindenbaum (bib12) 1995 Kelly, McPartlin, Goggins, Weir, Scott (bib7) Jun 1997; 65 Reynolds, Bottiglieri, Laundy (bib11) Jul 1993; 50 Angier, Boothe, Hutchings (bib5) Aug 31 1945; 102 Boulet, Yang, Mai (bib18) Jul 2008; 82 Matthews, Daubner (bib8) 1982; 20 Wald, Law, Jordan (bib17) Mar 14 1998; 351 Kalmbach, Choumenkovitch, Troen, Jacques, D'Agostino, Selhub (bib35) Dec 2008; 138 Yajnik, Deshpande, Jackson (bib32) Jan 2008; 51 Van Tonder, Metz, Green (bib13) Nov 1975; 34 Morris, Jacques, Rosenberg, Selhub (bib36) Jun 2010; 91 Philip, Buch, Moorthy (bib38) Sep 9 2015 Orjuela, Cabrera-Munoz, Paul (bib40) Dec 1 2012; 118 Berry, Carter, Yang (bib42) Jul 2007; 86 Dickinson (bib14) Oct 7 1995; 311 Moore, Ames, Mander (bib26) 2014; 39 Miller, Garrod, Allen, Haan, Green (bib29) Dec 2009; 90 Lucock, Wild, Smithells, Hartley (bib34) Sep 1989; 43 Kim (bib2) Nov 2004; 80 Morris MS, P.F. J, J. S. Unpublished. Solomon (bib30) Apr 2013; 61 Xu, Gammon, Wetmur (bib39) Apr 2007; 85 O'Neill, Vrana, Rosenfeld (bib3) 2014; 5 Selhub, Jacques, Wilson, Rush, Rosenberg (bib41) Dec 8 1993; 270 Bailey, Ayling (bib6) Sep 8 2009; 106 Partearroyo, Ubeda, Montero, Achon, Varela-Moreiras (bib46) Dec 2013; 5 Meadows, Bahous, Best, Rozen (bib44) 2015; 10 Dickinson (bib15) May 1995; 88 Jacques, Selhub, Bostom, Wilson, Rosenberg (bib20) May 13 1999; 340 Oakley (bib16) Jun 1997; 65 Oakley (10.1016/j.biochi.2016.04.010_bib16) 1997; 65 Reynolds (10.1016/j.biochi.2016.04.010_bib11) 1993; 50 Berry (10.1016/j.biochi.2016.04.010_bib42) 2007; 86 Sawangeri (10.1016/j.biochi.2016.04.010_bib47) 2016; 30 Moore (10.1016/j.biochi.2016.04.010_bib26) 2014; 39 Selhub (10.1016/j.biochi.2016.04.010_bib27) 2008; 29 Wald (10.1016/j.biochi.2016.04.010_bib17) 1998; 351 Kalmbach (10.1016/j.biochi.2016.04.010_bib35) 2008; 138 10.1016/j.biochi.2016.04.010_bib21 Meadows (10.1016/j.biochi.2016.04.010_bib44) 2015; 10 Yajnik (10.1016/j.biochi.2016.04.010_bib32) 2008; 51 Johnston (10.1016/j.biochi.2016.04.010_bib43) 2008; 63 Morris (10.1016/j.biochi.2016.04.010_bib23) 2007; 85 Partearroyo (10.1016/j.biochi.2016.04.010_bib46) 2013; 5 Wechsler (10.1016/j.biochi.2016.04.010_bib24) 1997 Mikael (10.1016/j.biochi.2016.04.010_bib45) 2013; 97 Bailey (10.1016/j.biochi.2016.04.010_bib6) 2009; 106 Xu (10.1016/j.biochi.2016.04.010_bib39) 2007; 85 Martens (10.1016/j.biochi.2016.04.010_bib10) 2002; 58 Angier (10.1016/j.biochi.2016.04.010_bib5) 1945; 102 Pfeiffer (10.1016/j.biochi.2016.04.010_bib25) 2005; 82 Selhub (10.1016/j.biochi.2016.04.010_bib49) 2007; 104 Troen (10.1016/j.biochi.2016.04.010_bib37) 2006; 136 Van Tonder (10.1016/j.biochi.2016.04.010_bib13) 1975; 34 Kelly (10.1016/j.biochi.2016.04.010_bib7) 1997; 65 Yang (10.1016/j.biochi.2016.04.010_bib19) 2006; 113 Dickinson (10.1016/j.biochi.2016.04.010_bib15) 1995; 88 Smith (10.1016/j.biochi.2016.04.010_bib4) 2008; 87 Matthews (10.1016/j.biochi.2016.04.010_bib8) 1982; 20 Kalmbach (10.1016/j.biochi.2016.04.010_bib33) 2011; 94 Savage (10.1016/j.biochi.2016.04.010_bib12) 1995 Lucock (10.1016/j.biochi.2016.04.010_bib34) 1989; 43 Brito (10.1016/j.biochi.2016.04.010_bib48) 2016; 103 Choumenkovitch (10.1016/j.biochi.2016.04.010_bib22) 2002; 132 Boulet (10.1016/j.biochi.2016.04.010_bib18) 2008; 82 WHO (10.1016/j.biochi.2016.04.010_bib1) 2015 Selhub (10.1016/j.biochi.2016.04.010_bib41) 1993; 270 Jacques (10.1016/j.biochi.2016.04.010_bib20) 1999; 340 Miller (10.1016/j.biochi.2016.04.010_bib29) 2009; 90 Dickinson (10.1016/j.biochi.2016.04.010_bib14) 1995; 311 Philip (10.1016/j.biochi.2016.04.010_bib38) 2015 Rickes (10.1016/j.biochi.2016.04.010_bib9) 1948; 107 Morris (10.1016/j.biochi.2016.04.010_bib36) 2010; 91 Morris (10.1016/j.biochi.2016.04.010_bib31) 2012; 60 Solomon (10.1016/j.biochi.2016.04.010_bib30) 2013; 61 Kim (10.1016/j.biochi.2016.04.010_bib2) 2004; 80 Selhub (10.1016/j.biochi.2016.04.010_bib28) 2009; 89 Orjuela (10.1016/j.biochi.2016.04.010_bib40) 2012; 118 O'Neill (10.1016/j.biochi.2016.04.010_bib3) 2014; 5 |
