Bioactive natural products from marine sponges belonging to family Hymedesmiidae

Natural products of marine origin exhibit extensive biological activities, and display a vital role in the exploration of new compounds for drug development. Marine sponges have been reported at the top with respect to the discovery of biologically active metabolites that have potential pharmaceutic...

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Vydané v:RSC advances Ročník 11; číslo 27; s. 16179 - 16191
Hlavní autori: Elgoud Said, Asmaa Abo, Mahmoud, Basma Khalaf, Attia, Eman Zekry, Abdelmohsen, Usama Ramadan, Fouad, Mostafa Ahmed
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Royal Society of Chemistry 30.04.2021
The Royal Society of Chemistry
Predmet:
Antiinfectives and antibacterials
Biological activity
Chemistry
Demospongiae
diterpenoids
drug development
Marine biology
Metabolites
Natural products
secondary metabolites
Sponges
ISSN:2046-2069, 2046-2069
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Shrnutí:Natural products of marine origin exhibit extensive biological activities, and display a vital role in the exploration of new compounds for drug development. Marine sponges have been reported at the top with respect to the discovery of biologically active metabolites that have potential pharmaceutical applications. The family Hymedesmiidae belonging to the Demospongiae class includes ten accepted genera, of which four genera were explored for their bioactive metabolites, namely Phorbas , Hamigera , Hemimycale , and Kirkpatrickia . Genus Phorbas has received more attention due to the isolation of various classes of compounds with unique structures mainly diterpenes, alkaloids, sesterterpenes, and steroids that exhibited diverse biological activities including: antiviral, antimicrobial, and anti-inflammatory, whereas anticancer compounds predominated. This review focuses on the isolated secondary metabolites from family Hymedesmiidae with their biological potential and covers the literature from 1989 to 2020. Natural products of marine origin exhibit extensive biological activities, and display a vital role in the exploration of new compounds for drug development.
Bibliografia:10.1039/d1ra00228g
Electronic supplementary information (ESI) available. See DOI
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ISSN:2046-2069
2046-2069
DOI:10.1039/d1ra00228g