| References_xml | – volume: 94 start-page: 343s year: Jul 2011 end-page: 347s ident: bib33 article-title: Determination of unmetabolized folic acid in human plasma using affinity HPLC publication-title: Am. J. Clin. Nutr. – volume: 340 start-page: 1449 year: May 13 1999 end-page: 1454 ident: bib20 article-title: The effect of folic acid fortification on plasma folate and total homocysteine concentrations publication-title: N. Engl. J. Med. – volume: 91 start-page: 1733 year: Jun 2010 end-page: 1744 ident: bib36 article-title: Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors publication-title: Am. J. Clin. Nutr. – year: 2015 ident: bib1 article-title: Optimal Serum and Red Blood Cell Folate Concentrations in Women of Reproductive Age for Prevention of Neural Tube Defects – volume: 65 start-page: 1790 year: Jun 1997 end-page: 1795 ident: bib7 article-title: Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements publication-title: Am. J. Clin. Nutr. – volume: 106 start-page: 15424 year: Sep 8 2009 end-page: 15429 ident: bib6 article-title: The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 20 start-page: 123 year: 1982 end-page: 131 ident: bib8 article-title: Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues publication-title: Adv. Enzyme Regul. – volume: 88 start-page: 357 year: May 1995 end-page: 364 ident: bib15 article-title: Does folic acid harm people with vitamin B12 deficiency? publication-title: QJM Mon. J. Assoc. Physicians – volume: 85 start-page: 193 year: Jan 2007 end-page: 200 ident: bib23 article-title: Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification publication-title: Am. J. Clin. Nutr. – volume: 97 start-page: 47 year: Jan 2013 end-page: 52 ident: bib45 article-title: Moderately high intake of folic acid has a negative impact on mouse embryonic development publication-title: Birth Defects Res. A Clin. Mol. Teratol. – volume: 89 start-page: 702s year: Feb 2009 end-page: 706s ident: bib28 article-title: Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency publication-title: Am. J. Clin. Nutr. – start-page: 237 year: 1995 end-page: 285 ident: bib12 article-title: Folate cobalamin interactions publication-title: Folate in Health and Disease – volume: 86 start-page: 265 year: Jul 2007 end-page: 267 ident: bib42 article-title: Cognitive impairment in older Americans in the age of folic acid fortification publication-title: Am. J. Clin. Nutr. – volume: 10 start-page: e0143738 year: 2015 ident: bib44 article-title: High dietary folate in mice alters immune response and reduces survival after malarial infection publication-title: PLoS One – volume: 58 start-page: 275 year: Mar 2002 end-page: 285 ident: bib10 article-title: Microbial production of vitamin B12 publication-title: Appl. Microbiol. Biotechnol. – volume: 43 start-page: 631 year: Sep 1989 end-page: 635 ident: bib34 article-title: Biotransformation of pteroylmonoglutamic acid during absorption: implications of Michaelis-Menten kinetics publication-title: Eur. J. Clin. Nutr. – volume: 82 start-page: 442 year: Aug 2005 end-page: 450 ident: bib25 article-title: Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999–2000 publication-title: Am. J. Clin. Nutr. – volume: 34 start-page: 397 year: Nov 1975 end-page: 410 ident: bib13 article-title: Vitamin B12 metabolism in the fruit bat (Rousettus aegyptiacus). The induction of vitamin B12 deficiency and its effect on folate levels publication-title: Br. J. Nutr. – volume: 138 start-page: 2323 year: Dec 2008 end-page: 2327 ident: bib35 article-title: A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate publication-title: J. Nutr. – volume: 63 start-page: 2 year: Jan 2008 end-page: 8 ident: bib43 article-title: Will increasing folic acid in fortified grain products further reduce neural tube defects without causing harm?: consideration of the evidence publication-title: Pediatr. Res. – volume: 104 start-page: 19995 year: Dec 11 2007 end-page: 20000 ident: bib49 article-title: In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 82 start-page: 527 year: Jul 2008 end-page: 532 ident: bib18 article-title: Trends in the postfortification prevalence of spina bifida and anencephaly in the United States publication-title: Birth Defects Res. Part A Clin. Mol. Teratol. – year: 1997 ident: bib24 article-title: Wechsler Adult Intelligence Scale—III – volume: 311 start-page: 949 year: Oct 7 1995 ident: bib14 article-title: No reliable evidence that folate is harmful in B-12 deficiency publication-title: BMJ (Clinical Research ed.) – volume: 132 start-page: 2792 year: Sep 2002 end-page: 2798 ident: bib22 article-title: Folic acid intake from fortification in United States exceeds predictions publication-title: J. Nutr. – volume: 80 start-page: 1123 year: Nov 2004 end-page: 1128 ident: bib2 article-title: Will mandatory folic acid fortification prevent or promote cancer? publication-title: Am. J. Clin. Nutr. – volume: 136 start-page: 189 year: Jan 2006 end-page: 194 ident: bib37 article-title: Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women publication-title: J. Nutr. – volume: 30 start-page: 102 year: 2016 Apr end-page: 107 ident: bib47 article-title: High folic acid intake reduces natural killer cell cytotoxicity in aged mice publication-title: J. Nutr. Biochem. – volume: 60 start-page: 1457 year: Aug 2012 end-page: 1464 ident: bib31 article-title: Vitamin B-12 and folate status in relation to decline in scores on the mini-mental state examination in the framingham heart study publication-title: J. Am. Geriatr. Soc. – volume: 85 start-page: 1098 year: Apr 2007 end-page: 1102 ident: bib39 article-title: A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users publication-title: Am. J. Clin. Nutr. – volume: 107 start-page: 396 year: Apr 16 1948 end-page: 397 ident: bib9 article-title: Crystalline vitamin B12 publication-title: Science – volume: 103 start-page: 250 year: 2016 Jan end-page: 257 ident: bib48 article-title: Vitamin B-12 treatment of asymptomatic deficient elderly Chileans improves conductivity in myelinated peripheral nerves, but high serum folate impairs B-12 status response assessed by the combined indicator cB-12 assessed by the combined indicator cB-12 publication-title: Am. J. Clin. Nutr. – year: Sep 9 2015 ident: bib38 article-title: Dihydrofolate Reductase 19-bp Deletion Polymorphism Modifies the Association of Folate Status with Memory in a Cross-sectional Multi-ethnic Study of Adults – volume: 270 start-page: 2693 year: Dec 8 1993 end-page: 2698 ident: bib41 article-title: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population publication-title: JAMA – volume: 61 start-page: 577 year: Apr 2013 end-page: 582 ident: bib30 article-title: Advanced age as a risk factor for folate-associated functional cobalamin deficiency publication-title: J. Am. Geriatr. Soc. – volume: 5 start-page: 289 year: 2014 ident: bib3 article-title: Maternal methyl supplemented diets and effects on offspring health publication-title: Front. Genet. – volume: 51 start-page: 29 year: Jan 2008 end-page: 38 ident: bib32 article-title: Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study publication-title: Diabetologia – volume: 118 start-page: 5912 year: Dec 1 2012 end-page: 5919 ident: bib40 article-title: Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake publication-title: Cancer – volume: 351 start-page: 834 year: Mar 14 1998 ident: bib17 article-title: Folic acid food fortification to prevent neural tube defects publication-title: Lancet (London, England) – volume: 39 start-page: 661 year: 2014 end-page: 668 ident: bib26 article-title: Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from three cohorts publication-title: J. Alzheimer's Dis. JAD – volume: 90 start-page: 1586 year: Dec 2009 end-page: 1592 ident: bib29 article-title: Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate publication-title: Am. J. Clin. Nutr. – volume: 87 start-page: 517 year: Mar 2008 end-page: 533 ident: bib4 article-title: Is folic acid good for everyone? publication-title: Am. J. Clin. Nutr. – volume: 50 start-page: 739 year: Jul 1993 end-page: 742 ident: bib11 article-title: Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein. New cause of an old syndrome publication-title: Arch. Neurol. – volume: 5 start-page: 4836 year: Dec 2013 end-page: 4848 ident: bib46 article-title: Vitamin B(12) and folic acid imbalance modifies NK cytotoxicity, lymphocytes B and lymphoprolipheration in aged rats publication-title: Nutrients – volume: 113 start-page: 1335 year: Mar 14 2006 end-page: 1343 ident: bib19 article-title: Improvement in stroke mortality in Canada and the United States, 1990 to 2002 publication-title: Circulation – volume: 65 start-page: 1889 year: Jun 1997 end-page: 1890 ident: bib16 article-title: Let's increase folic acid fortification and include vitamin B-12 publication-title: Am. J. Clin. Nutr. – volume: 102 start-page: 227 year: Aug 31 1945 end-page: 228 ident: bib5 article-title: Synthesis of a compound identical with the L. Casei factor isolated from liver publication-title: Science – volume: 29 start-page: S67 year: Jun 2008 end-page: S73 ident: bib27 article-title: The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status publication-title: Food Nutr. Bull. – reference: Morris MS, P.F. J, J. S. Unpublished. – volume: 43 start-page: 631 issue: 9 year: 1989 ident: 10.1016/j.biochi.2016.04.010_bib34 article-title: Biotransformation of pteroylmonoglutamic acid during absorption: implications of Michaelis-Menten kinetics publication-title: Eur. J. Clin. Nutr. – volume: 80 start-page: 1123 issue: 5 year: 2004 ident: 10.1016/j.biochi.2016.04.010_bib2 article-title: Will mandatory folic acid fortification prevent or promote cancer? publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/80.5.1123 – volume: 34 start-page: 397 issue: 3 year: 1975 ident: 10.1016/j.biochi.2016.04.010_bib13 article-title: Vitamin B12 metabolism in the fruit bat (Rousettus aegyptiacus). The induction of vitamin B12 deficiency and its effect on folate levels publication-title: Br. J. Nutr. doi: 10.1017/S0007114575000463 – volume: 103 start-page: 250 issue: 1 year: 2016 ident: 10.1016/j.biochi.2016.04.010_bib48 article-title: Vitamin B-12 treatment of asymptomatic deficient elderly Chileans improves conductivity in myelinated peripheral nerves, but high serum folate impairs B-12 status response assessed by the combined indicator cB-12 assessed by the combined indicator cB-12 publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.115.116509 – volume: 86 start-page: 265 issue: 1 year: 2007 ident: 10.1016/j.biochi.2016.04.010_bib42 article-title: Cognitive impairment in older Americans in the age of folic acid fortification publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/86.1.265 – volume: 113 start-page: 1335 issue: 10 year: 2006 ident: 10.1016/j.biochi.2016.04.010_bib19 article-title: Improvement in stroke mortality in Canada and the United States, 1990 to 2002 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.105.570846 – volume: 94 start-page: 343s issue: 1 year: 2011 ident: 10.1016/j.biochi.2016.04.010_bib33 article-title: Determination of unmetabolized folic acid in human plasma using affinity HPLC publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.111.013433 – volume: 5 start-page: 4836 issue: 12 year: 2013 ident: 10.1016/j.biochi.2016.04.010_bib46 article-title: Vitamin B(12) and folic acid imbalance modifies NK cytotoxicity, lymphocytes B and lymphoprolipheration in aged rats publication-title: Nutrients doi: 10.3390/nu5124836 – volume: 107 start-page: 396 issue: 2781 year: 1948 ident: 10.1016/j.biochi.2016.04.010_bib9 article-title: Crystalline vitamin B12 publication-title: Science doi: 10.1126/science.107.2781.396 – volume: 65 start-page: 1889 issue: 6 year: 1997 ident: 10.1016/j.biochi.2016.04.010_bib16 article-title: Let's increase folic acid fortification and include vitamin B-12 publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/65.6.1889 – volume: 91 start-page: 1733 issue: 6 year: 2010 ident: 10.1016/j.biochi.2016.04.010_bib36 article-title: Circulating unmetabolized folic acid and 5-methyltetrahydrofolate in relation to anemia, macrocytosis, and cognitive test performance in American seniors publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.2009.28671 – volume: 51 start-page: 29 issue: 1 year: 2008 ident: 10.1016/j.biochi.2016.04.010_bib32 article-title: Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study publication-title: Diabetologia doi: 10.1007/s00125-007-0793-y – volume: 351 start-page: 834 issue: 9105 year: 1998 ident: 10.1016/j.biochi.2016.04.010_bib17 article-title: Folic acid food fortification to prevent neural tube defects publication-title: Lancet (London, England) doi: 10.1016/S0140-6736(05)78966-2 – volume: 106 start-page: 15424 issue: 36 year: 2009 ident: 10.1016/j.biochi.2016.04.010_bib6 article-title: The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0902072106 – volume: 50 start-page: 739 issue: 7 year: 1993 ident: 10.1016/j.biochi.2016.04.010_bib11 article-title: Subacute combined degeneration with high serum vitamin B12 level and abnormal vitamin B12 binding protein. New cause of an old syndrome publication-title: Arch. Neurol. doi: 10.1001/archneur.1993.00540070055015 – ident: 10.1016/j.biochi.2016.04.010_bib21 – year: 2015 ident: 10.1016/j.biochi.2016.04.010_bib1 – volume: 58 start-page: 275 issue: 3 year: 2002 ident: 10.1016/j.biochi.2016.04.010_bib10 article-title: Microbial production of vitamin B12 publication-title: Appl. Microbiol. Biotechnol. doi: 10.1007/s00253-001-0902-7 – volume: 340 start-page: 1449 issue: 19 year: 1999 ident: 10.1016/j.biochi.2016.04.010_bib20 article-title: The effect of folic acid fortification on plasma folate and total homocysteine concentrations publication-title: N. Engl. J. Med. doi: 10.1056/NEJM199905133401901 – volume: 10 start-page: e0143738 issue: 11 year: 2015 ident: 10.1016/j.biochi.2016.04.010_bib44 article-title: High dietary folate in mice alters immune response and reduces survival after malarial infection publication-title: PLoS One doi: 10.1371/journal.pone.0143738 – volume: 20 start-page: 123 year: 1982 ident: 10.1016/j.biochi.2016.04.010_bib8 article-title: Modulation of methylenetetrahydrofolate reductase activity by S-adenosylmethionine and by dihydrofolate and its polyglutamate analogues publication-title: Adv. Enzyme Regul. doi: 10.1016/0065-2571(82)90012-7 – volume: 87 start-page: 517 issue: 3 year: 2008 ident: 10.1016/j.biochi.2016.04.010_bib4 article-title: Is folic acid good for everyone? publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/87.3.517 – volume: 63 start-page: 2 issue: 1 year: 2008 ident: 10.1016/j.biochi.2016.04.010_bib43 article-title: Will increasing folic acid in fortified grain products further reduce neural tube defects without causing harm?: consideration of the evidence publication-title: Pediatr. Res. doi: 10.1203/PDR.0b013e31815b8ec5 – volume: 65 start-page: 1790 issue: 6 year: 1997 ident: 10.1016/j.biochi.2016.04.010_bib7 article-title: Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/65.6.1790 – volume: 60 start-page: 1457 issue: 8 year: 2012 ident: 10.1016/j.biochi.2016.04.010_bib31 article-title: Vitamin B-12 and folate status in relation to decline in scores on the mini-mental state examination in the framingham heart study publication-title: J. Am. Geriatr. Soc. doi: 10.1111/j.1532-5415.2012.04076.x – volume: 39 start-page: 661 issue: 3 year: 2014 ident: 10.1016/j.biochi.2016.04.010_bib26 article-title: Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: combined data from three cohorts publication-title: J. Alzheimer's Dis. JAD doi: 10.3233/JAD-131265 – start-page: 237 year: 1995 ident: 10.1016/j.biochi.2016.04.010_bib12 article-title: Folate cobalamin interactions – year: 2015 ident: 10.1016/j.biochi.2016.04.010_bib38 – volume: 270 start-page: 2693 issue: 22 year: 1993 ident: 10.1016/j.biochi.2016.04.010_bib41 article-title: Vitamin status and intake as primary determinants of homocysteinemia in an elderly population publication-title: JAMA doi: 10.1001/jama.1993.03510220049033 – volume: 82 start-page: 442 issue: 2 year: 2005 ident: 10.1016/j.biochi.2016.04.010_bib25 article-title: Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999–2000 publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/82.2.442 – volume: 88 start-page: 357 issue: 5 year: 1995 ident: 10.1016/j.biochi.2016.04.010_bib15 article-title: Does folic acid harm people with vitamin B12 deficiency? publication-title: QJM Mon. J. Assoc. Physicians – volume: 118 start-page: 5912 issue: 23 year: 2012 ident: 10.1016/j.biochi.2016.04.010_bib40 article-title: Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake publication-title: Cancer doi: 10.1002/cncr.27621 – volume: 90 start-page: 1586 issue: 6 year: 2009 ident: 10.1016/j.biochi.2016.04.010_bib29 article-title: Metabolic evidence of vitamin B-12 deficiency, including high homocysteine and methylmalonic acid and low holotranscobalamin, is more pronounced in older adults with elevated plasma folate publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.2009.27514 – volume: 311 start-page: 949 issue: 7010 year: 1995 ident: 10.1016/j.biochi.2016.04.010_bib14 article-title: No reliable evidence that folate is harmful in B-12 deficiency publication-title: BMJ (Clinical Research ed.) doi: 10.1136/bmj.311.7010.949a – volume: 138 start-page: 2323 issue: 12 year: 2008 ident: 10.1016/j.biochi.2016.04.010_bib35 article-title: A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate publication-title: J. Nutr. doi: 10.3945/jn.108.096404 – volume: 132 start-page: 2792 issue: 9 year: 2002 ident: 10.1016/j.biochi.2016.04.010_bib22 article-title: Folic acid intake from fortification in United States exceeds predictions publication-title: J. Nutr. doi: 10.1093/jn/132.9.2792 – volume: 85 start-page: 193 issue: 1 year: 2007 ident: 10.1016/j.biochi.2016.04.010_bib23 article-title: Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/85.1.193 – year: 1997 ident: 10.1016/j.biochi.2016.04.010_bib24 – volume: 82 start-page: 527 issue: 7 year: 2008 ident: 10.1016/j.biochi.2016.04.010_bib18 article-title: Trends in the postfortification prevalence of spina bifida and anencephaly in the United States publication-title: Birth Defects Res. Part A Clin. Mol. Teratol. doi: 10.1002/bdra.20468 – volume: 30 start-page: 102 year: 2016 ident: 10.1016/j.biochi.2016.04.010_bib47 article-title: High folic acid intake reduces natural killer cell cytotoxicity in aged mice publication-title: J. Nutr. Biochem. doi: 10.1016/j.jnutbio.2015.12.006 – volume: 5 start-page: 289 year: 2014 ident: 10.1016/j.biochi.2016.04.010_bib3 article-title: Maternal methyl supplemented diets and effects on offspring health publication-title: Front. Genet. doi: 10.3389/fgene.2014.00289 – volume: 29 start-page: S67 issue: 2 Suppl. year: 2008 ident: 10.1016/j.biochi.2016.04.010_bib27 article-title: The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status publication-title: Food Nutr. Bull. doi: 10.1177/15648265080292S110 – volume: 61 start-page: 577 issue: 4 year: 2013 ident: 10.1016/j.biochi.2016.04.010_bib30 article-title: Advanced age as a risk factor for folate-associated functional cobalamin deficiency publication-title: J. Am. Geriatr. Soc. doi: 10.1111/jgs.12155 – volume: 89 start-page: 702s issue: 2 year: 2009 ident: 10.1016/j.biochi.2016.04.010_bib28 article-title: Folate-vitamin B-12 interaction in relation to cognitive impairment, anemia, and biochemical indicators of vitamin B-12 deficiency publication-title: Am. J. Clin. Nutr. doi: 10.3945/ajcn.2008.26947C – volume: 136 start-page: 189 issue: 1 year: 2006 ident: 10.1016/j.biochi.2016.04.010_bib37 article-title: Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women publication-title: J. Nutr. doi: 10.1093/jn/136.1.189 – volume: 102 start-page: 227 issue: 2644 year: 1945 ident: 10.1016/j.biochi.2016.04.010_bib5 article-title: Synthesis of a compound identical with the L. Casei factor isolated from liver publication-title: Science doi: 10.1126/science.102.2644.227 – volume: 104 start-page: 19995 issue: 50 year: 2007 ident: 10.1016/j.biochi.2016.04.010_bib49 article-title: In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0709487104 – volume: 97 start-page: 47 issue: 1 year: 2013 ident: 10.1016/j.biochi.2016.04.010_bib45 article-title: Moderately high intake of folic acid has a negative impact on mouse embryonic development publication-title: Birth Defects Res. A Clin. Mol. Teratol. doi: 10.1002/bdra.23092 – volume: 85 start-page: 1098 issue: 4 year: 2007 ident: 10.1016/j.biochi.2016.04.010_bib39 article-title: A functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users publication-title: Am. J. Clin. Nutr. doi: 10.1093/ajcn/85.4.1098 |
| SSID | ssj0005029 |
| Score | 2.5267453 |
| SecondaryResourceType | review_article |
| Snippet | The recent increase in the intake of folic acid by the general public through fortified foods and supplements, has raised safety concern based on early reports... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 71 |
| SubjectTerms | Aging - genetics Aging - immunology Aging - pathology anemia Australia Base Sequence Breast Neoplasms - chemically induced Breast Neoplasms - genetics Breast Neoplasms - immunology Breast Neoplasms - pathology central nervous system diseases cohort studies elderly erythrocytes Female Folate Folic acid Folic Acid - adverse effects Folic Acid - therapeutic use fortified foods genes genetic background Homocysteine homozygosity Humans India insulin resistance Killer Cells, Natural - immunology Killer Cells, Natural - pathology Latinos memory Methylmalonic acid National Health and Nutrition Examination Survey natural killer cells Neoplasm Proteins - genetics Neoplasm Proteins - immunology Polymorphism, Genetic pregnancy progeny risk Sequence Deletion Tetrahydrofolate Dehydrogenase - genetics Tetrahydrofolate Dehydrogenase - immunology Vitamin B12 women World Health Organization |
| Title | Excessive folic acid intake and relation to adverse health outcome |
| URI | https://dx.doi.org/10.1016/j.biochi.2016.04.010 https://www.ncbi.nlm.nih.gov/pubmed/27131640 https://www.proquest.com/docview/1795860395 https://www.proquest.com/docview/1825434530 |
| Volume | 126 |
| WOSCitedRecordID | wos000378963500012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: ScienceDirect database customDbUrl: eissn: 1638-6183 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0005029 issn: 0300-9084 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLbYhgQ8IOi4jMtkJMRbUBLn5sduKmIITUgM1DfLcWwt25pUbTp1_55zYiepmMrggRerShw38uccn2N__g4h7wOZRkbq1ENv34tin3l5bjKPmYIVKii0bnW6f35NT0-z6ZR_c_nylm06gbSqsvWaz_8r1HANwMajs_8Ad98oXIDfADqUADuUfwX8ZI3Mf6vmjQrWUpWor9TIS7tTsHD0N_Q6JaZjRtVhexipXjXqN_WCo7JW5-Ws7PH_rq_OV7kl2Ko6HzZslgNX7ARlhd2xB7eiECQ9-xQmBGsF4aOEmNJmmOnNZLhp6GzelFv21y4FXHzM25dD5lzSKsla6upG789nbfeHECNDwOYPs1HPEexu7ZC9MI05WKy98clk-mUg8Pgh7w5Dtoy923-KUs-umW1-x7a4ovUvzp6Qxy4woGML6FNyT1cjsj-uZFPPbugH2lJ12z2QEXlw3KXpG5FHG4qS--SoR5-26FNEn1r0KaBPO_RpU1OHPrXoU4f-M_Lj0-Ts-LPn0mR4KkqCxityKQMFnmCSaxTcw5Upk0RGZzJUxoTGoFMYQ5WCMygVYwWPwI4XQcYLrtlzslvVlX5JKEt0oEPFlWEQtksmE3BfA5lnsuDoyhwQ1nWiUE5DHlOZXImOLHghLAoCURB-JACFA-L1T82thsod9dMOH-H8QOvfCRhmdzz5roNTAAy49yUrXa-WAuadOEt8xuM_1MHVEhbFDNp5YcdC_77dMHq19c5r8nD4mN6Q3Wax0m_JfXXdlMvFIdlJp9mhG8K_AMUzl60 |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Excessive+folic+acid+intake+and+relation+to+adverse+health+outcome&rft.jtitle=Biochimie&rft.au=Selhub%2C+Jacob&rft.au=Rosenberg%2C+Irwin+H&rft.date=2016-07-01&rft.eissn=1638-6183&rft.volume=126&rft.spage=71&rft_id=info:doi/10.1016%2Fj.biochi.2016.04.010&rft_id=info%3Apmid%2F27131640&rft.externalDocID=27131640 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0300-9084&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0300-9084&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0300-9084&client=summon |